Middle atmopsheric cabon monoxide above Kiruna, Sweden, 2008-2015

This data set contains profiles of atmospheric carbon monoxide (CO) concentrations retrieved from measurements made by the Kiruna Microwave Radiometer (KIMRA), housed at the Swedish Institute for Space Physics, Kiruna. The data is retrieved on a standard pressure grid that is 62 layers, spaced approximately equally in altitude between 2 km and 124 km. The current time range of the data is December 2008 to May 2015, with data gaps corresponding to Summer periods when the CO concentrations in the middle atmosphere drop to very low values, or to non-operation of the instrument. The profile information is considered useful between approximately 48 km and 86 km, specifically where the measurement response is above 0.8. If the CO profiles are being compared to another data set with significantly higher altitude resolution, the averaging kernel matrix should be used to smooth the higher resolution data. The error in the profile from statistical noise on the measured spectrum is also provided. This work has been funded by the German Federal Ministry of Education and Research through the research project: Role Of the Middle atmosphere in Climate (ROMIC, https://romic.iap-kborn.de).

Simulations of forest loss in North America, the Amazon, and combined using the Community Earth System Model

The netcdf files in this archive comprise climate model output from Community Earth System Model for experiments looking at forest loss over Western North America and the Amazon. For further description of the model and configuration for these experiments please see the accompanying manuscript: Synergistic ecoclimate teleconnections from forest loss in different regions structure global ecological responses Elizabeth S. Garcia, Abigail L. S. Swann, Juan C. Villegas, David D. Breshears, Darin J. Law, Scott R. Saleska, and Scott C. Stark published in PLOS ONE, 2016. Contact information in README.txt

Advanced Analytical Microscopy at the Nanoscale: Applications in Wide Bandgap and Solid Oxide Fuel Cell Materials

The atomic-level structure and chemistry of materials ultimately dictate their observed macroscopic properties and behavior. As such, an intimate understanding of these characteristics allows for better materials engineering and improvements in the resulting devices. In our work, two material systems were investigated using advanced electron and ion microscopy techniques, relating the measured nanoscale traits to overall device performance. First, transmission electron microscopy and electron energy loss spectroscopy (TEM-EELS) were used to analyze interfacial states at the semiconductor/oxide interface in wide bandgap SiC microelectronics. This interface contains defects that significantly diminish SiC device performance, and their fundamental nature remains generally unresolved. The impacts of various microfabrication techniques were explored, examining both current commercial and next-generation processing strategies. In further investigations, machine learning techniques were applied to the EELS data, revealing previously hidden Si, C, and O bonding states at the interface, which help explain the origins of mobility enhancement in SiC devices. Finally, the impacts of SiC bias temperature stressing on the interfacial region were explored. In the second system, focused ion beam/scanning electron microscopy (FIB/SEM) was used to reconstruct 3D models of solid oxide fuel cell (SOFC) cathodes. Since the specific degradation mechanisms of SOFC cathodes are poorly understood, FIB/SEM and TEM were used to analyze and quantify changes in the microstructure during performance degradation. Novel strategies for microstructure calculation from FIB-nanotomography data were developed and applied to LSM-YSZ and LSCF-GDC composite cathodes, aged with environmental contaminants to promote degradation. In LSM-YSZ, migration of both La and Mn cations to the grain boundaries of YSZ was observed using TEM-EELS. Few substantial changes however, were observed in the overall microstructure of the cells, correlating with a lack of performance degradation induced by the H2O. Using similar strategies, a series of LSCF-GDC cathodes were analyzed, aged in H2O, CO2, and Cr-vapor environments. FIB/SEM observation revealed considerable formation of secondary phases within these cathodes, and quantifiable modifications of the microstructure. In particular, Cr-poisoning was observed to cause substantial byproduct formation, which was correlated with drastic reductions in cell performance.

Advanced 4DT flight guidance and control software system

The work presented in this thesis has been part of a Cranfield University research project. This thesis aims to design a flight control law for large cargo aircraft by using predictive control, which can assure flight motion along the flight path exactly and on time. In particular this work involves the modelling of a Boeing C-17 Globemaster III 6DOF model (used as study case), by using DATCOM and Matlab Simulink software. Then a predictive control algorithm has been developed. The majority of the work is done in a Matlab/Simulink environment. Finally the predictive control algorithm has been applied on the aircraft model and its performances, in tracking given trajectory optimized through a 4DT Research Software, have been evaluated.

Advanced studies on two animal models, murine and fish. RadKI21A626T mouse model: new insights into molecular mechanisms of enteric neuro-epithelial pathology. European sea bass: study of the effects of essential oils in different diets on the gastric system.

My PhD research period was focused on the anatomical, physiological and functional study of the gastrointestinal system on two different animal models. In two different contexts, the purpose of these two lines of research was contribute to understand how a specific genetic mutation or the adoption of a particular dietary supplement can affect gastrointestinal function. Functional gastrointestinal disorders are chronic conditions characterized by symptoms for which no organic cause can be found. Although symptoms are generally mild, a small subset of cases shows severe manifestations. This subset of patients may also have recurrent intestinal sub-occlusive episodes, but in absence of mechanical causes. This condition is referred to as chronic intestinal pseudo-obstruction, a rare, intractable chronic disease. Some mutations have been associated with CIPO. A novel causative RAD21 missense mutation was identified in a large consanguineous family, segregating a recessive form of CIPO. The present thesis was aimed to elucidate the mechanisms leading to neuropathy underlying CIPO via a recently developed conditional KI mouse carrying the RAD21 mutation. The experimental studies are based on the characterization and functional analysis of the conditional KI Rad21A626T mouse model. On the other hand aquaculture is increasing the global supply of foods. The species selected and feeds used affects the nutrients available from aquaculture, with a need to improve feed efficiency, both for economic and environmental reasons, but this will require novel innovative approaches. Nutritional strategies focused on the use of botanicals have attracted interest in animal production. Previous research indicates the positive results of using essential oils (EOs) as natural feed additives for several farmed animals. Therefore, the present study was designed to compare the effects of feed EO supplementation in two different forms (natural and composed of active ingredients obtained by synthesis) on the gastric mucosa in European sea bass.

Advanced X-ray techniques for the structural characterisation of Prussian Blue Analogue cathode materials

The thesis is dedicated to the implementation of advanced x-ray-based techniques for the investigation of the battery systems, more predominantly, the cathode materials. The implemented characterisation methods include synchrotron based x-ray absorption spectroscopy, powder x-ray diffraction, 2-dimensional x-ray fluorescence, full field transmission soft x-ray microscopy, and laboratory x-ray photoelectron spectroscopy. The research highlights the different areas of expertise for each described method, in terms of material characterisation, exploring their complementarities and intersections. The results are focused over manganese hexacyanoferrate and partially Ni substituted manganese hexacyanoferrate, through both organic and aqueous battery systems. In aqueous system, the modification of cathode composition has been observed with various techniques, indicating to the processes occurring in bulk, surface, locally or in long-range, including with the speciation by 2-dimensional scanning, and the time-resolution, by the implementation of the operando measurements. In organic media, the inhomogenisation of the cathode material during the aging process was investigated by the development of the special image treatment procedure for the maps, obtained from the transmission soft x-ray microscopy. It worth mentioning, that apart from the combination of the outcomes from the various x-ray measurements, the exploration of the new capabilities was also conducted, namely, probing the oxidation state of the element with the synchrotron-based 2-dimensional x-ray fluorescence technique, which, generally, with conventional set up, is not possible to achieve. The results and methodology from this thesis can, of course, be generalised on the characterisation of the other battery systems, and not only, as the x-ray techniques are one of the most informative and sophisticated methods for advanced structural investigation of the materials.

Study of an advanced transport system exploiting magnetic levitation: the Beckhoff XPlanar

The transport system is one of the most important components to be chosen in the design of an automatic machine. There is a wide variety of different choices that can be made in picking this element, each one having its own strengths and its own drawbacks. If it is desired to obtain some elaborate behaviour from the transport system, it is a good idea to think about some flexible and advanced solutions. Among these transport systems, the newest is the Beckhoff XPlanar. This transport system exploits magnetic levitation to move some passive magnetic movers on a completely customizable plane, in an entirely contact-free way. This provides a fast, clean, and noiseless motion, which is extremely desirable in a modern automatic machine. The purpose of this Thesis is to analyse the potentialities and the problems of this new device, starting from the basics. After having presented in detail the topic, an analysis on the hardware components needed to build this system is performed. Then, it is conducted a study on the concepts needed to know how to build a controller having the purpose of dealing with this system. After that, the various types of motion are studied and executed and, later on, some experiments on the real kit are carried out. These studies start from the diagnostic and involve other analyses that are used to test the limits of this transport system. In performing these analyses, it is noticed how the kit presents some problems in reaching the limits of the dynamics. Finally, two different types of station cycle are implemented, which are useful to get a rough idea on the potentialities of this new advanced transport system.

The Applicability Of Ordered Mesoporous Sba-15 And Its Hydrophobic Glutaraldehyde-bridge Derivative To Improve Ibuprofen-loading In Releasing System.

The mesoporous SBA-15 silica with uniform hexagonal pore, narrow pore size distribution and tuneable pore diameter was organofunctionalized with glutaraldehyde-bridged silylating agent. The precursor and its derivative silicas were ibuprofen-loaded for controlled delivery in simulated biological fluids. The synthesized silicas were characterized by elemental analysis, infrared spectroscopy, (13)C and (29)Si solid state NMR spectroscopy, nitrogen adsorption, X-ray diffractometry, thermogravimetry and scanning electron microscopy. Surface functionalization with amine containing bridged hydrophobic structure resulted in significantly decreased surface area from 802.4 to 63.0 m(2) g(-1) and pore diameter 8.0-6.0 nm, which ultimately increased the drug-loading capacity from 18.0% up to 28.3% and a very slow release rate of ibuprofen over the period of 72.5h. The in vitro drug release demonstrated that SBA-15 presented the fastest release from 25% to 27% and SBA-15GA gave near 10% of drug release in all fluids during 72.5 h. The Korsmeyer-Peppas model better fits the release data with the Fickian diffusion mechanism and zero order kinetics for synthesized mesoporous silicas. Both pore sizes and hydrophobicity influenced the rate of the release process, indicating that the chemically modified silica can be suggested to design formulation of slow and constant release over a defined period, to avoid repeated administration.