Impact of gestational diabetes and lactational insulin replacement on structure and secretory function of offspring rat ventral prostate

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cimetidine Reduces Alveolar Bone Loss in Induced Periodontitis in Rat Molars

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Circadian-rhythm of the endopeptidase 22.19 (ec 3.4.22.19) in the rat-brain

The endopeptidase 22.19 (EC 3.4.22.19) has been associated with the metabolism of neuropeptides by its ability to convert small enkephalin-containing peptides (8 to 13 amino acids) into enkephalins. In addition, this enzyme cleaves the Arg8-Arg9 bond of neurotensin and the Phe5-Ser6 bond of bradykinin. We analyzed the circadian variation of endopeptidase 22.19 in the whole and individual areas of the rat brain. Endopeptidase 22.19 activity was analyzed by high-performance liquid chromatography (HPLC) using bradykinin as an operative substrate. Enzymatic specific activities were analyzed by rhythmometric methods and indicate a circadian fluctuation of endopeptidase 22.19 specific activity (mU of enzyme/mg of protein) in the whole brain [p < 0.001, mesor (M) = 7.62, amplitude (A) = 2.89, and acrophase (phi) = 23:08 h], striatum (p < 0.001, M = 2.92, A = 0.62, phi-23:03 h), hypothalamus (p < 0.001, M = 3.15, A = 0.86, phi-01:12 h), periaqueductal gray matter (p < 0.005, M = 2.62, A = 0.34, phi = 22:35 h), and cerebellum (p < 0.0 14, M = 4.27, A = 0.88, phi = 17:12 h). The circadian rhythmicity in endopeptidase 22.19 specific activity suggests that light may have an effect on the peptidase activity in whole brain and in areas of the central nervous system and may be essential for the mechanisms of circadian fluctuations of neuropeptides in the brain.

Desenvolvimento e caracterização de compósitos de fibras naturais modificadas e híbridos: fibras da coroa do abacaxi/polipropileno e fibras da coroa do abacaxi/fibras de vidro/polipropileno

The concern with the environment preservation has done with that researchers as well as industries invest in the search for materials that come from renewable sources. Natural fibers, because they are ecologically correct and have low cost, have been studied as a possible substitute, even if partial, of synthetic fibers in the development of polymeric composites. In this context, the hybrid composites (natural/synthetic) increase considerably the range of application of natural composites. The auto industry, in its constant quest for good mechanical properties materials which are developed with sustainability, has in composites with hybrid reinforcement a very viable alternative. In the present work, the nature Crown pineapple fibers and nature Crown pineapple fibers treated with alkaline solution were studied in order to evaluate the influence of chemical treatment in its properties. For this techniques were used x-ray diffractometry, Thermogravimetry and Infrared Spectroscopy (FTIR). Composites have been developed using polypropylene, reinforced with pineapple fibers and pineapple fibers hybrids/glass fibres, both with levels of 5 and 10%. These composites were analyzed by Thermogravimetry techniques and tested by traction. The realization of this work indicated that although the chemical treatment did not affect the thermal stability of the fibers, caused an increase in crystallinity index fibers and decreased its hydrophilic. The tests performed on composite indicated that the composites process was suitable because it provided good dispersion of the polymer matrix. The addition of natural fibers from the pineapple's Crown, in a proportion of 10%, provided the greatest increase in modulus of elasticity (27%) when compared to the pure polymer

Estudo e caracterização térmica da curcumina e de uma forma polimórfica

This paper was prepared a polymorphic from of curcumin a natural bioactive compound widely used in Indian medicine in the treatment of a range of illnesses. The preparation was the polymorphic crystallization process and solvent mixtures of organic solvents in order to change the dielectric constant of the solution to obtain crystals. The crystal of curcumin has been studied and characterized by absorption spectroscopic in the infrared, X-ray diffraction powder method and by thermo analytical techniques: thermogravimetry and differential therma analysis (TG-DTA) and differential scanning calorimetry (DSC). The DSC of the pure compound (MP=180,19ºC) showed some differences compared the compound crystallized (MP=176.63ºC) in a mixture of solvents thus indicating the phenomenon of polymorphism, and TG-DTA curve of the compound crystallized showed that this was not a solvatomorphic. Finnally the techniques of X-ray diffraction technique FTIR and powder showed a structural change in the compound crystallized, profile-based graphics when compared to the pure compound, which proves that the compound crystallized it is a polymorph

Propriedades térnicas de géis e xerogéis híbridos de sílica/orgânico à base de GPTS-TEOS com diferentes concentrações de GPTS

In the present work the thermal characteristics of gels and xerogels of Silica/organic hybrids derived from different concentrations of GPTS-TEOS were investigated by thermal analysis (TG, DTA, and DSC). The preparation of gels of the Silica/organic hybrid matrix was held through the sol-gel process, consisting by the hydrolysis of alkoxides GPTS and TEOS in proportion (1:1) and (1:2) that was promoted in acidic conditions under reflux and stirring at 80oC/2h, producing the matrix in the colloidal state (sol). Gels were prepared by addition of NH4OH to the sol, promoting gelation of sol in sealed plastics containers. Part of the gels samples was analyzed by TG, DTS and DSC techniques in order to characterize water loss and degradation of the polymeric “epoxy” groups present in the structure of the silica derived from the GPTS alkoxide. Another set of samples was dried at 80oC/48h to obtain xerogels (dried gels) and analyzed by the same techniques. We obtained the characteristics temperatures of the matrix by the techniques DTA, DSC and TG, under measurements of thermal analysis until 800oC and 600oC in case of DSC. By thermal analysis (TG, DTA, and DSC) the main endothermic events (loss of water, melting, pyrolysis) and exothermic events (burning of the polymer) of the GPTS-TEOS matrix were determined

Estudo dos compostos voláteis da decomposição térmica dos anti-helmínticos Albendazol e Mebendazol

The albendazole and mebendazole drugs are benzimidazole derivatives and belong to the anthelmintic class. These drugs are particularly recommended for the treatment against worms present in the gastrointestinal tract of animals and humans, by acting directly on the worm metabolism. The need for thermally study drugs is related to all the parameters that these analyzes include: presence or absence of polymorphs, possible changes in the crystallinity of the drugs, as well as the quality control during the manufacturing process thereof. In this study the thermal behavior of anthelmintic albendazole and commercial mebendazole and its recrystallisation in organic solvents, such as acetic acid and formic acid in dimethylformamide to mebendazole, and albendazole were studied using TG-DSC techniques, TG-FTIR, FTIR and XRD. TG-DSC techniques were used so it could collect information about the thermal stability of the compounds steps for thermal decomposition process and also prove its melting temperature. For recrystallization of drugs in organic solvents, the TG-DSC curves were analyzed to compare and determine that the occurrence of polymorphs. The coupled TG-FTIR technique allowed the analysis of volatile products which were released during the thermal decomposition of the commercial mebendazole. The absorption spectroscopy in the infrared region was performed to mebendazole, and albendazole in order to show the difference in functional groups of both, comparing the spectra with commercial drugs and see if there was recrystallized changes in the absorption band where the drug was recrystallized or when heated. The diffraction technique by powder X-ray method was used for comparison of the crystal structures of commercial drugs and recrystallization in organic solvents to identify changes in crystallinity both, which might suggest the formation of polymorphs

Síntese, caracterização e estudo termoanalítico dos nicotinatos de alguns metais de transição bivalentes no estado sólido

Pós-graduação em Química - IQ

Síntese, Caracterização Estrutural e Análise do Potencial Catalítico, para a Preparação de Biodiesel, de Niobatos Não Estequiométricos com Estrutura Tungstênio Bronze

Pós-graduação em Química - IBILCE

Avaliação térmica e estrutural do bagaço de cana de açúcar pré-tratado com ozônio, ultrassom e micro-ondas para produção de etanol celulósico por hidrólise enzimática

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Programação térmica fetal e duração da fase de eclosão: efeitos sobre a qualidade na eclosão, variáveis sanguíneas, preferência térmica e resposta ao desafio térmico de pintos fêmeas

Pós-graduação em Zootecnia - FCAV

Evaluation of early changes induced by diuron in the rat urinary bladder using different processing methods for scanning electron microscopy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)