Screening for complex healing processes and psychological intervention in injured individuals

Introduction Injured individuals face a high risk for the development of psychological symptoms such as depression or anxiety, which influences early return to work after an accident. So far, it is unclear to which extent early psychological interventions can improve the ability to return to work. Purpose of the study The aim of the study was to investigate whether an improvement of the treatment-triage (by the screening questionnaire work and health [FAB]) influences early return to work and well being in injured individuals. Methods The study sample consists of injured individuals with different mental health-related or work-related disabilities after an accident. Participants are included eight weeks after an accident. Participants are randomly assigned to the intervention or to the control group. The intervention is an individualized psychotherapy consisting of cognitive-behavioral therapy and work related topics in an individual setting. Well being and work related actors are assessed at baseline and after six months. Results The recruitment is still ongoing. The preliminary results of this randomized controlled study will be presented at the conference. Conclusion An individualized psychotherapy might have the potential to improve the rehabilitation process in injured individuals and improve the ability to return to work.

Prometheus on Mars: Nineteenth-Century Science Fiction and the Language of Romanticism

The development of astrophysics in the nineteenth century drew mankind closer to the planets. For the first time, it was possible to give serious scientific consideration to the possibilities for life on other planets. The greatest leap, however, was in recognizing what was not known, and acknowledging the limits of human intuition. ‘Ideas,’ wrote Agnes M. Clerke, ‘have all at once become plastic’. As the scientific community tested the limits of scientific understanding, it became the role of science-fiction writers to imagine the universe beyond these limits. This paper will examine the ways in which nineteenth-century science fiction used the inheritance of the poetic language of Romanticism to reinstate the centrality of human being in the universe. I will explore the ways in which writers such as Edward Bulwer-Lytton (The Coming Race, 1871) and W. S. Lach-Szyrma (Aleriel, 1883) extended the Byronic hero to envisage extra-terrestrial utopias. The Hegelian systematic mythology described by Byron and Shelley had reimagined paradise and redemption on earth. Through science fiction, this mythology extended out towards the stars. A discourse on the possibilities of extra-terrestrial life became a Romantic discourse on the possibilities of being. The Byronic hero could now find a home not by escaping the shackles of religion, but as an angelic citizen of Venus or Mars. In this way, the paper will explore how science-fiction writers appropriated the language of Romantic poetry to build a bridge between the framework of scientific knowledge and the extent of human imagination.

Multifaceted impacts of sustainable land management in drylands: A review

Biophysical restoration or rehabilitation measures of land have demonstrated to be effective in many scientific projects and small-scale environmental experiments. However circumstances such as poverty, weak policies, or inefficient scientific knowledge transmission can hinder the effective upscaling of land restoration and the long term maintenance of proven sustainable use of soil and water. This may be especially worrisome in lands with harsh environmental conditions. This review covers recent efforts in landscape restoration and rehabilitation with a functional perspective aiming to simultaneously achieve ecosystem sustainability, economic efficiency, and social wellbeing. Water management and rehabilitation of ecosystem services in croplands, rangelands, forests, and coastlands are reviewed. The joint analysis of such diverse ecosystems provides a wide perspective to determine: (i) multifaceted impacts on biophysical and socio-economic factors; and (ii) elements influencing effective upscaling of sustainable land management practices. One conclusion can be highlighted: voluntary adoption is based on different pillars, i.e. external material and economic support, and spread of success information at the local scale to demonstrate the multidimensional benefits of sustainable land management. For the successful upscaling of land management, more attention must be paid to the social system from the first involvement stage, up to the long term maintenance.

Schumpeter and Personal Capitalism

In an earlier paper, I criticized Schumpeter's account of the obsolescence of the entrepreneur in Capitalism, Socialism, and Democracy. That account rests, I argued, on a confusion about the nature of scientific knowledge and its role in the competences of the firm. This paper is an attempt to take up the argument again, moving it away from the doctrine-historical into the provinces of the economics of organization. Drawing on the work of Max Weber, as well as on a case study of the Swiss watch industry, the paper argues for the ineradicable role of personal capitalism, properly understood.

The Nature of Genetic Engineering and the Uses and Potential Abuses of Biotechnology

Over the past decade the topic of genetic engineering has been has been readily debated in the media, but often these debates consist of political rhetoric and fail to offer objective information on the methods and the potential benefits to human health and their environment. In truth, humans have been manipulating the genomes of organisms for thousands of years, and it has been an evolution of scientific knowledge that has led to the more precise methods of genetic engineering. This paper discusses how scientists utilize natural processes to alter the genetic constituents of both prokaryotic and eukaryotic organisms, benefits to human health and the environment, as well as potential misuses of biotechnology such as bioterrorism.

Revising the National Ambient Air Quality Standards: The integration of science and policy

Under the Clean Air Act, Congress granted discretionary decision making authority to the Administrator of the Environmental Protection Agency (EPA). This discretionary authority involves setting standards to protect the public's health with an "adequate margin of safety" based on current scientific knowledge. The Administrator of the EPA is usually not a scientist, and for the National Ambient Air Quality Standard (NAAQS) for particulate matter (PM), the Administrator faced the task of revising a standard when several scientific factors were ambiguous. These factors included: (1) no identifiable threshold below which health effects are not manifested, (2) no biological basis to explain the reported associations between particulate matter and adverse health effects, and (3) no consensus among the members of the Clean Air Scientific Advisory Committee (CASAC) as to what an appropriate PM indicator, averaging period, or value would be for the revised standard. ^ This project recommends and demonstrates a tool, integrated assessment (IA), to aid the Administrator in making a public health policy decision in the face of ambiguous scientific factors. IA is an interdisciplinary approach to decision making that has been used to deal with complex issues involving many uncertainties, particularly climate change analyses. Two IA approaches are presented; a rough set analysis by which the expertise of CASAC members can be better utilized, and a flag model for incorporating the views of stakeholders into the standard setting process. ^ The rough set analysis can describe minimal and maximal conditions about the current science pertaining to PM and health effects. Similarly, a flag model can evaluate agreement or lack of agreement by various stakeholder groups to the proposed standard in the PM review process. ^ The use of these IA tools will enable the Administrator to (1) complete the NAAQS review in a manner that is in closer compliance with the Clean Air Act, (2) expand the input from CASAC, (3) take into consideration the views of the stakeholders, and (4) retain discretionary decision making authority. ^

Association of ALLHAT investigator characteristics with participant recruitment

Clinical trials are often not successful because of the inability to recruit a sufficient number of patients. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), the largest antihypertensive trial ever conducted, provided highly generalized results and successful recruitment of over 42,000 participants. The overall purpose of this study was to examine the association of investigator characteristics with anti-hypertensive (AHT) participant recruitment in ALLHAT. This secondary data analyses collected data from the ALLHAT investigator profile survey and related investigator characteristics to recruitment success. The sample size was 502 investigators, with recruitment data from 37,947AHT participants. Recruitment was dichotomized by categorizing all sites with recruitment numbers at or above the overall median recruitment number of 46 as "Successful Recruitment". Frequency distributions and univariate and multivariate logistic regression were conducted. When adjusting for all other factors, Hispanic ethnicity, suburban setting, Department of Veterans Affairs Medical Centers (VAMC) site type, number of clinical site staff working on the trial, study coordinator hours per week, medical conference sessions attended, the investigator's primary goal and the likelihood that a physician will convince a patient to continue on randomized treatment, have significant impacts on the recruitment success of ALLHAT investigators. Most of the ALLHAT investigators described their primary commitment as being towards their patients and not to scientific knowledge alone. However, investigators that distinguished themselves as leaders in research had greater recruitment success than investigators who were leaders in clinical practice. ALLHAT was a highly successful trial that proved that community based cardiovascular trials can be implemented on a large scale. Exploring characteristics of ALLHAT investigators provides data that can be generalized to sponsors, sites, and others interested in maximizing clinical trial recruitment numbers. Future studies should further evaluate investigator and study coordinator factors that impact cardiovascular clinical trial recruitment success.^

OXIDATIVE STRESS BASED STRATEGIES FOR ENHANCING THE EFFICACY OF HISTONE DEACETYLASE INHIBITORS (HDACi)

Histone deacetylase inhibitors (HDACi) are anti-cancer drugs that primarily act upon acetylation of histones, however they also increase levels of intracellular reactive oxygen species (ROS). We hypothesized that agents that cause oxidative stress might enhance the efficacy of HDACi. To test this hypothesis, we treated acute lymphocytic leukemia cells (ALL) with HDACi and adaphostin (ROS generating agent). The combination of two different HDACi (vorinostat or entinostat) with adaphostin synergistically induced apoptosis in ALL. This synergistic effect was blocked when cells were pre-treated with the caspase-9 inhibitor, LEHD. In addition, we showed that loss of the mitochondrial membrane potential is the earliest event observed starting at 12 h. Following this event, we observed increased levels of superoxide at 16 h, and ultimately caspase-3 activation. Pre-treatment with the antioxidant N-acetylcysteine (NAC) blocked ROS generation and reversed the loss of mitochondrial membrane potential for both combinations. Interestingly, DNA fragmentation and caspase-3 activity was only blocked by NAC in cells treated with vorinostat-adaphostin; but not with entinostat-adaphostin. These results suggest that different redox mechanisms are involved in the induction of ROS-mediated apoptosis. To further understand these events, we studied the role of the antioxidants glutathione (GSH) and thioredoxin (Trx). We found that the combination of entinostat-adaphostin induced acetylation of the antioxidant thioredoxin (Trx) and decreased intracellular levels of GSH. However, no effect on Trx activity was observed in either combination. In addition, pre-treatment with GSH ethyl ester, a soluble form of GSH, did not block DNA fragmentation. Together these results suggested that GSH and Trx are not major players in the induction of oxidative stress. Array data examining the expression of genes involved in oxidative stress demonstrated a differential regulation between cells treated with vorinostat-adaphostin and entinostat-adaphostin. Some of the genes differentially expressed between the combinations include aldehyde oxidase 1, glutathione peroxidase-5, -6, peroxiredoxin 6 and myeloperoxidase. Taken together, these experimental results indicate that the synergistic activity of two different HDACi with adaphostin is mediated by distinct redox mechanisms in ALL cells. Understanding the mechanism involved in these combinations will advance scientific knowledge of how the action of HDACi could be augmented in leukemia models. Moreover, this information could be used for the development of effective clinical trials combining HDACi with other anticancer agents.

A propósito de la pertinencia de una sociología del conocimiento "materialista"

Partiendo, por un lado, de la innegable constatación de que todo conocimiento científico es producido socialmente y, por el otro, del hecho de que lo considerado como Sociología del Conocimiento ha entrado en crisis en relación a la pertinencia de su objeto, el artículo pretende dar cuenta de las posibilidades de esa disciplina en el campo del materialismo histórico o Ciencia de la Historia. Una vez establecido ello, se aportan instrumentos generales para una sociología del pensamiento científico.

La sistematización como forma de producción de conocimiento científico, desde una perspectiva no positivista

Sistematización no es un término unívoco en el interior de la profesión Trabajo Social; así, para algunos autores sistematizar es producir conocimiento científico, mientras para otros al sistematizar se alcanza a conceptualizar la práctica, sin llegar a producir conocimiento científico de segundo orden. En este trabajo nos preguntamos si, desde una perspectiva epistemológica no positivista, puede considerarse a la sistematización como fuente de conocimiento científico. Para esto: analizamos el lugar que ocupa la experiencia en la producción de conocimiento; desarrollamos qué se considera conocimiento científico desde diferentes posturas epistemológicas; analizamos las diversas posiciones respecto a qué es sistematizar y proponemos una definición de sistematización que luego relacionamos con las características del conocimiento científico y las condiciones para lograrlo (desde una perspectiva no positivista).

El estilo institucional y las dinámicas de investigación de los profesores de tiempo completo : su impacto en el conocimiento científico en la Universidad de Colima

El objetivo de esta investigación es determinar mediante técnicas etnográficas el estilo institucional de los profesores para hacer investigación. Desde la perspectiva de los estudios institucionales es posible analizar de forma microscópica las dinámicas de los sujetos en la institución, considerado las reglas que se imponen mediante programas federales a las universidades públicas para lograr financiamiento externo, modificando el trabajo en investigación y la generación de conocimiento científico.

Funcionarios y políticas sobre el territorio en la Provincia de Buenos Aires : El Departamento de Ingenieros, 1875-1913

En esta ponencia estudiamos la conformación del Departamento de Ingenieros, sus múltiples atribuciones y los cambios que se fueron sucediendo entre su creación en 1875 y su supresión en 1913, un período fundamental para la provincia porque se trata de la época de las últimas entregas de tierra pública (más de 4 millones de hectáreas) y de los infructuosos intentos por controlar las inundaciones en la zona productiva ya ocupada. Nos interesa determinar la relación entre la toma de decisiones, la gestión técnica y económica, los cambios en la política y la economía bonaerense. Estudiamos las relaciones entre las distintas especialidades de la ingeniería y la agrimensura que llevaron a la conformación del Departamento de Ingenieros con muchas más atribuciones, entre las que se encuentran las que tenía el Departamento Topográfico. La creciente especialización de los saberes, evidentemente, estaba impactando no solamente en la disciplina, sino que se expresaba en la especificidad de las agencias estatales, que se iban complejizando para poder abarcar el cúmulo de intereses del estado y de la sociedad civil en torno al territorio

La edición en instituciones académicas : Normalización e interoperabilidad para favorecer el acceso y la visibilidad de la información publicada en revistas científicas

Este trabajo, que se encauza en una experiencia particular de cooperación entre bibliotecarios y editores de revistas científicas de humanidades y ciencias sociales, suscitada en la Facultad de Humanidades y Ciencias de la Educación de la Universidad Nacional de La Plata -Argentina- se propone: 1) reflexionar sobre el rol de los bibliotecarios en los equipos de edición científica y académica, resaltando la importancia de su participación para la correcta identificación y descripción de las contribuciones a las revistas a partir de la utilización de estándares internacionales que permitan su normalización y también la interoperabilidad con otros sistemas; 2) exponer y sistematizar la metodología de trabajo emprendida en la Facultad con sus revistas para favorecer el acceso y la visibilidad de la información en ellas publicada, en la que se involucran diversos actores y sectores de la institución para lograr la interoperabilidad entre los sistemas de información bibliográfica existentes tanto internos como externos a la institución. Como resultado del trabajo se explica la sistematización de la experiencia a fin de que pueda ser aprovechada por instituciones de características similares. Para concluir, se realizan una serie de comentarios finales sobre el rol central que ocupan los bibliotecarios en metodologías de trabajos como la aquí compartida. Se enfatiza en que los conocimientos acerca del control bibliográfico, la normalización de información y la ductilidad para interoperar sistemas de información posicionan a este profesional para trabajar junto a los editores en razón de lograr una efectiva accesibilidad al conocimiento científico editorial generado por la institución académica y una mayor visibilidad nacional, regional e internacional

Flujos informacionales en repositorios cooperativos : Consideraciones sobre algunas experiencias en instituciones académicas de América Latina

Este trabajo, de tipo descriptivo exploratorio, se propone efectuar un análisis de una serie de repositorios cooperativos pertenecientes a instituciones académicas de América Latina. Hace hincapié en la importancia de la cooperación como práctica de larga data en el ámbito de las bibliotecas, muchas de las cuales se han convertido en líderes o partícipes importantes tanto en la implementación como en el desarrollo de los repositorios en sus respectivas instituciones. Se toman en consideración los flujos informacionales que los atraviesan a fin de conocer cómo se delinean y desarrollan en el marco de instituciones académicas de cierta envergadura y complejidad, a través de un análisis de documentación. Se resaltan los modelos de flujos de información detectados en dichos repositorios cooperativos y cómo estos, desde su singularidad, favorecen la visibilidad y la difusión del conocimiento académico y científico existente en formato digital

Usos sociales del filme. Notas teórico-metodológicas y reseña de una práctica de investigación

El artículo presenta algunas de las principales coordenadas teórico-metodológicas de una investigación doctoral que, sustentada en el enfoque cualitativo ligado al uso de expresiones artístico-culturales, propone al filme como fuente primaria de análisis. Describe, además, las distintas etapas del 'trabajo de campo' sintetizando los recorridos, tareas y actividades realizadas para la conformación del corpus y la delimitación de su modo de abordaje. La puesta en común de estas notas teórico-metodológicas y de la reseña de la práctica investigativa pretende contribuir a la reflexión en torno a la importancia y pertinencia de la incorporación de corpus alternativos y múltiples en la generación de conocimiento científico en el campo de las Ciencias Sociales