937 resultados para ADENINE CLUSTERS


Relevância:

20.00% 20.00%

Publicador:

Resumo:

A busca por maior competitividade frente ao mercado cada vez mais concorrido, a perseguição pela maximização dos lucros nas organizações, e as maneiras para tornar as organizações mais eficientes são assuntos largamente debatidos em discussões nos ambientes empresariais e acadêmicos, áreas em que a administração é requerida para analisar o universo de possibilidades em busca dos objetivos acima. Principalmente sobre as pequenas e médias empresas (PME), os impactos dos custos decorrentes de falta de infraestruturas adequadas em transportes, movimentação de materiais e em logística em geral, tornam estas organizações menos competitivas. Uma das alternativas que deve ser apresentada é um agrupamento destas organizações em um mesmo espaço físico, os denominados clusters, a fim de compartilharem alguns destes custos, além de experiências para atingirem alguns ganhos também em escala. Na logística, existe a possibilidade de compartilhamento de diversos serviços, onde deverá ser identificada boa parte do potencial de ganho com este modelo, que é aplicado para diversos segmentos inclusive ao redor do mundo. Em especial no Brasil onde a carga tributária é elevada e muito complexa, quando se opta pelo modelo de cluster, haverá ganhos em escala inclusive na tributação fiscal das movimentações de mercadorias. Através do levantamento bibliográfico e a comparação de dados de diversos artigos e de instituições públicas e privadas, objetiva-se apresentar as vantagens das operações no modelo cluster, a possibilidade dos ganhos pelo cooperativismo existente nestes empreendimentos entre outras formas de benefícios possíveis na logística compartilhada pelas empresas do cluster, além de possíveis desvantagens e limitações. .  

Relevância:

20.00% 20.00%

Publicador:

Resumo:

This paper examines the link between cluster development and inward foreign direct investment. The conventional policy approach has been to assume that inward foreign direct investment (FDI) can stimulate significant clustering activity, thus generating significant spillovers. This paper, however, questions this and shows that, while clusters can generate significant productivity spillovers from FDI, this only occurs in pre-existing clusters. Further, the paper demonstrates that foreign-owned firms that enter clusters also appropriate spillovers when domestic firms undertake investment, raising the possibility that clusters are important locations for so called technology, or knowledge sourcing activities by MNEs. © 2006 Oxford University Press.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Comprehensive coverage of all aspects of Michael Porter's works Contributions from leading authorities across the disciplines Contains response from Porter Harvard professor, Michael Porter has been one of the most influential figures in strategic management research over the last three decades. He infused a rigorous theoretical framework of industrial organization economics with the then still embryonic field of strategic management and elevated it to its current status as an academic discipline. Porter's outstanding career is also characterized by its cross-disciplinary nature. Following his most important work on strategic management, he then made a leap to the policy side and dealt with a completely different set of analytical units. More recently he has made a foray into inner city development, environmental regulations, and health care services. Throughout these explorations Porter has maintained his integrative approach, seeking a road that links management case studies and the general model building of mainstream economics. With expert contributors from a range of disciplines including strategic management, economic development, economic geography, and planning, this book assesses the contribution Michael Porter has made to these respective disciplines. It clarifies the sources of tension and controversy relating to all the major strands of Porter's work, and provides academics, students, and practitioners with a critical guide for the application of Porter's models. The book highlights that while many of the criticisms of Porter's ideas are valid, they are almost an inevitable outcome for a scholar who has sought to build bridges across wide disciplinary valleys. His work has provided others with a set of frameworks to explore in more depth the nature of competition, competitive advantage, and clusters from a range of vantage points.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Pain is a ubiquitous yet highly variable experience. The psychophysiological and genetic factors responsible for this variability remain unresolved. We hypothesised the existence of distinct human pain clusters (PCs) composed of distinct psychophysiological and genetic profiles coupled with differences in the perception and the brain processing of pain. We studied 120 healthy subjects in whom the baseline personality and anxiety traits and the serotonin transporter-linked polymorphic region (5-HTTLPR) genotype were measured. Real-time autonomic nervous system parameters and serum cortisol were measured at baseline and after standardised visceral and somatic pain stimuli. Brain processing reactions to visceral pain were studied in 29 subjects using functional magnetic resonance imaging (fMRI). The reproducibility of the psychophysiological responses to pain was assessed at 1 year. In group analysis, visceral and somatic pain caused an expected increase in sympathetic and cortisol responses and activated the pain matrix according to fMRI studies. However, using cluster analysis, we found 2 reproducible PCs: at baseline, PC1 had higher neuroticism/anxiety scores (P ≤ 0.01); greater sympathetic tone (P < 0.05); and higher cortisol levels (P ≤ 0.001). During pain, less stimulus was tolerated (P ≤ 0.01), and there was an increase in parasympathetic tone (P ≤ 0.05). The 5-HTTLPR short allele was over-represented (P ≤ 0.005). PC2 had the converse profile at baseline and during pain. Brain activity differed (P ≤ 0.001); greater activity occurred in the left frontal cortex in PC1, whereas PC2 showed greater activity in the right medial/frontal cortex and right anterior insula. In health, 2 distinct reproducible PCs exist in humans. In the future, PC characterization may help to identify subjects at risk for developing chronic pain and may reduce variability in brain imaging studies. © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Self-sustained spin clusters are analytically linked to ergodicity breaking in fully connected Ising and Sherrington-Kirkpatick (SK) models, relating the less understood spin space to the well understood state space. This correspondence is established through the absence of clusters in the paramagnetic phase, the presence of one dominant cluster in the Ising ferromagnet, and the formation of nontrivial clusters in SK spin glass. Yet unobserved phenomena are also revealed such as a first order phase transition in cluster sizes in the SK ferromagnet. The method could be adapted to investigate other spin models. © 2013 American Physical Society.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Purpose: Ind suggests front line employees can be segmented according to their level of brand-supporting performance. His employee typology has not been empirically tested. The paper aims to explore front line employee performance in retail banking, and profile employee types. Design/methodology/approach: Attitudinal and demographic data from a sample of 404 front line service employees in a leading Irish bank informs a typology of service employees. Findings: Champions, Outsiders and Disruptors exist within retail banking. The authors provide an employee profile for each employee type. They found Champions amongst males, and older employees. The highest proportion of female employees surveyed were Outsiders. Disruptors were more likely to complain, and rated their performance lower than any other employee type. Contrary to extant literature, Disruptors were more likely to hold a permanent contract than other employee types. Originality/value: The authors augment the literature by providing insights about the profile of three employee types: Brand Champions, Outsiders and Disruptors. Moreover, the authors postulate the influence of leadership and commitment on each employee type. The cluster profiles raise important questions for hiring, training and rewarding front line banking employees. The authors also provide guidelines for managers to encourage Champions, and curtail Disruptors. © Emerald Group Publishing Limited.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The undisputed link of the agricultural sector with regional economies, along with the increased competition, fosters agri-business companies to rethink their business philosophy and to transform from isolated firms to members of more extended business formations. The paper examines a particular type of business network, the cluster. It focuses on the concept of clusters and on cluster-based strategies in the context of agriculture. In particular, the paper explores the value of clusters by taking into consideration the particularities of the agricultural sector. Potential benefits and constraints of agri-business cluster development are also presented.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background: Despite chronic pain being a feature of functional chest pain (FCP) its experience is variable. The factors responsible for this variability remain unresolved. We aimed to address these knowledge gaps, hypothesizing that the psychophysiological profiles of FCP patients will be distinct from healthy subjects. Methods: 20 Rome III defined FCP patients (nine males, mean age 38.7 years, range 28-59 years) and 20 healthy age-, sex-, and ethnicity-matched controls (nine males, mean 38.2 years, range 24-49) had anxiety, depression, and personality traits measured. Subjects had sympathetic and parasympathetic nervous system parameters measured at baseline and continuously thereafter. Subjects received standardized somatic (nail bed pressure) and visceral (esophageal balloon distension) stimuli to pain tolerance. Venous blood was sampled for cortisol at baseline, post somatic pain and post visceral pain. Key Results: Patients had higher neuroticism, state and trait anxiety, and depression scores but lower extroversion scores vs controls (all p < 0.005). Patients tolerated less somatic (p < 0.0001) and visceral stimulus (p = 0.009) and had a higher cortisol at baseline, and following pain (all p < 0.001). At baseline, patients had a higher sympathetic tone (p = 0.04), whereas in response to pain they increased their parasympathetic tone (p ≤ 0.008). The amalgamating the data, we identified two psychophysiologically distinct 'pain clusters'. Patients were overrepresented in the cluster characterized by high neuroticism, trait anxiety, baseline cortisol, pain hypersensitivity, and parasympathetic response to pain (all p < 0.03). Conclusions & Inferences: In future, such delineations in FCP populations may facilitate individualization of treatment based on psychophysiological profiling. © 2013 John Wiley & Sons Ltd.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Reaction conditions facilitating the site-selective direct aryl functionalisation at the C-8 position of adenine nucleosides have been identified. Many different aromatic components may be effectively cross-coupled to provide a diverse array of arylated adenine nucleoside products without the need for ribose or adenine protecting groups. The optimal palladium catalyst loading lies between 0.5 and 5 mol %. Addition of excess mercury to the reaction had a negligible affect on catalysis, suggesting the involvement of a homogeneous catalytic species. A study by transmission electron microscopy (TEM) shows that metal containing nanoparticles, ca. 3 nm with good uniformity, are formed during the latter stages of the reaction. Stabilised PVP palladium colloids (PVP=N-polyvinylpyrrolidone) are catalytically active in the direct arylation process, releasing homogenous palladium into solution. The effect of various substituted 2-pyridine ligand additives has been investigated. A mechanism for the site-selective arylation of adenosine is proposed. © 2008 Elsevier Ltd. All rights reserved.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

2000 Mathematics Subject Classification: 62H30

Relevância:

20.00% 20.00%

Publicador:

Resumo:

ACM Computing Classification System (1998): G.2, G.4.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

A cikk azt a kérdést vizsgálja, hogy milyen szerepet töltenek be a multinacionális vállalatok leányvállalatai a hazai klaszterekben, milyen a kapcsolatuk a klasztertag kis- és középvállalatokkal többek között a közös innovációban, a tudásközvetítésben, a klaszterek reputációjának növelésében. A felderítő kutatás a témát a hazai klaszterfejlesztési program, a Pólus Program által életre hívott három, úgynevezett akkreditált klaszter menedzsereivel, a klasztertag multinacionális vállalatok (MNV-k) hazai leányvállalatainak képviselőivel és a klasztertag KKV-k vezetőivel készült interjúk alapján mutatja be. A téma relevanciáját a program által potenciálisan indukált együttműködési folyamatok adják, mivel a klaszterfejlesztési pályázati konstrukciók úgy lettek kialakítva, hogy a klasztertag KKV-knak érdemes legyen nagyvállalatot is bevonniuk a közös innovációs és kutatás-fejlesztési projektekbe. A kutatási eredmények alapján az MNV leányvállalatainak leginkább a globális trendek és standardok klaszterbeli elterjesztésében van meghatározó szerepük, illetve a KKV-k és leányvállalatok közötti üzleti kapcsolatok alakításában kiemelt szerepe van a klasztermenedzsment szervezet tevékenységének. / === / The paper focuses on the topic which deals with the role of subsidiaries of multinational companies (MNC’s) in Hungarian industrial clusters in the fields of common innovation, knowledge transfer, and increasing the cluster’s reputation. The findings of the paper are based on an explorative research. Interviews were made with cluster managers, representatives of MNC’s subsidiaries, leaders of small and medium size (SME’s) enterprises operating in three accredited clusters created by the Hungarian cluster development program, the Pole Program. The relevance of the topic is given by the Program, which has induced potential cooperation between MNC’s subsidiaries and domestic SME’s in cluster environment in a way so the members of the cluster – SME’s and subsidiaries – were driven to cooperate in common innovation and R+D projects. The author’s research results suggest that MNC’s subsidiaries in Hungarian clusters seem to play a key role in the dissemination of global industrial trends and standards between the cluster members. The national cluster management organization can also play a decisive role in shaping business relationship between MNC’s and SME’s.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

A tanulmány célja a Magyarországon működő exportáló vállalatok jellemzőinek feltárása volt a 2009-es vállalati versenyképességi felmérés alapján. Több tanulmány vizsgálta a vállalatok exportteljesítményét vállalati méret és tulajdonosi szerkezet szerinti bontásban, az elemzésben a szerző viszont ettől eltérő szemléletmódot alkalmazott. A vállalatok exportteljesítménye áll (exportértékesítés volumene, aránya, exportárbevétel változása, jövedelmezőség), a vállalati csoportképzés, klaszterelemzés középpontjában. Három jól elkülöníthető klasztert sikerült azonosítani: a jelentős exporthányaddal és folyamatos növekedéssel jellemezhető sikeres exportáló vállalatok csoportját, a stagnálással, s gyakran csökkenő exportértékesítéssel jellemezhető vállalatcsoportot, s végül a harmadik klasztert azok a jelenleg még alacsony export-ár bevétellel és alacsony exportaránnyal jellemezhető vállalatok képezték, melyekre a növekedés és a kiugróan magas jövedelmezőség volt a jellemző. Az elemzés egyediségét az adja, hogy a vállalati versenyképességi felmérés adatbázisa lehetővé tette a különböző exportteljesítmények hátterében álló működési jellemzők vizsgálatát, amelynek eredményeit a cikk bemutatja. Fő következtetésként megállapítható, hogy a sikeres exportáló vállalatok csoportja mindegyik jellemző szerint jobb működési jellemzőkkel rendelkezik a másik két csoporthoz viszonyítva. / === / The purpose of the paper is to reveal the main characteristics of the Hungarian export oriented firms. It is based on the Hungarian Competitiveness Research Survey 2009. 85% of enterprises were small or medium size in the sample. The aim of the analysis was to identify main factors and tendencies of the overall export performance. Several papers discussed the export activities of firms according to their size and ownership structure in Hungary. A different method was used here. The overall export performance (measured by volume, change, and share of export revenues, and firm profitability ratios) was put in the centre of cluster analysis. Three different clusters were identified. Firms in the firstcluster had significant export performance and growth rate. The second cluster was the group of stagnating firms and the third one contained those whose export performance was low but signaled growth with excellent profitability ratios. The uniqueness of the paper derived from the Competitiveness Research Survey because it provided an opportunity to analyse the connection between export performance and other management and operational characteristics of enterprises. The paper may induce futher research in exploring main enterprise level factors of export performance of the Hungarian firms.