996 resultados para Hirsch, MoritzHirsch, MoritzMoritzHirsch


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zs.-gest. von H. Goldberg

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Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. Both spontaneous and treatment-induced clearance of HCV depend on genetic variation within the interferon-lambda locus, but until now no clear causal relationship has been established. Here we demonstrate that an amino-acid substitution in the IFNλ4 protein changing a proline at position 70 to a serine (P70S) substantially alters its antiviral activity. Patients harbouring the impaired IFNλ4-S70 variant display lower interferon-stimulated gene (ISG) expression levels, better treatment response rates and better spontaneous clearance rates, compared with patients coding for the fully active IFNλ4-P70 variant. Altogether, these data provide evidence supporting a role for the active IFNλ4 protein as the driver of high hepatic ISG expression as well as the cause of poor HCV clearance.

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H. Hildesheimer

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von Mendel Hirsch

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[Verf.: H. Somerhausen]

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von M. H. Friedländer

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nach d. Quellen bearb. von M. H. Friedländer

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von A. H. Heymann. Nach seiner Niederschrift im Auftr. seiner Kinder hrsg. von Heinrich Loewe