Virus del papiloma humano : presentación oral y su relación con el carcinoma espinocelular

El virus del papiloma humano (VPH) (HPV en su sigla en inglés) es un virus ADN con especial afinidad por células epiteliales, tanto cutáneas como mucosas, que incluyen el epitelio del cérvix, región anogenital y orofaríngea. Existen más de 120 subtipos de VPH subdivididos en dos grupos según su bajo o alto riesgo de inducir actividad oncogénica. En cavidad oral la manifestación clínica benigna de la infección es el papiloma plano.Sin embargo, un 12% de los carcinoma~ o rofaríngeos son causados por este virus. Se ha demostrado que la infección por VPH tiene un papel independiente como factor de riesgo para el desarrollo de carcinoma espinocelular en cavidad oral.

The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions

A simple mathematical model of bacterial transmission within a hospital was used to study the effects of measures to control nosocomial transmission of bacteria and reduce antimicrobial resistance in nosocomial pathogens. The model predicts that: (i) Use of an antibiotic for which resistance is not yet present in a hospital will be positively associated at the individual level (odds ratio) with carriage of bacteria resistant to other antibiotics, but negatively associated at the population level (prevalence). Thus inferences from individual risk factors can yield misleading conclusions about the effect of antibiotic use on resistance to another antibiotic. (ii) Nonspecific interventions that reduce transmission of all bacteria within a hospital will disproportionately reduce the prevalence of colonization with resistant bacteria. (iii) Changes in the prevalence of resistance after a successful intervention will occur on a time scale of weeks to months, considerably faster than in community-acquired infections. Moreover, resistance can decline rapidly in a hospital even if it does not carry a fitness cost. The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model.

Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract

Objective: To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal).

Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.

Infection of mucosal epithelium by papillomaviruses is responsible for the induction of genital and oral warts and plays a critical role in the development of human cervical and oropharyngeal cancer. We have employed a canine model to develop a systemic vaccine that completely protects against experimentally induced oral mucosal papillomas. The major capsid protein, L1, of canine oral papillomavirus (COPV) was expressed in Sf9 insect cells in native conformation. L1 protein, which self-assembled into virus-like particles, was purified on CsCl gradients and injected intradermally into the foot pad of beagles. Vaccinated animals developed circulating antibodies against COPV and became completely resistant to experimental challenge with COPV. Successful immunization was strictly dependent upon native L1 protein conformation and L1 type. Partial protection was achieved with as little as 0.125 ng of L1 protein, and adjuvants appeared useful for prolonging the host immune response. Serum immunoglobulins passively transferred from COPV L1-immunized beagles to naive beagles conferred protection from experimental infection with COPV. Our results indicate the feasibility of developing a human vaccine to prevent mucosal papillomas, which can progress to malignancy.

O efeito imediato da estimulação elétrica neuromuscular na função de deglutição em indivíduos com câncer de cabeça e pescoço após terapia antineoplásica

A estimulação elétrica neuromuscular (EENM) é uma recente técnica terapêutica no tratamento das disfagias orofaríngeas. Poucos estudos utilizaram a EENM em casos oncológicos, havendo muitas dúvidas sobre o método de aplicação e os resultados de diferentes condições de estimulação nessa população. Este trabalho teve por objetivo verificar o efeito imediato da EENM sensorial e motora, nas fases oral e faríngea da deglutição, em pacientes após tratamento do câncer de cabeça e pescoço. Para isso foi realizado um estudo transversal intervencional que incluiu 11 pacientes adultos e idosos (mediana de 59 anos) acometidos por câncer de cabeça e pescoço. Todos os indivíduos foram submetidos ao exame de videofluoroscopia da deglutição, no qual, de modo randomizado, foram solicitadas deglutições de 5 ml de alimentos nas consistências líquida, mel e pudim em três condições distintas: sem estimulação, com EENM sensorial, com EENM motora. Foi classificado o grau da disfunção da deglutição por meio da escala DOSS (Dysphagia Outcome and Severity Scale), a presença de estase de alimentos (escala de Eisenhuber), de penetração laríngea, aspiração laringotraqueal (Penetration and Aspiration Scale - PAS), além da medida do tempo de trânsito oral e faríngeo (em segundos). Para a comparação dos resultados, considerando os três estímulos aplicados, na escala de resíduos, na escala de penetração aspiração, na escala DOSS e no tempo de trânsito oral e faríngeo foi aplicado o teste de Friedman ou a análise de variância para medidas repetidas (de acordo com a distribuição dos dados). Para todos os testes foi adotado nível de significância de 5%. Os resultados demonstraram que houve melhora com a estimulação sensorial e motora na escala DOSS e na escala PAS para um paciente tratado de câncer de boca e outro de laringe e piora, em ambas as escalas, para dois pacientes (câncer de boca), sendo um para a estimulação motora e outro na sensorial. A aplicação da escala de Eisenhuber permitiu verificar que a EENM, tanto em nível sensorial como motor, modificou de forma variável a presença de resíduos para os casos de câncer de boca, enquanto para o paciente com câncer de laringe houve redução de resíduos em valécula/raiz da língua para a estimulação sensorial e motora, além de aumento de resíduos em parede posterior da faringe com o estímulo motor. Além disso, não foi encontrada diferença estatisticamente significante para o tempo de trânsito oral e faríngeo nas diferentes estimulações para todas as consistências testadas (p>0,05). Diante desses achados, concluiu-se que a EENM, em nível sensorial e motor, apresentou variável impacto imediato nas fases oral e faríngea da deglutição, podendo melhorar a função de deglutição de pacientes com significante disfagia após o tratamento para o câncer de cabeça e pescoço, no que se diz respeito ao grau da disfagia e à presença de penetração e aspiração.

Description of near attack, [1819 August]

One leaf containing a description by Croswell of nearly being run over by a carriage. The document is undated, but the date can be inferred from other diary entries in the collection.

Polissensibilização alimentar : um caso clínico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control study

Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza. A case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252. We selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95%CI: 0.33–1.50)). Regarding ILI Influenza A(H1N1)pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95%CI: 1.54–4.19)). The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.

Left: Livery & Sale Stables, J.A. Polhemus & Son, Proprs., Ann Arbor, Mich. Left: Buchoz's Block, Ann Arbor, Mich. Bottom: Orchestrian Hall, Fred Rettich, Proprietor, Ann Arbor, Mich.

Ann Arbor, Mich. businesses. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Constitution and by-laws ... Organized October 4th, 1865.

Mode of access: Internet.

Catalogs of Michigan-based automobile companies.

Mode of access: Internet.

Stockton's stories ...

Contains publisher's advertisements.

The novels and stories.

v. 1. The late Mrs. Null.--v. 2. The Squirrel Inn. The Merry Chanter.--v. 3. Rudder Grange.--v. 4. The hundredth man.--v. 5. Ardis Claverden.--v. 6. The great war syndicate. The stories of the three burglars. The knife that killed Po Hancy. Dusky philosophy.--v. 7. The house of Martha.--v. 8. Pomona's travels. Euphemia among the pelican's. The Rudder Grangers in England. Pomona's daughter.--v. 9. The adventures of Captain Horn.--v. 10. Mrs. Cliff's yacht.--v. 11. The great stone of Sardis. The water-devil.--v. 12. The girl at Cobhurst.--v. 13. The casting away of Mrs. Lecks and Mrs. Aleshine. The vizier of the two-horned Alexander.--v. 14. The associate hermits.--v. 15. Stories. [v.]1: The lady or the tiger? The discourager of hesitancy. The transferred ghost. The spectral mortgage. Every man his own letter-writer. Thar same old coon. Our story. Derelict. On the training of parents. A borrowed month. The baker of Barnbury. The watchmaker's wife.--v. 16. Stories. [v.]2: A tale of negative gravity. Asaph. The remarkable page. The Cloverfield's carriage. A story of assisted fate. My bull-calf. As one woman to another. Our fire-screen. My terminal moraine. Plain fishing.--v. 17. Stories. [v.]3: The griffin and the minor canon. Old Pipes and the dryad. The bee-man of Orn. The queen's museum. The clocks of Rondaine. Christmas before last; or, the fruit of the fragile palm. Prince Hassak's march. The battle of the third cousins. The banished king. The philopena. Amos Kilbright: his adscititious experiences. The Christmas shadrach. The bishop's ghost and the printer's baby. The philosophy of relative existences.--v. 18. Stories. [v.]4: The magic egg. "His wife's deceased sister." The widow's cruise. Captain Eli's best ear. Love before breakfast. The staying power of Sir Rohan. A piece of red calico. The Christmas wreck. My well and what came out of it. Mr. Tolman. My unwilling neighbor. Our archery club.--v. 19. Afield and afloat: The Buller-Podington compact. The romance of a mule-car. The governor-general. Old Applejoy's ghost. Struck by a boomerang. The skipper and El Capitan. "Come in, new year." A sailor's knot. The great staircase at Landover Hall. The ghosts in my toewer. The landsman's tale.--v. 20. Kate Bonnet: the romance of a pirate's daughter.--v. 21. John Gayther's garden.--v. 22. The captain's toll-gate.--v. 23. A bicycle of Cathay. With a memorial sketch of Mr. Stockton and a bibliography of his works.

A treatise of the law relative to merchant ships and seamen /

Includes bibliographical references and index.

Edward William Staebler in a Toledo steamer car

On verso: Ann Arbor