Berakhot : der Mišnatraktat "Lobsagungen"

von Hermann L. Strack. Mit Vokabular u. 3 Reg.

Die Juden, dürfen sie "Verbrecher von Religions wegen" genannt werden? : Aktenstücke zugl. als e. Beitr. zur Kennzeichnung d. Gerechtigkeitspflege in Preussen

ges. von Hermann L. Strack

Einleitung in den Talmud

von Hermann L. Strack

Joma : der Mischnatraktat "Versöhnungstag"

hrsg. und erklärt von Hermann L. Strack

Die Sprüche Jesus', des Sohnes Sirachs : der jüngst gefundene hebräische Text mit Anmerkungen und Wörterbuch

hrsg. von Hermann L. Strack

Rabbinica und Judaica

H. L. Strack

Pirqê aboth

hrsg. u. erkl. von Herm. L. Strack

Joma : der Mišnatraktat Versöhnungstag nach Handschriften und alten Drucken

hrsg., übers. u. mit Berücks. des Neuen Testaments erl. von Hermann L. Strack

A. Firkowitsch und seine Entdeckungen : ein Grabstein den hebräischen Grabschriften der Krim

von Hermann L. Strack

Der Blutaberglaube in der Menschheit, Blutmorde und Blutritus : zugleich eine Antwort auf die Herausforderung des "Osservatore Cattolico"

von Hermann L. Strack

Das Blut im Glauben und Aberglauben der Menschheit : mit besonderer Berücksichtigung der "Volksmedizin" und des "jüdischen Blutritus"

von Hermann L. Strack

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer.

Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and TWIST2. Here we investigate a possible epigenetic link between TWIST proteins and the tumor budding phenotype. TWIST1 and TWIST2 promoter methylation and protein expression were investigated in six cell lines and further correlated with tumor budding in patient cohort 1 (n = 185). Patient cohort 2 (n = 112) was used to assess prognostic effects. Laser capture microdissection (LCM) of tumor epithelium and stroma from low- and high-grade budding cancers was performed. In colorectal cancers, TWIST1 and TWIST2 expression was essentially restricted to stromal cells. LCM results of a high-grade budding case show positive TWIST1 and TWIST2 stroma and no methylation, while the low-grade budding case was characterized by negative stroma and strong hypermethylation. TWIST1 stromal cell staining was associated with adverse features like more advanced pT (p = 0.0044), lymph node metastasis (p = 0.0301), lymphatic vessel invasion (p = 0.0373), perineural invasion (p = 0.0109) and worse overall survival time (p = 0.0226). Stromal cells may influence tumor budding in colorectal cancers through expression of TWIST1. Hypermethylation of the tumor stroma may represent an alternative mechanism for regulation of TWIST1.

Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients.

IL-23 is a heterodimeric cytokine involved in inflammatory diseases; its role in cancer progression is controversial. Here we analyse the expression of IL-23 subunits (p40 and p19) and IL-23R in colorectal cancer with regard to disease progression, clinical-pathological and molecular aspects. Immunohistochemistry for IL-23p19, IL-23p40, IL-23R and CD8 was performed on a multi-punch tissue microarray of 195 colorectal cancers (cohort 1), matched normal tissue, adenoma and lymph node metastases. Results were compared with clinical-pathological features and CD8+ T-cell counts, then validated on two patient cohorts (cohort 2: n=341, cohort 3: n=139). Cytoplasmic/membranous expression of IL-23 (p19 and p40 subunits) and IL-23R, respectively were over-expressed in carcinomas versus adenomas and normal tissues (p<0.0001) but were reduced in lymph node metastases (p<0.0001). Nuclear IL-23p19 expression was observed in 23.1% and was associated with early TNM stage (p=0.0186), absence of venous (p=0.0124) and lymphatic invasion (p=0.01493), favorable survival (p=0.014) and absence of distant metastasis (p=0.0146; specificity: 100%). This unexpected cellular localization was confirmed by cell fractionation. The beneficial effect of nuclear IL-23p19 was restricted to tumours with CD8+ high counts. Results were validated on Cohorts 2/3. This multicenter study underlines the possible CD8(+)--dependency and beneficial effect of nuclear IL-23p19 on overall patient survival.

The Jew and human sacrifice : (Human blood and Jewish ritual) ; an historical and sociological inquiry

by Hermann L. Strack. The English transl. by Henry Blanchamp