Ledges State Park, 1925.

This booklet, no. 1 in the Park Booklet Series, contains general information, features, history, geology and photos of Ledges State Park.

Audit report on the City of Center Point, Iowa for the year ended June 30, 2014

Audit report on the City of Center Point, Iowa for the year ended June 30, 2014

Mise au point concernantl'utilisation du dosagede l'antigène carcino-embryonnaire (CEA)en clinique

The carcinoembryonic antigen (CEA) is a tumor marker defined by specific heterologous antisera. Elevated levels of circulating CEA have been detected by radioimmunoassay in 20-90 per cent of cases of colorectal carcinomas depending on the degree of tumor spread. The fact that elevation of CEA level can also be observed in other types of carcinomas and in several non malignant conditions greatly limit the value of the CEA test for the early diagnosis of colorectal carcinoma. Thus, the CEA assay should not be used as a screening test for cancer. Repeatecl CEA mesurements, however, appear to be of importance for the evaluation of tumor resection and the detection of tumor recurrence. The only localized tumors known to produce elevation of CEA above the levels observed in non malignant diseases are carcinomas of the large bowel and the pancreas. In carcinomas derived from other organs a marked increase of CEA level is always associated with the presence of distant metastasis. Therefore at the present time the clinical applications of the CEA radioimmunoassay should be limited to the differentiai diagnosis of patients with suspicion of primary colorectal or pancreatic carcinoma, to the detection of distant metastasis in other types of carcinomas and to the post operative follow up of patients who had elevated levels of CEA before surgery. Well-controlled studies are still needed to determine if therapeutic decisions based on CEA results can lead to improved survival.

Oral flurbiprofen metabolic ratio assessment using a single-point dried blood spot.

We investigated whether a single blood measurement using the minimally invasive technique of a finger prick to draw a blood sample of 5 µl (to yield a dried blood spot (DBS)) is suitable for the assessment of flurbiprofen (FLB) metabolic ratio (MR). Ten healthy volunteers who had been genotyped for CYP2C9 were recruited as subjects. They received FLB alone in session 1 and FLB with fluconazole in session 2. In session 3, the subjects were pretreated for 4 days with rifampicin and received FLB with the last dose of rifampicin on day 5. Plasma and DBS samples were obtained between 0 and 8 h after FLB administration, and urine was collected during the 8 h after administration. The pharmacokinetic profiles of the drugs were comparable in DBS and plasma. FLB's apparent clearance values decreased by 35% in plasma and DBS during session 2 and increased by 75% in plasma and by 30% in DBS during session 3. Good correlations were observed between MRs calculated from urine, plasma, and DBS samples.

Comparison of Roadway Roughness Derived from LIDAR and SFM 3D Point Clouds, HR-3001, 2015

This report describes a short-term study undertaken to investigate the potential for using dense three-dimensional (3D) point clouds generated from light detection and ranging (LIDAR) and photogrammetry to assess roadway roughness. Spatially continuous roughness maps have potential for the identification of localized roughness features, which would be a significant improvement over traditional profiling methods. This report specifically illustrates the use of terrestrial laser scanning (TLS) and photogrammetry using a process known as structure from motion (SFM) to acquire point clouds and illustrates the use of these point clouds in evaluating road roughness. Five roadway sections were chosen for scanning and testing: three gravel road sections, one portland cement concrete (PCC) section, and one asphalt concrete (AC) section. To compare clouds obtained from terrestrial laser scanning and photogrammetry, the coordinates of the clouds for the same section on the same date were matched using open source computer code. The research indicates that the technologies described are very promising for evaluating road roughness. The major advantage of both technologies is the large amount of data collected, which allows the evaluation of the full surface. Additional research is needed to further develop the use of dense 3D point clouds for roadway assessment.

Road Safety Audits for County Road X-23 from IA 2 to the South Corporate Limits of West Point and for County Road W-62 from US 218 to IA 27 in Lee County, Iowa, 2010

On October 20–21, 2009, two road safety audits were conducted in Lee County, Iowa: one for a 6 mile section of County Road X-23 from IA 2 to the south corporate limits of West Point and one for a 9.7 mile section of County Road W-62 from US 218 to IA 27. Both roads have high severe crash histories for the years of 2001 through 2008. Using these crash data, the Iowa Department of Transportation (Iowa DOT) has identified County Road X-23 as being in the top 5 percent of similar roads for run-off-road crashes. The Iowa DOT lists County Road W-62 as a high-risk rural road that has above-average crash numbers and is eligible for funding under the Federal High-Risk Rural Road Program. Considering these issues, the Lee County Engineer and Iowa DOT requested that road safety audits be conducted to address the safety concerns and to suggest possible mitigation strategies.

Modeling the Emergence of Social Structure from a Phylogenetic Point of View

Based on provious (Hemelrijk 1998; Puga-González, Hildenbrant & Hemelrijk 2009), we have developed an agent-based model and software, called A-KinGDom, which allows us to simulate the emergence of the social structure in a group of non-human primates. The model includes dominance and affiliative interactions and incorporate s two main innovations (preliminary dominance interactions and a kinship factor), which allow us to define four different attack and affiliative strategies. In accordance with these strategies, we compared the data obtained under four simulation conditions with the results obtained in a provious study (Dolado & Beltran 2012) involving empirical observations of a captive group of mangabeys (Cercocebus torquatus)

1210-007IJ Central Park Lake Final Report

The Central Park Lake Watershed Assessment and Management Plan identified four categories where improvements are needed to remove the 23 acre lake from the impaired waters list. These include the wastewater system, runoff from surrounding lands, in-lake nutrient re-suspension and runoff from hard surfaces within the park. The lake is currently impaired for bacteria, algae and pH. Through outcomes of the Watershed Assessment and Management Plan, this proposal includes for abandonment and reclamation of the single cell wastewater lagoon site, replacement with three conventional septic systems and construction of two wetlands. One of the wetlands is located on the same site as the reclaimed lagoon and the other is located to intercept sediment and trap nutrients transported by tile lines. The prescribed wastewater system improvements are based on assessment by grab samples test by the State Hygienic Lab, development of a Preliminary Engineering Report, soil analysis and communication with IDNR wastewater officials. The two wetland sites were assessed by officials from IDALS and the Jones County SWCD. This project is part of $1.7 million lake restoration effort to reclaim the 47 year old lake. The lake has a positive economic impact of more than $7.6 million annually and supports an average annual visitation of 58,145, according to the Iowa Lakes Valuation Project, conducted by Iowa State University.

Représentations sociales et représentations intimes de la maladie. Quelques réflexions d'un clinicien [Social and private representations of cancer. A clinician's point of view]

This paper discusses social representations in scientific communications and private ones that are linked to the individual imagination. Social representations, in a limited sense, are useful for the development of preventive messages, but of little benefit to clinical work. We highlight some non-explicit aspects of scientific discourse that impact on treatment: projected beliefs and values. We tackle the relationship between the concepts of representation, imagination, identity and temporality in the individual approach of the cancer patient.

GPS to LRM: Integration of Spatial Point Features with Linear Referencing Methods, 2001

Global positioning systems (GPS) offer a cost-effective and efficient method to input and update transportation data. The spatial location of objects provided by GPS is easily integrated into geographic information systems (GIS). The storage, manipulation, and analysis of spatial data are also relatively simple in a GIS. However, many data storage and reporting methods at transportation agencies rely on linear referencing methods (LRMs); consequently, GPS data must be able to link with linear referencing. Unfortunately, the two systems are fundamentally incompatible in the way data are collected, integrated, and manipulated. In order for the spatial data collected using GPS to be integrated into a linear referencing system or shared among LRMs, a number of issues need to be addressed. This report documents and evaluates several of those issues and offers recommendations. In order to evaluate the issues associated with integrating GPS data with a LRM, a pilot study was created. To perform the pilot study, point features, a linear datum, and a spatial representation of a LRM were created for six test roadway segments that were located within the boundaries of the pilot study conducted by the Iowa Department of Transportation linear referencing system project team. Various issues in integrating point features with a LRM or between LRMs are discussed and recommendations provided. The accuracy of the GPS is discussed, including issues such as point features mapping to the wrong segment. Another topic is the loss of spatial information that occurs when a three-dimensional or two-dimensional spatial point feature is converted to a one-dimensional representation on a LRM. Recommendations such as storing point features as spatial objects if necessary or preserving information such as coordinates and elevation are suggested. The lack of spatial accuracy characteristic of most cartography, on which LRM are often based, is another topic discussed. The associated issues include linear and horizontal offset error. The final topic discussed is some of the issues in transferring point feature data between LRMs.

05040-015 Viking Lake Watershed Final Report

Viking Lake State Park is beautiful resource which has been special to residents of Southwest Iowa and visitors from around the region. Unfortunately, Viking Lake itself is being impacted by non-point source pollution. Water quality conditions are becoming the reason that visitors are shying away from the park instead of flocking to it. To combat these non-point source problems the Viking Lake Water Quality Project has been initiated and $327,000 has been allocated through the Section 319/WSPF Program which will address water quality concerns in the watershed. Additionally, IDNR Fisheries is preparing for an entire renovation of Viking Lake in 2006. One funding gap remains, that may prevent this comprehensive water quality project from achieving a successful endpoint. Funds are still needed for the renovation of malfunctioning septic systems at Viking Village housing development which is adjacent to the park, and has been identified as a primary source of contamination entering the lake. The intent of this application is to secure funds so that these septic system problems can be corrected and water quality conditions of this important natural resource restored for public enjoyment.

U.S. 61 From Memorial Park Road in Burlington North to 1 Mile North of IA 78 in Louisa County. Des Moines & Louisa County, Iowa NHS-061-2(50) - 19-58, 2015

Iowa Department of Transportation (Iowa DOT) has re-initiated planning and preliminary design studies to improve U.S. 61 from Memorial Park Road in Burlington north to 1-mile north of IA 78 in Louisa County. The proposed project consists of improving approximately 18 miles of roadway from 2-lanes to 4-lanes and evaluating a potential bypass around Mediapolis.

Monsieur le Minotaure et son point de vue

Les visions hallucinées de Friedrich Dürrenmatt, l'un des plus importants écrivains suisses de l'après-guerre, au travers des dessins et des manuscrits consacrés aux mythes de la Pythie, du Minotaure et de Midas. L'itinéraire créatif de Friedrich Dürrenmatt, outre sa production littéraire bien connue, est constellé d'une intense activité de peintre, de dessinateur et de graveur sur cuivre, activité qui délimite un important terrain de confrontation des pensées et des thèmes caractérisant sa recherche. Ce volume, qui accompagne l'exposition organisée par le célèbre architecte tessinois Mario Botta, présente une sélection de dessins et de notes de voyage appartenant à la collection privée de Charlotte Kerr-Dürrenmatt. Ceux-ci ont trait aux mythes de la Pythie, du Minotaure et de Midas, auxquels Dürrenmatt a consacré tant de réflexions. Les thèmes de la mythologie grecque ont toujours été présents dans la recherche de l'auteur sur la condition humaine, au point qu'il en est parfois arrivé à se représenter, de manière autobiographique, comme le protagoniste des événements décrits. Ces oeuvres revêtent une importance fondamentale car elles mettent en valeur l'importance et la signification que l'écrivain attribue à cette activité, considérée comme " mineure " par la critique mais qu'il faut en revanche interpréter comme un complément important des métaphores écrites auxquelles renvoie toute sa pensée.