984 resultados para Moseley, James Richard, 1948-
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Ressenya de: Rafael Feito y Juan Ignacio López (eds.): Construyendo escuelas democráticas. Barcelona: Hipatia, 2008.
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Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As an acute response to such stretches the cytoskeleton can stiffen, increase traction forces and reinforce, as reported by some, or can soften and fluidize, as reported more recently by our laboratory, but in any given circumstance it remains unknown which response might prevail or why. Using a novel nanotechnology, we show here that in loading conditions expected in most physiological circumstances the localized reinforcement response fails to scale up to the level of homogeneous cell stretch; fluidization trumps reinforcement. Whereas the reinforcement response is known to be mediated by upstream mechanosensing and downstream signaling, results presented here show the fluidization response to be altogether novel: it is a direct physical effect of mechanical force acting upon a structural lattice that is soft and fragile. Cytoskeletal softness and fragility, we argue, is consistent with early evolutionary adaptations of the eukaryotic cell to material properties of a soft inert microenvironment.
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Käsikirjoitus
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OBJECTIVE: The main utility of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) lies in the staging of lung cancer. However, it can also be used to differentiate indeterminate pulmonary lesions, but its impact on the resection of benign lesions at surgery is unknown. The aim of this study was to compare the prevalence of benign lesions at thoracotomy carried out for suspected lung cancer, before and after the introduction of PET scanning in a large thoracic surgical centre. MATERIALS AND METHODS: We reviewed our prospectively recorded surgical database for all consecutive patients undergoing thoracotomy for suspected or proven lung cancer and compared the prevalence of benign lesions in 2 consecutive 2-year groups, before (group I) and after (group II) the introduction of FDG-PET scan respectively. RESULTS: Surgical resection was performed on 1233 patients during the study period. The prevalence of benign lesions at surgery in groups I and II was similar (44/626 and 41/607, both 7%), and also in group II between those who underwent FDG-PET scan and the remainder (21/301 and 20/306 respectively, both 7%). In group II, of the 21 patients with benign lesions, who underwent FDG-PET, 19 had a false positive scan (mean standardised uptake value 5.3 [range 2.6-12.7]). Of these, 13 and 4 patients respectively had non-diagnostic bronchoscopy and percutaneous transthoracic lung biopsy pre thoracotomy. There was no difference in the proportion of different benign lesions resected between group I and those with FDG-PET in group II. CONCLUSION: The introduction of FDG-PET scanning has not altered the proportion of patients undergoing thoracotomy for ultimately benign lesions, mainly due to the avidity for the isotope of some non-malignant lesions. Such false positive results need to be considered when patients with unconfirmed lung cancer are contemplated for surgical resection.
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In the 1940s, when the Governor of Puerto Rico was appointed by the US President and the Puerto Rican government was answerable only to the US Federal government, a large state-owned enterprise (SOE) sector was established on the island. Public services such as water, transportation and energy were nationalized, and several new manufacturing SOEs were created to produce cement, glass, shoes, paper and chalkboard, and clay products. These enterprises were created and managed by government-owned corporations. Later on, between 1948 and 1950, under the island’s first elected Governor, the government sold these SOEs to private groups. This paper documents both the creation and the privatization of the SOE sector in Puerto Rico, and analyzes the role played by ideology, political interests, and economic concerns in the decision to privatize them. Whereas ideological factors might have played a significant role in the building of the SOE sector, we find that privatization was driven basically by economic factors, such as the superior efficiency of private firms in the sectors where the SOEs operated, and by the desire to attract private industrial investment to the Puerto Rican economy.
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RESUM: Presentem al Dr. James M. Munyon, qui a principis del segle passat es dedicà a la manufactura i patent de remeis homeopàtics. Va ser perseguit per frau en múltiples ocasions però la seva gran fortuna li va permetre estendre el seu negoci fins a casa nostra, arribant a assolir grans cotes de popularitat. La revista ¡Cu-Cut! li dedicà tres caricatures els anys 1902 i 1903. A través de l"estudi de les mateixes hem pogut conèixer el Dr. Munyon, un intrús professional de principis del segle XX.
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Pons, Lily (Lucia) ; Votipka, Thelma (Alisa) ; Tucker, Richard (Edgardo) ; Hayward, Thomas (Arturo) ; McCracken, James (Normanno) ; Guarrera, Frank (Enrico) ; Scott, Norman (Raimondo) ; Chorus and Orchestra of the Metropolitan Opera Association, Cleva, Fausto, joht.
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The second half of eighteenth century is marked by the advancement of chemistry and geology. The first science acquired the law of conservation of mass and this science represented a important support to geology and mineralogy. We say that both became modern science that time. Our aim is to show up some interrelations between history of chemistry and history of geology by means of the study of Joseph Black's and James Hutton's works. We defend that it is positive to science education to understand and approach the relations among different and disciplinary areas of science.
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Aquest article es proposa explorar la possibilitat d'apropar a la concepció del liberalisme polític metafilosòfic de John Rawls des del punt de vista pragmatista de Richard Rorty. La proposta està motivada per les similituds que es poden observar entre elles respecte de la finalitat i la sortida d'una concepció política. El resultat final de l'article és ambigua: d'una banda, no sembla tan descabellat afirmar que la teoria de Rawls es pot llegir sense més dificultats des d'una perspectiva pragmàtica, d'altra banda, hi ha alguns aspectes importants en els quals un liberalisme polític de Rawls segueix sent incompatible amb una concepció política de Rorty