983 resultados para 60-459
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Vorbesitzer: Abraham Merzbacher
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Vorbesitzer: Bartholomaeusstift Frankfurt am Main;
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Welsch (Projektbearbeiter): "Der Verfasser appelliert an Bürger und Soldaten, Freundschaft miteinander zu schließen. Besonders die Soldaten erinnert er daran, daß sie auch Bürgersöhne sind, und daß sie ihre Gleichstellung mit den adligen Offizieren nur den Berliner Bürgern zu verdanken haben und deshalb nicht gegen sie kämpfen dürfen." [Führer, B.: Das Berlinische im Tagesschrifttum von 1848/49, S. 302]
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Welsch (Projektbearbeiter): Die bevorstehenden Wahlen sollen Ruhe, Ordnung und Gesetzmäßigkeit zeitigen; das Gleichgewicht zwischen Volk und Regierung nicht durch Übergriffe gestört werden. Daher sollen nur solche Wahlmänner gewählt werden, die für eine konstitutionelle Monarchie und die oktroyierte Verfassung eintreten.
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Welsch (Projektbearbeiter): Wahlprogramm von fünf Urwählern des sechzigsten Berliner Bezirks: die Verfassung vom 5. Dezember 1848 wird nicht in Frage gestellt, ist aber nur ein Entwurf, der der Weiterentwicklung bedarf. Mängel sind: die fehlende Diätenregelung ermöglicht faktisch nur Reichen die Mitgliedschaft in der ersten Kammer, das Ministerium kann bei Abwesenheit der Kammern Verordnungen mit Gesetzeskraft erlassen, das Steuerbewilligungsrecht der Kammern ist massiv eingeschränkt, Artikel 110 stellt wesentliche Grundrechte (Freiheit der Person, Unverletzlichkeit der Wohnung, Presse- und Vereinigungsfreiheit) zur Disposition. Ablehnung der beiden Extreme des Scheinkonstitutionalismus und der Anarchie.
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BACKGROUND Acute myeloid leukaemia mainly affects elderly people, with a median age at diagnosis of around 70 years. Although about 50-60% of patients enter first complete remission upon intensive induction chemotherapy, relapse remains high and overall outcomes are disappointing. Therefore, effective post-remission therapy is urgently needed. Although often no post-remission therapy is given to elderly patients, it might include chemotherapy or allogeneic haemopoietic stem cell transplantation (HSCT) following reduced-intensity conditioning. We aimed to assess the comparative value of allogeneic HSCT with other approaches, including no post-remission therapy, in patients with acute myeloid leukaemia aged 60 years and older. METHODS For this time-dependent analysis, we used the results from four successive prospective HOVON-SAKK acute myeloid leukaemia trials. Between May 3, 2001, and Feb 5, 2010, a total of 1155 patients aged 60 years and older were entered into these trials, of whom 640 obtained a first complete remission after induction chemotherapy and were included in the analysis. Post-remission therapy consisted of allogeneic HSCT following reduced-intensity conditioning (n=97), gemtuzumab ozogamicin (n=110), chemotherapy (n=44), autologous HSCT (n=23), or no further treatment (n=366). Reduced-intensity conditioning regimens consisted of fludarabine combined with 2 Gy of total body irradiation (n=71), fludarabine with busulfan (n=10), or other regimens (n=16). A time-dependent analysis was done, in which allogeneic HSCT was compared with other types of post-remission therapy. The primary endpoint of the study was 5-year overall survival for all treatment groups, analysed by a time-dependent analysis. FINDINGS 5-year overall survival was 35% (95% CI 25-44) for patients who received an allogeneic HSCT, 21% (17-26) for those who received no additional post-remission therapy, and 26% (19-33) for patients who received either additional chemotherapy or autologous HSCT. Overall survival at 5 years was strongly affected by the European LeukemiaNET acute myeloid leukaemia risk score, with patients in the favourable risk group (n=65) having better 5-year overall survival (56% [95% CI 43-67]) than those with intermediate-risk (n=131; 23% [19-27]) or adverse-risk (n=444; 13% [8-20]) acute myeloid leukaemia. Multivariable analysis with allogeneic HSCT as a time-dependent variable showed that allogeneic HSCT was associated with better 5-year overall survival (HR 0·71 [95% CI 0·53-0·95], p=0·017) compared with non-allogeneic HSCT post-remission therapies or no post-remission therapy, especially in patients with intermediate-risk (0·82 [0·58-1·15]) or adverse-risk (0.39 [0·21-0·73]) acute myeloid leukaemia. INTERPRETATION Collectively, the results from these four trials suggest that allogeneic HSCT might be the preferred treatment approach in patients 60 years of age and older with intermediate-risk and adverse-risk acute myeloid leukaemia in first complete remission, but the comparative value should ideally be shown in a prospective randomised study. FUNDING None.
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Montesquieu
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Max Eschelbacher
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Josef Lin
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Josef Meisl
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Karl Schwarz
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Selma Stern
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E. S.
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Max Bernheimer
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S.