Using percentiles to diagnose familial hypercholesterolemia in Portugal

Aims: Familial hypercholesterolemia (FH) is a genetic disorder of lipid metabolism, clinically characterised by high levels of low-density lipoprotein cholesterol (LDL-C) that leads to cholesterol accumulation in tendons and arteries, premature atherosclerosis and increased risk of premature coronary heart disease. In 1999, the Portuguese FH Study was established at the National Institute of Health to identify the genetic cause of hypercholesterolemia in individuals with a clinical diagnosis of FH and to perform an epidemiologic study to determine the prevalence and distribution of FH in Portugal. In the last 16 years, a genetic defect was identified in 749 patients, representing 3. 7 % of the cases estimated to exist in Portugal. Index patients were included in this study using the Simon Broome (SB) criteria. However, there are different FH clinical criteria to diagnose index cases. Since there are no clinical criteria to identify relatives with FH, the aim of this work was to investigate if a diagnostic tool based on population specific 95 th percentile improves the clinical identification of Portuguese FH patients comparing with SB criteria.

e_LIPID: Characterisation of the Lipid Profile in the Portuguese Population

AIM: Cardiovascular disease (CVD), particularly coronary heart disease and stroke, are the leading cause of morbidity and mortality worldwide. The common forms of CVD have a complex etiology in which interactions between multiple genetic and environmental factors play an important role. Dyslipidaemia is one of many independent cardiovascular risk factors that have been identified for CVD, and its correct identification is of great importance in order to implement specific interventions, especially for CVD prevention. The aim of this study was the construction of population specific lipid percentiles and the to present the characterization of the dyslipidaemia in the Portuguese population.

Bulletin.

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A bibliographical, antiquarian and picturesque tour in France and Germany /

The index is bound in the first volume.

Histoire de la littérature espagnole de G. Ticknor. Traduite de l'anglais en franc̦ais pour la première fois avec les notes et additions des commentateurs espagnols, d. Pascal de Gayangos et d. Henri de Vedia,

v.2-3 published by Hachette.

Madame de Longueville; études sur les femmes illustres et la société du XVIIe siècle. La jeunesse de Madame de Longueville.

Also published under title La jeunesse de Madame de Longueville.

La France sous Louis XV (1715-1774)

v. 1. Introduction: Règne de Louis XIV. La régence.--v. 2. La régence. Ministère du duc de Bourbon. Ministère de Fleury de 1727 à 1732.--v. 3. Ministère de Fleury de 1732 à 1743. Madame de Chateauroux de 1743 à 1745. Madame de Pompadour de 1745 à 1746.--v. 4. Madame de Pompadour de 1746 à 1757.--v. 5. Madame de Pompadour de 1757 à 1763.--v. 6. Madame de Pompadour de 1763 au 15 avril 1764. Ministère du duc de Choiseul, de 1764 au 24 décembre 1770. Madame du Barry, du 24 décembre 1770 à la mort de Louis XV.

The return of Louis XVIII;

Mode of access: Internet.

Mémoire sur la captivité de Madame la duchesse de Berry /

Mode of access: Internet.