Observatiunculae circa artem antiquarum gentium celebriorum numismata adornandi, in specie numi Sabinae expositio

Variantti A.

Brevis eisagoge ad studium juris civilis sveco-romani; cum collatione utriusque, secundum tria objecta

Invokaatio: Σὺν Θεω̣̃.

Coenobii Nadhenadals, in magno Finlandiae ducatu principis, succincta historia 1

Invokaatio: Q.B.V.

Annus in Israel jubilaeus

Invokaatio: In nomine Jesu.

Perì tês etymótetos, orthoepeías kaì emfaséos tû šilo

Variantti B.

Peri tês etymótētos, orthoepeías kai emfásiōs tû šilo

Variantti A.

Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis

Vascular calcification decreases compliance and increases morbidity. Mechanisms of this process are unclear. The role of oxidative stress and effects of antioxidants have been poorly explored. We investigated effects of the antioxidants lipoic acid (LA) and tempol in a model of atherosclerosis associated with elastocalcinosis. Male New Zealand white rabbits (2.5-3.0 kg) were fed regular chow (controls) or a 0.5% cholesterol (chol) diet+104 IU/day vitamin D2 (vitD) for 12 weeks, and assigned to treatment with water (vehicle, n=20), 0.12 mmol·kg-1·day-1 LA (n=11) or 0.1 mmol·kg-1·day-1 tempol (n=15). Chol+vitD-fed rabbits developed atherosclerotic plaques associated with expansive remodeling, elastic fiber disruption, medial calcification, and increased aortic stiffness. Histologically, LA prevented medial calcification by ∼60% and aortic stiffening by ∼60%. LA also preserved responsiveness to constrictor agents, while intima-media thickening was increased. In contrast to LA, tempol was associated with increased plaque collagen content, medial calcification and aortic stiffness, and produced differential changes in vasoactive responses in the chol+vitD group. Both LA and tempol prevented superoxide signals with chol+vitD. However, only LA prevented hydrogen peroxide-related signals with chol+vitD, while tempol enhanced them. These data suggest that LA, opposite to tempol, can minimize calcification and compliance loss in elastocalcionosis by inhibition of hydrogen peroxide generation.

Poenitentia ethnicorum, secundum principia philosophiae

Variantti B.

De metamorphosi Nebucadnezaris

Variantti B.

Ignis sacer

Invokaatio: Q.B.V.

De morbis viarum lacrimalium cognoscendis et curandis 1

Arkit: 1 arkintunnukseton lehti, A-C4 D2. - Viimeinen sivu tyhjä.

De oraculorum cessatione

Variantti B.

Fauna Fennica, sive enumeratio animalium 3

Arkit: 1 arkintunnukseton lehti, D2-D4, 8 arkintunnuksetonta lehteä. - . S. [2] ja [67-68] tyhjät.

De hordei in borealibus terris culti cito maturescendi habitu, et in re nostra rustica usu

Arkit: 1 arkintunnukseton lehti, A-C4 D2.

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system

Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment, suggesting an antidepressant-like effect. The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT) synthesis], NAN-190 (a 5-HT1A antagonist), ritanserin (a 5-HT2A/2C antagonist), ondansetron (a 5-HT3A antagonist), prazosin (an α1-adrenoceptor antagonist), SCH23390 (a D1 receptor antagonist), yohimbine (an α2-adrenoceptor antagonist), and sulpiride (a D2 receptor antagonist). A significant increase in 5-HT levels in the striatum was detected after acute administration, while 5-HT, norepinephrine and dopamine were significantly elevated after chronic treatment. Results indicated that H. gordonii possesses antidepressant-like activity in the FST by altering the dopaminergic, serotonergic, and noradrenergic systems.