La Bibliografía Científica de Fernando de Buen.

Si bien existen varios ensayos biográficos que enfocan diferentes momentos de su vida (ANÓNIMO, 1963, BAHAMONDE, 1962, LÓPEZ et al., 2015, NION, 2015, PEQUEÑO, 2015, SÁNCHEZ CARRILLO, 2001), hasta donde tenemos conocimiento, no se ha publicado aún una bibliografía completa de la obra del Dr. FERNANDO DE BUEN Y LOZANO (Fig. de tapa). Bibliografías parciales se encuentran, entre otros, en los autores arriba citados. Aquí nos atrevemos a hacer el intento, aunque en forma defectuosa, ya que muchas de sus publicaciones no las hemos podido consultar directamente (se señalan con un asterisco, *). En parte nos hemos basado en una compilación hecha por el propio DE BUEN, que abarca los años 1915 a 1949 (Fig. 1), aunque no siempre con los datos necesarios para una completa información sobre la publicación; en lo posible intentamos complementarla. En sus casi cincuenta años de actividad científica, llegó a producir casi 300 títulos, de variado contenido, aunque siempre relacionados con el medio acuático, sea marino o dulceacuícola. Esta producción se puede dividir en cuatro períodos, que comienza con su etapa española, europea y africana (marroquí), entre 1915 y 1937, durante la cual publicó más de 140 títulos. Como consecuencia de la Guerra Civil Española, en 1939 se radica en México, donde permanece desde el 12 de Julio de 1939 hasta Noviembre 1946, país al que regresa entre 1953 y 1957. Durante este período escribe unos 70 artículos. Entre esas dos etapas mexicanas, estuvo brevemente radicado en el Uruguay, desde el 26 de Noviembre de 1946 hasta 1953, sin duda la etapa de menor producción científica, con una docena trabajos. A ésta sigue el último período de su vida, en Chile (Fig. 2), la que lamentablemente termina trágicamente, en 1962. Durante este período publica más de 60 publicaciones, de los cuales, aparentemente, seis quedan inéditas. Cabe señalar que durante estas tres etapas de exilio americano, si bien sus publicaciones están mayoritariamente relacionadas con el país de residencia, hay algunas excepciones. Preivo a estas estadías en América, hay que mencionar tres europeas, fuera de España, a saber: en el Museo Oceanográfico de Mónaco (1919), en el Instituto Centrale di Biologia Marina, Messina, Italia (1919), y en el Laboratorio Arago, Banyuls sur Mer, Francia (1939). En general, puede considerarse que FERNANDO DE BUEN fue un investigador solitario, ya que solamente seis, de sus casi 300 trabajos, fueron publicados en colaboración: dos con su hermano SADÍ DE BUEN (#31 y 32), dos con F. FRADE (#115 y 116), y dos con MANUEL ZOZAYA (#162 y 176). En su obra científica hemos podido identificar la descripción original de 12 géneros, 9 subgéneros, 54 especies y 11 subespecies, como se indican en la Tabla I.

Significant improvements in optical power budgets of real-time optical OFDM PON systems.

Based on a comprehensive theoretical optical orthogonal frequency division multiplexing (OOFDM) system model rigorously verified by comparing numerical results with end-to-end real-time experimental measurements at 11.25Gb/s, detailed explorations are undertaken, for the first time, of the impacts of various physical factors on the OOFDM system performance over directly modulated DFB laser (DML)-based, intensity modulation and direct detection (IMDD), single-mode fibre (SMF) systems without in-line optical amplification and chromatic dispersion compensation. It is shown that the low extinction ratio (ER) of the DML modulated OOFDM signal is the predominant factor limiting the maximum achievable optical power budget, and the subcarrier intermixing effect associated with square-law photon detection in the receiver reduces the optical power budget by at least 1dB. Results also indicate that, immediately after the DML in the transmitter, the insertion of a 0.02nm bandwidth optical Gaussian bandpass filter with a 0.01nm wavelength offset with respect to the optical carrier wavelength can enhance the OOFDM signal ER by approximately 1.24dB, thus resulting in a 7dB optical power budget improvement at a total channel BER of 1 × 10(-3).

The pursuit of academic excellence and business engagement: Is it irreconcilable?

Universities currently need to satisfy the demands of different audiences. In light of the increasing policy emphasis on "third mission" activities, universities are attempting to incorporate these into their traditional missions of teaching and research. University strategies to accomplishing its traditional missions are well-honed and routinized, but the incorporation of the third mission is posing important strategic and managerial challenges for universities. This study explores the relationship between university-business collaborations and academic excellence in order to examine the extent to which academic institutions can balance these objectives. Based on data from the UK Research Assessment Exercise 2001 at the level of the university department, we find no systematic positive or negative relationship between scientific excellence and engagement with industry. Across the disciplinary fields reported in the 2001 Research Assessment Exercise (i. e. engineering, hard sciences, biomedicine, social sciences and the humanities) the relationship between academic excellence and engagement with business is largely contingent on the institutional context of the university department. This paper adds to the growing body of literature on university engagement with business by examining this activity for the social sciences and the humanities. Our findings have important implications for the strategic management of university departments and for higher education policy related to measuring the performance of higher education research institutions. © 2013 Akadémiai Kiadó, Budapest, Hungary.

Mirando al futuro: conexión directa con la investigación biomédica

Los estudios de Ciencias Biomédicas tienen una fuerte carga experimental y conexión con el mundo de la investigación que a muchos alumnos les cuesta reconocer, especialmente entre los de primer curso. Por ello, los autores hemos diseñado una actividad práctica integrada y evaluable para la asignatura Bioquímica II del Grado de Medicina, impartida en primer curso. Se pretendía conectar la asignatura con el mundo profesional de la investigación en Ciencias Biomédicas. El trabajo de los alumnos consistió en buscar la máxima información sobre el grupo que les hubiera correspondido, preparar una entrevista para realizar al investigador responsable del laboratorio y analizar su publicación más relevante, centrándose en la parte de su investigación que tiene que ver con nuestros estudios. El resultado ha sido satisfactorio a todos los niveles: los alumnos han obtenido buenas calificaciones y han valorado la actividad con un 3 sobre 4, los investigadores puntuaron mayoritariamente con la máxima calificación a los alumnos y los profesores estamos satisfechos con el aprovechamiento de los alumnos así como con la interacción con los investigadores y la integración con el resto de nuestros compañeros docentes. Entendemos que la actividad debe mejorarse de cara al futuro, sobre todo en relación al ítem peor valorado por los alumnos: la conexión entre lo explicado en clase y lo aprendido en el laboratorio.

Prediction of 30-day mortality in older patients with a first acute myocardial infarction

This study sought predictors of mortality in patients aged >or=75 years with a first ST-segment elevation myocardial infarction (STEMI) and evaluated the validity of the GUSTO-I and TIMI risk models. Clinical variables, treatment and mortality data from 433 consecutive patients were collected. Univariable and multivariable logistic regression analyses were applied to identify baseline factors associated with 30-day mortality. Subsequently a model predicting 30-day mortality was created and compared with the performance of the GUSTO-I and TIMI models. After adjustment, a higher Killip class was the most important predictor (OR 16.1; 95% CI 5.7-45.6). Elevated heart rate, longer time delay to admission, hyperglycemia and older age were also associated with increased risk. Patients with hypercholesterolemia had a significantly lower risk (OR 0.46; 95% CI 0.24-0.86). Discrimination (c-statistic 0.79, 95% CI 0.75-0.84) and calibration (Hosmer-Lemeshow 6, p = 0.5) of our model were good. The GUSTO-I and TIMI risk scores produced adequate discrimination within our dataset (c-statistic 0.76, 95% CI 0.71-0.81, and c-statistic 0.77, 95% CI 0.72-0.82, respectively), but calibration was not satisfactory (HL 21.8, p = 0.005 for GUSTO-I, and HL 20.6, p = 0.008 for TIMI). In conclusion, short-term mortality in elderly patients with a first STEMI depends most importantly on initial clinical and hemodynamic status. The GUSTO-I and TIMI models are insufficiently adequate for providing an exact estimate of 30-day mortality risk.

Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina

Sonic Hedgehog (Shh) signaling is an important determinant of vertebrate retinal ganglion cell (RGC) development. In mice, there are two major RGC populations: (1) the Islet2-expressing contralateral projecting (c)RGCs, which both produce and respond to Shh; and (2) the Zic2-expressing ipsilateral projecting RGCs (iRGCs), which lack Shh expression. In contrast to cRGCs, iRGCs, which are generated in the ventrotemporal crescent (VTC) of the retina, specifically express Boc, a cell adhesion molecule that acts as a high-affinity receptor for Shh. In Boc −/− mutant mice, the ipsilateral projection is significantly decreased. Here, we demonstrate that this phenotype results, at least in part, from the misspecification of a proportion of iRGCs. In Boc−/− VTC, the number of Zic2-positive RGCs is reduced, whereas more Islet2/Shh-positive RGCs are observed, a phenotype also detected in Zic2 and Foxd1 null embryos.

Standardized review of atrial anatomy for cardiac electrophysiologists

2.691 JCR (2013) Q2, 50/125 Cardiac & cardiovascular systems, 51/122 Medicine, research & experimental

Choking RECtified: embodied expertise beyond Dreyfus

On a Dreyfusian account performers choke when they reflect upon and interfere with established routines of purely embodied expertise. This basic explanation of choking remains popular even today and apparently enjoys empirical support. Its driving insight can be understood through the lens of diverse philosophical visions of the embodied basis of expertise. These range from accounts of embodied cognition that are ultra conservative with respect to representational theories of cognition to those that are more radically embodied. This paper provides an account of the acquisition of embodied expertise, and explanation of the choking effect, from the most radically enactive, embodied perspective, spelling out some of its practical implications and addressing some possible philosophical challenges. Specifically, we propose: (i) an explanation of how skills can be acquired on the basis of ecological dynamics; and (ii) a non-linear pedagogy that takes into account how contentful representations might scaffold skill acquisition from a radically enactive perspective.

Centenarians and their hearts: a prospective registry with comprehensive geriatric assessment, electrocardiogram, echocardiography, and follow-up

Background Data on the cardiac characteristics of centenarians are scarce. Our aim was to describe electrocardiogram (ECG) and echocardiography in a cohort of centenarians and to correlate them with clinical data. Methods We used prospective multicenter registry of 118 centenarians (28 men) with a mean age of 101.5 ± 1.7 years. Electrocardiogram was performed in 103 subjects (87.3%) and echocardiography in 100 (84.7%). All subjects underwent a follow-up for at least 6 months. Results Centenarians with abnormal ECG were less frequently females (72% vs 93%), had higher rates of previous consumption of tobacco (14% vs 0) and alcohol (24% vs 12%), and scored lower in the perception of health status (6.8 ± 2.0 vs 8.3 ± 6.8). Centenarians with significant abnormalities in echocardiography were less frequently able to walk 6 m (33% vs 54%). Atrial fibrillation/flutter was found in 27 subjects (26%). Mean left ventricular (LV) ejection fraction was 60.0 ± 10.5%. Moderate or severe aortic valve stenosis was found in 16%, mitral valve regurgitation in 15%, and aortic valve regurgitation in 13%. Diastolic dysfunction was assessed in 79 subjects and was present in 55 (69.6%). Katz index and LV dilation were independently associated with the ability to walk 6 m. Age, Charlson and Katz indexes, and the presence of significant abnormalities in echocardiography were associated with mortality. Conclusions Centenarians have frequent ECG alterations and abnormalities in echocardiography. More than one fifth has atrial fibrillation, and most have diastolic dysfunction. Left ventricular dilation was associated with the ability to walk 6 m. Significant abnormalities in echocardiography were associated with mortality.