Influência da sinvastatina na reparação óssea de mandíbulas da ratas ovariectomizadas e nos níveis de colesterol sanguíneo

Pós-graduação em Biopatologia Bucal - ICT

Efeito do extrato insaponificável de abacate e soja na doença periodontal induzida, na osseointegração de implantes e no reparo de defeitos críticos de calvaria de ratos

Pós-graduação em Odontologia - FOAR

Estudo experimental do polietileno poroso de alta densidade (MEDPOR) fixado ao leito cirúrgico corticalizado e decorticalizado: análise histológica em cães

The aim of this study was to evaluate the influence of the bed in High Density Porous Polyethylene (Medpor) implants integration. Two different kind of beds -- corticalized and decorticalized -- were made in six dogs. The animals were killed thirty, sixty and ninety days after implantation. Blocks including implant and adjacent bone were harvested, submitted to histological procedures, stained in hematoxiline-eosine and analyzed in optic microscope. The results demonstrated an absence of infection and foreign body reaction associated with High Density Porous Polyethylene (Medpor) implants. Furthermore, bony and fibrovascular ingrowth could be observed into its pores. The best integration was noted in decorticalized group, in which occurred a greater bony and fibrovascular ingrowth in comparison to the corticalized group

Indicadores de depressão e de declínio cognitivo em idosos institucionalizados: um estudo de caso

This case study objectified investigating the symptomatology prevalence for depression (DP) and cognitive decline (CD) on institutionalized elderly’s; verifying the existence of correlations between DP and CD with age, gender and scholarity; and analyzing the possible correlations between symptomatology for DP and CD. For the realization of this research were selected, in two Elderly’s Long-Permanence Institutions (ELPIs), 24 subjects, which were classified according to gender, scholarity and age group. To verify the occurrence of CD, the Mini Mental State Examination (MMSE) was applied and, for the incidence of DP, the Geriatric Depression Scale (GDS) was applied. The data were tabulated and descriptively analyzed. For the study of the relations between quantitative variables, the Pearson correlation test was utilized and also the Spearmann test when necessary; for the comparison between two independent groups, the Student's t-test was utilized; for the verification of the association between gender, scholarity, DP and CD indicatives, the Pearson's X2 test and, due to theoretical restriction, the Fisher's exact test were utilized. The level of 5% probability was adopted for the rejection of nullity's hypothesis on all the tests. The research demonstrated that 50% of the research' subjects presented DP indicatives and 54.2% presented CD indicatives. Associations between: gender and DP (p = 0.414), gender and CD (p = 0.219), scholarity and CD (p = 0.527) were not observed. Positive regular correlation was verified between age and DP (r = 0.557; p = 0.005) and negative regular correlation was verified between DP and CD (r = -0.406; p = 0.049). The data suggest that DP might be a reaction to CD perceived by the subject. However, the hypothesis that indicates DP as a risk factor for CD and DM cannot be overruled, which suggests the importance of monitoring and treating depressive episodes on elderly populations.

Para além da leitura linear: uma contribuição ao processo de compreensão

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da integração de esferas de hidroxiapatita sintética e de polietileno poroso em cavidades evisceradas de coelhos

Para a recuperação da estética facial,há necessidade de reposição do volume orbitário perdido em decorrência de eviscerações ou enucleações. Este estudo foi realizado com os objetivos de avaliar comparativamente a biocompatibilidade e a manutenção do volume orbitário com o uso de esferas de hidroxiapatita sintética e de polietileno poroso, na reconstrução de cavidades evisceradas de coelhos. Métodos: Para isso foram utilizados 56 coelhos albinos, submetidos à evisceração do olho direito, com colocação de esferas de hidroxiapatita sintética (G1 – 28 animais) ou polietileno poroso (G2 – 28 animais).Quatro coelhos de cada grupo foram sacrificados em 7 momentos experimentais: 7, 15, 30, 60, 90, 120 e 180 dias após a evisceração. Após o sacrifício, o conteúdo da cavidade orbitária direita foi removido e seccionado na porção central em duas hemi-metades,uma das quais foi preparada para exame histopatológico; exame ultra-estrutural em microscópio eletrônico de varredura foi feito em dois animais de 7, 60 e 180 dias, de ambos os grupos experimentais. Resumo 118 Resultados: Observou-se aos 7 dias, tecido conjuntivo frouxo, constituído de células inflamatórias e hemáceas, em meio à rede de fibrina, principalmente na periferia da esfera de hidroxiapatita e chegando até ao centro da esfera de polietileno; a reação tecidual tornou-se mais densa com o passar do tempo. Decorridos 60 dias, observou-se em G1, início de metaplasia óssea que se acentuou ao longo do experimento. Em todos os momentos experimentais, a inflamação,predominantemente macrofágica, foi muito mais acentuada em G1.O volume da cavidade esclero-corneana foi melhor mantido em G2. Conclusão: a esfera de hidroxiapatita sintética provoca mais inflamação que a de polietileno poroso e é menos eficiente na manutenção do volume orbitário... (Resumo completo, clicar acesso eletrônico abaixo)

A presença das mulheres nas ciências exatas

Most well-known and studied names in schoolbooks are men's. It gives one the idea that the world of numbers does not belong to female individuals. In order to verify that this thought is a misconception, a research is carried out about women who, despite all prejudice, have faced many adversities, leaving us many contributions on exact sciences and being relevant until the present date. Nowadays, there is not as much sexual discrimination. Women’s under-representation in exact sciences is due to other motives, such as issues of choice and the option of part-time jobs for professional/familiar balance. Maybe because of this, women have little acknowledgment, as it can be seen in Nobel Prize, where of its 851 awards, only 44 were for women. They are present at different degrees of education, such as licentiate graduation, bachelor’s or master’s, but still outnumbered. The number of female graduates was higher than male’s, according to collected data from Mathematics licentiate graduation Department from 2000 until 2012 in UNESP, Guaratinguetá campus

A territorialização do setor sucroalcooleiro no Pontal do Paranapanema: estudo de caso do município de Martinópolis - SP

The sugarcane agribusiness has expanded by Brazil in recent years, especially with government incentives, which funded the construction and expansion of distilleries and sugar mills and alcohol throughout the national territory, as well as the expansion of the cultivation of sugarcane sugar. The state of São Paulo is the main focus of expansion in the sector, and its municipalities impacted significantly. The Pontal do Paranapanema is one of the last frontiers of cane sugar in the state, so that the culture has brought transformations mainly from 2003. Thus, we take the case of the municipality of Martinópolis analysis, which investigated some transformations in economic dynamics from 2004, the year he began the deployment of Plant Athena. For this, we conducted interviews with several subjects and analyzed statistical data from IBGE, LUPA, MAPA and CANASAT. Aware that these changes are limited to the capitalist market economy, we analyze the benefits and disadvantages brought by the activity of the plant for the population as part of economic growth characteristic of this scenario, taking it to the very prospect of local subjects. Alongside this growth, all other forms of inequality and exploitation of surplus value also grow which is not understood or perceived by residents. Hence the need to confront views and discourses on development promoted by the alcohol sector

Avaliação do efeito da gastrectomia na motilidade e no esvaziamento gástrico em ratos por biosusceptometria de corrente alternada

The study of gastrointestinal tract (GIT) functions is necessary due to the increasing number of pathologies associated with it. Directly influencing the quality of life, the gastrointestinal tract provides a number of parameters that, when analyzed, allow us to describe its dysfunctions. Thus, many techniques can be combined to obtain these properties related to the GIT. However, these techniques are often invasive, require surgery, catheter insertion, or to build a temporal model of these functions, require the sacrifice of animals in a series of data collection. The technique used in this study has the advantage of having a low operating cost, being free of ionizing radiation, non-invasive and is known as biosusceptometry AC (BAC), used to evaluate the properties of the GI tract by monitoring the position and concentration of materials magnetically marked. The sensor consists of two pairs of coils, one reference and one for detection. A fixed base line separates the sensing and reference coils, and also functions as support for the instrumentation. It is also important to note that the detection coils are arranged in a first order (subtraction) gradiometric way. The objective of this study was to analyze the effects of gastrectomy in gastric emptying and gastrointestinal transit time of solid food in rats using a BAC system associated with magnetic markers. To realize this study was constructed a dedicated BAC sensor, built to analyze these GIT properties. Data acquisition was obtained by aligning the magnetic sensor with the stomach and colon of the animal at pre-determined intervals. Thus, when approaching the magnetic material of the sensor, the balance created between the two sides of the sensor is broken. This imbalance can be measured, digitized and acquired. Tracer was used as a ration magnetically marked with ferrite... (Complete abstract click electronic access below)

Biosusceptometria de corrente alternada para avaliação do trânsito gastrintestinal de alimentos líquidos em ratos

The gastrointestinal tract is the main route of nutrients absorption and drugs delivery. Is important to know the parameters related to the tract, like gastric emptying and gastrointestinal transit, in order to better understand the behavior of different kind of meals or drugs passing through the GIT. Many techniques are used to study these parameters, such as manometry, scintigraphy, phenol red, activated charcoal and carbon-13 reading. However, these methods use radiation, are invasive and require animal sacrifice. As an alternative proposal, the Alternate Current Biosusceptometry (ACB), a magnetic technique, has proved to be effective for these studies with small animals, in a noninvasive way, low cost, radiation free and avoiding the animal death. Associating the ACB to magnetic micro or nanoparticles used as tracers, it is possible to observe the meal behavior inside of the GIT. Focusing meanly on liquid meals digestion, this paper had the objective to evaluate the efficiency of the ACB technique in gastric emptying and gastrointestinal transit evaluation of liquid meals in rats. To perform the experiments, magnetic nanoparticles (ferrite, MgFe2O4) were used on a 1,5 ml solution introduced by gavage on similar weight and age rats. The sensor made by 2 pairs of coils, capable of generating and detecting magnetic fields, creates a field on the interest place and when this field is in contact with the marked meal, it changes, resulting on a variation of the measured voltage. The voltage variation is analyzed and is obtained a particle concentration on the interest region. The results showed that is possible to apply the ACB technique on the GIT evaluation of liquid particles digestion, gastric emptying and meal cecum arrival time curves were obtained and from that, is possible to observe a pattern of gastrointestinal transit. Both mean process time values were acquired, proving the technique capability of ...

Efeitos do treinamento físico sobre o perfil metabólico, ósseo, endócrino e leucocitário de ratos recém-desmamados

As influências do exercício físico crônico sobre o tecido ósseo e hematológico de ratos Wistar têm sido investigados na literatura, porém são raros os trabalhos que abordam tais aspectos numa faixa etária mais precoce, na qual os efeitos podem ser benéficos ou até prejudiciais ao desenvolvimento. Assim, os principais objetivos deste estudo foram investigar os efeitos do treinamento físico regular e predominantemente aeróbio sobre aspectos endócrinos e metabólicos, sobre o tecido ósseo e sistema imunológico. Foram utilizados ratos machos, da linhagem Wistar, recém-desmamados (30 dias), mantidos no Biotério do Laboratório de Biodinâmica do Departamento de Educação Física, sob condições controladas (temperatura ambiente controlada de 25ºC e fotoperíodo de 12h claro/12h escuro). Os animais foram distribuídos em dois grupos experimentais: grupo sedentário (GS) e grupo treinado (GT). Os animais treinados foram submetidos a um protocolo de natação, 5 vezes/semana, 1 hora/dia, com carga de 5% em relação ao peso corporal, durante 6 semanas consecutivas, em água com temperatura controlada (32±2ºC). Ao final do período experimental, foram coletadas amostras de sangue para contagem total e diferencial de leucócitos e hematócrito. Após o sacrifício, foram coletadas amostras de soro para dosagem de glicose, proteínas totais, triglicérides, colesterol e amostras do fígado e músculo para a determinação dos teores de glicogênio, e tíbia para determinação do comprimento e área ósseas. Os dados foram apresentados como média ± desvio padrão. Para identificar diferenças estatísticas entre os grupos utilizou-se teste-t de Student para amostras independentes. O nível de significância foi pré-estabelecido em 5%. Pôde-se constatar que o treinamento físico regular realizado ...(Resumo completo clicar acesso eletrônico abaixo)

Saúde mental do idoso: percepções relacionadas com o envelhecimento em interface com o atendimento de saúde na atenção básica

Worldwide, growth is seen in the elderly population, which has prompted the use oftechnologies of care that include all stages of life and for that use, it is necessary toprepare professionals to meet this growing demand population. This work aims to understand how old people feel by their condition and identify how old people perceive this treatment in the Family Health Unit. The research is characterized asqualitative and Minayo second analysis was used Bardin. After, thematicinterviews, it was possible to appreciate the topics: Good, dissatisfaction through the life and likes / dislikes of the service unit. This work can be seen that the elderlywho were well, allied to good living with this family, with spouses, autonomy, respect they encounter in society. And when compared with those who have a complaint, we find that lack of family and age restrictions and diseases are the main complaints

Bendito: a narrativa em fluxos transmídia

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da integração de implantes de silicone com superfícies lisa, texturizada e de poliuretano em cavidades anoftálmicas evisceradas de coelhos

Pós-graduação em Bases Gerais da Cirurgia - FMB

Aspectos histopatológicos e expressão de receptores hormonais (AR e ERα) na próstata de ratos expostos ao Di-n-Butil-Ftalato (DBP) desde o período fetal, iniciados pela N-Metil-N-Nitrosuréia (MNU)

Tendo em vista a problemática mundial com relação à degradação dos materiais plásticos e sua dispersão no meio ambiente, e diante de estudo realizado anteriormente onde se observou alterações histopatológicas e bioquímicas na próstata de animais expostos ao DBP (Di-N-Butil-ftalato) no período perinatal, este estudo teve por objetivo avaliar o potencial carcinogênico do DBP administrado desde o período fetal e após iniciação pelo MNU em um modelo de carcinogênese prostática. Ratas prenhes foram divididas em 4 grupos experimentais: 2 tratados: n=16/grupo (TDBP100 e TDBP500) e 2 controles: n=8/grupo (CN e CMNU). O grupo TDBP100 foi exposto ao DBP (100 mg/kg) e o TDBP500 a 500 mg/kg do 15º. dia de gestação (DG15) até a 21º. dia pósnatal (DPN21), enquanto que os animais controle receberam o veículo. Após o desmame, os machos foram separados e os grupos tratados e CMNU receberam dose única de MNU (50 mg/Kg, i.p.) na 6ª. semana pós-natal. Metade dos animais tratados (n=8/grupo) continuaram recebendo o DBP (DBP100+ e DBP500+) após o desmame em doses semanais até o dia do sacrifício (DPN180), enquanto os demais foram mantidos pelo mesmo período sem tratamento (DBP100- e DBP500-).Após a aplicação do MNU, os animais foram submetidos a injeções semanais de Cipionato de Testosterona (promotor) 2mg/aplicação. No dia do sacrifício, o sangue foi coletado, os órgãos reprodutores foram pesados e fragmentos do lobo ventral da próstata foram processados para inclusão em resina e Paraplast para as análises estruturais; e imunocitoquímicas para a detecção de AR e ER. Fragmentos de próstata ventral foram congelados e estocados a -80ºC e após extração das proteínas, estas foram destinadas à reação de Western Blot para avaliar a expressão das mesmas proteínas. Houve diminuição na distância anogenital nos animais DBP500 no DPN1 quando comparado com o grupo controle apontando para o efeito efetivo do DBP ...