Extratos, frações ativas e/ou compostos isolados de casearia sylvestris, formulações farmacêuticas e seus usos

A presente invenção refere-se a extratos, frações ativas e/ou compostos isolados de Caseana sylvest ris. Adicionalmente, o presente pedido provê formulações farmacêuticas contendo os ditos ingredientes ativos e suas aplicações como medicamentos indicados no tratamento de distúrbios do trato gastrintestinal, preferencialmente, úlcera gastroduodenal.

Processo de obtenção de extratos de casearia sylvestris, processos de obtenção de frações ativas, extratos, frações ativas, uso de extratos e frações ativas, composição, unidade de dosagem, método para prevenir, tratar, combater ou suspender distúrbios gastrintestinais, medicamento e principio ativo

A presente invenção refere-se a uma droga antiulcerogênica, mais particularmente, a uma droga que compreende uma fração ativa da planta Casearia sylvestris como componente eficaz. De forma particular a invenção trata de uma droga útil no tratamento de distúrbios do trato gastrintestinal, principalmente no tratamento de úlcera gastroduodenal, sendo que apresenta ação citoprotetora, age tanto em úlceras leves como moderadas e graves e, sendo seletiva, não apresenta ação abortiva.

A new clinical sign probably associated to left hemiplegia with left hemineglect syndrome: the crossed legs

Objetivo : Descrever um novo sinal clínico associado à síndrome de negligência unilateral (SNU) em pacientes com acidente vascular cerebral isquêmico (AVCi). Método : Em 150 pacientes com acidente vascular cerebral isquêmico, foram realizadas tomografias de crânio e aplicada a National Institute of Health Stroke Scale. Aqueles pacientes com lesões vasculares à direita, hemiplegia esquerda e perna direita persistentemente cruzada sobre a esquerda, foram submetidos a testes específicos para SNU. Trinta pacientes também com lesões vasculares à direita, hemiplegia esquerda, porém sem evidências de permanecerem com as pernas cruzadas, foram submetidos aos mesmos testes clínicos. Resultados : Entre 150 pacientes com AVCi, 9 apresentaram lesão vascular cerebral à direita, hemiplegia esquerda e tendência em permanecer com a perna direita cruzada sobre a esquerda. Em 8 deles, testes específicos realizados nos primeiros dias de internação, confirmaram SNU à esquerda. Um paciente morreu antes que os testes pudessem ser aplicados. Dos 30 pacientes que não cruzaram as pernas, os testes foram normais em 20. Dez pacientes apresentaram alterações mínimas, insuficientes para o diagnóstico de SNU. Conclusão : A perna direita cruzada sobre a esquerda pode representar um novo sinal semiológico associado à hemiplegia esquerda e SNU à esquerda.

Rendimentos de cortes, proporção tecidual da carcaça e composição centesimal da carne de caprinos jovens em função do grupo racial e do peso corporal de abate

The purpose of this study was to evaluate the commercial cuts, loin tissues and composition proportions in meant from five racial groups: Alpine, ½ Boer + ½ Alpine (½ BA), ½ Anglo Nubian + ½ Alpine (½ ANA), ¾ Boer + ¼ Alpine (¾ BA), ¼ Boer + ¼ Alpine + ½ Anglo Nubian (Tricross), submitted to three slaughter weights (25, 30 and 35kg) in feedlot, using a complete diet. The crossing of Boer and Anglo Nubian with Alpine females only improved, in kids, the yield of cuts considered third category such as neck and rib. Slaughter body weights between 30 and 35kg should be preferred due to increase in the proportion of the loin, reduction in the proportion of the neck in Alpine and increase in the leg in Alpine and ¾ Boer, beyond the appropriate amounts of intermuscular fat and muscle.

Rendimentos de carcaça, cortes comerciais e não-componentes da carcaça de cordeiros Santa Inês alimentados com feno de erva-sal e concentrado

This work aimed to evaluate the carcass yields, commercial cuts and non-carcass components of Santa Inês lambs fed with 30, 40, 50 or 60% of oldman saltbush hay with concentrated. Were used 32 castrated lambs at 8 months old and initial body weight of 22 + 1.97kg, housed individually and slaughtered after 60 days of feedlot. The weights of hot and cold carcass decreased linearly with the inclusion of saltbush hay in the diet, however, there was no effect for true carcass yield and commercial cuts: shoulder (19.26%), neck (8.52%) ribs (26.57%) and leg (33.88%). There was a linear decrease for ribeye area and fat thickness when the level of hay in the diet increased. The weights and yields of skin, liver, heart, kidneys with perirenal fat, omental and mesenteric fats decreased linearly with the inclusion of hay in the diet, while the content (%) of gastrointestinal tract increased. The increased proportion of saltbush hay in the diet of lambs provided adequate true carcass yield and commercial cuts, however, reduces the ribeye area and fat thickness, important measurements in the qualitative evaluation of the lamb's carcass.

Determinação dos mecanismos de ação envolvidos no efeito antiulcerogênico, antidiarreico e anti-inflamatório da Insulina Vegetal (Cissus sicyoides Linneu) em modelos animais

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Avaliação dos mecanismos de ação envolvidos na atividade antiulcerogênica de Serjania marginata frente á doença ulcerosa péptica experimental

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Determinantes genéticos, bioquímicos e clínicos na resposta ao uso de hidroxiureia na doença falciforme

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ecological relevance of sentinels' biomarker responses: A multi-level approach

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo de fase clínica I utilizando membrana de quitosana dopada com hormônios derivados de plaquetas

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Extratos padronizados para o tratamento de doenças crônicas: Serjania marginata Casar. (Sapindaceae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Elucidação dos mecanismos de ação do monoterpeno β-mirceno sobre as úlceras pépticas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Correlação entre equilíbrio, assimetria de passos e descarga de peso em indivíduos hemiparéticos

Introduction: Hemiparesis is the most common sequels after Stroke. One of the side effects of the motor skills evident in hemiparesis is the tendency to remain in asymmetric posture, with lower distribution of weight on the side hemiparetic, which ends up leading to a deficit in balance. This set of changes can cause an asymmetrical type of gait, marked by difference between the lengths of the steps these individuals. Objective: The purpose of this study was to analyze the balance, the discharge of weight in the lower limbs and asymmetry of steps in hemiparetic individuals and sees if there is correlation between those variables. Method: A group of 12 hemiparetic individuals (55,33 ± 8,92 years), both sex, who suffered from strokes participated. All subjects performed the assessment of bilateral discharge of weight, the length of the steps and balance (Berg Balance Scale). The results for the difference in the discharge of weight of the lower limbs, asymmetry of the step and the performance on the test of balance were analyzed using the Sperman Correlation Coefficient with a significance level of 5% (p ≤ 0.05). Results: We found a significant correlation between balance and asymmetry of the steps (R = -0.72 and p = 0007), however, found no significant correlation between discharge of weight on each leg and the symmetry of the steps (R =- 0.07 and p = 0, 81) and between discharge of weight and balance (R =- 0.08 and p = 0.79) in these hemiparetic individuals. Conclusion: Can be conclude that hemiparetic individuals of these study show deficits in balance, difference in weight between the discharge of the lower limbs and asymmetry of step and correlation between the asymmetry of the step and balance.

The triple near-Earth asteroid (153591) 2001 SN263: an ultra-blue, primitive target for the Aster space mission

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Contribuição da amplitude de movimento articular do joelho na marcha de crianças com paralisia cerebral espástica

Individuals with spastic cerebral palsy show muscle weakness, difficulties in the control of agonist and antagonist muscles, decreased range of motion and tonus and sensibility alterations, especially in knee joint. These problems can interfere on the performance of functional activities such gait. The aim of this study was to analyze the contribution of knee range of motion on gait of hemiplegic and diplegic children considering their asymmetries. Twelve children, 6 hemiplegics e 6 diplegics from 7 to 12 years of age (age average= 9,5 ± 1,93) took part. Spasticity was assessed by the Ashworth’s Modified Scale and the passive knee range of motion by an eletrogoniometer. The task was to walk on a walkway of 8m long, in their preferred speed, in 6 attempts, been 3 on right and 3 on left sagital planes. Eigth passive markers were bilaterally fixed for the kinematic record. Orthogonally to the walkway, two digital camcorders were assembled on the sagital plane. The fotogrametric procedures were performed by the Dvideow 6.3 software. The Matlab 7.0.1 software was used to filter and to calculate the dependent variables. The U test of Mann- Whitney found differences to the cerebral palsy type for knee extension/hiperextension (U = - 2.943; p= 0.003), knee relative angle at heel contact (U = - 5.992; p= 0.001) and knee range during stride (U = - 4.099; p= 0.001). The Wilcoxon’s test revealed differences according to the asymmetries for the hemiplegics only for the knee relative angle at heel contact (T= - 2.635; p<0.008). The contributions of passive knee range of motion, revealed by the Spearman correlations, for the more afected limb of the diplegics, showed that the knee extension/hiperextension interfere on the cadence, stride duration and step width; the knee relative angle at heel contact change the stride length and duration and cadence; and the...(Complete abstract click electronic access below)