Exposure to nonsteroidal anti-inflammatory drugs and weight loss and hospitalization in non-small cell lung cancer patients

Background. Cancer cachexia is a common syndrome complex in cancer, occurring in nearly 80% of patients with advanced cancer and responsible for at least 20% of all cancer deaths. Cachexia is due to increased resting energy expenditure, increased production of inflammatory mediators, and changes in lipid and protein metabolism. Non-steroidal anti-inflammatory drugs (NSAIDs), by virtue of their anti-inflammatory properties, are possibly protective against cancer-related cachexia. Since cachexia is also associated with increased hospitalizations, this outcome may also show improvement with NSAID exposure. ^ Design. In this retrospective study, computerized records from 700 non-small cell lung cancer patients (NSCLC) were reviewed, and 487 (69.57%) were included in the final analyses. Exclusion criteria were severe chronic obstructive pulmonary disease, significant peripheral edema, class III or IV congestive heart failure, liver failure, other reasons for weight loss, or use of research or anabolic medications. Information on medication history, body weight and hospitalizations was collected from one year pre-diagnosis until three years post-diagnosis. Exposure to NSAIDs was defined if a patient had a history of being treated with NSAIDs for at least 50% of any given year in the observation period. We used t-test and chi-square tests for statistical analyses. ^ Results. Neither the proportion of patients with cachexia (p=0.27) nor the number of hospitalizations (p=0.74) differed among those with a history of NSAID use (n=92) and those without (n=395). ^ Conclusions. In this study, NSAID exposure was not significantly associated with weight loss or hospital admissions in patients with NSCLC. Further studies may be needed to confirm these observations.^

Heart Failure Monitoring System Based on Wearable and Information Technologies

In Europe, Cardiovascular Diseases (CVD) are the leading source of death, causing 45% of all deceases. Besides, Heart Failure, the paradigm of CVD, mainly affects people older than 65. In the current aging society, the European MyHeart Project was created, whose mission is to empower citizens to fight CVD by leading a preventive lifestyle and being able to be diagnosed at an early stage. This paper presents the development of a Heart Failure Management System, based on daily monitoring of Vital Body Signals, with wearable and mobile technologies, for the continuous assessment of this chronic disease. The System makes use of the latest technologies for monitoring heart condition, both with wearable garments (e.g. for measuring ECG and Respiration); and portable devices (such as Weight Scale and Blood Pressure Cuff) both with Bluetooth capabilities

La iglesia de Santiago de los españoles en Roma y su entorno entre los siglos XV y XIX. Una historia a través del dibujo

Plaza Navona representa una de las visitas obligadas de Roma, pero solo algunos advertirán en ella la presencia española en la sala de exposiciones del Instituto Cervantes o en la inmediata Libreria Española. Todavía serán menos los que se percatarán de la huella española dejada en aquella iglesia de fachada anónima situada, en el extremo sur de la plaza: la antigua iglesia de Santiago de los Españoles. La presente tesis pretende, utilizando el dibujo como guía, herramienta y fin del proceso de análisis y estudio, reconstruir el proceso de conformación y construcción de la que fue iglesia española principal, cuya fundación hace patente el destacado papel jugado por la “nación” castellana en Roma durante la Edad Media; y en torno a la que se aglutinaron las actividades religiosas, diplomáticas y financieras de los castellanos que vivieron en la actual capital italiana. Se intentará recrear en el tiempo la que es hoy la iglesia de Nuestra Señora del Sagrado Corazón, sometiéndola a una restitución gráfica disciplinada, homogénea y objetiva en la medida de lo posible de las varias etapas que la han caracterizadas, desde su fundación hasta cuando en 1878 España se deshizo de ella, ya en ruina, vendiéndola. Como nos comenta Gaetano Moroni, de todas las comunidades nacionales que se encontraban en Roma la española parece ser efectivamente una de las más rica y prestigiosa. Aunque lo que no cuenta Moroni no haya sido todavía demostrado, dicho enunciado resulta de todas formas interesante puesto que pone el acento sobre el hecho de que ya desde el siglo X parece ser habitual de ocupar y reutilizar antiguas ruinas, usándolas como base para la construcción de hospitales para los peregrinos. Esta operación se hizo particularmente frecuente sobre todo antes del Gran Jubileo de 1450: de hecho desde la primera mitad del Quattrocento se fundan distintas iglesias y hospitales nacionales para acoger y prestar una adecuada asistencia y socorro a los innumerables peregrinos que llegaban a la ciudad, edificios que se van construyendo sobre los restos de antiguos edificios de época romana. Prueba de ello es en efecto la fundación originaria de la iglesia y hospital de los Españoles que, parte del conjunto de edificios que compone la Plaza Navona, situada en el corazón de Campo Marzio y cuya posición y forma corresponden a la del antiguo Estadio de Domiciano, y que ahora es en sus dimensiones, en su imagen arquitectónica y en su consistencia material, el resultado de la definición proyectual y de las transformaciones que se llevaron a cabo sobre lo que quedaba del antiguo templo español del siglo XV, entre finales del ‘800 y los años 30 del siglo XX . Transformaciones devastadoras, huellas grabadas o canceladas que encuentran una justificación en los acontecimientos históricos reflejados en el patrimonio urbano. El análisis de todas las fuentes permite trazar, si no la totalidad, buena parte de las modificaciones que la antigua iglesia de Santiago ha sufrido. La construcción del templo se puede dividir en tres momentos decisivos: una primera etapa de fundación en 1450-1478 en la que la iglesia tenía fachada y entrada en via de la Sapienza, hoy Corso Rinascimento; una segunda de significativa ampliación hacia Plaza Navona con una nueva fachada monumental hacia ese espacio público en 1496-1500; y una última importante ampliación entre 1525-1526, llevada a cabo por el arquitecto Antonio da Sangallo el Joven. Tras la intensa vida del templo, en el siglo XVIII, éste cae en ruina y finalmente es vendido en 1878 a la orden de los misioneros franceses de Nuestra Señora del Sagrado Corazón que la reconvierten en iglesia reformando totalmente el conjunto en 1881, según proyecto de Luca Carimini. En 1936, en plena fase de rectificación de trazados urbanos por obra del régimen fascista, según proyecto de Arnaldo Foschini, se mutila su extremidad hacia vía de la Sapienza dejando su estado tal y como se contempla en la actualidad. ABSTRACT The objective of this thesis is the reconstruction of the design and edification process -using drawings and sketches as a guide, tool and the end of the analytical process- of a church which was once the preeminent Spanish church in medieval Rome, known today as Nostra Signora del Sacro Cuore (Our Lady of the Sacred Heart). The founding of this church illustrates the important role held by the Castillian “nation” in Rome during the Middle Ages. It was the focal point of all the religious, diplomatic and economic activities of the Castillian community residing in today’s Italian capital. The aim of this proyect is a recreation the church in time by submitting it to a disciplined, homogenous and objective graphic restitution of the various stages most characteristic the temple, starting from its foundation until 1878 when, in a state of ruins, the church was finally sold off by Spain. Gaetano Moroni once commented that of all the international communities found in Rome, the Spanish community seemed to be one of the wealthiest and most prestigious. Such a statement proves interesting as it emphasizes that starting in the 10th century we see there was a widespread custom of occupying and reusing old ruins for use as the bases of new constructions of hospitals for pilgrims. This custom became especially frequent just before the Jubilee Year of 1450: in fact, in the first half of the Quattrocento we see the founding of many different national churches and hospitals which provided shelter and care to the countless pilgrims arriving in the city, buildings which were constructed on top of the ruins of ancient buildings left over from Roman times. Proof of this is the original foundation of the Spanish church and hospital forming part of the Piazza Navona, built upon and following the outline of the Stadium of Domitian, in the heart of Campo Marzio. Now, in its dimensions, its architectural image and its material substance, it represents the predominant result of the planning definitions and the transformations which affected the old 15th-century Spanish temple. Ocurring between the end of the 19th century and the 1930s, the transformations were devastating, erasing original peculiarities and engraving new ones, transformations made justifiable by the historical events reflected in its urban environs. Analyzing all sources allows us to trace, even if not in entirety, still a sizeable portion of the modifications undergone by the old Church of Saint James. The construction of the temple can be divided into three decisive moments: its foundation, from 1450 to 1478, when the church’s façade and main door looked out on to the Via della Sapienza, today’s central avenue of Corso del Rinascimento; the second stage being a major expansion towards the Piazza Navona (1496-1500) with a new, monumental façade facing the public space; and the third was the last significant expansion, carried out from 1525 to 1526 by the architect Antonio da Sangallo the Younger. Despite an intense and bustling life during the Modern Age, in the 18th century the church began to fall into ruin and was finally sold in 1878 to the order of French missionaries of Our Lady of the Sacred Heart, who reconverted it into a church and completely renovated the structure in 1881 in a project supervised by Luca Carimini. In 1936, the corrective urban redesign of Rome carried out by the fascist regime and implemented by Arnaldo Foschini mutilated the part bordering Via della Sapienza, leaving it as we see it today.

A Plausibilidade da Interpretação da Religião pela Literatura Uma proposta fundamentada em Paul Ricoeur e Mikhail Bakhtin exemplificada com José Saramago

Religião e literatura é o tema geral desta tese de doutoramento. Contudo, a preocupação específica é a plausibilidade da interpretação da religião pela literatura. Isso porque os estudiosos dessa área têm normalmente partido da pressuposição de que essa plausibilidade existe. Por isso geralmente não a problematizam e nem se preocupam em fundamentá-la. A proposta desta pesquisa é justamente desenvolver um embasamento teórico que ajude a suprir essa lacuna. Portanto, esta tese mantém como preocupação de fundo uma questão epistemológica. Para levar adiante esse projeto, levanta-se a hipótese de que o discurso indireto da literatura caracterizado pela metáfora, especialmente o romance com a sua possibilidade polifônica e carnavalesca, tem a capacidade de revelar traços específicos do fenômeno religioso de modo diferente do que fazem os discursos diretos da filosofia e das ciências, de tal forma que dá à literatura condições de proceder a uma interpretação plausível e heurística da religião. A fundamentação teórica para o desenvolvimento da hipótese é baseada na teoria da metáfora, do texto e da narrativa de Paul Ricoeur e nos conceitos de dialogismo, polifonia, carnavalização e literatura prosaica de Mikhail Bakhtin. Com a finalidade de exemplificar, na prática, a pertinência do material teórico desenvolvido, o romance O Evangelho Segundo Jesus Cristo, de José Saramago é interpretado. Metodologicamente, o trabalho está dividido em três pontos: primeiro a literatura e o conhecimento da realidade; segundo a literatura como intérprete da religião e terceiro, a interpretação exemplar do romance.(AU)

A Plausibilidade da Interpretação da Religião pela Literatura Uma proposta fundamentada em Paul Ricoeur e Mikhail Bakhtin exemplificada com José Saramago

Religião e literatura é o tema geral desta tese de doutoramento. Contudo, a preocupação específica é a plausibilidade da interpretação da religião pela literatura. Isso porque os estudiosos dessa área têm normalmente partido da pressuposição de que essa plausibilidade existe. Por isso geralmente não a problematizam e nem se preocupam em fundamentá-la. A proposta desta pesquisa é justamente desenvolver um embasamento teórico que ajude a suprir essa lacuna. Portanto, esta tese mantém como preocupação de fundo uma questão epistemológica. Para levar adiante esse projeto, levanta-se a hipótese de que o discurso indireto da literatura caracterizado pela metáfora, especialmente o romance com a sua possibilidade polifônica e carnavalesca, tem a capacidade de revelar traços específicos do fenômeno religioso de modo diferente do que fazem os discursos diretos da filosofia e das ciências, de tal forma que dá à literatura condições de proceder a uma interpretação plausível e heurística da religião. A fundamentação teórica para o desenvolvimento da hipótese é baseada na teoria da metáfora, do texto e da narrativa de Paul Ricoeur e nos conceitos de dialogismo, polifonia, carnavalização e literatura prosaica de Mikhail Bakhtin. Com a finalidade de exemplificar, na prática, a pertinência do material teórico desenvolvido, o romance O Evangelho Segundo Jesus Cristo, de José Saramago é interpretado. Metodologicamente, o trabalho está dividido em três pontos: primeiro a literatura e o conhecimento da realidade; segundo a literatura como intérprete da religião e terceiro, a interpretação exemplar do romance.(AU)

Brandon/Hill selected list of print books and journals for the small medical library*

After thirty-six years of biennial updates, the authors take great pride in being able to publish the nineteenth version (2001) of the “Brandon/Hill Selected List of Print Books and Journals for the Small Medical Library.” This list of 630 books and 143 journals is intended as a selection guide for health sciences libraries or similar facilities. It can also function as a core collection for a library consortium. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals, by an alphabetical title listing. Due to continuing requests from librarians, a “minimal core list” consisting of 81 titles has been pulled out from the 217 asterisked (*) initial-purchase books and marked with daggers (†*) before the asterisks. To purchase the entire collection of 630 books and to pay for 143 2001 journal subscriptions would require $124,000. The cost of only the asterisked items, books and journals, totals $55,000. The “minimal core list” book collection costs approximately $14,300.

Brandon/Hill selected list of print books and journals in allied health*

This list of 424 books and 77 journals is intended as a selection guide for print literature to be used in a library supporting allied health educational programs or allied health personnel in either an academic or health care setting. Because of the impossibility of covering the large number and wide variety of allied health professions and occupations, the recommended publications are focused primarily on the educational programs listed and recognized by the American Medical Association and other accrediting bodies. Books and journals are categorized by subject; the book list is followed by an author/editor index, and the subject list of journals by an alphabetical title listing. Items suggested for initial purchase (167 books and 31 journals) are indicated by asterisks. To purchase the entire collection of books and journals (2000 subscriptions) would require an expenditure of about $31,970. The cost of only the asterisked items totals $12,515.

Docket books and fee book, 1791-1806

Consists of 7 notebooks and 1 account book. Notebooks list cases heard before the Massachusetts Court of Common Pleas for Middlesex and Worcester counties and the Massachusetts Supreme Judicial Court (March 1794-Sept. 1797; Sept. 1800-March 1802; June 1805-September 1806) and before the New Hampshire Court of Common Pleas for Hillsborough and Merrimack counties (March 1798-March 1805). The account book includes cases from Sept. 1791-July 1797.

Hādhā kitāb Kurūm ʻarāyis al-tahānī sharḥ Ṣalawāt Ibn Mashīsh al-Dānī / taʼlīf al-Imām al-Fāḍil al-Ṣūfī al-Humām al-Shaykh Muṣṭafá al-Bakrī al-Ṣiddīqī al-Khalwatī : manuscript, 1840

Author's own abridgement of his longer commentary on Moroccan sufi Ibn Mashīsh's prayer book known as Ṣalawāt. Longer version is titled: Rawḍāt al-ʻarshīyah fī al-kalām ʻala al-Ṣalawāt al-Mashīshīyah.

Small Town Downtown Revitalization: Applying the Main Street Approach to the towns of Perth and Carleton Place, Ontario

The downtown main street of small towns is traditionally the economic, cultural, and social heart of the community, thereby requiring particular attention from planners and researchers alike. Considering modern threats to main streets including suburban sprawl and "big box" development, revitalization strategies are essential to ensuring longevity and vitality of small towns’ cores, in terms of economy, built environment, heritage, and identity. The Main Street Approach was established to mitigate challenges by providing a revitalization tool-kit for small Canadian towns, focusing on organization, marketing and promotion, economic and commercial development, and design and physical improvements. To better understand existing municipal tools for downtown revitalization in Ontario, a comparative analysis of the towns of Carleton Place and Perth's policies was conducted using the four pillars of the Main Street Approach as benchmark for best practice, and recommendations for other small towns to better incorporate revitalization policies were suggested.

Network Analyis Approach to Find New Candidate Genes and Pathways Involved in the Pathophysiology of Familial Hypercholesterolemia

Introduction: Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD) due to lifelong elevated plasma low-density lipoprotein (LDL) levels. Worldwide only 40 % of patients (FH+) with a clinical diagnosis of FH carry a mutation in any of the three genes (namely: LDLR, APOB, PCSK 9) that are currently known to be associated to the disease. We guess that the remaining 60 % of the patients (FH-) probably includes a high percentage of individuals with a polygenic form of dyslipidemia or an environmental form of hypercholesterolemia and a small percentage of individuals with mutations in some novel genes, never associated before with dyslipidemias. Here we present the preliminary results of an integrative approach intended to identify new candidate genes and to dissect pathways that can be dysregulated in the disease.

Jesus before Pilate; a monograph of the crucifixion; political and legal history of the trial of Jesus under the Jewish and Roman criminal law, with an account of the office, powers, public acts and private character of Tiberius Caesar ... and others connected with the trial; embracing the Acts of Pontius Pilate, translatd from the oldest manuscripts, with proof of their antiquity and discussion of authenticity;

Disbound Original Held in Oak Street Library Facility.

Supplementary catalogue of Chinese books and manuscripts in the British Museum /

Mode of access: Internet.

The builder's complete assistant, or, A library of arts and sciences, absolutely necessary to be understood by builders and workmen in general : viz. I. Arithmetick, vulgar and decimal, in whole numbers and fractions. II. Geometry, lineal, superficial, and solid. III. Architecture, universal. IV. Mensuration. V. Plain trigonometry. VI. Surveying of land, &c. VII. Mechanick powers. VIII. Hydrostaticks : illustrated by above thirteen hundred examples of lines, superficies, solids, mouldings, pedestals, columns, pilasters, entablatures, pediments, imposts, block cornices, rustick quoins, frontispieces, arcades, porticos, &c. : proportioned by modules and minutes, according to Andrea Palladio, and by equal parts : likewise great varieties of trussed roofs, timber bridges, centerings, arches, groins, twisted rails, compartments, obelisks, vases, pedestals for bustos, sun-dials, fonts, &c. and methods for raising heavy bodies by the force of levers, pulleys, axes in peritrochio, screws, and wedges, as also water, by the common pump, crane, etc. : wherein the properties, and pressure of the air on water, &c. are explained : the whole exemplified by 77 large quarto copper-plates /

All of the numbered plates in the atlas are double plates, and thus are counted twice in the adjusted plate count.

The life and times of Jesus the Messiah;

"List of authorities": v. 1, p. [xxi]-xxvi.