Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension

Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients.

maintenance model for systems with phase-type distributed times to failure

Magdeburg, Univ., Fak. für Mathematik, Diss., 2010

Catalogue of type specimens in Chicago Natural History Museum : Porifera / Matthew H. Nitecki --

v.13:no.6(1965)

Catalogue of type specimens of fishes in Chicago Natural History Museum [by] Marion Grey.

v.32:no.3(1947)

Catalogue of type specimens of recent fishes in Field Museum of Natural History / Myriam Ibarra and Donald J. Stewart.

n.s. no.35(1987)

Catalogue of type specimens of reptiles and amphibians in Chicago Natural History Museum.

v.36:no.4(1958)

Catalogue of the type material of Phasmatodea (Insecta) deposited in Brazilian museums

The type material of Phasmatodea deposited in Brazilian museums and institutions is listed for the first time. New synonyms are proposed: Phibalosoma paulense Toledo Piza, 1938, Phibalosoma rochai Toledo Piza, 1938, Bacteria tuberculata Toledo Piza, 1938 and Bacteria tuberculata var. argentina Toledo Piza, 1938 are junior synonyms of Cladomorphus phyllinus (Gray, 1835). Nineteen new combinations are established.

Catalogue of type specimens of Foraminifera in the Walker Museum of Paleontology / Matthew H. Nitecki --.

v.13:no.2(1961)

Supplementary catalogue of type specimens of reptiles and amphibians in Field Museum of Natural History / Hymen Marx.

v.69:no.2(1976)

Catalogue of type specimens of mammals in Chicago Natural History Museum [by] Colin Campbell Sanborn.

v.32:no.4(1947)

Catalogue of type and referred specimens of fossil Echinozoa (Echinoidea and Cyclocystoidea) in Field Museum of Natural History / [by] Julia Golden -- and Matthew H. Nitecki --.

v.20:no.2(1970)

Catalogue of type and referred specimens of fossil Stelleroidea in Field Museum of Natural History / [by] Julia Golden -- and Matthew H. Nitecki --.

v.20:no.4(1970)

Catalogue of type and referred specimens of Echinozoa (Edrioasteroidea) in Field Museum of Natural History / [by] Julia Golden -- and Matthew H. Nitecki --.

v.20:no.3(1970)

Type fossil Miscellanea (worms, problematica, conoidal shells, trace fossils) in Field Museum / Gerald Glenn Forney --, Daniel T. Jenkins -- and Matthew H. Nitecki --.

v.37:no.1(1977)

A catalogue of type specimens of fossil fishes in the Field Museum of Natural History / John Clay Bruner --.

n.s. no.23(1992)