Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39)

The incretin hormone glucagon-like peptide-1(7-36)amide (GLP-1) has been deemed of considerable importance in the regulation of blood glucose. Its effects, mediated through the regulation of insulin, glucagon, and somatostatin, are glucose-dependent and contribute to the tight control of glucose levels. Much enthusiasm has been assigned to a possible role of GLP-1 in the treatment of type 2 diabetes. GLIP-l's action unfortunately is limited through enzymatic inactivation caused by dipeptidylpeptidase IV (DPP IV). It is now well established that modifying GLP-1 at the N-terminal amino acids, His7 and Ala8, can greatly improve resistance to this enzyme. Little research has assessed what effect Glu9-substitution has on GLP-1 activity and its degradation by DPP IV. Here, we report that the replacement of Glu9 of GLP-1 with Lys dramatically increased resistance to DPP IV. This analogue (Lys9)GLP-1, exhibited a preserved GLP-1 receptor affinity, but the usual stimulatory effects of GLP-1 were completely eliminated, a trait duplicated by the other established GLP-1-antagonists, exendin (9-39) and GLP-1 (9-36)amide. We investigated the in vivo antagonistic actions of (Lys9)GLP-1 in comparison with GLP-1(9-36)amide and exendin (9-39) and revealed that this novel analogue may serve as a functional antagonist of the GLP-1 receptor.

FLQ, the Fastest Quadratic Complexity Bound on the Values of Positive Roots of Polynomials

In this paper we present F LQ, a quadratic complexity bound on the values of the positive roots of polynomials. This bound is an extension of FirstLambda, the corresponding linear complexity bound and, consequently, it is derived from Theorem 3 below. We have implemented FLQ in the Vincent-Akritas-Strzeboński Continued Fractions method (VAS-CF) for the isolation of real roots of polynomials and compared its behavior with that of the theoretically proven best bound, LM Q. Experimental results indicate that whereas F LQ runs on average faster (or quite faster) than LM Q, nonetheless the quality of the bounds computed by both is about the same; moreover, it was revealed that when VAS-CF is run on our benchmark polynomials using F LQ, LM Q and min(F LQ, LM Q) all three versions run equally well and, hence, it is inconclusive which one should be used in the VAS-CF method.

On the Asymptotic Behavior of the Ratio between the Numbers of Binary Primitive and Irreducible Polynomials

This work was presented in part at the 8th International Conference on Finite Fields and Applications Fq^8 , Melbourne, Australia, 9-13 July, 2007.

Analog of Favard's Theorem for Polynomials Connected with Difference Equation of 4-th Order

Orthonormal polynomials on the real line {pn (λ)} n=0 ... ∞ satisfy the recurrent relation of the form: λn−1 pn−1 (λ) + αn pn (λ) + λn pn+1 (λ) = λpn (λ), n = 0, 1, 2, . . . , where λn > 0, αn ∈ R, n = 0, 1, . . . ; λ−1 = p−1 = 0, λ ∈ C. In this paper we study systems of polynomials {pn (λ)} n=0 ... ∞ which satisfy the equation: αn−2 pn−2 (λ) + βn−1 pn−1 (λ) + γn pn (λ) + βn pn+1 (λ) + αn pn+2 (λ) = λ2 pn (λ), n = 0, 1, 2, . . . , where αn > 0, βn ∈ C, γn ∈ R, n = 0, 1, 2, . . ., α−1 = α−2 = β−1 = 0, p−1 = p−2 = 0, p0 (λ) = 1, p1 (λ) = cλ + b, c > 0, b ∈ C, λ ∈ C. It is shown that they are orthonormal on the real and the imaginary axes in the complex plane ...

Polynomials of Pellian Type and Continued Fractions

We investigate infinite families of integral quadratic polynomials {fk (X)} k∈N and show that, for a fixed k ∈ N and arbitrary X ∈ N, the period length of the simple continued fraction expansion of √fk (X) is constant. Furthermore, we show that the period lengths of √fk (X) go to infinity with k. For each member of the families involved, we show how to determine, in an easy fashion, the fundamental unit of the underlying quadratic field. We also demonstrate how the simple continued fraction ex- pansion of √fk (X) is related to that of √C, where √fk (X) = ak*X^2 +bk*X + C. This continues work in [1]–[4].

Discriminant Sets of Families of Hyperbolic Polynomials of Degree 4 and 5

∗ Research partially supported by INTAS grant 97-1644

Generalization of a Conjecture in the Geometry of Polynomials

In this paper we survey work on and around the following conjecture, which was first stated about 45 years ago: If all the zeros of an algebraic polynomial p (of degree n ≥ 2) lie in a disk with radius r, then, for each zero z1 of p, the disk with center z1 and radius r contains at least one zero of the derivative p′ . Until now, this conjecture has been proved for n ≤ 8 only. We also put the conjecture in a more general framework involving higher order derivatives and sets defined by the zeros of the polynomials.

On Representations of Algebraic Polynomials by Superpositions of Plane Waves

* The author was supported by NSF Grant No. DMS 9706883.

On a Five-Diagonal Jacobi Matrices and Orthogonal Polynomials on Rays in the Complex Plane

∗ Partially supported by Grant MM-428/94 of MESC.

Self-similar parabolic plasmonic beams

We demonstrate that an interplay between diffraction and defocusing nonlinearity can support stable self-similar plasmonic waves with a parabolic profile. Simplicity of a parabolic shape combined with the corresponding parabolic spatial phase distribution creates opportunities for controllable manipulation of plasmons through a combined action of diffraction and nonlinearity. © 2013 Optical Society of America.

A Note on a Classical Generating Function for the Jacobi Polynomials

Mathematics Subject Classification: 33C45.

Fractional Extensions of Jacobi Polynomials and Gauss Hypergeometric Function

2000 Mathematics Subject Classification: 26A33, 33C45

Polynomial Expansions for Solutions of Higher-Order Bessel Heat Equation in Quantum Calculus

Mathematics Subject Class.: 33C10,33D60,26D15,33D05,33D15,33D90

Rolle's Theorem for Complex Polynomials with Real Coefficients

Let p(z) be an algebraic polynomial of degree n ¸ 2 with real coefficients and p(i) = p(¡i). According to Grace-Heawood Theorem, at least one zero of the derivative p0(z) is on the disk with center in the origin and radius cot(¼=n). In this paper is found the smallest domain containing at leas one zero of the derivative p0(z).

Hermite Polynomials and the Zero-Distribution of Riemann's Zeta Function

AMS Subject Classification 2010: 11M26, 33C45, 42A38.