Student mathematical textbook of James Freeman, 1774

Manuscript volume containing portions of text copied from Nicholas Saunderson’s Elements of algebra, Nicholas Hammond’s The elements of algebra, and John Ward’s The young mathematician’s guide. The volume is divided into two main parts: the first is titled Concerning the parts of Arithmetick (p. 1-98) and the second, The elements of Algebra, extracted from Hammond, Ward & Saunderson (p. 99-259).

Commonplace book of Nathaniel Freeman, 1786-1787

Nathaniel Freeman made entries in this commonplace book between 1786 and 1787, while he was an undergraduate at Harvard College. The book includes the notes Freeman took during three of Hollis Professor Samuel Williams' "Course of Experimental Lectures," and cover Williams' lectures on "The Nature & Properties of Matter," "Attraction & Repulsion," and "The Nature, Kind, & Affections [?] of Motion." These notes also include one diagram. The book also includes forensic compositions on the subjects of capital punishment, the probability of "the immortality of the soul," and "whether there be any disinterested benevolence." It also includes a poem Freeman composed for his uncle, Edmund Freeman; an anecdote about Philojocus and Gripus; an essay called "Character"; a draft of a letter to the Harvard Corporation requesting that, in light of the public debt, the Commencement ceremonies be held privately to lower expenses and exhibit the merits of economy; and an "epistle" to his father, requesting money. This epistle begins: "Most honored sire, / Thy son, poor Nat, in humble strains, / Impell'd by want, thy generous bounty claims."

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFα, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. Our data also demonstrate that RHBDL4-dependent trafficking control is regulated by G-protein coupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including EGFR signaling. We propose that RHBDL4 reorganizes trafficking events within the early secretory pathway in response to GPCR signaling. Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of specific membrane protein cargoes.

First Annual IMACS Report: A global International Society for Heart and Lung Transplantation Registry for Mechanical Circulatory Support

The first annual report of the International Society for Heart and Lung Transplantation (ISHLT) Mechanically Assisted Circulatory Support (IMACS) registry provides global data on 5,942 patients from 31 countries. This initial report focuses on patient demographics, survival, device types, adverse events, competing outcomes, and a risk factor analysis.

Performance testing and system characterization. DOE Hybrid Test Vehicle phase III: final report.

Energy Department, Washington, D.C.

Stoping methods and cost,

Mode of access: Internet.

The history of the Norman conquest of England : its causes and its results /

v. 1. The preliminary history to the election of Eadward the Confessor. 1877.--v. 2. The reign of Eadward the Confessor. 1877.--v. 3. The reign of Harold and the interregnum. 1875.--v. 4. The reign of William the Conqueror. 1876.--v. 5. The effects of the Norman conquest. 1876.--v. 6. Index volume. 1879.

A treatise on the law of executions in civil cases and of proceedings in aid and restraint thereof.

Mode of access: Internet.