The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

Open Door Newsletter of the Library, Winter 2007

The Open Door newsletter is produced by the Iowa Commission for the Blind. It is published twice a year with information about the library programs and what is going on.

Open Door Newsletter of the Library, Winter 2009

The Open Door newsletter is produced by the Iowa Commission for the Blind. It is published twice a year with information about the library programs and what is going on.

CrossRoads, Winter 2009

Quarterly publication of the Governor's Traffic Safety Bureau, Iowa Department of Public Safety containing traffic safety and related information and news articles

IOWATER, Vol. 1, no.1, Winter 2000

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

IOWATER, Vol. 2, no.1, Winter 2001

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

IOWATER, Vol. 2, no.1, Winter 2001

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

IOWATER, Vol. 3, no.1, Winter 2002

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

IOWATER, Vol. 4, no.1, Winter 2003

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

IOWATER, Vol. 1, Winter 2005

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.