Leicester, Massachusetts, 1855 (Image 1 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the town of Leicester, Worcester County, Massachusetts, by E.M. Woodford. It was published by Richard Clark in 1855. Scale [ca. 1:15,840]. This layer is image 1 of 2 total images, representing the southern portion of the two sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town district boundaries, and more. Relief is shown by hachures. Includes views of local buildings in margins. Includes also insets: Plan of Leicester. Scale [ca. 1:4,060] -- Plan of Clappville. Scale [ca. 1:4,060]. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Leicester, Massachusetts, 1855 (Image 2 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the town of Leicester, Worcester County, Massachusetts, by E.M. Woodford. It was published by Richard Clark in 1855. Scale [ca. 1:15,840]. This layer is image 2 of 2 total images, representing the northern portion of the two sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town district boundaries, and more. Relief is shown by hachures. Includes views of local buildings in margins. Includes also insets: Plan of Leicester. Scale [ca. 1:4,060] -- Plan of Clappville. Scale [ca. 1:4,060]. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Systemic and local immune responses in sheep after Neospora caninum experimental infection at early, mid and late gestation.

Besides its importance in cattle, Neospora caninum may also pose a high risk as abortifacient for small ruminants. We have recently demonstrated that the outcome of experimental infection of pregnant sheep with 10(6) Nc-Spain7 tachyzoites is strongly dependent on the time of gestation. In the current study, we assessed peripheral and local immune response in those animals. Serological analysis revealed earlier and higher IFN-γ and IgG responses in ewes infected at early (G1) and mid (G2) gestation, when abortion occurred. IL-4 was not detected in sera from any sheep. Inflammatory infiltrates in the placenta mainly consisted of CD8+ and, to a lesser extent, CD4+ T cells and macrophages (CD163+). The infiltrate was more intense in sheep infected at mid-gestation. In the foetal mesenchyme, mostly free tachyzoites were found in animals infected at G1, while those infected in G2 displayed predominantly particulate antigen, and parasitophorous vacuoles were detected in sheep infected at G3. A similar pattern of placental cytokine mRNA expression was found in all groups, displaying a strengthened upregulation of IFN-γ and IL-4 and milder increases of TNF-α and IL-10, reminiscent of a mixed Th1 and Th2 response. IL-12 and IL-6 were only slightly upregulated in G2, and TGF-β was downregulated in G1 and G2, suggestive of limited T regulatory (Treg) cell activity. No significant expression of TLR2 or TLR4 could be detected. In summary, this study confirms the pivotal role of systemic and local immune responses at different times of gestation during N. caninum infection in sheep.

Sheep.

[From Jasper Cropsey Sketch book, 1855-1856]

Sheep.

[From Jasper Cropsey Sketch book, 1855-1856]

Sheep.

[From Jasper Cropsey Sketch book, 1855-1856]

A catalogue of pictures by British artists, in the possession of Sir John Fleming Leicester, bart., with etchings from the whole collection. Including the pictures in his gallery at Tabley House, Cheshire; executed by permission of the proprietor; and accompanied with historical and biographical notices.

Mode of access: Internet.