Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinical trial

Background: Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life.Methods/Design: A prospective, consecutive, double blind, randomized controlled clinical trial is proposed to address the effect of dialysis on sleep, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life in patients with CKD. The measurement protocol will include body weight (kg); height (cm); body mass index calculated as weight/height(2); circumferences (cm) of the neck, waist, and hip; heart and respiratory rates; blood pressures; Mallampati index; tonsil index; heart rate variability; maximum ventilatory pressures; negative expiratory pressure test, and polysomnography (sleep study), as well as the administration of specific questionnaires addressing sleep apnea, excessive daytime sleepiness, depression, anxiety, stress, and quality of life.Discussion: CKD is a major public health problem worldwide, and its incidence has increased in part by the increased life expectancy and increasing number of cases of diabetes mellitus and hypertension. Sleep disorders are common in patients with renal insufficiency. Our hypothesis is that the weather weight gain due to volume overload observed during interdialytic period will influence the degree of collapsibility of the upper airway due to narrowing and predispose to upper airway occlusion during sleep, and to investigate the negative influences of haemodialysis in the physiological variables of sleep, and autonomic nervous system, and respiratory mechanics and thereby compromise the quality of life of patients.

Fermentação, cinética e degradação ruminal em ovinos alimentados com fontes de carboidratos associadas ao óleo

The objective this work was to evaluate the degradation, fermentation and kinetics of passage rumen fluid en sheep fed diets containing different carbohydrate associated with the oil. Four rumen cannulated sheep were allotted in 4 x 4 latin square. The treatments consisted of diets with high neutral detergent soluble fiber and diets with high starch associated or not with 4,2% of oil. Incubation times were 3, 6, 12, 24, 48, 72, 96 and 120 hours and ruminal fluid was collected at 0, 2, 4, 6, 8, 10, 12, and 24 hours after feeding. Diets high neutral detergent fiber soluble resulted in greater degradation of dry matter, crude protein, neutral detergent fiber soluble and starch, and higher pH values, butyric acid production, dilution rate and ruminal recycling compared with diets high starch content. The inclusion of 4,2% oil the different carbohydrate sources had no influence on the fermentation kinetics and degradation of the fiber. High content of neutral detergent soluble fiber in the diet favors the ruminal fermentation compared to the high starch content.

A utilização de glicerina em dietas para bovinos altera a microbiota ruminal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The influence of the use of stabilizer bracelet in a child with choreoathetoid cerebral palsy

Introduction: The use of stabilizer bracelet is a frequent treatment for movement disorders to strengthen muscles and adjust coordination. Still questions remain regarding the benefi t of using loads to decrease involuntary movements and the best load and placement. Objective: To measure the infl uence of the stabilizer bracelet on the kinematics and spatiotemporal parameters in planar movements performed by the upper limb. Method: One child, who has the spastic diplegy type of cerebral palsy with choreoathetoid component, and a control child without cerebral palsy, both female and 7 years old, were subjected to analysis of movements in relation to displacement, velocity, linear acceleration, and the calculation of mean square error (MSE) with and without use of stabilizer bracelet with loads of 25, 50, and 75% of the supported maximum load. Results: After comparing data between subjects, a difference was found between patient and control in all situations and variables. An inter-individual comparison using 25% of the maximum load showed the smallest difference with the NDE. Discussion and Conclusion: This therapeutic option is low cost, easy to apply, and does not signifi cantly interfere in the aesthetic of the individual. Therefore, physiotherapists may prescribe this for activities that require greater control of the upper limb because for the case studied the upper limb movement was more effi cient with the use of the stabilizer bracelet.

Consumo, digestibilidade e balanço de nitrogênio de cordeiros alimentados com alto teor de amido ou fibra solúvel em detergente neutro associados ao óleo de girassol

The aim of this study was to evaluate the effect of different carbohydrate sources associated with sunflower oil on intake, digestibility of nutrients and nitrogen balance in diets of lambs. Twenty lambs were used, assigned in a completely randomized design with a 2 x 2 factorial arrangement of treatments with two sources of neutral detergent soluble carbohydrate, starch and neutral detergent soluble fiber, with and without the inclusion of 4.2% sunflower oil. The dry matter intake was not affected by carbohydrate sources and the inclusion of oil. Diets with a high percentage of starch provided higher digestibility of dry matter, starch and ether extract. The different sources of carbohydrates had no interference on digestibility of organic matter, crude protein, neutral detergent soluble fiber, nonfiber carbohydrates, neutral detergent fiber, hemicellulose and acid detergent fiber. The addition of oil in the diets increased the digestibility of ether extract. The combination of 4.2% oil in the diet high in soluble neutral detergent fiber had no influence on the nutrient digestibility, otherwise, the addition of oil at high starch diet caused a significant reduction in the digestibility of organic matter, neutral detergent fiber, hemicellulose and nonfiber carbohydrates. The quantities of nitrogen intake, absorbed and retained, did not differ as sources of carbohydrates and oil inclusion in the diet. The association of 4.2 % sunflower oil to the different sources of carbohydrates in the diet does not affect consumption and nitrogen metabolism in lambs. The addition of 4.2 % oil in the diet with high starch (28% of DM diet) promotes reduction in digestibility of organic matter, of fibrous and nonfibrous carbohydrate in the diet.

Desempenho e digestibilidade de componentes nutritivos de dietas contendo subprodutos de leaginosas na alimentação de cordeiros

The aim of this work was evaluate introduction of byproducts of oleaginous in lambs feeding. Diets were composed for 30% of Tifton hay and 70% of concentrate based on corn grain, soybean meal, soybean cake, sunflower cake and peanut cake, limestone and mineral mixture, as dites: FS - control with soybean meal, TS - soybean cake as part of the concentrate, TG sunflower cake as part of the concentrate and TA - peanut cake as part of the concentrate. For performance evaluating 24 Santa Ines lambs with initial age and weight of 70 days and 19 +/- 2 kg, according to a completely randomized design. For digestive evaluate, weight Santa Ines sheep with initial age and weight of 70 days and 16 +/- 1.2 kg, adapted to the use of bag, for collect feces. Animals were distributed in a replicated 4 x 4 Latin Square and means were compared by Tukey's test with 5% significance level. By the performance trial, duration of confinement, weight gain, fed conversion and the dry matter intake were not affected (P>0,05), with averages of 54.29 days, 259 g/day, 4.29 kg of DM/kg and 1.32 kg/day, respectively. There were no difference P>0,05) for intake DM, OM, CP, CT and CE among diets, digestibility trial with averages of 76.23; 74.47; 76.44; 41.12; 73.00 and 93.00%, respectively. There were no differences for digestibility DM, OM, CP, ADF, CT and NCF. The partial substitution of the soybean meal for byproducts of oleaginous was a good proteic alternative in the feeding of lambs.

Alterações morfohidrográficas do setor de fundo de vale do rio Piracicaba sob influência do reservatório de Barra Bonita (SP)

O homem modifica o ambiente ao seu redor gerando alterações “nos elementos que se encontram em contato direto com suas atividades, como a cobertura vegetal, as formas do relevo e a rede hidrográfica” (CASSETI, 1994). Assim, destacam-se as áreas submetidas ao represamento, cujos reflexos incidem diretamente sobre as formas do relevo. Desta forma, a geomorfologia atua como uma ciência de análise das alterações ocorridas na rede de drenagem e nas feições geomorfológicas, e a cartografia geomorfológica antecipa-se como instrumento da geomorfologia. O objetivo principal da pesquisa foi identificar e analisar as alterações morfohidrográficas e morfométricas provocadas pela construção do reservatório de Barra Bonita no curso final do Rio Piracicaba. A orientação metodológica vincula-se à Teoria Geral dos Sistemas Aplicada à Geografia e à análise da dinâmica de sistemas morfohidrográficos. Para as técnicas, foram confeccionados mapas geomorfológicos e de uso e ocupação das terras dos anos de 1962 (ano anterior à construção da barragem) e 2007 (selecionado como ponto de partida para a análise das alterações morfohidrográficas). Em 1962 existiam barras de meandro, canais e meandros abandonados, terraços fluviais, diques marginais, lagos e lagos de meandros. Em 2007 estes são comprometidos devido à mudança de nível de base local, fato demonstrado pelo desaparecimento de meandros e canais abandonados nas planícies aluviais, fragmentação de terraços fluviais, mudança de foz pelos canais tributários do rio principal e surgimento de novas lagoas. Para o uso, no ano de 1962 existiam grandes áreas de vegetação de “campo úmido”, atrelado à feição geomorfológica “planície aluvial”, que se encontrou alagada no ano de 2007. Foram também calculados os índices de sinuosidade, densidade de meandramento, número de meandros, área... (Resumo completo, clicar acesso eletrônico abaixo)

A transformação e revalorização do espaço do centro histórico de Santos/SP

The city of Santos always had its importance recognised by the respectful role of flowing off the coffee production between the end of 19th and beginning of 20th centuries. All effervescence of this period brought changes to the central area of the city, located near the port. Beginning in the 1970s, some changes in the politics and in the city's urban space made its cafes, theaters, stores and traditional residencies find itselves in decadence imposed by the negligence of the public power. The Historic Downtown of Santos changed to a forgotten and depreciated space and remained that way for many years, reflecting negatively in the preservation of the arquitetonic heritage of the city. The present project aims to analyse the transformation of the current space of the Hitoric Downtown of Santos from the beginning of the 20th century and its recent revaluation through the public politics of the city

Caracterização estrutural da porção central da Bacia de Santos e seu embasamento continental adjacente, através de interpretação de imagens de satélites e geofísicas

The Santos Basin is located in the Brazilian continental margin and includes the coast of Santa Catarina, Paraná, São Paulo and Rio de Janeiro states. Its northern limit is the Campos Basin through the High of Cabo Frio and the southern one with the Pelotas Basin through the Platform of Florianópolis, totaling an area of approximately 350,000 square kilometers in a water depth of 3,000 m. The Paranapanema Lineament has WNW / ESE direction, and extends from the area filled by the Paraná Basin, on the border between the states of Sao Paulo and Parana, lasting up to near the ocean floor along with the fracture zone of Rio de Janeiro. The Capricorn Lineament is a feature inherited from the separation between the continents of Africa and South America, and is the main structural feature NW / SE of the Santos Basin center-south region. These two structures together with other ones with continental origin may be associated with structural features in the sediments from the Santos Basin. This work aims to characterize the structures operating in the central portion of the Santos Basin based on subsurface data in the offshore area (2D seismic) together with data from the surface of the continental basement in a way to correlate the Santos Basin structures with the continental regional traits. This data interpolation showed that the structural features of the continent operates on the submerged zone, the seismic sections show these structural trends for the Paranapanema Lineament / Fracture Zone of Rio de Janeiro, Capricorn Lineament and two fault zones that exhibit structures typical of a transfer zone

Caracterização de sedimentos do testemunho NAP61-1 da plataforma continental da bacia de Santos por meio de susceptibilidade magnética

A parameter commonly used in investigations of environmental magnetism is the magnetic susceptibility (MS), which is the quantitative measure of the ability of magnetization of a specific material in the presence of an induced magnetic field. The present study aimed to determine the magnetic susceptibility of sediments collected on the continental shelf near the Santos Basin, southeast of the São Sebastião island (25°57.97’S 45°07.81'W), seeking to identify the possible source area of terrigenous sediments and the flow patterns of siliciclastic sediment yield in the area. It was used particle size analysis and contents of organic matter and calcium carbonate to characterize the sediments, besides paleomagnetism parameters. The analyzed material - core NAP61-1 - was collected using the piston corer sampler in 60 meters water depth, recovering 3.98 meters of sediment core. As from experiments, cyclicity was observed in relative abundance between sand and silt, most likely due to rapid and cyclical variations in the depositional environment. In general, the MS values are low, and show that the sand supply (terrigenous material) has a certain consistency, probably having the same origin. More absolute age is still necessary to establish clearly the events marked here

Modelagem matemática e simulação computacional de derrames de óleo em corpos d'água: um estudo de caso na região do Porto de Santos

The objective of this work is to accomplish studies of mathematical modeling and computational simulation of oil spills in water bodies. For this reason, a case study in the region of the Port of Santos was developed using the softwares SisBAHIA and ADIOS2 for the simulation of different hypothetical scenarios of oil spilling on the surface of water, aiming to obtain information that contribute to the reduction of the possible environmental impacts that can be caused by such accidents. The results generated in the different simulations had shown that the obtained data can be extremely useful to subsidize the elaboration of mitigation plans, the mapping of risk areas or even the proposal of emergencial strategies in cases of real accidents, configuring the modeling and the simulation as important and modern tools for the environmental planning and management.

Projeto Porto para todos: Proposta de modernização e revitalização da paisagem da área portuária de Santos-SP

O Porto de Santos, o maior e mais importante porto da América Latina, é afetado por diversos problemas que também afligem muitos portos no Brasil e no mundo, como o trânsito complicado, estacionamentos mal planejados, áreas abandonadas, deterioração das áreas urbanas próximas ao porto, além da falta de interação entre porto e a cidade, resultando em um espaço totalmente dissociado de sua vizinhança. Trabalhando o conceito do turismo na região, este trabalho propõe a revitalização e a requalificação de áreas deterioradas e ociosas da zona portuária, cuja área de atuação se concentra na faixa entre o Terminal Marítimos de Passageiros do Porto de Santos (Concais) e a área próxima ao Ferry Boat, onde ocorre a Travessia de Balsas Santos-Guarujá, propondo uma experiência única tanto para os cidadãos santistas, como para o turista que desembarca no Concais e pretende conhecer outras partes da cidade ou mesmo as praias do Guarujá. Com isso propõe a implantação de áreas ajardinadas e praças, e equipamentos de lazer e turismo entre outros, beneficiando a população, otimizando a atividade portuária e gerando mais ônus para a cidade, além de finalmente integrar eficientemente a área portuária à urbana, destacando cada vez mais os pontos fortes e característicos da cidade

Carvão (Sporisorium scitamineum) e podridão-abacaxi (Ceratocystis paradoxa) em cana-de-açúcar (Saccharum spp.): uma revisão

Sugarcane (Saccharum sp.) is an important grass cultivated in tropical and subtropical regions of the world, such as in Br, Ind, and Ch, and has its biomass being raw material for production of sugar, fuel ethanol, and some other derivatives. Fungal diseases infect sugarcane fields worldwide, damaging crops and thus, causing great economic losses. Fungal specialized structures act during all Pathogen-Host Relationship Cycle (PHRC) (survival, dissemination, infection, colonization, and reproduction of pathogen), maintaining fungal populations in cultivation soil, infecting plants in following crops and vegetative propagation of sugarcane by infected seeds may allow fungal transportation into regions where diseases haven’t occured before. Biotechnological methods and approaches have significantly contributed to understanding of the relationship among parasite and host, as to diseases management (control, detection, and prevention). Some techniques have daily applications in Agriculture, while others are only used in research and to breeding of host resistant varieties. Among notable diseases, smut (Sporisorium scitamineum) and pineapple disease (Ceratocystis paradoxa) are important because they cause damage and losses in sugarcane regions, although there are different periods for each one to occur. This work aims to review the PHRC for each patosystem, the biotechnological methods and approaches and its perspectives in the study and management of these diseases. As environment is an important factor to the effectiveness of PHRC, one chapter is dedicated to Global Climate Change (GCC) and its possible influences over these diseases in a longterm period

Análise de patologias de estradas vicinais para proposta de intervenção mínima visando a sua perenização

The unpaved back roads, despite their simplicity, are of paramount importance to the municipalities that their economy basis are in agri-livestock and a large portion of their population lives in rural areas, as it is from these pathways that flow of production is performed and ensuring access of the rural population to urban centers is allowed. Aiming the importance of these rural roads, this work studies the case of pathologies found in local roads of São Luiz do Paraitinga, located in the Vale do Paraíba upstate São Paulo, due to lack of a periodic maintenance program the roads not withstood the heavy rains late in the year 2009 and early 2010, generating major impacts on society and the economy of the city. From surveys conducted in the field, it was analyzed the various pathologies found (pathology drainage, slope and platform) checking also the nature of their occurrence, therefore propose solutions for intervention in rural roads, to decrease the susceptibility of these roads during the rainy season