Assessing the Functionality and Biocompatibility of a Wireless Contact Lens Sensor for 24 hour-intraocular Pressure Monitoring in Volunteers: Preliminary Results

Purpose: In vitro studies in porcine eyes have demonstrated a good correlation between induced intraocular pressure variations and corneal curvature changes, using a contact lens with an embedded microfabricated strain gauge. Continuous 24 hour-intraocular pressure (IOP) monitoring to detect large diurnal fluctuation is currently an unmet clinical need. The aims of this study is to evaluate precision of signal transmission and biocompatibility of 24 hour contact lens sensor wear (SENSIMED Triggerfish®) in humans. Methods: After full eye examination in 10 healthy volunteers, a 8.7 mm radius contact lens sensor and an orbital bandage containing a loop antenna were applied and connected to a portable recorder. Best corrected visual acuity and position, lubrication status and mobility of the sensor were assessed after 5 and 30 minutes, 4, 7 and 24 hours. Subjective comfort was scored and activities documented in a logbook. After sensor removal full eye examination was repeated, and the registration signal studied. Results: The comfort score was high and did not fluctuate significantly, except at the 7 hour-visit. The mobility of the contact lens was minimal but its lubrication remained good. Best corrected visual acuity was significantly reduced during the sensor wear and immediately after its removal. Three patients developed mild corneal staining. In all but one participant we obtained a registration IOP curve with visible ocular pulse amplitude. Conclusions: This 24 hour-trial confirmed the functionality and biocompatibility of SENSIMED Triggerfish® wireless contact lens sensor for IOP-fluctuation monitoring in volunteers. Further studies with a range of different contact lens sensor radii are indicated.

Dramatic decline of serogrup C meningococcal disease incidence in Catalonia (Spain) 24 months after a mass vaccination programme of children and young people

STUDY OBJECTIVES The objective of this study was to evaluate the effectiveness of a mass vaccination programme carried out in Catalonia (Spain) in the last quarter of 1997 in response to an upsurge of serogroup C meningococcal disease (SCMD). DESIGN Vaccination coverage in the 18 month to 19 years age group was investigated by means of a specific vaccination register. Vaccination effectiveness was calculated using the prospective cohort method. Cases of SCMD were identified on the basis of compulsory reporting and microbiological notification by hospital laboratories. Vaccination histories were investigated in all cases. Unadjusted and age adjusted vaccination effectiveness referred to the time of vaccination and the corresponding 95% confidence intervals (CI) were estimated at 6, 12, 18 and 24 months of follow up. SETTING All population aged 18 months to 19 years of Catalonia. MAIN RESULTS A total of seven cases of SCMD were detected at six months of follow up (one in the vaccinated cohort), 12 cases at 12 months (one in the vaccinated cohort), 19 cases at 18 months (two in the vaccinated cohort) and 24 at 24 months (two in the vaccinated cohort). The age adjusted effectiveness was 84% (95%CI 30, 97) at six months, 92% (95%CI 63, 98) at 12 months, 92% (95% CI 71, 98) at 18 months and 94% (95%CI 78, 98) at 24 months. In the target population, cases have been reduced by more than two thirds (68%) two years after the vaccination programme. In the total population the reduction was 43%. CONCLUSION Vaccination effectiveness has been high in Catalonia, with a dramatic reduction in disease incidence in the vaccinated cohort accompanied by a relevant reduction in the overall population. Given that vaccination coverage was only 54.6%, it may be supposed that this vaccination effectiveness is attributable, in part, to the herd immunity conferred by the vaccine.

Hexaclorobenceno: 1as jornadas nacionales : Barcelona, 23-24 de mayo de 1988: libro de actas

El volum recull les 20 comunicacions presentades durant la cel·lebració d'aquestes jornades.L'objectiu d'aquestes jornades era reunir en un fòrum comú tots els investigadors i grups que estudien a Espanya l'hexaclorobenzè des dels diferents punts de vista possibles.

Hexaclorobenceno : 1as jornadas nacionales: Barcelona, 23-24 de mayo de 1988: programa y resumenes de ponencias y comunicaciones

L'obra recull el programa d'aquestes jornades i els resums de les ponències i comunicacions que s'hi varen presentar.

Hexaclorobenceno: 1as jornadas nacionales : Barcelona, 23-24 de mayo de 1988: libro de actas

El volum recull les 20 comunicacions presentades durant la cel·lebració d'aquestes jornades.L'objectiu d'aquestes jornades era reunir en un fòrum comú tots els investigadors i grups que estudien a Espanya l'hexaclorobenzè des dels diferents punts de vista possibles.

EPI Update, May 24, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Friday Facts, May 24, 2013, Vol. 175

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Trayectorias docentes e investigadoras en la universidad. 24 historias de vida profesional. Los efectos de los cambios en el trabajo y la vida profesional de los docentes universitarios

[spa] Este texto forma parte de un proyecto de investigación Los efectos de los cambios sociales en el trabajo y la vida profesional de los docentes universitarios, parcialmente financiado por el Ministerio de Ciencia e Innovación (SEJ2006-01876), en el que nos planteamos explorar los cambios los ámbitos de la legislación, laorganización institucional, la investigación, la gestión y la docencia en los últimos treinta años. El principal objetivo del estudio era profundizar en nuestra comprensión sobre el impacto del cambio económico, social, cultural, tecnológico y laboral que están experimentando las universidades españolas en la vida y la identidad profesional del personal docente e investigador, teniendo en cuenta el contexto nacional y europeo. Estapublicación recoge la 24 historias de vida profesional realizas con o sobre otros tantos docentes universitarios. Sus relatos analizados y contextualizados, significan una contribución significativa al conocimiento basado en la investigación sobre el saber profesional y la experiencia laboral en las universidades españolas, y en consecuencia, a nuestra comprensión sobre cómo los académicos se están enfrentando con los cambios actuales.

Iowa Crop and Weather Report, June 24, 2013 Vol 13, no.16

Report produced by the The Department of Agriculture and Land Stewardship, Climatology Bureau. Iowa Secretary of Agriculture Bill Northey today commented on the Iowa Crops and Weather report released by the USDA National Agricultural Statistical Service. The report is released weekly from April through October.

Actas del IX Coloquio sobre lenguas y culturas paleohispánicas, Acta Palaeohispanica IX, Barcelona 20-24 de octubre de 2004, Palaeohispanica 5, Zaragoza, 1.150 p.

La revista Palaeohispánica, en su número cinco, ha realizado un meritorio y encomiable esfuerzo al acoger en su interior las Actas del IX Coloquio sobre lenguas y culturas paleohispánicas, celebrado en Barcelona los días 20 a 24 de octubre de 2004. Las 1.150 páginas del volumen pueden dar una idea de la complejidad de la tarea, de la que han sido editores J. Velaza Frías, F. Beltrán Lloris, C. Jordán Cólera y B. Díaz Ariño. En la nota editorial que precede al volumen los responsables dejan claras dos satisfacciones, que sin duda alguna compartirán todos aquéllos que se dedican a temas relacionados con la antigua Hispania: la coincidencia del primer lustro de vida de una revista multidisciplinar y las dos décadas alcanzadas por los ya veteranos coloquios, que, con el mismo fin, han venido reuniendo un número creciente de investigadores.

Iowa Crop and Weather Report, August 19, 2013 Vol 13, no.24

Report produced by the The Department of Agriculture and Land Stewardship, Climatology Bureau. Iowa Secretary of Agriculture Bill Northey today commented on the Iowa Crops and Weather report released by the USDA National Agricultural Statistical Service. The report is released weekly from April through October.