Coordenades clàssiques de Shadowlands de Richard Attenborough (sobre la vida i obra de C. S. Lewis)

L'objectiu d'aquest article és mostrar els parámetres clàssics de Shadowlands de R. Attenborough, amb guió de W. Nicholson, sobre la vida i obra de C. S. Lewis. Basant-se en una anàlisi acurada dels textos de Lewis, l'autor proposa d'interpretar l'oposició Lewis / Gresham com la traducció en la vida real de la oposició entre els temperaments platònic o idealista i aristotèlic o materialista que ja mencionava Coleridge. En qualsevol cas, són moltes les referències clàssiques que cal tenir en compte si volem comprendre fins a quin punt el cristianisme de Lewis és també un cristianisme clàssic, és a dir, grecollatí.

Coordenadas clásicas de Shadowlands de Richard Attenborough (sobre la vida y obra de C. S. Lewis)

El objetivo de este artículo es mostrar los parámetros clásicos de Shadowlands de R. Attenborough, con guión de W. Nicholson, sobre la vida y obra de C. S. Lewis. Basándose en un análisis minucioso de los textos de Lewis, el autor propone interpretar la oposición Lewis / Gresham como la traducción en la vida real de la oposición entre los temperamentos platónico o idealista y aristotélico o materialista que ya mencionaba Coleridge. En cualquier caso, son muchas las referencias clásicas que hay que tener en cuenta si se quiere comprender hasta qué punto el cristianismo de Lewis es también un cristianismo clásico, es decir grecolatino.

Classical parameters of Shadowlands by Richard Attenborough (On C. S. Lewis's Life and Work)

The aim of this article is to show the classical parameters of Shadowlands by R. Attenborough, with a screenplay by W. Nicholson, on C. S. Lewis's life and work. Based upon an accurate reading of Lewis's works, the author of this article proposes to interpret the opposition Lewis / Gresham as the translation into the real life of the opposition between the Platonic or idealistic and the Aristotelian or materialistic temperaments which was already maintained by Coleridge. In any case, there are many classical references which must be taken into account in order to understand to what extent C. S. Lewis's Christianity is also a classic Christianity, that is, a Greek and Latin one.

Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.

Dendritic cells (DCs) can release hundreds of membrane vesicles, called exovesicles, which are able to activate resting DCs and distribute antigen. Here, we examined the role of mature DC-derived exovesicles in innate and adaptive immunity, in particular their capacity to activate epithelial cells. Our analysis of exovesicle contents showed that exovesicles contain major histocompatibility complex-II, CD40, and CD83 molecules in addition to tumor necrosis factor (TNF) receptors, TNFRI and TNFRII, and are important carriers of TNF-alpha. These exovesicles are rapidly internalized by epithelial cells, inducing the release of cytokines and chemokines, but do not transfer an alloantigen-presenting capacity to epithelial cells. Part of this activation appears to involve the TNF-alpha-mediated pathway, highlighting the key role of DC-derived exovesicles, not only in adaptive immunity, but also in innate immunity by triggering innate immune responses and activating neighboring epithelial cells to release cytokines and chemokines, thereby amplifying the magnitude of the innate immune response.

Multi-Atlas based Segmentation of Head and Neck CT Images using Active Contour

This paper presents the segmentation of bilateral parotid glands in the Head and Neck (H&N) CT images using an active contour based atlas registration. We compare segmentation results from three atlas selection strategies: (i) selection of "single-most-similar" atlas for each image to be segmented, (ii) fusion of segmentation results from multiple atlases using STAPLE, and (iii) fusion of segmentation results using majority voting. Among these three approaches, fusion using majority voting provided the best results. Finally, we present a detailed evaluation on a dataset of eight images (provided as a part of H&N auto segmentation challenge conducted in conjunction with MICCAI-2010 conference) using majority voting strategy.

Constitutively active mutants of the beta1-adrenergic receptor.

We provide the first evidence that point mutations can constitutively activate the beta(1)-adrenergic receptor (AR). Leucine 322 of the beta(1)-AR in the C-terminal portion of its third intracellular loop was replaced with seven amino acids (I, T, E, F, C, A and K) differing in their physico-chemical properties. The beta(1)-AR mutants expressed in HEK-293 cells displayed various levels of constitutive activity which could be partially inhibited by some beta-blockers. The results of this study might have interesting implications for future studies aiming at elucidating the activation process of the beta(1)-AR as well as the mechanism of action of beta-blockers.