Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.

The activation of heat shock genes by diverse forms of environmental and physiological stress has been implicated in a number of human diseases, including ischemic damage, reperfusion injury, infection, neurodegeneration, and inflammation. The enhanced levels of heat shock proteins and molecular chaperones have broad cytoprotective effects against acute lethal exposures to stress. Here, we show that the potent antiinflammatory drug indomethacin activates the DNA-binding activity of human heat shock transcription factor 1 (HSF1). Perhaps relevant to its pharmacological use, indomethacin pretreatment lowers the temperature threshold of HSF1 activation, such that a complete heat shock response can be attained at temperatures that are by themselves insufficient. The synergistic effect of indomethacin and elevated temperature is biologically relevant and results in the protection of cells against exposure to cytotoxic conditions.

The role of alcohol, marijuana and other drugs in the accidents of injured drivers. [Revised edition].

National Highway Traffic Safety Administration, Washington, D.C.

Homelessness, alcohol, and other drugs : proceedings of a conference held in San Diego, California, February 2-4, 1989.

Mode of access: Internet.

A bill to prevent the manufacture, shipment, and sale ofadulterated or misbranded food, drink, drugs, and cosmetics, and to regulate traffic therein : to prevent the false advertisement of food, drink, drugs, and cosmetics : and for other purposes.

Mode of access: Internet.

Advertising for over-the-counter drugs : public record 215-51, 16 CFR part 450 : report of the presiding officer on proposed trade regulation rule /

Cover title.

Selected topics in algebraic geometry; report of the Committee on rational transformations:

Bibliography at end of each chapter.

The Pharmacy and drugs act 14th March, 1908, as amended March 14, 1910. With amendment of March 15, 1918 and March 18, 1924.

Mode of access: Internet.

Marijuana, other drugs and their relation to highway safety: a report to the Congress.

Mode of access: Internet.

Laws relative to food and drugs.

Mode of access: Internet.

Vaughan's "Freedmen's pension bill." : being an appeal in behalf of men released from slavery : a plea for American freemen and a rational proposition to grant pensions to persons of color emancipated from slavery /

Mode of access: Internet.

Report of the National Conference on Orphan Drugs : the path to promise : May 18-19, 1988, George Washington University, Washington, D.C. / [sponsored jointly by] the National Institutes of Health and the Pharmaceutical Manufacturers Association.

Mode of access: Internet.

Substance use in popular music videos /

"June 2002"

Outpatient prescription drugs : data collection and editing in the 1996 Medical Expenditure Panel Survey (HC-010A).

"June 2001."

The people's own book of recipes and information for the million : containing directions for the preservation of health, for the treatment of the sick and the conduct of the sick-room : with a full discussion of the more porminent diseases that afflict the human family, with full directions for their rational treatment : also, 1000 practical and useful recipes, embracing every department of domestic economy and human industry : with copious notes and emendations, explanatory and suggestive /

Recipes for domestic wines, cider, etc., on p. 306-315.

Shaker sermons, scripto-rational : containing the substance of Shaker theology : together with replies and criticisms logically and clearly set forth /

Frontispiece is a portrait of H.L. Eads engraved by J.C. Buttre.