Handling of Uncertainty in Life Cycle Inventory by Correlated Multivariate Lognormal Distributions: Application to the Design of Supply Chain Networks

Poster presented in the 24th European Symposium on Computer Aided Process Engineering (ESCAPE 24), Budapest, Hungary, June 15-18, 2014.

Handling of Uncertainty in Life Cycle Inventory by Correlated Multivariate Lognormal Distributions: Application to the Design of Supply Chain Networks

In this work, we analyze the effect of incorporating life cycle inventory (LCI) uncertainty on the multi-objective optimization of chemical supply chains (SC) considering simultaneously their economic and environmental performance. To this end, we present a stochastic multi-scenario mixed-integer linear programming (MILP) coupled with a two-step transformation scenario generation algorithm with the unique feature of providing scenarios where the LCI random variables are correlated and each one of them has the desired lognormal marginal distribution. The environmental performance is quantified following life cycle assessment (LCA) principles, which are represented in the model formulation through standard algebraic equations. The capabilities of our approach are illustrated through a case study of a petrochemical supply chain. We show that the stochastic solution improves the economic performance of the SC in comparison with the deterministic one at any level of the environmental impact, and moreover the correlation among environmental burdens provides more realistic scenarios for the decision making process.

A Defensive "stand-by reaction" at Critical Moments of the Reproductive Life Cycle

Investigation about the psychological experiences of the reproductive life cycle showed that in critical moments special reactions may happen. These reactions seem to be defensive in nature, are set in motion in order to promote some kind of emotional protection and are performed in two opposite directions: a) a decreasing of the contact with aggressive impulses and b) an increasing of the use of rationalization and denial of frustrating situations. Examples of those rearrangements were observed at samples of: 1) pregnant women in obstetric high-risk consultation, 2) infertile couples waiting for infertility consultations and 3) pregnant women waiting for amniocentesis results. These data seem to be in accordance with the classical psychological points of view: a) gestation should be considered as a period of protection, b) during pregnancy a “primary maternal preoccupation” (Winnicot, 1958) emerges leading to the mobilization of all resources available for pregnant women and c) along gestational development psychological changes show how flexible maternal functioning may become. What was not expected is that in the absence of pregnancy, infertile couples should behave very similarly to what it is observed when pregnancy is in danger or when medical problems about the mother’s or the baby’s health arise in the horizon. Due to its “freezing” consequences upon emotional development we propose that this kind of reaction will be designated as “stand-by reaction”.

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite

Parasite proteases play key roles in several fundamental steps of the Plasmodium life cycle, including haemoglobin degradation, host cell invasion and parasite egress. Plasmodium exit from infected host cells appears to be mediated by a class of papain-like cysteine proteases called 'serine repeat antigens' (SERAs). A SERA subfamily, represented by Plasmodium falciparum SERA5, contains an atypical active site serine residue instead of a catalytic cysteine. Members of this SERAser subfamily are abundantly expressed in asexual blood stages, rendering them attractive drug and vaccine targets. In this study, we show by antibody localization and in vivo fluorescent tagging with the red fluorescent protein mCherry that the two P. berghei serine-type family members, PbSERA1 and PbSERA2, display differential expression towards the final stages of merozoite formation. Via targeted gene replacement, we generated single and double gene knockouts of the P. berghei SERAser genes. These loss-of-function lines progressed normally through the parasite life cycle, suggesting a specialized, non-vital role for serine-type SERAs in vivo. Parasites lacking PbSERAser showed increased expression of the cysteine-type PbSERA3. Compensatory mechanisms between distinct SERA subfamilies may thus explain the absence of phenotypical defect in SERAser disruptants, and challenge the suitability to develop potent antimalarial drugs based on specific inhibitors of Plasmodium serine-type SERAs.

A topical outline for the teaching of family health : a life-cycle approach (nursing and midwifery) /

"Project no. AID-PHA/CM/C-73-33"--T.p. verso.

Life and ways of the two-year-old, a teacher's study,

Mode of access: Internet.

Men of Michigan : a collection of the portraits of men prominent in business and professional life in Michigan.

Mode of access: Internet.

Life-cycle costing manual for the Federal Energy Management Program : a guide for evaluating the cost effectiveness of energy conservation and renewable energy projects for new and existing federally owned and leased buildings and facilities /

"Issued originally December 1980 ; revised May 1982 ; revised November 1987."

The life cycle and epizootiology of the rabbit trematode, Hasstilesia tricolor (Stiles and Hassall, 1894) Hall, 1916. (Trematoda: Brachylaemidae).

Thesis (Ph.D.)--Cornell Univ., June 1954.

The devotional life of the Sunday school teacher /

Mode of access: Internet.

Life and work of an Indian saint; being the autobiography of Swami Sivaganacharya, a great social reformer and religious teacher--founder of the Santi Asrama, Muttra, U.P. and a patron of the Vedic Mission, Madras.

Pt.1, suppl.1: List of books written by Swami Siv [a] ganacharya.

The men of New York: a collection of biographies and portraits of citizens of the Empire state prominent in business, professional, social, and political life during the last decade of the nineteenth century ...

Mode of access: Internet.

Sol. Smith's Theatrical apprenticeship. Comprising a sketch of the first seven years of his professional life ; together with anecdotes and sketches of adventure in after years.

Added t.-p.illustrated ; illustrations by Darley.

The life of Miss Anne Catley, celebrated singing performer of the last century : including an account of her introduction to public life, her professional engagements in London and Dublin, and her various adventuresand intrigues.

Mode of access: Internet.

Costs of HUD multifamily housing programs : a comparison of the development, financing and life cycle costs of Secton 8, Public Housing, and otheer major HUD programs /

"HUD-PDR-708"--P. [4] of cover.