Monitoring influenza vaccine effectiveness using the national influenza surveillance system

Background: Flu vaccine composition is reformulated on a yearly basis. As such, the vaccine effectiveness (VE) from previous seasons cannot be considered for subsequent years, and it is necessary to monitor the VE for each season. This study (MonitorEVA- monitoring vaccine effectiveness) intends to evaluate the feasibility of using the national influenza surveillance system (NISS) for monitoring the influenza VE. Material and methods: Data was collected within NISS during 2004 to 2014 seasons. We used a case-control design where laboratory confirmed incident influenza like illness (ILI) patients (cases) were compared to controls (ILI influenza negative). Eligible individuals consisted on all aged individuals that consult a general practitioner or emergency room with ILI symptoms with a swab collected within seven days of symptoms onset. VE was estimated as 1- odds ratio of being vaccinated in cases versus controls adjusted for age and month of onset by logistic regression. Sensitivity analyses were conducted to test possible effect of assumptions on vaccination status, ILI definition and timing of swabs (<3 days after onset). Results: During the 2004-2014 period, a total of 5302 ILI patients were collected but 798 ILI were excluded for not complying with inclusion criteria. After data restriction the sample size in both groups was higher than 148 individuals/ season; minimum sample size needed to detect a VE of at least 50% considering a level of significance of 5% and 80% power. Crude VE point estimates were under 45% in 2004/05, 2005/06, 2011/12 and 2013/14 season; between 50%-70% in 2006/07, 2008/09 and 2010/11 seasons, and above 70% in 2007/08 and 2012/13 season. From season 2006/07 to 2013/14, all crude VE estimates were statistically significant. After adjustment for age group and month of onset, the VE point estimates decreased and only 2008/09, 2012/13 and 2013/14 seasons were significant. Discussion and Conclusions: MonitorEVA was able to provide VE estimates for all seasons, including the pandemic, indicating if the VE was higher than 70% and less than 50%. When comparing with other observational studies, MonitorEVA estimates were comparable but less precise and VE estimates were in accordance with the antigenic match of the circulating virus/ vaccine strains. Given the sensitivity results, we propose a MonitorEVA based on: a) Vaccination status defined independently of number of days between vaccination and symptoms onset; b) use of all ILI data independent of the definition; c) stratification of VE according to time between onset and swab (< 3 and ≥3 days).

Age, Period and Cohort effects in the Decline of Party Identification in Germany

Party identification traditionally is seen as an important linkage mechanism, connecting voters to the party system. Previous analyses have suggested that the level of party identity is in decline in Germany, and in this article, we first expand previous observations with more recent data. These suggest that the erosion of party identity continues up to the present time. An age-period-cohort analysis of the panel data of the SOEP panel suggests that period effects are significantly negative. Furthermore, it can be observed that throughout the 1992-2009 observation period, education level and political interest have become more important determinants of party identity. Contrary to some of the literature, therefore, it can be shown that the loss of party identity is concentrated among groups with lower levels of political sophistication, indicating that the socio-economic profile of the group with a sense of party identification has become more distinct compared to the population as a whole. In the discussion, we investigate the theoretical and democratic consequences of this trend.

U.S. immigration policy and the national interest : the final report and recommendations of the Select Commission on Immigration and Refugee Policy with supplemental views by commissioners.

"Submitted to the Congress and the President of the United States pursuant to Public Law 95-412."

U.S. immigration policy and the national interest /

Originally published March 1981 as U.S. immigration policy ... final report and recommendations of the Select Commission on Immigration and Refugee Policy.

A report from the National Hispanic Conference on Law Enforcement and Criminal Justice, July 28-30, 1980, Washington, D.C.

Item 968-H-1

Proceedings of the National Hispanic Conference on Alcoholism, sponsored by the National Institute on Alcohol Abuse and Alcoholism, September 7-10, 1980, San Antonio, Texas.

Cover title: Alcoholism and the Hispanic, a mutual concern.

Historical sketch of Mount Holyoke seminary. Founded at South Hadley, Mass., in 1837. Prepared in compliance with an invitation from the commissioner of education, representing the Department of the interior in matters relating to the national centennial of 1876.

Mode of access: Internet.

The National Highway Traffic Safety Administration 1980-1981 workshops on alcohol and occupant restraints - eastern series. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Evaluation of minimum drinking age laws using the National Electronic Injury Surveillance System. Final report.

Mode of access: Internet.

Support for highway safety programs - a report to the Secretary of Transportation by the National Highway Safety Advisory Committee.

Mode of access: Internet.

Outstanding dissertations in bilingual education recognized by the National Advisory Council on Bilingual Education, 1979.

"Summaries of eight dissertations."

A compendium of bilingual education and related projects at the national institute of education /

Compilation of abstracts of current bilingual research projects funded through the National Institute of Education.