Supporting Cubane’s Renaissance: Metathesis reactions on 4-iodo-1-vinylcubane and Stetter reaction on 1-iodocubane-4-carboxaldehyde

Cubane is a peculiar cube-shaped alkane molecule with a rigid, regular structure. This makes it a good scaffold, i.e. a molecular platform to which the substituents are arranged in a specific and fixed orientation. Moreover, cubane has a body diagonal of 2.72 Å, very similar to the distance across the benzene ring, i.e. 2.79 Å. Thus, it would be possible to use cubane as a scaffold in medicinal and material chemistry as a benzene isostere 1,2. This could lead to advantages in terms of solubility and toxicity and could provide novel properties. For this purpose, the possibility of performing “modern organic chemistry” on the cubane scaffold has to be studied. This project was entirely carried out in the framework of the Erasmus+ mobility programme at the Trinity College (Dublin, IRL) under the supervision of prof. M. O. Senge. The main goal of this project was to widen the knowledge on cubane chemistry. In particular, it was decided to test reactions that were never applied to the scaffold before, such as metathesis of 4-iodo-1-vinylcubane and Stetter reaction of 1-iodocubane-4-carboxaldehyde. These two molecules were synthesized in 10 and 9 steps respectively from commercially available cyclopentanone, following a known procedure. Unfortunately, metathesis with different olefins, such as styrene, α,β unsaturated compounds and linear α-olefins failed under different conditions, highlighting cubane behaves as a Type IV, challenging olefin under metathesis conditions. Even the employment of a specific catalyst for hindered olefins failed in the cross-coupling with linear α-olefins. On the other hand, two new molecules were synthesized via Stetter reaction and benzoin condensation respectively. Even if the majority of the reactions were not successful, this work can be seen as an inspiration for further investigation on cubane chemistry, as new questions were raised and new opportunities were envisioned.

Addressing surprise and uncertain futures in marine science, marine governance, and society

On an increasingly populated planet, with decreasing biodiversity and limited new opportunities to tap unexploited natural resources, there is a clear need to adjust aspects of marine management and governance. Although sectarian management has succeeded in addressing and managing some important threats to marine ecosystems, unintended consequences are often associated with overlooking nonlinear interactions and cumulative impacts that increase the risk of surprises in social-ecological systems. In this paper, we begin to untangle science-governance-society (SGS) interdependencies in marine systems by considering how to recognize the risk of surprise in social and ecological dynamics. Equally important is drawing attention to our state of preparedness, adaptation, and timeliness of response in ecosystem governance and society, which involve fostering transformations away from rigid and nonintegrated structures of governance. More inclusive decision-making processes, deeper understanding of complexity, and colearning across SGS can help to build constructive solutions that are likely to benefit multiple stakeholders and build capacity to understand and respond to change.

Legal requirements on secondary use of medical data in the EU and USA – A case study

The use of secondary data in health care research has become a very important issue over the past few years. Data from the treatment context are being used for evaluation of medical data for external quality assurance, as well as to answer medical questions in the form of registers and research databases. Additionally, the establishment of electronic clinical systems like data warehouses provides new opportunities for the secondary use of clinical data. Because health data is among the most sensitive information about an individual, the data must be safeguarded from disclosure.

A internacionalização de PME: o caso da Carvalheira, Bastos Lda.

Atualmente, a internacionalização é uma estratégia adotada por muitas empresas, independentemente da sua dimensão com o intuito de enfrentar o abrandamento económico no seu mercado doméstico e impulsionar o seu crescimento. No caso das PME, as principais razões que as levam a sair do seu mercado doméstico e a arriscar em mercados externos prendem-se com motivações reativas e muitas vezes exógenas, como sejam a saturação do mercado doméstico, as pressões da concorrência e as relações com os clientes. Assim, a crise financeira no país, aliada à crise no setor da construção civil, leva esta PME portuguesa, do ramo da carpintaria de limpo, a procurar novas oportunidades no exterior. No entanto, como tem consciência da falta de experiência e conhecimento nos mercados internacionais, começa por abordar os mercados numa lógica de procura de novas oportunidades, aproveitando as oportunidades que lhe são dirigidas e vendo nestas uma forma de aprofundar relacionamentos e ganhar experiência neste âmbito. Posteriormente, este conhecimento e experiência permitir-lhe-á enveredar por uma estratégia de internacionalização mais ativa, abandonando/diminuindo a lógica de oportunidade e apostando numa lógica mais estruturada e planeada. Este trabalho, ao tirar proveito de um único estudo de caso, pretende analisar a perspetiva evolutiva da empresa, e como uma estratégia empreendedora, a confiança e a incorporação em redes de relacionamentos facilitam o processo de abertura aos mercados externos.

A potencialidade do PROEJA: histórias dos estudantes evadidos do IFRS Câmpus Rio Grande

A presente investigação situa-se na área da integração da Educação Profissional com Educação Básica na Modalidade de Jovens e Adultos (PROEJA) e busca a compreensão das vivências dos estudantes do curso no Câmpus Rio Grande que integra o Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul (IFRS-RG). Faz parte também dos objetivos identificar as contribuições do curso para a socialização desses estudantes e os significados atribuídos ao curso. Em função da elevada taxa de evasão, a pesquisa foi desenvolvida com estudantes que não concluíram o curso. A hermenêutica filosófica constitui-se na epistemologia que ancora teoricamente a abordagem metodológica. A Análise Textual Discursiva foi a metodologia qualitativa adotada para a análise do material empírico constituído centralmente pelas histórias contadas pelos estudantes. Eles contam sua passagem pelo PROEJA, desde o ingresso até a sua evasão. Foram produzidos dados quantitativos além de levantamentos para conhecer o contexto da trajetória escolar dos estudantes. Esses elementos subsidiaram a análise qualitativa das informações. Como resultados foram encontradas: uma taxa de evasão geral da ordem de 57%. Nos dois primeiros módulos ocorreu 87 % de toda a evasão do curso. Em todo o período de oferecimento do curso, ou seja sete anos, apenas três estudantes concluíram o mesmo. Pela análise qualitativa, emergiram cinco categorias que tratam: a) do ingresso no PROEJA e dos desencontros nesse processo; b) do estudante com suas peculiaridades, dificuldades e significados; c) do ser professor no PROEJA; d) do curso pelo viés da formação integrada; e) dos componentes constituintes da evasão. Como conclusões a pesquisa aponta para a inadequação do curso em seus diversos aspectos. Reforça que a construção curricular adaptada de um curso existente foi um equívoco. A formação dos professores e gestores promoveu a proposta de um curso repleto de contradições. Mesmo com todos os distanciamentos, o curso promoveu um ensino de qualidade na formação humana e por isso os estudantes desenvolveram sentimentos positivos quanto ao curso. Promoveu os estudantes a novas oportunidades na sua vida social, inclusive com ingresso na universidade. A tese geral aponta para a potencialidade do PROEJA do Câmpus Rio Grande, na transformação da realidade do sujeito, apesar do alto índice de evasão e da inadequação do curso.

Computer-based tools for assessing micro-longitudinal patterns of cognitive function in older adults

Patterns of cognitive change over micro-longitudinal timescales (i.e., ranging from hours to days) are associated with a wide range of age-related health and functional outcomes. However, practical issues with conducting high-frequency assessments make investigations of micro-longitudinal cognition costly and burdensome to run. One way of addressing this is to develop cognitive assessments that can be performed by older adults, in their own homes, without a researcher being present. Here, we address the question of whether reliable and valid cognitive data can be collected over micro-longitudinal timescales using unsupervised cognitive tests.In study 1, 48 older adults completed two touchscreen cognitive tests, on three occasions, in controlled conditions, alongside a battery of standard tests of cognitive functions. In study 2, 40 older adults completed the same two computerized tasks on multiple occasions, over three separate week-long periods, in their own homes, without a researcher present. Here, the tasks were incorporated into a wider touchscreen system (Novel Assessment of Nutrition and Ageing (NANA)) developed to assess multiple domains of health and behavior. Standard tests of cognitive function were also administered prior to participants using the NANA system.Performance on the two “NANA” cognitive tasks showed convergent validity with, and similar levels of reliability to, the standard cognitive battery in both studies. Completion and accuracy rates were also very high. These results show that reliable and valid cognitive data can be collected from older adults using unsupervised computerized tests, thus affording new opportunities for the investigation of cognitive function.

Analysis of the entrepreneurial profile of students attending higher education in Portugal: the Carland Entrepreneurship Index application

Background The societal changes have created new necessities in terms of health care and of professionals with diverse skills. The institutions of higher education should promote the development of an entrepreneurial profile in students which may boost the exploration of new opportunities. Objectives: To identify the entrepreneurial profile in the students in higher education and its relationship to some personal characteristics and training. Methods Correlational quantitative study, accomplished with 1,604 students from 18 institutions of polytechnic Institutes of Portugal. The collection of data occurred between July and November/2015. The Carland Entrepreneurship Index (CEI) entrepreneurial skills questionnaire was applied, along with the acquisition of socio-demographic variables of the students. Data was analysed with the SPSS 23.0. The study followed the ethical requirements. Results The (CEI) application, allowed us to note that 75.7 % of the students presented an entrepreneurial profile, 20.8 % a Micro entrepreneurial profile and 3.4 % a Macro entrepreneurial. Additionally, we verified that older students (r = 0.193, p < = 0.000), of the male gender (Female = 0.55; Male, M= 0.580 p < 0.000), that had already worked or would like to work for others, showed the greatest entrepreneurial potential (Yes M= 0.60; No 0.54; p < 0.000), along with those who participated in entrepreneurial contents during their training (Did not participate M= 0.53; Participated 0.58; p < 0.000). Conclusions The entrepreneurial profile is related with some social demographic characteristics of the students; however, the educational institutions may have a preponderant role in the development of that profile, which may contribute to a greater contribution in the wellbeing of the populations.

The virtual class as a knowledge democratization model

This paper presents the conceptualization and use of a virtual classroom in the course EIF-200 Fundamentos de Informática, first course in the Information Systems Engineering career of the Universidad Nacional of Costa Rica. The virtual classroom is seen as a complement to the class and is conceived as a space that allows to centralize teaching resources, thereby promoting the  democratization of knowledge among students and teachers. Furthermore, this concept of virtual classroom helps to reduce the culture of individualism, present many times in university teaching practices, and contributes to create new opportunities to learn from other colleagues within a culture of reflection, analysis and respectful dialogue aimed to improve the teaching practices.

Avaliação da sensibilidade médica para o risco de gravidez não planeada

Prémio em Contraceção 2012 da Sociedade Portuguesa de Contraceção

A study of computational methods to analyze gene expression data

The recent advent of new technologies has led to huge amounts of genomic data. With these data come new opportunities to understand biological cellular processes underlying hidden regulation mechanisms and to identify disease related biomarkers for informative diagnostics. However, extracting biological insights from the immense amounts of genomic data is a challenging task. Therefore, effective and efficient computational techniques are needed to analyze and interpret genomic data. In this thesis, novel computational methods are proposed to address such challenges: a Bayesian mixture model, an extended Bayesian mixture model, and an Eigen-brain approach. The Bayesian mixture framework involves integration of the Bayesian network and the Gaussian mixture model. Based on the proposed framework and its conjunction with K-means clustering and principal component analysis (PCA), biological insights are derived such as context specific/dependent relationships and nested structures within microarray where biological replicates are encapsulated. The Bayesian mixture framework is then extended to explore posterior distributions of network space by incorporating a Markov chain Monte Carlo (MCMC) model. The extended Bayesian mixture model summarizes the sampled network structures by extracting biologically meaningful features. Finally, an Eigen-brain approach is proposed to analyze in situ hybridization data for the identification of the cell-type specific genes, which can be useful for informative blood diagnostics. Computational results with region-based clustering reveals the critical evidence for the consistency with brain anatomical structure.

Iron metabolism: a double-edged sword in the resistance of glioblastoma to therapies

International audience

Accessing dental anxiety online support groups: An exploratory qualitative study of motives and experiences

Objectives: In recent years, Internet access has grown markedly providing individuals with new opportunities for online information retrieval, psychological advice and support. The objectives of the present study were to explore the context through which dentally anxious individuals access an online support group and the nature of their online experiences. Methods: An online questionnaire was completed by 143 individuals who accessed the Dental Fear Central online support group bulletin board. Qualitative analysis was conducted on the responses. Results: Analysis revealed three emergent themes which reflected the motives and experiences of individuals: ‘Searching for help’, ‘Sharing fears’ and ‘I feel empowered’. Conclusion: This exploratory study suggests that for most individuals accessing this online support group was a positive and beneficial experience. Practice Implications: Online support groups may represent a convenient and beneficial tool that may assist certain individuals to confront their debilitating anxiety/phobia and successfully receive dental care.

L’espace comme matériau : l’architecture moderne et le complexe du Bauhaus à Dessau

Pour respecter les droits d’auteur, la version électronique de ce mémoire a été dépouillée de certains documents visuels. La version intégrale du mémoire a été déposée à la Division de la gestion des documents et des archives.

Social support in cyberspace: A content analysis of communication within a Huntington’s Disease online support group

Objective: Huntington’s Disease (HD) is an inherited disorder, characterised by a progressive degeneration of the brain. Due to the nature of the symptoms, the genetic element of the disease and the fact that there is no cure, HD patients and those in their support network often experience considerable stress and anxiety. With an expansion in Internet access, individuals affected by HD have new opportunities for information retrieval and social support. The aim of this study is to examine the provision of social support in messages posted to a HD online support group bulletin board. Methods: In total, 1313 messages were content analysed using a modified version of the Social Support Behaviour Code developed by Cutrona & Suhr (1992). Results: The analysis indicates that group members most frequently offered informational (56.2%) and emotional support (51.9%) followed by network support (48.4%) with esteem support (21.7%) and tangible assistance (9.8%) least frequently offered. Conclusion: This study suggests that exchanging informational and emotional support represents a key function of this online group. Practice implications: Online support groups provide a unique opportunity for health professionals to learn about the experiences and views of individuals affected by HD and explore where and why gaps may exist between evidence-based medicine and consumer behaviour and expectations.

Federal Crop Insurance Program Expands in 2016 and 2017 to Cover More Organic Crops

Organic agriculture represents one of the fastest growing segments of U.S. agriculture (USDA-RMA). With this in mind, the USDA’s Risk Management Agency (RMA) continues to expand crop insurance options for organic growers. In 2016 and 2017, organic producers in Maryland will see additional crops with organic crop insurance options. Increasing crop insurance options will allow this segment of producers new opportunities to manage their risks.