Transplante de medula óssea para suporte de células tronco hematopoiéticas em cães acometidos por linfoma

Lymphoma represents the most prevalent hematopoietic malignancy in small animal medicine. It is highly responsible to chemotherapy and therefore several protocols are used as therapeutic tools. For that reason, the bone marrow transplantation, enshrined in human medicine through initial trial in canine patients, has increasingly become the focus of studies in order to make it a reality also in veterinary medicine. First, the treatment with the chosen chemotherapy protocol is made. As complete remission of lymphoma is observed, it must be initiated the bone marrow harvesting. The obtained material is subjected to the processes of erythrocyte depletion, plasma depletion, cryoprotectants addition, total nuclear cells counting, hematopoietic progenitor quantification, analysis of cell viability and freezing. Following that, with radiotherapy or application of cyclophosphamide, the conditioning phase of the patient who is receiving the transplantation is carried out. The bags containing hematopoietic stem cells are then thawed and transplanted into the receptor organism. Support with hematopoietic stem cells allows the use of lethal doses of chemotherapy or radiotherapy and has been shown to considerably raise the disease remission time and survival rate of the canine patients

Estudo descritivo e preliminar das questões éticas, educativas e legais do uso de animais como recurso didático no ensino superior

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Influência da atividade de forragem, números de adultos e de larvas, na diferenciação de castas de Mischocyttarus cerberus styx Richards, 1940 (Hymenoptera, Vespidae, Mischocyttarini)

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As dificuldades de implantação de atividades experimentais investigativas no ensino de Química

Dissatisfaction with certain aspects of the educational processes of the traditional teaching has always existed, and new teaching methods have been routinely studied. The experimental investigative activity is one of those alternative practices. In this type of activity the experimentation is inserted with an investigative approach, in which the student must build the concept, with proposals that represent solutions to the excited problems. In the teaching of chemistry, specifically, the need and importance of experimentation is evident, beyond motivate students, aid in the understanding of chemical concepts relating them to reality. Realizing the contributions of this methodology for teaching and learning, through this research was conducted to understand the difficulties encountered by teachers for planning and implementation of these activities in the teaching of chemistry and therefore the reasons for the dominance of traditional teaching method. The subjects were undergraduate students of chemistry course that developed and implemented differentiated learning activities for teaching and teachers who accompanied the high school students who participated in the university extension project Inclusion Science and University students and teachers from public: Teaching and Learning Chemistry focuses on research and practice”. Through the data it was possible to identify some factors that affect and hinder the implementation of experimental activities in general, not only the investigative. However, despite the difficulties experienced by undergraduates, the majority considered the activity as an alternative teaching method interesting and innovative, able to produce interest, motivation and participation of students with subsequent learning. As well as the teachers, what with all the difficulties that they had declared facing when applying experimental activities, they admitted the pedagogical... (Complete abstract click electronic access belo)

O ensino de física nos primeiros anos da educação básica: possibilidades lúdicas e experimentais

We discuss in the work the importance of experiential activities for Physics Teaching in the first years at Elementary Education. For this we start from the experience provided by the Teaching Project Initiation under Pibid CAPES, linked to the Department of Education from the Institute of Biosciences and activities of the Graduate Diploma in Physics Supervised, at Rio Claro Campus, São Paulo State, in partnership with Basic Education schools of the city. Based on some patterns and studies on the Teaching of Science in Elementary Education and particularly in the Ferreira’s work with Instrumentation for Physics Teaching, Electrostatic was chosen as base theme. We opted for the use of didactic experiments that provided in its construction the utilization of low cost materials, easy access and portability. Teaching strategies were aimed at inserting experiential activities during Elementary School I (first and third years of elementary school), intending to rescue the trial of Physics Education and Science for Basic Education. These experimental teaching activities were analyzed in this paper from the perspective of playfulness. We argue that experimentation with recreational attributes when properly used provides the interaction of individuals with the knowledge of Physical Sciences

Uso do método de Monte Carlo para simulação e detecção do espectro de raios-X gerado com feixes de elétrons em alvo de Molibdênio, utilizando o Geant4

The huge demand for procedures involving ionizing radiation promotes the need for safe methods of experimentation considering the danger of their biological e ects with consequent risk to humans. Brazilian's legislation prohibits experiments involving this type of radiation in humans through Decree 453 of Ministry of Health with determines that such procedures comply with the principles of justi cation, optimization and dose limitation. In this line, concurrently with the advancement of available computer processing power, computing simulations have become relevant in those situations where experimental procedures are too cost or impractical. The Monte Carlo method, created along the Manhattan Project duringWorldWar II, is a powerful strategy to simulations in computational physics. In medical physics, this technique has been extensively used with applications in diagnostics and cancer treatment. The objective of this work is to simulate the production and detection of X-rays for the energy range of diagnostic radiology, for molybdenum target, using the Geant4 toolkit. X-ray tubes with this kind of target material are used in diagnostic radiology, speci cally in mammography, one of the most used techniques for screening of breast cancer in women. During the simulations, we used di erent models for bremsstrahlung available in physical models for low energy, in situations already covered by the literature in earlier versions of Geant4. Our results show that although the physical situations seems qualitatively adequate, quantitative comparisons to available analytical data shows aws in the code of Geant4 Low Energy source

Validação de uma câmara para exposição experimental a vapores, pela via respiratória, pelo sistema nose only exposure system

A exposição experimental a vapores de solventes pela via respiratória pode ser realizada em câmaras de dois tipos: a que expõe todo o animal por imersão na atmosfera experimental e aquela em que a exposição se dá apenas pelo nariz. O sistema para exposição apenas pelo nariz, denominado de NOES- Nose Only Exposure System, tem as vantagens de utilizar menos material, ter uma atmosfera continuamente renovada, produzir exposição mais uniforme entre os animais, ser mais facilmente controlado e evitar a penetração dos solventes por outras vias. A desvantagem está no fato na restrição do tempo do experimento por provocar estresse ao animal. O projeto experimental consistiu na validação de uma câmara de exposição para ratos, do tipo NOES, dotada de 44 portas, através da avaliação da homogeneidade e da estabilidade das concentrações de voláteis na atmosfera a ser inalada, utilizando etanol combustível como agente químico para os testes. Os resultados indicaram que a variabilidade das concentrações entre os planos da câmara (portas da camada superior e inferior), entre portas de exposição e, também, entre as médias apuradas para cada tempo não diferem expressivamente entre si. Assim, pode-se considerar que o equipamento mostrou-se adequado para manter a homogeneidade e a estabilidade das concentrações durante as 6 horas de experimentação, para o etanol combustível

Experimentos de baixo custo para o ensino de eletrostática no nível fundamental

The experimentation in the teaching of physics has been extensively studied over the years because of its potential as a tool demonstration of physics phenomena studied in classroom. In such a perspective view of the action of apprentice student involving teaching future teachers of physics, under the Program PIBID CAPES, developed since 2009, seeks ways to improve the teaching of physics experiments using the theme chosen for the electrostatic work was . In this particular work, we report the development of the project in a State School located in the city of Rio Claro, in two rooms in the 9th grade in elementary school. It is planned with the activities of teaching physics at this level of education, look at how two different ways of displaying the contents of electrostatics in a playful way for elementary students and implement a library of experiments so that students can take the experiments to their homes

As atividades experimentais no ensino de física

This work was developed from a literature search in order to provide teachers of physics theoretical and methodological requirements for the use of experimentation in physics teaching, with the aim of contributing to the teaching practice of these teachers and, consequently, for improving teaching this discipline. Therefore, to deal in the course of this research, the goals and types of practical activities, new information and communication technologies that fit the experimental approaches and the role of the teacher in this context, specifying the variables that influence and relate with experimental activities. Studies are presented on the methodology and planning of experimental activities to draw attention to the teacher and the important issues relevant to the preparation of these activities as, for example, the proposed objectives and types of discourse and existing approaches for the conduct of practical activities. In this sense, the trend is highlighted for walks where the approach of practical activities, within the context of practices interactionist and are pointed out strengths and weaknesses of different types of activities presented. We also highlight aspects of the learning process associated with some theoretical reference that are on that subject, as Piaget, Vigotski and Ausubel, so that the teacher can apply the concepts in their theories worked in the practical lessons of physics

O discurso do uso de animais nas pesquisas de Educação Física

It is possible in many countries, perhaps all, there is business groups of pharmaceuticals industry, cosmetics together with the universities that use animals in scientific research and testing for the creation of new products and medicines. Currently is growing discussion about standards and criteria for the use of these animals (guinea pigs) and also increases the number of debates on ethical issues in research with animal models. This research seeks to portray the reality of the use of animals in scientific research academic at the University, specifically to research in physical education, as it has used animals in the areas of Physiology of Sport and Physical Activity, Nutrition for Athletes, among others. Initially is shown the pre-reflection, exposing the laws governing the subject, treating the animal experimentation with regard to its history and the issues of speciesism and the methodological mistake. It reveals what it is and as is the use of animals in education and the inability of the student to change that reality, to refuse to participate in the cruel activity, and even they are aware of their rights as in the case of the withdrawal of consciousness. Presents researchers and universities not use animals and ends the pre-debate showing Who is really the most animal research at the university by providing alternatives for them. We conducted a literature survey on animal experimentation, research universities, and alternative methods. The following is the phenomenon in understanding and awareness of the researchers who use animals in their research, conducting a phenomenological analysis of his speeches, revealing the meanings of their animal research. The focus of this study is, therefore, the analysis of discourses of researchers who carried out research using animal experiments (guinea pigs). The phenomenon of understanding of the researchers about their research is made clear... (Complete abstract click ectronic access below)

O uso de experimentos didáticos como ferramenta para o ensino de física nos anos iniciais da educação básica

When it comes to teaching physics in the early years of elementary school, the first question is: but there are opportunities to teach concepts to children of such complexity? This study sought to examine approaches and strategies to enter the Basic Education in Physics. To this end, we used low cost materials testing, taking as its starting point the work of Ferreira (1978) instrumentation for Teaching Physics, particularly with the theme electrostatics. The present study was made from the use of prototypes developed with the materials cited. Observations were made in the classroom looking for, from the records of teaching, analyzing the behavior of children and their arguments, possibilities for Physics Teaching this age group as well as some evidence of their cognitive development. In teaching discussions were held with students of the early years of elementary school involving conceptual and phenomenological aspects, adapting such knowledge at the level of logical and mathematical thinking that was still under development. The work shows that it is possible to work on electrostatic physical concepts with children belonging to the age group of nine to ten years. With the support of the group Pibid Physics city of Rio Claro, I realize my observations and practices at the Municipal School Marcelo Schmidt, which proved to be available and open for acceptance of this proposal

Avaliação da atividade do tipo ansiolítica e antidepressiva do óleo essencial de Cananga odorata por meio de procedimento sequencial em camundongos

Os distúrbios do sistema nervoso central mais comuns relatados no mundo são a ansiedade e a depressão, com grande incidência de casos nos quais aparecem juntos. Os tratamentos utilizados na clínica além de não serem efetivos na totalidade dos casos podem, por vezes, apresentar diversos efeitos não desejados. Assim, na busca novas drogas mais efetivas e com menor incidência de efeitos adversos, a Cananga odorata (Lam.) Hook. f. & Thomson aparece como uma alternativa. Esta espécie vegetal é utilizada na aromaterapia como na prevenção do estresse, ansiedade e depressão (BIRD, 2003). A busca de novas ferramentas terapêuticas depende do uso de animais de experimentação, e com as discussões na sociedade científica sobre o uso de animais, há uma maior preocupação em se desenvolver novas técnicas experimentais onde se possa aplicar os conceitos dos 3Rs objetivando a redução (Replacement) do número de animais, sua substituição (Reduction) e o refinamento (Refinement) das técnicas experimentais. Neste trabalho avaliou-se a atividade ansiolítica e antidepressiva do óleo essencial (OE) de Cananga odorata, em animais que foram sucessivamente submetidos a testes para avaliar a atividade motora, ansiolítica e antidepressiva. Camundongos machos foram tratados por via oral com OE nas doses de 0,1; 1, 10 e 100 mg/kg, e após 30 minutos foram submetidos ao teste do Campo Aberto, da Caixa Claro-Escuro e Suspensão pela Cauda, nesta ordem, com um intervalo de 30 minutos entre eles. Os resultados indicaram que a seqüência de testes é adequada para a avaliação destas atividades com economia de tempo, animais e drogas

O ensino do desenho para crianças e jovens

Through my experiences as a teacher assistant in a free course design, I seek to understand the intentions and needs of children and youth with the design, so as to work it in a more consistent as the season and wishes of each student. For this I seek aid in studies on children's drawing of Derdyk Edith and also in observing the relationships that children and young people have with the drawing held in my practice as a teacher. Still reflect on the design in some of its particulars, especially concerning the optics of some artists and scholars of the practice of drawing. At the end of the study, propose suggestions for practices to be developed with children and young people who would be various forms of working drawing with experimental forms of building graphics, aiming so that students can add these unique experiences to broaden their understanding of design as well as its arch graphic possibilities. Thus inspired, especially in Derdyk considerations about the experimental design, I can conclude that through experimentation, we can offer young people a diverse thinking design and the possibilities of conceiving it.

Análise das alterações temporais dos fragmentos de vegetação no centro experimental do Instituto Agronômico, Campinas, utilizando técnicas de sensoriamento remoto e geoprocessamento

O presente estudo tem como objetivo principal realizar um levantamento temporal das áreas de vegetação no Centro Experimental de Campinas (CEC), uma fazenda de propriedade do Instituto Agronômico (IAC), a partir de técnicas de geoprocessamento e fotointerpretação. O local de estudo situa-se no município de Campinas - SP, e a área em questão foi escolhida por estar situada dentro de uma propriedade do estado e por apresentar uma grande mudança histórica no que diz respeito à vegetação. Também por que, apesar de ser um centro de experimentação agrícola, esse estudo demonstrara como num intervalo de quarenta anos a consciência ecológica muda radicalmente dentro do Centro. Para a realização deste trabalho, foram utilizadas fotografias aéreas digitais da fazenda dos vôos referentes aos anos de 1964, 1972 e 2002, todas de propriedade do acervo do Laboratório de Geoprocessamento do Centro de Conservação dos Solos do IAC. Alem da foto de satélite da fazenda obtida no software Google Earth, com data de 2006. Analisando imagens e mapas, observou-se como a área vegetada aumentou no Centro Experimental de Campinas nesse intervalo de quarenta e dois anos, passando de 7,55% (52.383 ha) em 1964 para 34,13% (236,497 ha) da área total do centro em 2006. Também pode-se ver que hoje há uma preocupação muito grande com a manutenção e conservação dessas matas.

Interação genótipo x ambiente para produção de grãos e podridões de colmo em milho

Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV