Caracterização in vitro de técnica biomagnética empregando magnetômetros 3D para avaliar tempo de trânsito esofagiano

The biomagnetic techniques use different magnetic field detectors to measure parameters of the human physiology. Those techniques present the advantage of being noninvasive and radiation free. Among them we can show up the Superconducting Quantum Interference Device (SQUID), the Current Alternate Biosusceptometry (ACB) and, more recently, the employment of anisotropic magnetoresistive sensors. Those magnetic sensors have a low cost and good sensitivity to measure different physiological parameters using magnetic markers. The biomagnetic techniques have being used successfully through study on the characteristics of the gastrointestinal tract. Recent research, the magnetoresistors were used to evaluate the transit time and localization of magnetic sources in different parts of the gastrointestinal tract. The objective of this work is the characterization, with in vitro tests, of a biomagnetic instrumentation using two 3-axis magnetoresistors arranged in a gradiometric coplanar setup to evaluate esophageal transit time, analyze and compare the results of experimental signals and the magnetic theory, as well as evaluate the instrumentation gain with use of tri-axial sensor front to the mono-axial sensor. The instrumentation is composed by two three-axis sensing magnetometers, precision power supply and amplifier electronic circuits. The sensors fixed in a coplanar setup were separate by distance of 18 cm. The sensitivity tests had been carried through using a cylindrical magnet (ø = 4 mm and h = 4 mm) of neodymium-iron-boron (grid 35). The tests were done moving the permanent magnet on the sensors parallel axis, simulating the food transit in... (Complete abstract click electronic access below)

Efeitos da corticoterapia pré-natal e durante a puberdade sobre a morfofisiologia do lobo ventral da próstata de ratos senis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise citogenética clássica, molecular e ultraestrutural em escorpiões da família Buthidae: um enfoque evolutivo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Expressão proteica das enzimas metabolizadoras de drogas no carcinoma de células escamosas de boca em pacientes jovens

Pós-graduação em Biopatologia Bucal - ICT

Histomorfologia da glande peniana e do báculo de morcegos molossideos e vespertilionideos: uma abordagem comparativa (Chiroptera, Mammalia)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aplicação da análise de séries temporais para detecção e prognóstico de danos em estruturas inteligentes

Pós-graduação em Engenharia Mecânica - FEIS

Zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance

BackgroundDiabetes is associated with long-term damage, dysfunction and failure of various organs, especially the eyes, kidneys, nerves, heart and blood vessels. The risk of developing type 2 diabetes increases with age, obesity and lack of physical activity. Insulin resistance is a fundamental aspect of the aetiology of type 2 diabetes. Insulin resistance has been shown to be associated with atherosclerosis, dyslipidaemia, glucose intolerance, hyperuricaemia, hypertension and polycystic ovary syndrome. The mineral zinc plays a key role in the synthesis and action of insulin, both physiologically and in diabetes mellitus. Zinc seems to stimulate insulin action and insulin receptor tyrosine kinase activity.ObjectivesTo assess the effects of zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance.Search methodsThis review is an update of a previous Cochrane systematic review published in 2007. We searched the Cochrane Library (2015, Issue 3), MEDLINE, EMBASE, LILACS and the ICTRP trial register (frominception toMarch 2015). There were no language restrictions. We conducted citation searches and screened reference lists of included studies.Selection criteriaWe included studies if they had a randomised or quasi-randomised design and if they investigated zinc supplementation compared with placebo or no intervention in adults with insulin resistance living in the community.Data collection and analysisTwo review authors selected relevant trials, assessed risk of bias and extracted data.Main resultsWe included three trials with a total of 128 participants in this review. The duration of zinc supplementation ranged between four and 12 weeks. Risk of bias was unclear for most studies regarding selection bias (random sequence generation, allocation concealment) and detection bias (blinding of outcome assessment). No study reported on our key outcome measures (incidence of type 2 diabetes mellitus, adverse events, health-related quality of life, all-cause mortality, diabetic complications, socioeconomic effects). Evaluation of insulin resistance as measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) showed neutral effects when comparing zinc supplementation with control (two trials; 114 participants). There were neutral effects for trials comparing zinc supplementation with placebo for total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (2 studies, 70 participants). The one trial comparing zinc supplementation with exercise also showed neutral effects for total cholesterol, HDL and LDL cholesterol, and a mean difference in triglycerides of -30 mg/dL (95% confidence interval (CI) -49 to -10) in favour of zinc supplementation (53 participants). Various surrogate laboratory parameters were also analysed in the included trials.Authors'conclusionsThere is currently no evidence on which to base the use of zinc supplementation for the prevention of type 2 diabetes mellitus. Future trials should investigate patient-important outcome measures such as incidence of type 2 diabetes mellitus, health-related quality of life, diabetic complications, all-cause mortality and socioeconomic effects.

Influência da temperatura de armazenamento na qualidade das inflorescências de estrelítzia (strelitzia reginae banks ex aiton)

This work was based to study the influence of the storage temperature (cold and room temperature) in the quality of inflorescences strelitzia. The scapes were selected, labeled and there were zero problems concerning mechanical damage, disease and/or plagues. Subsequently this period, the scapes were moved randomly to recipients with water, in which two postharvest trials were conducted. In experiment 1, the flower scapes were placed in buckets with water from public supply and sanitation department and taken to a cold room at temperature of 7.5 degrees C and RH of 90%, for a twelve day period. For the experiment 2, were kept under the same conditions but at room temperature for a period of six days. In both experiments, the visual analysis: color, gloss, stains (by assigning notes), opening and drop florets (count) were evaluated at intervals of four days in cold and every 48 hours at ambient temperature conditions. In both experiments, the visual analysis: color, gloss, stains (by assigning notes), opening and drop florets (count) were evaluated at intervals of four days in cold and every 48 hours at ambient temperature conditions. The sepal is the organ that showed greater loss in coloration. The variable gloss showed the same pattern for the two experiments. Incidences of stains on the inflorescences occurred in patches at room temperature. The scapes increased number of florets open in cold. This tendency did not occur at room temperature. No were observed differences in the fall of florets. Conclude that the storage temperature does not contribute to postharvest quality of strelitzia.

Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação do método da quebra do grafite para estimação da sensibilidade de transdutores piezelétricos utilizados na técnica da Impedância Eletromecânica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Procedimentos de avaliação em terapia de casais a partir de múltiplos instrumentos

Conjugal problems may damage parents and children relationships favoring the appearance of behavior problems, as well as causing psychological problems. Given the lack of studies which value several interrelated behavioral repertoires, the present paper aims at presenting assessment results employing multiple instruments in regards to the three couples that sought clinical services at a University clinic. Results indicated that participants were presenting communication deficits, problem solving difficulties, and problems in expressing affection confirming literature findings. Problems in other areas were also reported, which influenced the marital relationship. It stands out that the children were presenting indications of behavior problems. The relevance of data collection applying different instruments is discussed, and it is necessary that intervention programs consider individual difficulties, besides setting up singular objectives for each person searching for service.

An Overview of Historical Beaver Management in Arizona

In the mid-1820s, Anglo-American fur trappers, known as "mountain men," entered Arizona and began trapping beaver (Castor canadensis). In Arizona there have been a number of famous mountain men such as Sylvester and James Pattie, Ewing Young, Jededia Smith, and Bill Williams who trapped along the waterways in northern and southern Arizona. Although the heyday of mountain men lasted only a few decades due to a population decline of beaver, management of these animals continues to this day. The purpose of managing beavers shifted from monetary gain to controlling wildlife damage. During the late 1900s, beaver were still widely distributed in limited numbers throughout much of the state. We provide a historical overview of beaver management in Arizona with emphasis on the mountain men, recreational trapping, wildlife damage management, and beaver research in Arizona.

BADGERS (Taxidea taxus) AS OCCASIONAL PESTS IN AGRICULTURE

The badger (Taxidea taxus). because of its strong propensity for digging, is considered North America's fossorial carnivore, feeding mostly on ground squirrels, pocket gophers, and mice throughout much of the western and midwestern continent. Badger excavations, primarily in search of food, produce mounds and deep holes which can damage alfalfa and other crops and damage farm equipment and water systems. Depredations include poultry, waterfowl, and eggs. Overall, the badger is considered a relatively minor vertebrate pest. As a furbearer it is considered a renewable natural resource. Most local pest problems are currently reduced through leghold trapping and shooting. Habitat modification through continuous rodent control is effective and a long-lasting badger control method.

THE HANDBOOK OF WILDLIFE DEPREDATION TECHNIQUES: A SYNOPSIS

In 1979, the Game Division Administration of the Wyoming Game and Fish Department (WGFD) appointed John Demaree and Tim Fagan to develop a handbook that would address the ever increasing problem of wildlife depredation. Field personnel were often times at a loss on how to deal with or evaluate the assorted types of damage situations they were encountering. Because Wyoming requires landowners to be reimbursed for damage done by big and trophy game and game birds to their crops and livestock, an evaluation and techniques handbook was desperately needed. The initial handbook, completed in January 1981, was 74 pages, and both John and I considered it a masterpiece. It did not take long, however, for this handbook to become somewhat lacking in information and outdated. In 1990, our administration approached us again asking this time for an update of our ten-year-old handbook. John and I went to work, and with the assistance of Evin Oneale of the Wyoming Cooperative Fish and Wildlife Research unit, and Bill Hepworth and John Schneidmiller of the WGFD, have just completed the second edition. This edition is over 600 pages and titled "The Handbook of Wildlife Depredation Techniques." Neither of us care to be around when a third edition is needed. In this handbook we have attempted to cover any type of damage situation our personnel may encounter. Although the primary function of this manual is to inform department personnel about proper and uniform damage prevention and evaluation techniques, it also provides relative and pertinent information concerning the many aspects of wildlife depredation. Information for this handbook has been compiled from techniques developed by our personnel, personnel from other states and provinces, and published data on wildlife depredation. There are nine chapters, a reprint, and Appendix section in this handbook. We will briefly summarize each chapter regarding its contents.

Phospholipase D2:A Pivotal Player Modulating RBL-2H3 Mast Cell Structure

The current study examined the role of PLD2 in the maintenance of mast cell structure. Phospholipase D (PLD) catalyzes hydrolysis of phosphatidylcholine to produce choline and phosphatidic acid (PA). PLD has two isoforms, PLD1 and PLD2, which vary in expression and localization depending on the cell type. The mast cell line RBL-2H3 was transfected to overexpress catalytically active (PLD2CA) and inactive (PLD2CI) forms of PLD2. The results of this study show that PLD2CI cells have a distinct star-shaped morphology, whereas PLD2CA and RBL-2H3 cells are spindle shaped. In PLD2CI cells, the Golgi complex was also disorganized with dilated cisternae, and more Golgi-associated vesicles were present as compared with the PLD2CA and RBL-2H3 cells. Treatment with exogenous PA led to the restoration of the wild-type Golgi complex phenotype in PLD2CI cells. Conversely, treatment of RBL-2H3 and PLD2CA cells with 1% 1-Butanol led to a disruption of the Golgi complex. The distribution of acidic compartments, including secretory granules and lysosomes, was also modified in PLD2CI cells, where they concentrated in the perinuclear region. These results suggest that the PA produced by PLD2 plays an important role in regulating cell morphology in mast cells. (J Histochem Cytochem 60:386-396, 2012)