Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93.

BACKGROUND: The International Breast Cancer Study Group (IBCSG) conducted two complementary randomized trials to assess whether a treatment-free gap during adjuvant chemotherapy influenced outcome. PATIENTS AND METHODS: From 1993 to 1999, IBCSG Trials 13-93 and 14-93 enrolled 2215 premenopausal and postmenopausal women with axillary node-positive, operable breast cancer. All patients received cyclophosphamide (Cytoxan, C) plus either doxorubicin (Adriamycin, A) or epirubicin (E) for four courses followed immediately (No Gap) or after a 16-week delay (Gap) by classical cyclophosphamide, methotrexate, and fluorouracil (CMF) for three courses. The median follow-up was 7.7 years. RESULTS: The Gap and No-Gap groups had similar disease-free survival (DFS) and overall survival (OS). No identified subgroup showed a statistically significant difference, but exploratory subgroup analysis noted a trend towards decreased DFS for Gap compared with No Gap for women with estrogen receptor (ER)-negative tumors not receiving tamoxifen, especially evident during the first 2 years. CONCLUSIONS: A 16-week gap between adjuvant AC/EC and CMF provided no benefit and may have increased early recurrence rates in patients with ER-negative tumors.

Lottery Action, Vol. 15, no. 14 July 12-August 3, 2008

Iowa Lottery Authority Newsletter For Lottery Retailers

Kansanedustaja Pertti Salolainen 14/4 1971

Kirje 14.4.1971

EPI Update, November 14, 2008

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Fil. dr Johannes Salminen 14.2.1967 Härstädes

Kirje

Evaluación de la contaminación marina en la Bahía Ferrol, Chimbote. 14 - 18 Julio 1994

Evalúa la calidad del medio marino en la Bahía de Ferrol, Chimbote; donde se realizó un muestreo simultáneo por mar y playa, durantre una época de intensa actividad industrial pesquera. Los resultados del análisis concluyen en que la bahía presenta signos serios de deterioro ambiental, con el desarrollo de procesos eutróficos que conllevan a una pérdida de condiciones ambientales apropiadas, en perjuicio de los recursos hidrobiológicos costeros.

Maaherra Urho Kiukas 14/6 1966

Kirje 14.6.1966

The lesser cotton leafworm, Anomis impasta (Guenée) (Lepidoptera, Noctuidae), in cotton

Anomis impasta (Guenée) is a species that shows remarkable morphological and behavioral similarities with the cotton leafworm Alabama argillacea (Hübner). During two growing cotton seasons, A. impasta was observed feeding on leaves and flower bracts of cotton and monitored. Furthermore, a study was conducted under laboratory conditions to generate biological information about this species with larvae feeding cotton squares and leaves. Larvae fed on cotton squares exhibited delayed development (18.5 ± 0.18 days) and lower pupal weight (140.8 ± 2.26 mg) compared to larvae fed on cotton leaves (14.0 ± 0.07 days and 169.3 ± 2.06 mg). Thus, one generation cycle of A. impasta was obtained by feeding the larvae with cotton leaves. The mean (minimum-maximum) values for the duration of eggs, larvae and pupae were: 3.0 (3-4), 14.8 (14-18), and 9.7 (7-14) days, respectively. The viability of the eggs, larvae, and pupae were 43.7, 98.3, and 94.7%, respectively. Females lived on average 25.2 days (ranging from 15 to 37 days) and produced 869 eggs (from 4 to 1,866 eggs). The successful development and reproduction of A. impasta on cotton, especially, on the cotton leaves, suggest the potential of this species to reach a pest status in cotton. The similarities with A. argillacea, as discussed in this study, can be one of the reasons for low reference to A. impasta in the field. Therefore, the information provided here will allow researchers and growers to distinguish these two cotton defoliators.

Executive Order Number Twelve, April 14, 2009

This Executive Order made the creation of the Iowa Accountability and Transparency Board and the report of the State of Iowa's efforts to implement the AARA