1000 resultados para Música i malalties reumàtiques


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This study aims to investigate the music and the existing music education in Central Temple of the Evangelical Assembly of God Church of Natal/RN. The research question asks how are the musical practices, teaching and learning music that happens in this place. I used the qualitative approach conducting a case study. The theoretical framework were Arroyo (1999, 2000a, 2000b, 2002), Kraemer (2000), Souza (1996), Souza (2000, 2008, 2009), Green (1997), Queiroz (2004a, 2004b, 2005, 2007, 2010, 2011, 2013), Geertz (1989), Nettl (1992) and Merrian (1964). I conducted semi-structured interviews and participant observation with the direction of the music department, teaching coordination, students, teachers, musicians and conductors of the church. The study revealed that the relationship between music and education is beyond just a musical training, there are many relationships established as faith, belief in God and devotion. It was found that the views of musicians and conductors think the music teaching in the church to play in worship and praise God. In the musical training of students, he was working not only musical content; It was understood that music is a mediator of meanings that go beyond experiences and musical practices. The worship of God and the worship featuring musical practices and their effects are direct music classes. The research contributes to reflection and understanding of music and music education happens in the evangelical church and a greater understanding in the relationship between music education and the cultural context where it happens.

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The little interest in reading and the large presence of deviations in writing observed in the texts of students of the 5th grade of a public school in RN, led us to question the motives of this problem. Thus, the idea to organize and develop teaching sequences with a variety of possibilities of reading and production through the text genres. The practice with the textual genres in elementary school extends the use of reading and writing and improves the quality of learning. In this way, the school, as one of the most active spheres in social practices of the language, we justify this work with the use of text genres as facilitators for teaching and learning the mother tongue. For this purpose, we draw as the main objective to talk about the work with textual genres from the development of didactic sequences, as well as encourage students to take a more reflexive attitude toward language and its uses, as discursive social practices. The development of the study with the text genres was made through the application of didactic sequences in the school context of elementary school classes, from 5th grade. Specifically were chosen, the letter, note, music, poetry, fable and the tale. The study is anchored in the reflections of the following theorists and researchers: Bakhtin (2011), Miller (1994), Marcuschi (2008) and Bronckart (1999) on the text genres; Marcuschi (2005) and Dolz and Schneuwly (2004) that approve a teaching-learning proposal focused on textual genres, giving a meaning to language in the construction of the knowledge and Dolz and Schneuwly (2004) regarding the didactic sequence; other theoretical orientations: PCN (1998), Lerner (2005), among others. The methodology followed the action research guidelines, in a qualitative approach perspective. The instruments of research included questionnaire, observations, readings and productions. The results pointed the students' interest in relation to the activities developed in the didactic sequences and consequently improvement in the students‘ own writings. In this sense, we reiterate the need to contamplate in the teaching activities the diversity of texts and genres and, not only due to its social relevance, therefore the student should be able to use the language in various way and adapt their texts to situations of oral and written interlocution.

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O presente relatório de Mestrado foi elaborado no âmbito do Mestrado em Educação em Educação Pré-Escolar, no ano letivo 2014/2015, na Escola Superior de Educação e Ciências Socias do Instituto Politécnico de Leiria. Apresenta-se dividido em duas partes que remetem para o percurso de desenvolvimento pessoal e profissional na Prática de Ensino Supervisionada no contexto de creche e no contexto de jardim-de-infância. A parte I é relativa às vivências em contexto de creche e é dividida em dois pontos. Em primeiro lugar exponho uma componente reflexiva sobre o meu percurso formativo durante a Prática Pedagógica em contexto de creche, onde reflito sobre as experiências vividas com as crianças. No segundo ponto revelo o ensaio investigativo desenvolvido com duas crianças que teve por base a questão “Quais as formas de interação que as crianças estabelecem entre si quando escutam música, na sala de atividades?”. Os principais resultados revelaram que as crianças interagiam com os seus pares essencialmente através do olhar e do sorriso. A parte II é igualmente dividida em dois pontos. Inicialmente dou a conhecer a dimensão reflexiva que assentou nas experiências e aprendizagens que decorreram da Prática Pedagógica em contexto de jardim-de-infância. Segue-se o projeto “Investigando os caracóis com as crianças” onde dou a conhecer o trabalho desenvolvido com as crianças no âmbito da Metodologia de Trabalho de Projeto. Esta metodologia permitiu-me compreender o carácter ativo da criança na construção das suas aprendizagens e a importância da motivação e interesses das crianças nesse processo.

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O presente relatório refere-se ao Mestrado em Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico e apresenta-se dividido em duas partes. A parte I corresponde à dimensão reflexiva na qual se apresenta uma reflexão acerca do percurso desenvolvido ao longo das Práticas Pedagógicas nos vários contextos: Creche, Jardim-de-Infância e 1.º Ciclo do Ensino Básico. Esta parte encontra-se estruturada de acordo com um conjunto de referentes: observação, planificação e intervenção, dificuldades e, por último, aprendizagens. Além disso, inclui-se o papel reflexivo e investigativo do educador e professor. A parte II apresenta a dimensão investigativa referente a um estudo realizado numa turma de 3.º ano de escolaridade, que incidiu na temática da integração pedagógica da Música no processo de ensino e aprendizagem da área curricular de Português. Esta investigação dispõe de um caráter qualitativo, uma vez que se pretendeu compreender as potencialidades da integração pedagógica da Música no processo de ensino e aprendizagem do Português. Após a organização e análise dos dados recolhidos pode sugerir-se que a utilização da canção, enquanto instrumento de integração, proporcionou aos alunos diversas aprendizagens no domínio da Música e na área de Português.

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El carácter innovador y feminista del mediometraje Margarita y el lobo (1969) supuso la censura total de la película y el ostracismo hacia su directora, la entonces estudiante de la EOC, Cecilia Bartolomé. En este artículo repasamos sus anteriores cortometrajes para desgranar los primeros matices de protesta así como la utilización de la expresión musical como vehículo del discurso feminista en Margarita y el lobo. A través de los planteamientos de la musicóloga Susan McClary que abordan sexualidad, género y feminismo concluimos con una visión del análisis de género en las obras musicales, al vincular sus es­tudios al film de Bartolomé. Del mismo modo, analizamos la función que cumple la música en el medio­metraje. Para ello, examinamos el repertorio de canciones presente en Margarita y el lobo para terminar reconociendo la función discursiva y referencial como piezas claves en la película de la directora.

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Dissertação de Mestrado apresentada ao Instituto Superior de Psicologia Aplicada para obtenção de grau de Mestre na especialidade de Psicologia Clínica.

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Escuchar música parece tener un efecto en las emociones que experimenta el alumnado desde sus primero años de escolarización. Sin embargo, esta relación parece estar mediada por factores sociales, culturales y cognitivos. La revisión de la literatura muestra la complejidad de la relación entre música y emociones, al mismo tiempo que los vínculos entre emociones y aprendizaje. Por tal motivo, es necesario que los estudiantes universitarios de Educación Infantil (EI) conozcan los fundamentos básicos de los recursos musicales. En este estudio se plantearon como objetivos: 1) que el alumnado de Magisterios de EI experimentase los efectos de la música durante su propia formación; 2) comprobar los cambios emocionales de la música en dichos estudiantes; 3) recoger la perspectiva de los estudiantes de EI sobre la música como recurso en la escuela. Para ello se desarrolló un estudio mixto con un grupo de 50 estudiantes de Educación de la Universidad de Málaga. Se utilizó la entrevista semiestructurada y el autoinforme como instrumentos de recogida de datos. Los resultados muestran la complejidad de la relación entre emociones y la música, así como la valoración positiva del alumnado para utilizar la música en el ejercicio profesional, si bien, sugieren un uso desde teorías psicopedagógicas bien contrastadas.

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La investigación acerca de esta arpista, compositora, profesora, escritora y gestora catalana, de pensamiento liberal y feminista, y de acciones filantrópicas, fue realizada básicamente a través de escritos de prensa española y extranjera. Su madre recopilará durante veinte años un valioso álbum que resume la vida artística de Esmeralda, desde los 13 hasta los 33 años; el mismo se conserva en la Biblioteca de Catalunya (Barcelona) en proceso de restauración, pero ha podido ser consultado y digitalizado. Los múltiples viajes que realizó como intérprete solista, dan como resultado una documentación dispersa en el mundo que ha sido muy difícil de recolectar. Clotilde Cerdà i Bosch (Barcelona 28-02-1861 – Sta. Cruz de Tenerife 12-04-1926), usa el seudónimo Esmeralda Cervantes propuesto por Victor Hugo e Isabel II de Borbón. Nace de padres intelectuales, Ildefonso Cerdà i Sunyer (urbanista, autor del Eixemple de Barcelona) y Clotilde Bosch (pintora, hija de un banquero). Los padres se separan cuando la niña tiene 3 años y desde entonces vive en la única compañía materna. Protegida por Isabel II de Borbón y la Condesa de Montijo, se forma en París y Viena como intérprete del arpa. En París vivía con la desterrada reina Isabel II, en el Palacio Blavatsky, donde su madre era dama de honor. El texto subsiguiente está estructurado en nueve apartados. Los dos primeros refieren cronológicamente el entorno, los estudios y las primeras actuaciones musicales de la intérprete en Europa y las Américas, con remarcados éxitos. El tercer capítulo deja ver el ingreso de Esmeralda Cervantes en el mundo periodístico con la fundación de su primer periódico L’Étoile Polaire en París y la segunda gira americana de conciertos, más breve que la anterior...

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Académico - Licenciaturas

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Abstract This communication reflects the work done in the Department of Civil Engineering and Architecture at the University of Beira Interior (Portugal), and still ongoing, in the framework of the project ORFEUS - The Tridentine Reform and music in the cloistral silence: the Monastery of S. Bento de Cástris (Project FCT EXPL/EPH-PAT/2253/2013) and aims to bring the debate to a contribution to the study of the specificity of the monastery of St. Bento de Cástris in the context of Cistercian architecture, in which the shape and the music are intertwined. In this way, two dissertations have been developed in Architecture (integrated master course of architecture of the University of Beira Interior) within the project ORFEUS, which are divided by the importance and contributions of the Cistercian Architecture in contemporary religious architecture, the morphology of the Cistercian churches and the relationship between architecture and music in the specific case study of the church of the monastery of St. Bento de Cástris. Resumo Esta comunicação reflecte o trabalho desenvolvido no Departamento de Engenharia Civil e Arquitectura da Universidade da Beira Interior, e ainda em curso, no âmbito do Projecto ORFEUS - A Reforma tridentina e a música no silêncio claustral: o mosteiro de S. Bento de Cástris (Projecto FCT EXPL/EPH- PAT/2253/2013) e pretende-se com esta comunicação trazer a debate um contributo para o estudo da especificidade do Mosteiro de S. Bento de Cástris, no contexto da arquitectura cisterciense, no qual a forma e a música se entrelaçam. Neste sentido foram desenvolvidas duas dissertações de mestrado integrado em Arquitectura, no âmbito do Projecto ORFEUS, que se repartem pela importância e contributos da Arquitectura Cisterciense na Arquitectura religiosa contemporânea, a morfologia das igrejas cistercienses e a relação entre a arquitectura e música patente no estudo de caso da igreja do Mosteiro de S. Bento de Cástris.

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Snakebite is a neglected disease and serious health problem in Brazil, with most bites being caused by snakes of the genus Bothrops. Although serum therapy is the primary treatment for systemic envenomation, it is generally ineffective in neutralizing the local effects of these venoms. In this work, we examined the ability of 7,8,3'-trihydroxy-4'-methoxyisoflavone (TM), an isoflavone from Dipteryx alata, to neutralize the neurotoxicity (in mouse phrenic nerve-diaphragm preparations) and myotoxicity (assessed by light microscopy) of Bothrops jararacussu snake venom in vitro. The toxicity of TM was assessed using the Salmonella microsome assay (Ames test). Incubation with TM alone (200 μg/mL) did not alter the muscle twitch tension whereas incubation with venom (40 μg/mL) caused irreversible paralysis. Preincubation of TM (200 μg/mL) with venom attenuated the venom-induced neuromuscular blockade by 84% ± 5% (mean ± SEM; n = 4). The neuromuscular blockade caused by bothropstoxin-I (BthTX-I), the major myotoxic PLA2 of this venom, was also attenuated by TM. Histological analysis of diaphragm muscle incubated with TM showed that most fibers were preserved (only 9.2% ± 1.7% were damaged; n = 4) compared to venom alone (50.3% ± 5.4% of fibers damaged; n = 3), and preincubation of TM with venom significantly attenuated the venom-induced damage (only 17% ± 3.4% of fibers damaged; n = 3; p < 0.05 compared to venom alone). TM showed no mutagenicity in the Ames test using Salmonella strains TA98 and TA97a with (+S9) and without (-S9) metabolic activation. These findings indicate that TM is a potentially useful compound for antagonizing the neuromuscular effects (neurotoxicity and myotoxicity) of B. jararacussu venom.

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Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients. Experimental single cohort study conducted in the outpatient clinic of a university hospital. Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol. 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment. Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP.

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Phase I trials use a small number of patients to define a maximum tolerated dose (MTD) and the safety of new agents. We compared data from phase I and registration trials to determine whether early trials predicted later safety and final dose. We searched the U.S. Food and Drug Administration (FDA) website for drugs approved in nonpediatric cancers (January 1990-October 2012). The recommended phase II dose (R2PD) and toxicities from phase I were compared with doses and safety in later trials. In 62 of 85 (73%) matched trials, the dose from the later trial was within 20% of the RP2D. In a multivariable analysis, phase I trials of targeted agents were less predictive of the final approved dose (OR, 0.2 for adopting ± 20% of the RP2D for targeted vs. other classes; P = 0.025). Of the 530 clinically relevant toxicities in later trials, 70% (n = 374) were described in phase I. A significant relationship (P = 0.0032) between increasing the number of patients in phase I (up to 60) and the ability to describe future clinically relevant toxicities was observed. Among 28,505 patients in later trials, the death rate that was related to drug was 1.41%. In conclusion, dosing based on phase I trials was associated with a low toxicity-related death rate in later trials. The ability to predict relevant toxicities correlates with the number of patients on the initial phase I trial. The final dose approved was within 20% of the RP2D in 73% of assessed trials.

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Pyrimidine-5'-nucleotidase type I (P5'NI) deficiency is an autosomal recessive condition that causes nonspherocytic hemolytic anemia, characterized by marked basophilic stippling and pyrimidine nucleotide accumulation in erythrocytes. We herein present two African descendant patients, father and daughter, with P5'N deficiency, both born from first cousins. Investigation of the promoter polymorphism of the uridine diphospho glucuronosyl transferase 1A (UGT1A) gene revealed that the father was homozygous for the allele (TA7) and the daughter heterozygous (TA6/TA7). P5'NI gene (NT5C3) gene sequencing revealed a further change in homozygosity at amino acid position 56 (p.R56G), located in a highly conserved region. Both patients developed gallstones; however the father, who had undergone surgery for the removal of stones, had extremely severe intrahepatic cholestasis and, liver biopsy revealed fibrosis and siderosis grade III, leading us to believe that the homozygosity of the UGT1A polymorphism was responsible for the more severe clinical features in the father. Moreover, our results show how the clinical expression of hemolytic anemia is influenced by epistatic factors and we describe a new mutation in the P5'N gene associated with enzyme deficiency, iron overload, and severe gallstone formation. To our knowledge, this is the first description of P5'N deficiency in South Americans.

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The aim of this work was to characterize the effects of partial inhibition of respiratory complex I by rotenone on H2O2 production by isolated rat brain mitochondria in different respiratory states. Flow cytometric analysis of membrane potential in isolated mitochondria indicated that rotenone leads to uniform respiratory inhibition when added to a suspension of mitochondria. When mitochondria were incubated in the presence of a low concentration of rotenone (10 nm) and NADH-linked substrates, oxygen consumption was reduced from 45.9 ± 1.0 to 26.4 ± 2.6 nmol O2 mg(-1) min(-1) and from 7.8 ± 0.3 to 6.3 ± 0.3 nmol O2 mg(-1) min(-1) in respiratory states 3 (ADP-stimulated respiration) and 4 (resting respiration), respectively. Under these conditions, mitochondrial H2O2 production was stimulated from 12.2 ± 1.1 to 21.0 ± 1.2 pmol H2O2 mg(-1) min(-1) and 56.5 ± 4.7 to 95.0 ± 11.1 pmol H2O2 mg(-1) min(-1) in respiratory states 3 and 4, respectively. Similar results were observed when comparing mitochondrial preparations enriched with synaptic or nonsynaptic mitochondria or when 1-methyl-4-phenylpyridinium ion (MPP(+)) was used as a respiratory complex I inhibitor. Rotenone-stimulated H2O2 production in respiratory states 3 and 4 was associated with a high reduction state of endogenous nicotinamide nucleotides. In succinate-supported mitochondrial respiration, where most of the mitochondrial H2O2 production relies on electron backflow from complex II to complex I, low rotenone concentrations inhibited H2O2 production. Rotenone had no effect on mitochondrial elimination of micromolar concentrations of H2O2. The present results support the conclusion that partial complex I inhibition may result in mitochondrial energy crisis and oxidative stress, the former being predominant under oxidative phosphorylation and the latter under resting respiration conditions.