Fitoplancton del mar peruano, verano 2010

Los volúmenes de plancton presentaron un rango entre 0,008 y 5,251 mL.m-3 localizados frente a Punta La Negra y Salaverry, promedio 0,61 mL.m-3. El fitoplancton de red fue muy abundante y predominó en el 52% de las estaciones costeras conformado por especies de afloramiento. A 10 m de profundidad el fitoplancton registró una variación entre 69,32x103 cels.L-1 (San Juan) y 2.439,76x103 cels.L-1 (Chimbote), diversidad (H’) entre 0,05 bits.cel-1 (1 mn de Ilo) y 2,84 bits.cel-1 (7 mn de San Juan), y uniformidad entre 0,02 (Ilo) y 0,921 (San Juan). Las diatomeas Cerataulina pelagica y Chaetoceros spp. fueron las que aportaron las mayores densidades celulares en la zona costera. La distribución de los indicadores biológicos demostraron una relación con las condiciones ambientales, cuando Protoperidinium obtusum, indicador de Aguas Costeras Frías (ACF) se distribuyó desde Paita hasta Mollendo (30 mn), Ceratium breve, indicador de AES fue registrado de manera normal al norte de los 6°S asociado en algunas estaciones a Ceratium praelongum y C. incisum, indicadores de Aguas Subtropicales Superficiales (ASS).

A participatory approach to tactical forest planning

Jyrki Kangas ... [et al.]

Pièces relatives à l'histoire de la ville de TULLE. III

Contient : Pièces diverses ; originaux et copies, parmi lesquels on remarque les suivants : ; Notice généalogique sur la maison d'Aubusson ; Généalogie de la famille de Varie ; Extrait des titres de la maison de Sainte-Aulaire ; Mandement d'André-Daniel de Sainte-Aulaire, évêque de Tulle, touchant l'usage des oeufs durant le carême (25 février 1710) ; Billet d'invitation au sacre dudit évêque (29 octobre 1702) ; imprimé ; Extrait des archives de Pompadour ; Extrait de registres d'hommages de l'évêché de Limoges ; Extrait des archives de Pompadour ; Billet d'invitation aux obsèques d'Antoine de Baluze, résident à la cour de Pologne (13 septembre 1681) ; imprimé ; Deux lettres d'A[ndré]-D[aniel de Sainte-Aulaire], évêque de Tulle, à Baluze (7 novembre 1715 et 4 juillet 1710) ; originaux ; Lettre du maréchal-duc de la Feuillade à Baluze (Versailles, 22 décembre 1688) ; original ; Lettre de Teyssier de Regis à Baluze (Uzerche, 21 janvier 1689) ; original ; Billet du maréchal-duc de La Feuillade à Baluze (24 février 1687) ; Extrait d'un registre du Trésor des chartes, certifié par G.-J.-B. de Goth, duc d'Epernon (20 février 1687), envoyé par lui au maréchal de La Feuillade ; Lettre de Duverdier à Baluze (Tulle, 14 février 1686) ; Deux lettres de l'abbé de Fouilhac à Baluze (s. d.) ; « Harangue prononcée dans l'officialité de Tulle par Me Jean-Baptiste Brossard, » copie de la main de Baluze ; « Carmen in laudem J.-B. Brossard, » en vers latins ; page détachée d'un imprimé ; Recueil de copies de la main de Baluze : ; Lettre de M. Lejeune, sans adresse (Paris, 7 avril 1674) ; Harangue prononcée par devant messieurs du chapitre de Tulle par Me Etienne Courrèze ; Harangue adressée à Mascaron, lors de son avènement au siège de Tulle, par le doyen de cette ville, Pierre de La Rue (1672) ; Harangue prononcée par M. le conseiller Lagarde au jour de son installation (4 septembre 1674) ; Requête burlesque de Me Jean-Baptiste Brossard à messieurs du sénéchal et du présidial de Tulle ; Mandement du roi au trésorier de l'Épargne de payer au sieur Baluze la somme de mille livres (26 octobre 1663) ; Deux quittances délivrées par Guillaume, évêque de Tarse, au nom d'Etienne Baluze (1540) ; originaux, parchemin ; Quittance donnée par les syndics de l'église de Tulle à M. Baluze, commissaire enquêteur au sénéchal de ladite ville (21 novembre 1625) ; Généalogie de la famille Baluze ; Lettre de M. de Fenis à M. Baluze, avocat à Tulle (Bordeaux, 7 mars 1596) ; original ; Pièces concernant Antoine de Baluze : ; Deux lettres écrites [à Et. Baluze ?] de Varsovie par J.-C. de Baluze (s. d. et 12 juin 1716) ; Mémoire envoyé par le même original ; Lettre de [Marie-Louise], reine de Pologne à Louis XIV (28 janvier 1662) ; Lettre de J.-C. Baluze (19 décembre 1683) ; Lettre de recommandation [du roi de Pologne] pour Baluze ; Lettre de Jean-Casimir, roi de Pologne, à [Henri de la Motte-Houdancourt], archevêque d'Auch (18 mai 1663) ; Lettres du même à Louis XIV (20 janvier 1662 et 11 janvier 1664) ; Lettre du même au cardinal Mazarin (12 juillet 1660) ; original ; Lettre sans adresse de François Le Hérisson (Léopol en Russie, 30 novembre 1662) ; Note sur la carrière d'Antoine de Baluze en Pologne ; Deux lettres écrites de Varsovie par J.-C. Baluze (16 novembre et 31 août 1714) ; Notice, de la main de Baluze, sur son cousin Antoine Baluze ; Notice du même sur Jean-Casimir Baluze, fils d'Antoine ; Dissertatio de sanctis Claro, Laudo, Vlfardo, Baumado, par Et. Baluze ; imprimé, Tulle, 1656, 40 pages in-8° ; « Noel paschal, ou hymne sacro-burlesque pour l'heureux avènement de Monseigneur de Tulle [Louis de Rechignevoisin de Guron] en son evesché, par le sieur de Chateaunières, » envoyé d'Uzerche le 29 juin 1654

"Meditatiunculae Guidi Ubaldi ex pmarchionibus Montis Sanctae Mari de rebus mathematicis".

Saisi en 1798 dans la bibliothèque de la famille Albani à Rome; cf. B.n.F., département des Manuscrits, Archives Modernes 520; Laffitte, Bulletin du Bibliophile, 1989/2, 309.

Prospective study evaluating the predictability of need for retreatment with intravitreal ranibizumab for age-related macular degeneration.

PURPOSE: To investigate the rhythm and predictability of the need for retreatment with intravitreal injections of ranibizumab for neovascular age-related macular degeneration (nAMD). METHODS: This prospective study enrolled 39 patients with treatment-naïve nAMD. After three loading doses of intravitreal ranibizumab, patients underwent an intensified follow-up for 12 months (initially weekly, then with stepwise increases to every 2 weeks and to monthly after each injection). Patients were retreated on an as-needed basis if any fluid or increased central retinal thickness (CRT) (>50 μm) was found on spectral domain optical coherence tomography (OCT). Statistical analysis included patients who received at least two retreatments (five injections). RESULTS: A mean of 7.5 injections (range 0-12) were given between months 3 and 15. The mean visual acuity increased by 13.1 and 12.6 ETDRS letters at months 12 and 15 respectively. Two or more injection-retreatment intervals were found in 31 patients. The variability of their intra-individual intervals up to 14 weeks was small (SD 0-2.13 weeks), revealing a high regularity of the retreatment rhythm. The SD was correlated with the mean interval duration (r = 0.89, p < 0.001). The first interval was a good predictor of the following intervals (regression coefficient =0.81). One retreatment criterion was stable in 97 % of patients (cysts or subretinal fluid). CONCLUSION: The results of this study demonstrate a high intra-individual predictability of retreatment need with ranibizumab injections for nAMD. These findings may be helpful for developing individualized treatment plans for maintained suppression of disease activity with a minimum of injections and visits.

Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula.

The most widely used formula for estimating glomerular filtration rate (eGFR) in children is the Schwartz formula. It was revised in 2009 using iohexol clearances with measured GFR (mGFR) ranging between 15 and 75 ml/min × 1.73 m(2). Here we assessed the accuracy of the Schwartz formula using the inulin clearance (iGFR) method to evaluate its accuracy for children with less renal impairment comparing 551 iGFRs of 392 children with their Schwartz eGFRs. Serum creatinine was measured using the compensated Jaffe method. In order to find the best relationship between iGFR and eGFR, a linear quadratic regression model was fitted and a more accurate formula was derived. This quadratic formula was: 0.68 × (Height (cm)/serum creatinine (mg/dl))-0.0008 × (height (cm)/serum creatinine (mg/dl))(2)+0.48 × age (years)-(21.53 in males or 25.68 in females). This formula was validated using a split-half cross-validation technique and also externally validated with a new cohort of 127 children. Results show that the Schwartz formula is accurate until a height (Ht)/serum creatinine value of 251, corresponding to an iGFR of 103 ml/min × 1.73 m(2), but significantly unreliable for higher values. For an accuracy of 20 percent, the quadratic formula was significantly better than the Schwartz formula for all patients and for patients with a Ht/serum creatinine of 251 or greater. Thus, the new quadratic formula could replace the revised Schwartz formula, which is accurate for children with moderate renal failure but not for those with less renal impairment or hyperfiltration.

Microrganismos solubilizadores de fosfatos e o crescimento de pínus e eucalipto

Os microrganismos solubilizadores de fosfatos desempenham importante papel no suprimento de fósforo para as plantas. Isso tem motivado pesquisas em programas de inoculação controlada. O processo de seleção envolve várias etapas. Microrganismos isolados de cultivos de Pinus e Eucalyptus e selecionados em meio de cultura foram avaliados em 28 experimentos realizados em casa de vegetação com substrato ou solo de floresta ou de viveiro, esterilizados, sem ou com adubação fosfatada (fosfato monocálcico, fosfato de Araxá ou de Catalão). Em relação à produção de matéria seca, em um experimento, houve efeito positivo de três isolados (177, 251 e 310A); em outro, verificou-se efeito negativo de dois isolados (177 e 261). No teor de P no tecido foi verificado efeito positivo em sete tratamentos, envolvendo oito isolados (62, 177, 189, 198, 251, 262, 310A e 310B) e dois efeitos negativos (177 e 198). Quanto ao conteúdo de P na planta, foram verificados efeitos positivos em quatro experimentos, envolvendo os isolados 62, 189, 198, 251 e 310A. Os resultados obtidos na nutrição e no crescimento das plantas com a inoculação dos isolados 62, 189, 251 e 310A indicam a existência de potencial para ser utilizado em processos de seleção que visem à produção de inoculantes.

Occurrence and molecular diversity of the Fit insect toxin locus in plant-beneficial pseudomonads

The application of plant-beneficial pseudomonads provides a promising alternative to chemical pest management in agriculture. The fact that Pseudomonas fluorescens CHA0 and Pf-5, both well-known biocontrol agents of fungal root diseases, exhibit also potent insecticidal activity is of particular interest, as these plant-beneficial bacteria naturally colonize the rhizosphere of important crop plants. Insecticidal activity in these strains depends on a novel locus encoding the production of a protein toxin termed Fit (for P. fluorescens insecticidal toxin). To gain a better understanding of the ecological relevance of the Pseudomonas anti-insect activity, we have begun to investigate the occurrence and molecular diversity of the Fit toxin genes among root-associated pseudomonads. To this end, we have screened a large world-wide collection of fluorescent Pseudomonas sp. isolated from the roots of different plant species using molecular fingerprinting techniques. The strains are already well characterized for exoproduct patterns and disease-suppressive ability and are currently being tested for insecticidal activity in a greater wax moth larvae assay system.

Is Less Chemotherapy Detrimental in Adults with Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) Treated with High-Dose Imatinib? Results of the Prospective Randomized Graaph-2005 Study

Aim: To compare a less intensive regimen based on high-dose imatinib (IM) to an intensive IM/HyperCVAD regimen in adults with Ph+ ALL, in terms of early response and outcome after stem cell transplantation (SCT). Methods: Patients aged 18-60 years with previously untreated Ph+ ALL not evolving from chronic myeloid leukemia were eligible if no contra-indication to chemotherapy and SCT (ClinicalTrials.gov ID, NCT00327678). After a steroid prephase allowing Ph and/or BCR-ABL diagnosis, cycle 1 differed between randomization arms. In arm A (IM-based), IM was given at 800 mg on day 1-28, combined with vincristine (2 mg, day 1, 8, 15, 22) and dexamethasone (40 mg, day 1-2, 8-9, 15-16, and 22-23) only. In arm B (IM/HyperCVAD), IM was given at 800 mg on day 1-14, combined with adriamycin (50 mg/m2, day 4), cyclophosphamide (300 mg/m2/12h, day 1, 2, 3), vincristine (2 mg, day 4 and 11), and dexamethasone (40 mg, day 1-4 and 11-14). All patients received a cycle 2 combining high-dose methotrexate (1 g/m2, day 1) and AraC (3 g/m2/12h, day 2 and 3) with IM at 800 mg on day 1-14, whatever their response. Four intrathecal infusions were given during this induction/consolidation period. Minimal residual disease (MRD) was centrally evaluated by quantitative RQ-PCR after cycle 1 (MRD1) and cycle 2 (MRD2). Major MRD response was defined as BCR-ABL/ABL ratio <0.1%. Then, all patients were to receive allogeneic SCT using related or unrelated matched donor stem cells or autologous SCT if no donor and a major MRD2 response. IM/chemotherapy maintenance was planned after autologous SCT. In the absence of SCT, patients received alternating cycles 1 (as in arm B) and cycles 2 followed by maintenance, like in the published IM/HyperCVAD regimen. The primary objective was non-inferiority of arm A in term of major MRD2 response. Secondary objectives were CR rate, SCT rate, treatment- and transplant-related mortality, relapse-free (RFS), event-free (EFS) and overall (OS) survival. Results: Among the 270 patients randomized between May 2006 and August 2011, 265 patients were evaluable for this analysis (133 arm A, 132 arm B; median age, 47 years; median follow-up, 40 months). Main patient characteristics were well-balanced between both arms. Due to higher induction mortality in arm B (9 versus 1 deaths; P=0.01), CR rate was higher in the less intensive arm A (98% versus 89% after cycle 1 and 98% versus 91% after cycle 2; P= 0.003 and 0.006, respectively). A total of 213 and 205 patients were evaluated for bone marrow MRD1 and MRD2. The rates of patients reaching major MRD response and undetectable MRD were 45% (44% arm A, 46% arm B; P=0.79) and 10% (in both arms) at MRD1 and 66% (68% arm A, 63.5% arm B; P=0.56) and 25% (28% arm A, 22% arm B; P=0.33) at MRD2, respectively. The non-inferiority primary endpoint was thus demonstrated (P= 0.002). Overall, EFS was estimated at 42% (95% CI, 35-49) and OS at 51% (95% CI, 44-57) at 3 years, with no difference between arm A and B (46% versus 38% and 53% versus 49%; P=0.25 and 0.61, respectively). Of the 251 CR patients, 157 (80 arm A, 77 arm B) and 34 (17 in both arms) received allogeneic and autologous SCT in first CR, respectively. Allogeneic transplant-related mortality was similar in both arms (31.5% versus 22% at 3 years; P=0.51). Of the 157 allografted patients, 133 had MRD2 evaluation and 89 had MRD2 <0.1%. In these patients, MRD2 did not significantly influence post-transplant RFS and OS, either when tested with the 0.1% cutoff or as a continuous log covariate. Of the 34 autografted patients, 31 had MRD2 evaluation and, according to the protocol, 28 had MRD2 <0.1%. When restricting the comparison to patients achieving major MRD2 response and with the current follow-up, a trend for better results was observed after autologous as compared to allogeneic SCT (RFS, 63% versus 49.5% and OS, 69% versus 58% at 3 years; P=0.35 and P=0.08, respectively). Conclusions: In adults, the use of TK inhibitors (TKI) has markedly improved the results of Ph+ ALL therapy, now close to those observed in Ph-negative ALL. We demonstrated here that chemotherapy intensity may be safely reduced when associated with high-dose IM. We will further explore this TKI-based strategy using nilotinib prior to SCT in our next GRAAPH-2013 trial. The trend towards a better outcome after autologous compared to allogeneic SCT observed in MRD responders validates MRD as an important early surrogate endpoint for treatment stratification and new drug investigation in this disease.

Mémoire sur la vallée de Carol dépendante de la Cerdagne françoise

Ancien possesseur : Argenson, Antoine-René de Voyer (1722-1787 ; marquis de Paulmy d')

EEG Patterns and Imaging Correlations in Encephalopathy: Encephalopathy Part II.

SUMMARY:: The EEG patterns seen with encephalopathies can be correlated to cerebral imaging findings including head computerized tomography and MRI. Background slowing without slow-wave intrusion is seen with acute and chronic cortical impairments that spare subcortical white matter. Subcortical/white matter structural abnormalities or hydrocephalus may produce projected slow-wave activity, while clinical entities involving both cortical and subcortical regions (diffuse cerebral abnormalities) engender both background slowing and slow-wave activity. Triphasic waves are seen with hepatic and renal insufficiency or medication toxicities (e.g., lithium, baclofen) in the absence of a significant cerebral imaging abnormality, Conversely, subcortical/white matter abnormalities may facilitate the appearance of triphasic waves without significant hepatic, renal, or toxic comorbidities. More specific syndromes, such as Jakob-Creutzfeldt disease, autoimmune limbic encephalitis, autoimmune corticosteroid-responsive encephalopathy with thyroid autoimmunity, sepsis-associated encephalopathy, and acute disseminated encephalomyelitis, have imaging/EEG changes that are variable but which may include slowing and epileptiform activity. This overview highlighting EEG-imaging correlations may help the treating physician in the diagnosis, and hence the appropriate treatment, of patients with encephalopathy.