Old Plum, panels 1-4

Kano Sansetsu; 5 ft. 8 47/64 in.x 15 ft. 11 9/64 in.; four sliding doors (fusuma) ink, color and gold on paper

教導新叢書 1至4號. 新聞雜誌 56, 61至62號

Mode of access: Internet.

Index to recent reference lists [no. 1-4] 1884-1890.

[I] 1884/5. (Contrib. no. 20) 1885. Repub. from Bulletin no. 32, Oct., 1885.--[II] 1885/86. (Contrib. no. 24) 1887. Repub. from Bulletin no. 36, 1887.--III. 1887. (Contrib. no. 29) 1888. Repub. from Bulletin no. 39, 1888.--IV. 1890. (Contrib. no. 40) 1891. Repub. from Bulletin no. 48, 1891.

Organizational maintenance manual : truck, utility, 1/4-ton, 4X4, M151A2 (2320-00-177-9258), truck, utility, 1/4-ton, 4X4, M825 (2320-00-177-9257), 106MM recoilless rifle, truck, ambulance, frontline, 1/4-ton, 4X4, M718A1 (2410-11-177-9256).

Description based on vol. 1.

Organizational maintenance manual : truck, utility, 1/4 ton, 4x4, M151 (2320-542-4783), M151A1 (2320-763-1092), M151A2 (2320-177-9258); truck, utility, 1/4 ton, 4x4, M151A1C (2320-763-1091), M825 (2320-177-9257) with 106 mm recoilless rifle; truck, ambulance, front line, 1/4 ton, 4x4 ....

Includes index.

Reports of cases determined in the United States District court of the district of Hawaii ... v. 1-4; [August, 1900-January 15, 1917]

"Rules of the United States District court for the territory of Hawaii, adopted as compiled January 31, 1918, based on Compiled rules of May 5, 1902, as amended": v. 4, p. 793-875

Fragm. lat. III 34 - Liber Sextus Decretalium (1.4.1 - 4; 1.6.43 - 46; 1.22.2 - 3.3; 3.4.23 - 24), ohne Glosse

Trägerband: Inc. qu. 738; Inc. qu. 913; 'Vocabularius Ex quo'; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Fragm. lat. I 80 - Psalterium (Ps 67,31 - 36; 68,1 - 4; 73,10 - 23; 88,8 - 25)

Trägerband: Inc. fol. 237; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

A stable rearrangement product of humulene-4,5-epoxide

Humulene-4,5-monoepoxide, 1, may rearrange to the cyclopropyl diol 2 during chromatography over silica. The rearrangement can be reversed with acid.

A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones

Many important natural products contain the furan-2(5H)-one structure. The structure of this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents. By developing different reaction schemes at the three sites available for attachment on the furan-2(5H)-one scaffold, combinatorial chemistry techniques can be employed to assemble libraries of novel furan 2(5H)-ones. These libraries can then be entered into various biological screening programmes. This approach will enable a vast diversity or compounds to be examined, in the hope or finding new biologically active Iead structures. The work in this thesis has investigated the potential that combinatorial chemistry has in the quest for new biologically active lead structures based on the furan-2(5H)-one structure. Different reactions were investigated with respect to their suitability for inclusion in a library. Once sets of reactions at the various sites had been established, the viability of these reactions in the assembly of combinatorial libraries was investigated. Purification methods were developed, and the purified products entered into suitable biological screening tests. Results from some of these tests were optimised using structure activity relationships, and the resulting products re-screened. The screening tests performed were for anticancer and antimicrobial activity, cholecystokinin (CCK-B) antagonism and anti-inflammatory activity (in the quest for novel cyclo-oxygenase (COX-2) selective non-steroidal anti-inflammatory drugs). It has been shown that many reactions undergone by the furan-2(5H)-one structure are suitable for the assembly of a combinatorial library. Investigation into the assembly of different libraries has been carried out with initial screening results included. From this work, further investigation into combinatorial library assembly and structure activity relationships of screened reaction products can be undertaken.

The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate

Background: D-myo-inositol-1,2,6-triphosphate (a-trinositol, AT) is a polyanionic molecule capable of chelating divalent metal ions with anti-tumour and anti-cachectic activity in a murine model. Methods: To investigate the role of zinc in this process, mice bearing cachexia-inducing MAC16 tumour were treated with AT, with or without concomitant administration of ZnSO4. Results: At a dose of 40mgkg-1, AT effectively attenuated both weight loss and growth of the MAC16 tumour, and both effects were attenuated by co-administration of Zn2+. The concentration of zinc in gastrocnemius muscle increased with increasing weight loss, whereas administration of AT decreased the levels of zinc in plasma, skeletal muscle and tumour, which were restored back to control values after administration of ZnSO4. Conclusion: These results suggest that zinc is important in both tumour growth and cachexia in this animal model.

Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones

Oxazepam (4a) has been used as overall starting material in the synthesis of novel 2-substituted 1,4-benzodiazepines. By reacting Oxazepam 4a with commercially available hydrazines, hydrazides, semicarbazide, aminoguanidine and N,N-dimethylamino aniline in ethanol under acetic conditions, a series of diazenyl-1,4-benzodiazepines 5a-5i and 2-amino- 1,4-benzodiazepine 5k were obtained in good yields. These novel compounds served as new chemical entities (NCE) for testing in mice. The diazo-benzodiazepine 5d has shown a promising antidepressant effect in initial experiments in vivo at a dose of 5 mg/kg. The highly coloured 2-aminobenzodiazepine derivative 5k showed over a dose range from 5-50 mg/kg an analgesic effect in mice. © Singh et al.

(Table 4+5, Page 290) Distribution of Mn, Fe, Cu. Pb, Zn, Ni and Co in single manganese nodules

Chemical analyses of manganese nodules from the Central Pacific Basin show that their chemical composition varies regionally, although that of the associated sediments is markedly uniform throughout the basin. Mn content varies from 16 to 32% in average. Its higher value is generally found in nodules from siliceous clay and a few from deep-sea clay. Fe content tends to enrich in nodules from deep-sea clay area. Most manganese nodules, except those from deep-sea clay, are remarkably depleted in Fe compared with ones from the other Pacific regions. Mostly, Cu and Ni contents exceed 1% in nodules from siliceous clay, and decrease towards the northwest of the basin where deep-sea clay is distributed. The inter-element relationship between manganese nodules and associated sediments suggests that the mechanism of incorporation of major and minor elements in nodules is apparently different from that of the associated sediments. This finding seems to provide a new interpretation on the problem why manganese nodules having low accumulation rate are not buried by the associated sediments with greater sedimentation rate and then occur on sediment-seawater interface.