Through the European Looking Glass: Citizenship Tests in the USA, Australia, and Canada

Discussing new or recently reformed citizenship tests in the USA, Australia, and Canada, this article asks whether they amount to a restrictive turn of new world citizenship, similar to recent developments in Europe. I argue that elements of a restrictive turn are noticeable in Australia and Canada, but only at the level of political rhetoric, not of law and policy, which remain liberal and inclusive. Much like in Europe, the restrictive turn is tantamount to Muslims and Islam moving to the center of the integration debate.

Detection of Leishmania RNA virus in Leishmania parasites.

BACKGROUND Patients suffering from cutaneous leishmaniasis (CL) caused by New World Leishmania (Viannia) species are at high risk of developing mucosal (ML) or disseminated cutaneous leishmaniasis (DCL). After the formation of a primary skin lesion at the site of the bite by a Leishmania-infected sand fly, the infection can disseminate to form secondary lesions. This metastatic phenotype causes significant morbidity and is often associated with a hyper-inflammatory immune response leading to the destruction of nasopharyngeal tissues in ML, and appearance of nodules or numerous ulcerated skin lesions in DCL. Recently, we connected this aggressive phenotype to the presence of Leishmania RNA virus (LRV) in strains of L. guyanensis, showing that LRV is responsible for elevated parasitaemia, destructive hyper-inflammation and an overall exacerbation of the disease. Further studies of this relationship and the distribution of LRVs in other Leishmania strains and species would benefit from improved methods of viral detection and quantitation, especially ones not dependent on prior knowledge of the viral sequence as LRVs show significant evolutionary divergence. METHODOLOGY/PRINCIPAL FINDINGS This study reports various techniques, among which, the use of an anti-dsRNA monoclonal antibody (J2) stands out for its specific and quantitative recognition of dsRNA in a sequence-independent fashion. Applications of J2 include immunofluorescence, ELISA and dot blot: techniques complementing an arsenal of other detection tools, such as nucleic acid purification and quantitative real-time-PCR. We evaluate each method as well as demonstrate a successful LRV detection by the J2 antibody in several parasite strains, a freshly isolated patient sample and lesion biopsies of infected mice. CONCLUSIONS/SIGNIFICANCE We propose that refinements of these methods could be transferred to the field for use as a diagnostic tool in detecting the presence of LRV, and potentially assessing the LRV-related risk of complications in cutaneous leishmaniasis.

Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials.

BACKGROUND: High cost, poor compliance, and systemic toxicity have limited the use of pentavalent antimony compounds (SbV), the treatment of choice for cutaneous leishmaniasis (CL). Paromomycin (PR) has been developed as an alternative to SbV, but existing data are conflicting. METHODOLOGY/PRINCIPAL FINDINGS: We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials, without language restriction, through August 2007, to identify randomized controlled trials that compared the efficacy or safety between PR and placebo or SbV. Primary outcome was clinical cure, defined as complete healing, disappearance, or reepithelialization of all lesions. Data were extracted independently by two investigators, and pooled using a random-effects model. Fourteen trials including 1,221 patients were included. In placebo-controlled trials, topical PR appeared to have therapeutic activity against the old world and new world CL, with increased local reactions, when used with methylbenzethonium chloride (MBCL) compared to when used alone (risk ratio [RR] for clinical cure, 2.58 versus 1.01: RR for local reactions, 1.60 versus 1.07). In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82). No significant difference in efficacy was found between parenteral PR and parenteral SbV in the new world CL (0.88; 0.56-1.38). Systemic side effects were fewer with topical or parenteral PR than parenteral SbV. CONCLUSIONS/SIGNIFICANCE: Topical PR with MBCL could be a therapeutic alternative to SbV in selected cases of the old world CL. Development of new formulations with better efficacy and tolerability remains to be an area of future research.

Origins and evolution of VNTR loci: The apolipoprotein B 3$\sp\prime$ VNTR

I studied the apolipoprotein (apo) B 3$\sp\prime$ variable number tandem repeat (VNTR) and did computer simulations of the stepwise mutation model to address four questions: (1) How did the apo B VNTR originate? (2) What is the mutational mechanism of repeat number change at the apo B VNTR? (3) To what extent are population and molecular level events responsible for the determination of the contemporary apo B allele frequency distribution? (4) Can VNTR allele frequency distributions be explained by a simple and conservative mutation-drift model? I used three general approaches to address these questions: (1) I characterized the apo B VNTR region in non-human primate species; (2) I constructed haplotypes of polymorphic markers flanking the apo B VNTR in a sample of individuals from Lorrain, France and studied the associations between the flanking-marker haplotypes and apo B VNTR size; (3) I did computer simulations of the one-step stepwise mutation model and compared the results to real data in terms of four allele frequency distribution characteristics.^ The results of this work have allowed me to conclude that the apo B VNTR originated after an initial duplication of a sequence which is still present as a single copy sequence in New World monkey species. I conclude that this locus did not originate by the transposition of an array of repeats from somewhere else in the genome. It is unlikely that recombination is the primary mutational mechanism. Furthermore, the clustered nature of these associations implicates a stepwise mutational mechanism. From the high frequencies of certain haplotype-allele size combinations, it is evident that population level events have also been important in the determination of the apo B VNTR allele frequency distribution. Results from computer simulations of the one-step stepwise mutation model have allowed me to conclude that bimodal and multimodal allele frequency distributions are not unexpected at loci evolving via stepwise mutation mechanisms. Short tandem repeat loci fit the stepwise mutation model best, followed by microsatellite loci. I therefore conclude that there are differences in the mutational mechanisms of VNTR loci as classed by repeat unit size. (Abstract shortened by UMI.) ^

Archaeological silence and ecorefuges: arid events in the Puna of Atacama during the Middle Holocene

This paper briefly summarizes presearch concerning the mid-Holocene in the western slope of the puna de Atacama (20–25°S). Proxy data and dates from palynological, limnological, geomorphological archives were compared with data recovered from the archaeological sites in high altitude basins, intermediate ravines and piemontane paleowetlands. Due to exceptionally favorable conditions, numerous Early Holocene archaeological sites were found. In contrast, the lack of occupations in previously populated areas suggests a decline in human activity during the arid mid-Holocene. In this context, two key concepts are introduced: ecorefuge or ecological refuge, and archaeological silence (silencio arqueológico). The first refers to the particular favorable locations occupied by human groups during the mid-Holocene. The second provides a better understanding about the impact of the arid interval during this period on human adaptations in the most barren territories of the New World.

A prospective cohort study evaluating the state of medical readiness in the United States Air Force and risk factors to improve the medical readiness posture

A cohort of 418 United States Air Force (USAF) personnel from over 15 different bases deployed to Morocco in 1994. This was the first study of its kind and was designed with two primary goals: to determine if the USAF was medically prepared to deploy with its changing mission in the new world order, and to evaluate factors that might improve or degrade USAF medical readiness. The mean length of deployment was 21 days. The cohort was 95% male, 86% enlisted, 65% married, and 78% white.^ This study shows major deficiencies indicating the USAF medical readiness posture has not fully responded to meet its new mission requirements. Lack of required logistical items (e.g., mosquito nets, rainboots, DEET insecticide cream, etc.) revealed a low state of preparedness. The most notable deficiency was that 82.5% (95% CI = 78.4, 85.9) did not have permethrin pretreated mosquito nets and 81.0% (95% CI = 76.8, 84.6) lacked mosquito net poles. Additionally, 18% were deficient on vaccinations and 36% had not received a tuberculin skin test. Excluding injections, the overall compliance for preventive medicine requirements had a mean frequency of only 50.6% (95% CI = 45.36, 55.90).^ Several factors had a positive impact on compliance with logistical requirements. The most prominent was "receiving a medical intelligence briefing" from the USAF Public Health. After adjustment for mobility and age, individuals who underwent a briefing were 17.2 (95% CI = 4.37, 67.99) times more likely to have received an immunoglobulin shot and 4.2 (95% CI = 1.84, 9.45) times more likely to start their antimalarial prophylaxsis at the proper time. "Personnel on mobility" had the second strongest positive effect on medical readiness. When mobility and briefing were included in models, "personnel on mobility" were 2.6 (95% CI = 1.19, 5.53) times as likely to have DEET insecticide and 2.2 (95% CI = 1.16, 4.16) times as likely to have had a TB skin test.^ Five recommendations to improve the medical readiness of the USAF were outlined: upgrade base level logistical support, improve medical intelligence messages, include medical requirements on travel orders, place more personnel on mobility or only deploy personnel on mobility, and conduct research dedicated to capitalize on the powerful effect from predeployment briefings.^ Since this is the first study of its kind, more studies should be performed in different geographic theaters to assess medical readiness and establish acceptable compliance levels for the USAF. ^

Molecular Phylogenetics of Mole Crabs (Hippidae : Emerita)

Mole crabs of the genus Emerita (Family Hippidae) inhabit many of the temperate and tropical sandy beaches of the world. The nine described species of this genus are rarely sympatric, and most are endemic to broad biogeographic regions. The phylogenetic relationships among the species have not yet been investigated. Based on presumed morphological synapomorphics, it has been suggested that the species inhabiting the New World constitute a monophyletic group, as do the species inhabiting the Old World, The relationships within the New World species were previously studied using sequence data from Cytochrome Oxidase I and 16S rRNA mitochondrial genes; the results strongly suggested that one of the species, Emerita analoga, was very divergent from the other taxa examined. This observation prompted uncertainty about monophyly of the New World species. The goal of the present study was to elucidate the relationships among the species within the genus Emerita. Partial sequences for the mitochondrial COI and 16S rRNA genes for all nine species of the genus (and several outgroups) were examined. Phylogenetic analyses suggest that E. analoga is closer to the Old World taxa than to the other New World species; thus the New World Emerita species do not constitute a monophyletic group.

TRANSOVARIAL TRANSMISSION OF YELLOW FEVER VIRUS BY A SYLVATIC VECTOR, HAEMAGOGUS EQUINUS (THEOBALD)

The potential of a sylvatic vector to act as reservoir of yellow fever virus was assessed in Haemagogus equinus (Theobald). Mosquitoes from the Maje'75 laboratory colony and a Panamanian human isolated strain of yellow fever virus were used. Female mosquitoes infected with yellow fever virus had a minimum transovarial transmission rate of 1:5745. This is the first time transovarial transmission of yellow fever virus has been demonstrated in a New World sylvatic vector. Transovarial transmission of yellow fever virus in this sylvatic mosquito species may be an alternative mechanism for biological survival of the virus during adverse periods or in the absence of susceptible vertebrate hosts. ^

La configuración alegórica del espacio en William Faulkner : Absalom, Absalom!, Go Down Moses y The Sound and the Fury

El artículo analiza la configuración del espacio en tres novelas de William Faulkner como parte de un continuum iniciado en el período colonial: la idea del Nuevo Mundo generada por los puritanos y la adaptación de esa idea y de su manifestación retórica a las circunstancias inauguran la tópica que caracteriza a la literatura norteamericana y que Faulkner, echando mano de un imaginario autorreferencial, resignifica y enriquece con connotaciones innovadoras.

La tempestad y el progreso : una aproximación a la sociedad global de la información

En las últimas décadas, la sociedad de la información se ha convertido en una cuestión de debate. Es un paradigma emergente sobre los nuevos modelos de ciencia, de producción de conocimiento e innovación tecnológica. Complejidad y cambio son dos características definidoras de este fenómeno sistémico. El autor propone una aproximación a los desafíos y problemas más importantes en la era de la información. Según los pensadores analizados, esta área de investigación comprende el conjunto de nuevas tecnologías en un proceso multidimensional relacionado con el desarrollo del capitalismo global, y particularmente con la expansión de las empresas multinacionales. La sociedad de la información representa un nuevo orden mundial, sustentado en el mito ideológico y hegemónico del progreso. El artículo tiene dos objetivos: a) identificar algunas de las principales categorías y conceptos utilizados en la discusión; b) presentar un esquema desarrollado para el examen de sus impactos y consecuencias.

El comercio librario y la transmisión de la filosofía a Hispanoamérica : (siglos XVI al XVIII)

La transmisión de la filosofía al continente americano puede rastrearse materialmente por medio del examen de las redes comerciales que procuraron la numerosa llegada de libros que alimentaron a las primeras bibliotecas coloniales. En ellas se resguardaron variadas obras filosóficas y humanísticas fueron fundamentales en la promoción y desarrollo de la cultura escrita y la educación. Al revisar algunos aspectos centrales del comercio, el control librario y la colección de obras afines en las primeras bibliotecas privadas y religiosas, se pretende reconstruir al menos en sus rasgos característicos el devenir de la filosofía en el Nuevo Mundo.

Transformaciones territoriales y análisis geográfico en ámbitos patagónicos de montaña : La comarca andina del paralelo 42

El estudio de las transformaciones territoriales en esta parte del Sur del país obedece en especial a dos circunstancias de distinta índole. La primera vinculada a la investigación y su potencial trascendencia teórica y práctica en contextos académicos y profesionales interesados por comprender las características de la instalación humana en ámbitos sujetos a importantes cambios. La segunda responde al desenvolvimiento incierto de las comarcas andino patagónicas frente a hechos, propuestas y proyectos referentes a cuestiones de decisiva impronta regional. Se trata de territorios en plena gestación identitaria, donde es habitual lo dubitativo y confuso, aún desde perspectivas históricas y literarias, que son en las que normalmente se asientan las raíces regionales. En los recientes años '90 y en concordancia con los ajustes propios del nuevo orden mundial, se observan re-acomodamientos locales inscriptos en modalidades que obligan a la revisión profunda. Modalidades postmodernas que pueden identificarse como espacios de consumo. Es la condición cultural la que imprime nuevas estructuras espaciales de fuertes proyecciones anímicas enraizadas en lo simbólico y lo estético, donde las transformaciones se suceden a partir de una resignificación de la naturaleza. Desde allí es que se hacen planteos hipotéticos en busca de explicaciones, atendiendo a las valorizaciones que existen para con la Patagonia Andina. Aquellas que implican una preeminencia singular de los aspectos afectivos y emocionales por sobre los económicos, aunque con el turismo como el vector principal de transformación y a cuyo derredor se entremezclan situaciones conflictivas. Es ésta la dirección del análisis que busca esclarecer dudas a partir de la producción de conocimiento geográfico con sentido 'examinador' de la realidad. Fenómenos como los de dispersión, neoruralidad y fragmentación espacial, se muestran como los resultados más visibles en materia paisajística y con ello estamos ante un marco problemático y complejo. Con la sistematización de una significativa cantidad de información involucrada y una fuerte carga empírica proveniente de la convivencia profesional de varios años con la mayor parte de los problemas abordados, se presenta un aporte al cuerpo teórico de la Geografía preocupada por los ámbitos montanos, así como también su proyección hacia la explicación geográfica regional y su eventual insumo para el Planeamiento y la Gestión Territorial. Se analiza el conjunto territorial ofreciendo una perspectiva integradora en escenarios novedosos que, desde nuestra disciplina pueden abordarse con la posibilidad cierta de orientar una importante cantidad de estudios sectoriales que ya se manifiestan, en particular por requerimientos políticos. Con la Comarca Andina del Paralelo 42 en el foco del análisis, la tesis se abocó a incursionar en la realidad andino patagónica, identificando, sistematizando y valorando los conflictos de estirpe territorial como camino explicativo.

'La mucha destemplanza de la tierra' : Una aproximación al relato de Maximiliano de Transilvano sobre el descubrimiento del Estrecho de Magallanes

Una de las empresas más emblemáticas en la historia del descubrimiento, conquista y colonización del Nuevo Mundo es la que comanda Hernando de Magallanes y concluye Sebastián Elcano en procura de encontrar una nueva ruta hacia las islas Molucas, paraíso de la especiería. Este artículo propone una lectura de la carta escrita en latín por Maximiliano Transilvano, Secretario de Carlos V, firmada a los pocos días del retorno de los sobrevivientes (5 de octubre de 1522) de la travesía interoceánica. El análisis se detiene en el episodio del desembarco en Puerto San Julián, en las costas patagónicas argentinas, y en el modo en que ingresa en la escritura un espacio geográfico hostil e intimidante, generador de violencia y enfrentamientos

Al encuentro de los territorios del siglo XXI

Se deslizaban los últimos años de un siglo que llegaba a su fin, sus últimos estertores se hacían oír, mientras se podía vislumbrar que un mundo nuevo quería nacer desde las disputas entre regiones manifiestas en las relaciones de poder y las transformaciones emergentes en sus territorios. América Latina como reservorio de recursos naturales, capaz de autosustentarse, desde su destino como continente estratégico productor para los países consumidores de energéticos, alimentos y, por qué no, de inteligencia, plantea escenarios permanentes de cambios. Lentamente pasada la magia que ha envuelto el inicio de un nuevo milenio, determinó, impuso y manifestó la puesta en valor -desde el camino recorrido por varias décadas- de los resultados obtenidos por la evolución de la línea de investigación que fuera objeto constante de reflexión.