[Dom Pedro II de Alcantara] / Charles Jacotin

Donateur : Jackson, James (1843-1895)

Dedication of monuments erected by the state of Iowa,commemorating the death, suffering and valor of her soldiers on the battlefields of Vickburg, Lookout Mountain, Missionary Ridge, Shiloh, and in the Confederate prison at Andersonville,November twelfth to twenty-sixth, nineteen hundred and six,1908.

This book contains information on the dedication ceremony of Iowa monuments on the southern battlefields from the civil war and their final transfer made to the care of the general government. It includes history of the battles, photos and maps.

Memorial exercises in honor of William Boyd Allison : in Hall of House of Representatives, State Capitol, Des Moines, Iowa, Tuesday, September 8, 1908

Program of the memorial in honor of William Boyd Allison, senior Senator of the State of Iowa, who died at his home in Dubuque, Iowa, August 4, 1908. It includes full text of remarks presented at the memorial by dignitaries in attendance.

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

Machado-Joseph disease is the most frequently found dominantly-inherited cerebellar ataxia. Over-repetition of a CAG trinucleotide in the MJD1 gene translates into a polyglutamine tract within the ataxin 3 protein, which upon proteolysis may trigger Machado-Joseph disease. We investigated the role of calpains in the generation of toxic ataxin 3 fragments and pathogenesis of Machado-Joseph disease. For this purpose, we inhibited calpain activity in mouse models of Machado-Joseph disease by overexpressing the endogenous calpain-inhibitor calpastatin. Calpain blockage reduced the size and number of mutant ataxin 3 inclusions, neuronal dysfunction and neurodegeneration. By reducing fragmentation of ataxin 3, calpastatin overexpression modified the subcellular localization of mutant ataxin 3 restraining the protein in the cytoplasm, reducing aggregation and nuclear toxicity and overcoming calpastatin depletion observed upon mutant ataxin 3 expression. Our findings are the first in vivo proof that mutant ataxin 3 proteolysis by calpains mediates its translocation to the nucleus, aggregation and toxicity and that inhibition of calpains may provide an effective therapy for Machado-Joseph disease.

Voyage autour du monde sur la frégate "la Vénus" pendant les années 1836-1839. Tome 10 / , publié... par Abel Du Petit-Thouars,...

Comprend : Botanique ; Zoologie... Oiseaux... ; Zoologie... Reptiles... ; Physique... ; Zoologie... Poissons ; Zoologie... Oiseaux... ; Zoologie. Mammifères

Voyage autour du monde sur la frégate "la Vénus" pendant les années 1836-1839. Tome 1 / , publié... par Abel Du Petit-Thouars,...

Comprend : Botanique ; Zoologie... Oiseaux... ; Zoologie... Reptiles... ; Physique... ; Zoologie... Poissons ; Zoologie... Oiseaux... ; Zoologie. Mammifères