Measurement and stability of the pointing of the BepiColombo Laser Altimeter under thermal load

The BepiColombo Laser Altimeter (BELA) has been selected to fly on ESA׳s BepiColombo mission to Mercury. The instrument will be the first European laser altimeter designed for interplanetary flight. This paper describes the setup used to characterize the angular movements of BELA under the simulated environmental conditions that the instrument will encounter when orbiting Mercury. The system comprises a laser transmitter and a receiving telescope, which can move with respect to each other under thermal load. Tests performed using the Engineering Qualification Model show that the setup is accurate enough to characterize angular movements of the instrument components to an accuracy of ≈10 μrad. The qualification instrument is thermally stable to operate during all mission phases around Mercury proving that the transmitter and receiver sections will remain within the alignment requirements during its mission.

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.

BACKGROUND REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide. We tested the hypothesis that near complete inhibition of factor IXa with pegnivacogin during percutaneous coronary intervention, followed by partial reversal with anivamersen, would reduce ischaemic events compared with bivalirudin, without increasing bleeding. METHODS We did a randomised, open-label, active-controlled, multicentre, superiority trial to compare REG1 with bivalirudin at 225 hospitals in North America and Europe. We planned to randomly allocate 13,200 patients undergoing percutaneous coronary intervention in a 1:1 ratio to either REG1 (pegnivacogin 1 mg/kg bolus [>99% factor IXa inhibition] followed by 80% reversal with anivamersen after percutaneous coronary intervention) or bivalirudin. Exclusion criteria included ST segment elevation myocardial infarction within 48 h. The primary efficacy endpoint was the composite of all-cause death, myocardial infarction, stroke, and unplanned target lesion revascularisation by day 3 after randomisation. The principal safety endpoint was major bleeding. Analysis was by intention to treat. This trial is registered at ClinicalTrials.gov, identifier NCT01848106. The trial was terminated early after enrolment of 3232 patients due to severe allergic reactions. FINDINGS 1616 patients were allocated REG1 and 1616 were assigned bivalirudin, of whom 1605 and 1601 patients, respectively, received the assigned treatment. Severe allergic reactions were reported in ten (1%) of 1605 patients receiving REG1 versus one (<1%) of 1601 patients treated with bivalirudin. The composite primary endpoint did not differ between groups, with 108 (7%) of 1616 patients assigned REG1 and 103 (6%) of 1616 allocated bivalirudin reporting a primary endpoint event (odds ratio [OR] 1·05, 95% CI 0·80-1·39; p=0·72). Major bleeding was similar between treatment groups (seven [<1%] of 1605 receiving REG1 vs two [<1%] of 1601 treated with bivalirudin; OR 3·49, 95% CI 0·73-16·82; p=0·10), but major or minor bleeding was increased with REG1 (104 [6%] vs 65 [4%]; 1·64, 1·19-2·25; p=0·002). INTERPRETATION The reversible factor IXa inhibitor REG1, as currently formulated, is associated with severe allergic reactions. Although statistical power was limited because of early termination, there was no evidence that REG1 reduced ischaemic events or bleeding compared with bivalirudin. FUNDING Regado Biosciences Inc.

Az 1848/49-iki magyar szabadságharcz és a zsidók

irta Bernstein Bela

Bruxas e princesas : Sobre rivalidade femenina e a construção da imagem da boa esposa

En el mito de Psique, narrado por Apuleyo en El Asno de Oro, encontramos el origen de diversos motivos narrativos, presentes en los cuentos de hadas. Estas historias tienen personajes que pasan por una especie de rito de iniciación y deben demostrar que son dignas de una recompensa muy deseada: un matrimonio feliz. Para alcanzar la felicidad, las heroínas necesitan superar desafíos. Quienes imponen obstáculos a esas princesas son las villanas de las historias. Las dos imágenes femininas representan una lucha entre el bien y el mal. Buscamos en nuestro trabajo hacer una conexión entre el mito de Psique y los cuentos de hadas de Blancanieves, Cenicienta y la Bella Durmiente, para demostrar que las heroínas de estas historias, para ser dignas de un final feliz, necesitan superar desafíos, que sirven para sacralizar el sentimiento amoroso y mejorar la imagen de la buena esposa

Bruxas e princesas : Sobre rivalidade femenina e a construção da imagem da boa esposa

En el mito de Psique, narrado por Apuleyo en El Asno de Oro, encontramos el origen de diversos motivos narrativos, presentes en los cuentos de hadas. Estas historias tienen personajes que pasan por una especie de rito de iniciación y deben demostrar que son dignas de una recompensa muy deseada: un matrimonio feliz. Para alcanzar la felicidad, las heroínas necesitan superar desafíos. Quienes imponen obstáculos a esas princesas son las villanas de las historias. Las dos imágenes femininas representan una lucha entre el bien y el mal. Buscamos en nuestro trabajo hacer una conexión entre el mito de Psique y los cuentos de hadas de Blancanieves, Cenicienta y la Bella Durmiente, para demostrar que las heroínas de estas historias, para ser dignas de un final feliz, necesitan superar desafíos, que sirven para sacralizar el sentimiento amoroso y mejorar la imagen de la buena esposa

Bruxas e princesas : Sobre rivalidade femenina e a construção da imagem da boa esposa

En el mito de Psique, narrado por Apuleyo en El Asno de Oro, encontramos el origen de diversos motivos narrativos, presentes en los cuentos de hadas. Estas historias tienen personajes que pasan por una especie de rito de iniciación y deben demostrar que son dignas de una recompensa muy deseada: un matrimonio feliz. Para alcanzar la felicidad, las heroínas necesitan superar desafíos. Quienes imponen obstáculos a esas princesas son las villanas de las historias. Las dos imágenes femininas representan una lucha entre el bien y el mal. Buscamos en nuestro trabajo hacer una conexión entre el mito de Psique y los cuentos de hadas de Blancanieves, Cenicienta y la Bella Durmiente, para demostrar que las heroínas de estas historias, para ser dignas de un final feliz, necesitan superar desafíos, que sirven para sacralizar el sentimiento amoroso y mejorar la imagen de la buena esposa

Literature review of elasmobranch bycatch and retention rate

To address growing concern over the effects of fisheries non-target catch on elasmobranchs worldwide, the accurate reporting of elasmobranch catch is essential. This requires data on a combination of measures, including reported landings, retained and discarded non-target catch, and post-discard survival. Identification of the factors influencing discard vs. retention is needed to improve catch estimates and to determine wasteful fishing practices. To do this we compared retention rates of elasmobranch non-target catch in a broad subset of fisheries throughout the world by taxon, fishing country, and gear. A regression tree and random forest analysis indicated that taxon was the most important determinant of retention in this dataset, but all three factors together explained 59% of the variance. Estimates of total elasmobranch removals were calculated by dividing the FAO global elasmobranch landings by average retention rates and suggest that total elasmobranch removals may exceed FAO reported landings by as much as 400%. This analysis is the first effort to directly characterize global drivers of discards for elasmobranch non-target catch. Our results highlight the importance of accurate quantification of retention and discard rates to improve assessments of the potential impacts of fisheries on these species.