Judaica seu veterum scriptorum profanorum de rebus Judaicis fragments

coll. Fr. Carolus Meier

Evaluation of colon cancer histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial.

The aim of our study was to evaluate the quality of histo- and cytomorphological features of PAXgene-fixed specimens and their suitability for histomorphological classification in comparison to standard formalin fixation. Fifteen colon cancer tissues were collected, divided into two mirrored samples and either formalin fixed (FFPE) or PAXgene fixed (PFPE) before paraffin embedding. HE- and PAS-stained sections were scanned and evaluated in a blinded, randomised ring trial by 20 pathologists from Europe and the USA using virtual microscopy. The pathologists evaluated histological grading, histological subtype, presence of adenoma, presence of lymphovascular invasion, quality of histomorphology and quality of nuclear features. Statistical analysis revealed that the reproducibility with regard to grading between both fixation methods was rather satisfactory (weighted kappa statistic (k w) = 0.73 (95 % confidence interval (CI), 0.41-0.94)), with a higher agreement between the reference evaluation and the PFPE samples (k w = 0.86 (95 % CI, 0.67-1.00)). Independent from preservation method, inter-observer reproducibility was not completely satisfactory (k w = 0.60). Histomorphological quality parameters were scored equal or better for PFPE than for FFPE samples. For example, overall quality and nuclear features, especially the detection of mitosis, were judged significantly better for PFPE cases. By contrast, significant retraction artefacts were observed more frequently in PFPE samples. In conclusion, our findings suggest that the PAXgene Tissue System leads to excellent preservation of histomorphology and nuclear features of colon cancer tissue and allows routine morphological diagnosis.

"Was hat die jüdische Gemeinde Königsbergs König Friedrich I. im besondern zu verdanken?" : Vortrag, gehalten am 15. Januar 1901 im Verein für jüd. Geschichte u. Litteratur zu Königsberg i. Pr.

von Ed. Birnbaum

Andenken an die verewigte Frau Commerzienräthin Lea Kaulla, geb. Kaulla, Geboren den 27. Sept. 1781, Gestorben den 1. Febr. 1849

Titelbl. gestempelt: Privatbibl. Karl Rohm sen.; hs Notiz auf Titelbl.: seltener Privatdruck aus der Privatbibl. eines militanten Antisemiten

Zeitgenossen in Biographieen und Porträts : ein Volksbuch

Boberach: Behandelt werden Alexander Freiherr von Soiron, Jakob Venedey, Oskar von Wydenbrugk, Gottlieb Christian Schüler, Heinrich Freiherr von Gagern, Ernst Moritz Arndt, Carl Theodor Welcker, Friedrich Ludwig Jahn, Franz Schuselka, Friedrich Siegmund Jucho, Johann Gustav Moritz Heckscher, Felix Fürst von Lichnowsky, Friedrich Christoph Dahlmann, Anton Ritter von Schmerling, Franz Raveaux, Heinrich Simon, Johann Jacoby, Robert Blum, Johann Erzherzog von Österreich, Louis Cavaignac, Friedrich Hecker, Friedrich von Wrangel, Joseph Wenzel Graf Radetzky, Joseph Freiherr Jellachich von Buszin, Hermann Rollett, Alphonse de Lamartine, Georg Jung, Louis Napoleon, Ernst Alfred Fürst zu Windischgrätz, Ferdinand Freiligrath, Ludwig Kossuth, Emanuel Geibel

Bibliothek der neuesten Land- und Seereisen

für die Jugend bearbeitet von K.F.W. Wander

Friedrich Beer

Karl Schwarz

Friedrich Wilhelm IV. König von Preußen : ein Lebensbild

herausgegeben und verlegt von dem Haupt-Verein für christliche Erbauungsschriften in den Preußischen Staaten ; [Wilhelm Ziethe]

Birne: König Karl von Württemberg

Fr. Lucas