(Table T1) Correlations between marker beds and drill holes for ODP Leg 171B sites

More than 50 discrete volcanic ash layers were recovered at the five drill sites of the Blake Nose depth transect (Leg 171B, western central Atlantic). The majority of these ash layers are intercalated with Eocene hemipelagic sediments with a pronounced frequency maximum in the upper Eocene. Several ash layers appear to be deposited from volcanic fallout with little or no indication of secondary remobilization. They provide excellent stratigraphic markers for a correlation of the Leg 171B drill sites. Other ash layers were probably redeposited from volcaniclastic-rich turbidity currents, but they still represent geologically instantaneous events that can be used in stratigraphic correlation between adjacent drill holes. Additional nonvolcanic marker beds, like the suspect late Eocene impact event layer, were included in our hole-to-hole correlations. Stratigraphic and downcore positions of marker beds were compiled and plotted against existing composite depth records that were constructed to guide high-resolution sampling. Comparison of our correlation with the spliced composite sections of each drill site reveals several minor and some major discrepancies. These may result from drilling distortion or missing sections, from the lack of unambiguous criteria for the synchronism of ash layers, or from the systematic exclusion of marker-bed data in the construction of the spliced record. Integration of both correlation approaches will help eliminate most of the observed discrepancies.

A characterization of globally consistent databases and their correct access paths /

"Supported in part by NSF grant MCS-80-03308."

La commare oriccoglitrice del Ecc. S. Scipione Mercurii ... : diuisa in tre libri.

Mode of access: Internet.

Itinerario da Terra Sancta, e suas particularidades /

Es la primera edición de la obra que tuvo posteriores reediciones.

Seien 100-wa,

Furoku Shibusawa Seien Sensei shōden Ōsawa Masamichi hen: p. 965-1052.

Ke shan ji : 50 juan, shi yi 12 juan, xu shi yi 1 juan /

Mode of access: Internet.

Fan Wenzheng gong shu du /

Mode of access: Internet.

Mahābhāsȳa pradīpoddyota /

Issued in parts, 1899-1921, as: New ser. no. 939, 948, 958, 962, 969, 970974, 978, 989, 1000, 1002, 1005, 1011, 1018, 1022, 1029, 1048, 1052, 1063, 1075 1101, 1105, 1117, 1124, 1136, 1162, 1167, 1182, 1185, 1207, 1216, 1231, 1268, 1346, 1436, 1443. 700/1:1 :

High-precision TIMS U-series and AMS C-14 dating of a coral reef lagoon sediment core from southern South China Sea

Accurate dating of lagoon sediments has been a difficult problem, although lagoon profiles, usually with high deposition rates, have a great potential for high-resolution climate reconstruction. We report 26 high-precision TIMS U-series dates (on 25 coral branches) and five AMS C-14 dates (on foraminifera) for a 15.4-m long lagoon core from Yongshu Reef, Nansha area, southern South China Sea. All the dates are in the correct stratigraphical sequence, providing the best chronology so far reported for lagoon deposits. The results reveal a similar to 4000-a continuous depositional history, with sedimentation rates varying from 0.8 to 24.6 mm a(-1), with an average of 3.85 mm a(-1), which corresponds to an average net carbonate accumulation rate of similar to 2700 g CaCO3 m(-2) a(-1), significantly higher than the mean value (800 +/- 400 g CaCO3 m(-2) a(-1)) used for lagoons in general in previous studies of global carbonate budget. Episodes of accelerated depositions within the last 1000 years correlate well with strong storm events identified by U-series dates of storm-transported coral blocks in the area. However, in the longer term, the sedimentation rates during the past 1000 years were much higher than earlier on, probably due to more vigorous wave-reef interaction as a result of relative sea-level fall since 500 AD and expansion of reef flat area, supplying more sediments. The coral TIMS U-series ages and foraminifera AMS 14C dates reveal intriguing apparent radiocarbon reservoir ages (R) from 572 to 1052 years, which are much higher than global mean values of similar to 400 years. (c) 2006 Elsevier Ltd. All rights reserved.

A EDUCAÇÃO PARA AS RELAÇÕES ÉTNICO-RACIAIS NA FORMAÇÃO CONTINUADA DOS PROFESSORES DA BAIXADA SANTISTA: DEZ ANOS APÓS A INSTITUCIONALIZAÇÃO DA LEI 10.639/03

O presente trabalho discute a implementação da Lei Federal 10.639/03, nas escolas estaduais da Região da Baixada Santista, após dez anos de institucionalização. Investigou-se sobre a formação continuada dos professores, relacionando-a como, em sua prática pedagógica, os docentes vêm inserindo os conteúdos da História e Cultura da África e dos Afro-brasileiros que se tornaram obrigatórios pela Lei. A pesquisa realizada com os professores das disciplinas de História, Língua Portuguesa e Artes do Ensino Médio, que lecionam nos municípios de Guarujá, Santos, Cubatão e Bertioga, foi contextualizada com a realidade local e com os cursos de formação continuada para a temática das Relações Étnico-Raciais. Foram levados em consideração os saberes institucionais e não institucionais, implicados na prática reflexiva, no sentido de buscar métodos de ensino como o multiculturalismo que pudesse contemplar todas as etnias que compõem o povo brasileiro, elevando a autoestima dos afrodescendentes, indígenas ou asiáticos e primando por uma valorização da pluralidade cultural e do espírito de cidadania e alteridade. O processo de pesquisa qualitativa envolveu análise bibliográfica e documental, aplicação de: pesquisa-ação, questionários semiestruturados via internet, realização de entrevistas e análise de experiência pedagógica. Os dados empíricos analisados evidenciaram que não obstante algumas experiências exitosas, os professores, em sua maioria, consideram que obtiveram pouca ou quase nenhuma informação a respeito da lei e dos conteúdos que ela implica, nestes dez anos. Esse fato denota a necessidade de maiores investimentos na formação docente, por parte do governo, bem como maiores políticas de incentivo aos docentes que os estimulem a buscar formação continuada e adoção de práticas reflexivas e críticas voltadas para a educação e as relações étnico-raciais, aliando-se à necessidade de uma sociedade contemporânea pluriétnica e multicultural.

A importância da embalagem nas preferências dos consumidores: um estudo de caso na indústria do azeite

O presente estudo tem como objetivo avaliar de que modo o packaging design influencia na tomada de decisão de compra dos consumidores no mercado do azeite gourmet. Pretende-se, também, estudar uma solução de packaging design para a marca Oliveiras Gold Portugal (OGP), que permita aumentar o seu potencial atrativo na perspetiva do grupo alvo (target), definido pela marca. Começou-se por analisar as políticas de marketing-mix com o objetivo de compreender a importância da embalagem na política de marketing de uma marca. O marketing-mix, além de grande responsável pela definição dos canais de distribuição e comercialização do produto, é também responsável pelas influências sobre o consumidor. Estudou-se, igualmente, a importância da embalagem de produto como elemento potencialmente influenciador no ato da tomada de decisão de compra. Tal estudo permitiu perceber que o consumidor é estimulado de várias formas, sendo o fator estético um dos mais importantes instigadores. A cor, altura e forma, são os três principais atributos que influenciam a decisão do consumidor no momento da compra. No entanto, tanto o material como a usabilidade são cruciais. Na maioria das situações, representam um fator de escolha. Diferenças entre vidro e Polietileno Tereftalato (PET) proporcionam diferentes condições e proteção no armazenamento do produto, contribuindo ainda para a questão estética na visão do consumidor. Questões ergonómicas devem também ser levadas em conta, considerando a sua relação com a usabilidade e funcionalidade. De modo a analisar o potencial da proposta desenvolvida, optou-se por um enfoque qualitativo, nomeadamente na realização de entrevistas individuais semiestruturadas e, posteriormente, testes à embalagem. Os resultados relativos à proposta de packaging parecem indicar caraterísticas inovadoras, nomeadamente a forma triangular e cónica, os detalhes ergonómicos e o design característico e diferenciador da marca.

Data visualization during the early stages of drug discovery

Multidimensional compound optimization is a new paradigm in the drug discovery process, yielding efficiencies during early stages and reducing attrition in the later stages of drug development. The success of this strategy relies heavily on understanding this multidimensional data and extracting useful information from it. This paper demonstrates how principled visualization algorithms can be used to understand and explore a large data set created in the early stages of drug discovery. The experiments presented are performed on a real-world data set comprising biological activity data and some whole-molecular physicochemical properties. Data visualization is a popular way of presenting complex data in a simpler form. We have applied powerful principled visualization methods, such as generative topographic mapping (GTM) and hierarchical GTM (HGTM), to help the domain experts (screening scientists, chemists, biologists, etc.) understand and draw meaningful decisions. We also benchmark these principled methods against relatively better known visualization approaches, principal component analysis (PCA), Sammon's mapping, and self-organizing maps (SOMs), to demonstrate their enhanced power to help the user visualize the large multidimensional data sets one has to deal with during the early stages of the drug discovery process. The results reported clearly show that the GTM and HGTM algorithms allow the user to cluster active compounds for different targets and understand them better than the benchmarks. An interactive software tool supporting these visualization algorithms was provided to the domain experts. The tool facilitates the domain experts by exploration of the projection obtained from the visualization algorithms providing facilities such as parallel coordinate plots, magnification factors, directional curvatures, and integration with industry standard software. © 2006 American Chemical Society.

Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics

Context - Diffusion tensor imaging (DTI) studies in adults with bipolar disorder (BD) indicate altered white matter (WM) in the orbitomedial prefrontal cortex (OMPFC), potentially underlying abnormal prefrontal corticolimbic connectivity and mood dysregulation in BD. Objective - To use tract-based spatial statistics (TBSS) to examine WM skeleton (ie, the most compact whole-brain WM) in subjects with BD vs healthy control subjects. Design - Cross-sectional, case-control, whole-brain DTI using TBSS. Setting - University research institute. Participants - Fifty-six individuals, 31 having a DSM-IV diagnosis of BD type I (mean age, 35.9 years [age range, 24-52 years]) and 25 controls (mean age, 29.5 years [age range, 19-52 years]). Main Outcome Measures - Fractional anisotropy (FA) longitudinal and radial diffusivities in subjects with BD vs controls (covarying for age) and their relationships with clinical and demographic variables. Results - Subjects with BD vs controls had significantly greater FA (t > 3.0, P = .05 corrected) in the left uncinate fasciculus (reduced radial diffusivity distally and increased longitudinal diffusivity centrally), left optic radiation (increased longitudinal diffusivity), and right anterothalamic radiation (no significant diffusivity change). Subjects with BD vs controls had significantly reduced FA (t > 3.0, P = .05 corrected) in the right uncinate fasciculus (greater radial diffusivity). Among subjects with BD, significant negative correlations (P < .01) were found between age and FA in bilateral uncinate fasciculi and in the right anterothalamic radiation, as well as between medication load and FA in the left optic radiation. Decreased FA (P < .01) was observed in the left optic radiation and in the right anterothalamic radiation among subjects with BD taking vs those not taking mood stabilizers, as well as in the left optic radiation among depressed vs remitted subjects with BD. Subjects having BD with vs without lifetime alcohol or other drug abuse had significantly decreased FA in the left uncinate fasciculus. Conclusions - To our knowledge, this is the first study to use TBSS to examine WM in subjects with BD. Subjects with BD vs controls showed greater WM FA in the left OMPFC that diminished with age and with alcohol or other drug abuse, as well as reduced WM FA in the right OMPFC. Mood stabilizers and depressed episode reduced WM FA in left-sided sensory visual processing regions among subjects with BD. Abnormal right vs left asymmetry in FA in OMPFC WM among subjects with BD, likely reflecting increased proportions of left-sided longitudinally aligned and right-sided obliquely aligned myelinated fibers, may represent a biologic mechanism for mood dysregulation in BD.