547 resultados para Imunidade inata


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Pós-graduação em Medicina Veterinária - FCAV

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Pós-graduação em Ciência Animal - FMVA

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The development of populations of gastrointestinal parasites resistant to antihelmintics has led to seeks new alternatives its control. Stimulation of natural immunity by means of animal nutrition has shown promising results in controlling nematodes in sheep. The addition of protected fat sources, containing essential fatty acids, may be an alternative due to many effects, among them, regulation of immunity expression and regulation of the inflammatory response by immune effectors. The aim of this study was to estimate correlations between haematological and parasitological patterns, animal performance through weight and body condition, under the influence of protected fat in ewes. Fifty Santa Ines sheep, in the final third of pregnancy or postpartum, in paddocks of Panicum maximum, received, individually, 200 g per day of concentrate, isonitrogenous and isocaloric diets, with or without the addition of protected fat. In general, except for total leukocytes and eosinophils, almost all of Pearson correlation coefficients of other variables were significant. However, the protected fat, in the amount offered, had no antihelmintic effect.

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The aim of this study was to evaluate the serum protein concentration in newborns fed with colostrum derived from healthy cows (n = 10), cows with subclinical mastitis (n = 10) and cows with clinical mastitis (n = 10). 30 Holstein cows were assigned to their respective groups according to macroscopic examination of colostral secretion, somatic cell count, CMT and presence of bacteria in colostrum samples. Blood samples of the calves were collected immediately after birth, at 24 and 48 hours after ingestion of colostrum. The total protein was measured by the biuret method and the concentrations of immunoglobulin A (IgA), immunoglobulin G (IgG), transferrin, albumin and haptoglobin was determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). No differences were obser- ved amongst groups in the concentrations of albumin, total protein and IgA. In animals from cows with subclinical and clinical mastitis haptoglobin concentrations were higher than those of healthy animals. The concentrations of IgG and transferrin were significantly lower in calves from cows with mastitis. We concluded that the ingestion of colostrum from infected and uninfected glands from cows with mastitis (GII e GIII) is unlikely to be an important contributor to the high rate of failure of passive transfer of immunoglobulins in calves.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The main function of the immune system is the defense against infection, being composed by the leukocytes that modulate the immune response, which can be innate or adaptive. The physical exercise can causes positive or negative alterations in the total or relative number of leukocytes. When the exercise has a low or moderate intensity it`s considered beneficial for improving the function of the cells responsible for the defense and to reduce the risk of infectious illnesses. The type 2 diabetes is related to an incapacity of the body in rightly respond to insulin, associated to an resistance to its actions. The purpose of this research was to make a study of the immune system characteristics, as well as the type 2 diabetes and the relation among both and the physical exercise. So, it was analyzed a group of type 2 diabetics coming from Diabetics House of Franca -SP, treated through a program of mix physical training. Two collections of blood were pre and post training program for the pair comparable of the participants. It was found positive alterations of the subpopulations of leukocytes that show a probable improvement of the immunological state what allows us to suggest about a possible improvement of the immunological activity, what would be measured by the activation of these cells forward to an inflammatory/infectious condition. So, we suggest that future studies involving diabetes, immune system and physical exercise be encouraged.

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Pós-graduação em Ciência e Tecnologia Animal - FEIS

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Introdução: Hanseníase e Tuberculose são enfermidades associadas à supressão da imunidade celular do tipo TH1. As manifestações clínicas da hanseníase são usualmente cutâneas e da tuberculose (Tbc) tegumento-pulmonares. O objetivo é demonstrar a presença de ambas as enfermidades no mesmo paciente. Relato do caso: Paciente masculino, 59 anos, em uso de prednisona 40mg/d há 6 meses devido a um quadro “alérgico”, com queixa de úlcera peri-anal dolorosa e sangrante. Ao exame apresentava úlcera fagedênica peri-anal e inguinal fistulizado e pápulas normocrômicas no antebraço. Histopatológico de lesão nodular e da úlcera mostra infiltrado granulomatoso com BAAR +,interpretado como hanseníase multibacilar. O tratamento não resultou em melhora das lesões inguinais e perianal. Novos exames demonstraram serem as lesões ulceradas causadas pelo Mycobacterium tuberculosis, por cultura, e as lesões pápulo-nodulares serem Mycobacterium leprae, por PCR. Tratamento para ambas foi eficaz. O M.leprae e M.tuberculosis são patógenos intracelulares obrigatórios e a defesa do hospedeiro está diretamente associada à imunidade celular. Mesmo em países endêmicos para ambas as enfermidades a associação das duas doenças é de ocorrência excepcional. O uso da corticoterapia utilizada para quadro alérgico (ENH) facilitou a ocorrência da Tbc. O caso relata a importância dos métodos auxiliares diagnósticos em caso de difícil interpretação clínica.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)