1.° Flores et notabilia, è Senecae libris ab anonymo collecta. — 2.° M. T. Ciceronis paradoxa. — 3.° Sancti Gregorii Nazianzeni apologeticus de fuga sua in Pontum. — 4.° Ejusdem oratio de nativitate Christi. — 5.° Ejusdem oratio de baptismo. — 6.° Sancti Hieronymi liber de viris illustribus : accedit Gennadii de eodem argumento liber, cujus finis desideratur. — Hujusce codicis pars decimo quarto, pars decimo quinto saeculo videtur exarata.

Mazarinaeus

1.° Abstractiones è libris Senecae. — 2.° Marbodi, Rhedonensis, carmen de lapidibus pretiosis, cum anonymi commentario. — 3.° Nonnulla ad historiam naturalem pertinentia. — 4.° Anonymus de Sacramentis. — 5.° Fragmenta ad opticam pertinentia.

Mazarinaeus

Affymetrix Whole-Transcript Human Gene 1.0 ST array is highly concordant with standard 3' expression arrays.

The recently released Affymetrix Human Gene 1.0 ST array has two major differences compared with standard 3' based arrays: (i) it interrogates the entire mRNA transcript, and (ii) it uses DNA targets. To assess the impact of these differences on array performance, we performed a series of comparative hybridizations between the Human Gene 1.0 ST and the Affymetrix HG-U133 Plus 2.0 and the Illumina HumanRef-8 BeadChip arrays. Additionally, both RNA and DNA targets were hybridized on HG-U133 Plus 2.0 arrays. The results show that the overall reproducibility of the Gene 1.0 ST array is best. When looking only at the high intensity probes, the reproducibility of the Gene 1.0 ST array and the Illumina BeadChip array is equally good. Concordance of array results was assessed using different inter-platform mappings. Agreements are best between the two labeling protocols using HG-U133 Plus 2.0 array. The Gene 1.0 ST array is most concordant with the HG-U133 array hybridized with cDNA targets. This may reflect the impact of the target type. Overall, the high degree of correspondence provides strong evidence for the reliability of the Gene 1.0 ST array.

VIP Connection Newsletter, January 2003, Vol. 3, no. 1

Iowa Lottery Authority Player Information Newsletter

The Security Blanket, November 2001, Vol.1, no.3

Newsletter for Information Technology Department

ERPN, Enterprise Resource Planning Newsletter, April 2001, Vol.1, no.3

Newsletter for Information Technology Department

Iowa 100% E News, April 2001, Vol.1, no.3

Newsletter for Information Technology Department

Bordeaux, voyage présidentiel, cortège devant le palais de justice [1/3/20] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58297

Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.

Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both receptors trigger signaling pathways, including those that activate RhoGTPases such as RhoA and Rac1. This sequence of events modulates cell adhesion to the ECM and cell migration. Using a neuron-astrocyte model, we have reported that the neuronal protein Thy-1 engages αVβ3 integrin and syndecan-4 to induce RhoA activation and strong astrocyte adhesion to their underlying substrate. Thus, because cell-cell interactions and strong cell attachment to the matrix are considered antagonistic to cell migration, we hypothesized that Thy-1 stimulation of astrocytes should preclude cell migration. Here, we studied the effect of Thy-1 expressing neurons on astrocyte polarization and migration using a wound-healing assay and immunofluorescence analysis. Signaling molecules involved were studied by affinity precipitation, western blotting and the usage of specific antibodies. Intriguingly, Thy-1 interaction with its two receptors was found to increase astrocyte polarization and migration. The latter events required interactions of these receptors with both the RGD-like sequence and the heparin-binding domain of Thy-1. Additionally, prolonged Thy-1-receptor interactions inhibited RhoA activation while activating FAK, PI3K and Rac1. Therefore, sustained engagement of integrin and syndecan-4 with the neuronal surface protein Thy-1 induces astrocyte migration. Interestingly we identify here, a cell-cell interaction that despite initially inducing strong cell attachment, favors cell migration upon persistent stimulation by engaging the same signaling receptors and molecules as those utilized by the extracellular matrix proteins to stimulate cell movement.

3-amino-1,2,4-triazole inhibits macrophage NO synthase.

Murine macrophages activated by interferon-gamma and lipopolysaccharide become leishmanicidal through a process involving L-arginine-derived nitrogen oxidation products. Both nitrite secretion and parasite killing by activated macrophages were inhibited by 3-amino-1,2,4-triazole as well as the related compound, 3-amino-1,2,4-triazine. Moreover, NO synthase activity in cytosolic extracts of activated cells was inhibited by both compounds. 4-amino-1,2,4-triazole, an isomer of 3-amino-1,2,4-triazole, was without effect. Our results suggest that besides its known inhibitory effect on catalases and peroxidases, 3-amino-1,2,4-triazole is an inhibitor of NO synthase. The resemblance between the tautomeric form of 3-amino-1,2,4-triazole and the guanidino group of L-arginine, the natural substrate for NO synthase, might be responsible for the observed inhibition.

1/3/20, M. Deschanel à Bordeaux, sortie de la cathédrale [St André] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58298

D-3 2002-1 Dependent Adult Abuse Report, January-June 2002

Adult dependent abuse report from the Iowa Department of Human Services

1/3/20, Bordeaux, voyage présidentiel, sortie de la cathédrale [St André] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58299