931 resultados para Baxter, David


Relevância:

20.00% 20.00%

Publicador:

Resumo:

von J. Norden. Hrsg. vom "Verein f. jüd. Geschichte u. Litteratur"

Relevância:

20.00% 20.00%

Publicador:

Resumo:

hrsg. vom Verband d. Vereine f. Jüdische Geschichte u. Litteratur in Deutschland. Mit Beitr. von W. Bacher [u.a.]

Relevância:

20.00% 20.00%

Publicador:

Resumo:

von Samuel Krauß

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Diese Ausg. ist im Freimann-Kat. nicht enthalten; Seiten auch in der Druckvorlage teilw. in schlechter Qualität

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome. Methods We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group). Patients had confirmed occlusions in the proximal anterior intracranial circulation and an absence of large ischemic-core lesions. The primary outcome was the severity of global disability at 90 days, as assessed by means of the modified Rankin scale (with scores ranging from 0 [no symptoms] to 6 [death]). Results The study was stopped early because of efficacy. At 39 centers, 196 patients underwent randomization (98 patients in each group). In the intervention group, the median time from qualifying imaging to groin puncture was 57 minutes, and the rate of substantial reperfusion at the end of the procedure was 88%. Thrombectomy with the stent retriever plus intravenous t-PA reduced disability at 90 days over the entire range of scores on the modified Rankin scale (P<0.001). The rate of functional independence (modified Rankin scale score, 0 to 2) was higher in the intervention group than in the control group (60% vs. 35%, P<0.001). There were no significant between-group differences in 90-day mortality (9% vs. 12%, P=0.50) or symptomatic intracranial hemorrhage (0% vs. 3%, P=0.12). Conclusions In patients receiving intravenous t-PA for acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, thrombectomy with a stent retriever within 6 hours after onset improved functional outcomes at 90 days.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Leipzig, Univ., Diss., 1892