Anabolic-androgenic steroid treatment induces behavioral disinhibition and downregulation of serotonin receptor messenger RNA in the prefrontal cortex and amygdala of male mice

Nandrolone is an anabolic-androgenic steroid (AAS) that is highly abused by individuals seeking enhanced physical strength or body appearance. Supraphysiological doses of this synthetic testosterone derivative have been associated with many physical and psychiatric adverse effects, particularly episodes of impulsiveness and overt aggressive behavior. As the neural mechanisms underlying AAS-induced behavioral disinhibition are unknown, we investigated the status of serotonergic system-related transcripts in several brain areas of mice receiving prolonged nandrolone administration. Male C57BL/6J mice received 15 mg/kg of nandrolone decanoate subcutaneously once daily for 28 days, and different sets of animals were used to investigate motor-related and emotion-related behaviors or 5-HT-related messenger RNA (mRNA) levels by real-time quantitative polymerase chain reaction. AAS-injected mice had increased body weight, were more active and displayed anxious-like behaviors in novel environments. They exhibited reduced immobility in the forced swim test, a higher probability of being aggressive and more readily attacked opponents. AAS treatment substantially reduced mRNA levels of most investigated postsynaptic 5-HT receptors in the amygdala and prefrontal cortex. Interestingly, the 5-HT(1B) mRNA level was further reduced in the hippocampus and hypothalamus. There was no alteration of 5-HT system transcript levels in the midbrain. In conclusion, high doses of AAS nandrolone in male mice recapitulate the behavioral disinhibition observed in abusers. Furthermore, these high doses downregulate 5-HT receptor mRNA levels in the amygdala and prefrontal cortex. Our combined findings suggest these areas as critical sites for AAS-induced effects and a possible role for the 5-HT(1B) receptor in the observed behavioral disinhibition.

Oscar Wilde’s “The Happy Prince” : The Hidden Messages and the Debate on the Target Audience

Oscar Wilde’s fairytales have been read to children for more than a century. Nevertheless, since the time of their publication in 1888 and 1891, the target audience of The Happy Prince and Other Tales and A House of Pomegranates have been the concern of critics. Delving into the context behind the rich and colourful imagery, one can find implications of homosexuality, the Paterian aesthetic and religious connotations. According to Carol Tattersall, The Happy Prince and Other Tales successfully mislead the public that it is innocent of any intention to undermine established standards of living or writing. Tattersall’s argument is based on comparing the first collection to Wilde’s second, A House of Pomegranates, which was perceived as “offensive and immoral” (136). On the other hand, William Butler Yeats states in his introduction to The Complete Works of Oscar Wilde that overall the reviewers of The Happy Prince and Other Tales were hostile because of Wilde’s aesthetic views (ixxvi). But Yeats overlooks the fact that Wilde was very pleased and proud, dashing notes to friends and reviewers and signing copies to many people (Tattersall 129). In general, the reception of Wilde’s first collection was more positive than that of the second because it was milder and more subtle in its controversial themes.

Filmljudets funktioner i krigsfilm : En audio-visuell analys av Apocalypse Now och Saving Private Ryan

I denna uppsats har filmljudet i krigsfilmerna Apocalypse Now och Saving Private Ryan undersökts. Detta har gjorts för att försöka bidra med ökad förståelse för filmljudets användningsområde och funktioner, främst för filmerna i fråga, men även för krigsfilm rent generellt. Filmljud i denna kontext omfattar allt det ljud som finns i film, men utesluter dock all ickediegetisk musik. Båda filmerna har undersökts genom en audio-visuell analys. En sådan analys görs genom att detaljgranska båda filmernas ljud- och bildinnehåll var för sig, för att slutligen undersöka samma filmsekvens som helhet då ljudet och bilden satts ihop igen. Den audio-visuella analysmetod som nyttjats i uppsatsen är Michel Chions metod, Masking. De 30 minuter film som analyserades placerades sedan i olika filmljudzoner, där respektive filmljudzons ljudinnehåll bland annat visade vilka främsta huvudfunktioner somfilmljudet hade i dessa filmer. Dessa funktioner är till för att bibehålla åskådarens fokus och intresse, att skapa närhet till rollkaraktärerna, samt att tillföra en hög känsla av realism och närvaro. Intentionerna med filmljudet verkade vara att flytta åskådaren in i filmens verklighet, att låta åskådaren bli ett med filmen. Att återspegla denna känsla av realism, närvaro, fokus samt intresse, visade sig också vara de intentioner som funnits redan i de båda filmernas förproduktionsstadier. Detta bevisar att de lyckats åstadkomma det de eftersträvat. Men om filmljudet använts på samma sätt eller innehar samma funktioner i krigsfilm rent genrellt går inte att säga.I have for this bachelor’s thesis examined the movie sound of the classic warfare movies Apocalypse Now and Saving Private Ryan. This is an attempt to contribute to a more profound comprehension of the appliance and importance of movie sound. In this context movie sound implies all kinds of sounds within the movies, accept from non-diegetic music. These two movies have been examined by an audio-visual analysis. It's done by auditing the sound and picture content separately, and then combined to audit the same sequence as a whole. Michel Chion, which is the founder of this analysis, calls this method Masking. The sound in this 30 minute sequence was then divided into different zones, where every zone represented a certain main function. These functions are provided to create a stronger connection to the characters, sustain the viewers interest and bring a sense of realism and presence. It seems though the intention with the movies sound is to bring the viewers to the scene in hand, and let it become their reality. To mirror this sense of realism, presence, focus and interest, proves to be the intention from an early stage of the production. This bachelor’s thesis demonstrates a success in their endeavours. Although it can’t confirm whether the movie sound have been utilized in the same manner or if they posess the same functions to warefare movies in general.

Filmljudets funktioner i dramafilm : En audio-visuell analys av filmen The King's Speech

Johansson, Fredrik (2012). Filmljudets funktioner i dramafilm – En audio-visuell analys av filmen The King´s Speech. Examensuppsats inom Ljudproduktion, Högskolan Dalarna, Akademin för språk och medier, Falun. I denna uppsats undersöktes filmljudet i dramafilmen The King´s Speech. Detta för att ta reda på vilka funktioner filmljudet fyller i de valda sekvenserna ur nämnda film, samt hur ljudet är placerat i filmens flerkanalsmix. Filmen granskades med hjälp av en audio-visuell analys. Denna metod går ut på att ljudet och bilden undersöks separat, för att sedan åter kombineras och analyseras som helhet. Den audio-visuella analysmetod som använts kommer från ljudteoretikern Michel Chion, och kallas Masking. Resultatet av den audio-visuella analysen pekade mot att ljudets huvudsakliga funktioner var att skapa en realistisk skildring av karaktärer och omgivningar, skapa en känsla av närvaro, samt att skapa och bibehålla olika perspektiv i den narrativa världen. Den stora majoriteten av ljud visade sig vara placerade i centerkanalen, medan främst ickediegetisk musik och ambiensljud var placerade i front- och surroundkanalerna. Detta kanalanvändande tycktes gynna de funna funktionerna, främst genom att bidra till känslan av närvaro och realism, genom att omsluta filmpubliken med ambienta ljud.

Om du vill ha fred, förbered dig på krig : en studie i den militära styrkans betydelse

Denna uppsats kretsar kring att pröva hur en av de främsta företrädarna för den realistiska skolan, förklarar de amerikanska anfallen mot Afghanistan (2001) och Irak (2003). Hans namn är Robert Kagan och uppsatsen syftar till ge en realists tolkning till varför USA handlade som man gjorde. Man måste därför försöka uppfatta världen utifrån USA:s horisont och försöka tolka samt sätta sig in i den amerikanska positionen på den internationella arenan. Problemformuleringarna kretsar kring att få insikt i grundstenarna i Kagans teori, samt hur Kagans grundsyn skiljer sig gentemot den idealistiska. Vidare hur USA:s militära styrka, enligt Kagan, påverkar dess beteende på den internationella arenan, men även hur Kagan ser på USA:s kommande globala engagemang. Robert Kagans bok Om paradiset och makten USA och Europa i den nya världsordningen kommer att utgöra fundamentet i studien. I boken kretsar bl.a. Kagans resonemang kring att USA och Europa distanserar från varandra, men även kring militär styrka. Därför ger boken oss en väldigt bra bild av USA:s position på den internationella arenan. Kagans resonemang vävs sedan ihop med kritik, realism, idealism och geopolitik. Slutsatsen blir att grundstenarna i Kagans resonemang återfinns i den s.k. realismteorin, men även till viss del i geopolitiken. Han sätter stor vikt vid militära medel och ser staterna som de mest betydelsefulla aktörerna, samt ser världen som allmänt hotfull. Han realistiska resonemang grundas på amerikanska spelregler och ledarskap på den internationella arenan. Skillnaden mellan Kagans grundsyn och den idealistiska bottnar främst i idealisternas fokusering på integration mellan stater. Vidare att de sätter tilltro till internationell rätt, samt har ett mer multilateralt förhållningssätt till omvärlden. Kagan menar vidare att starka stater är mer villiga att använda tvång och hot i internationella relationer. De bedömer dessutom hot och risker annorlunda jämfört med svagare stater. Enligt Kagan beter sig USA som en internationell sheriff på den globala arenan och beteendet bottnar i militär styrka. Vidare anser Kagan att USA har haft samma kurs i flera århundraden. USA har expanderat in i Europa och Asien och aldrig dragit sig tillbaka. Man hade redan före den 11 september 2001 fokuserat på Kina som motspelare. Dessutom, menar Kagan, att USA varit villiga att satsa på ny militär teknik, vilken kan förändra krigföringen. Han skriver även att både Clinton och Bushadministrationen varit grundade på att USA är en nödvändig nation, samt att amerikaner vill beskydda och sprida det liberala systemet i världen.

La thématique de l’eau dans l’œuvre de Marguerite Duras

The aim of this thematic study is to examine how the water motif is used in Marguerite Duras’s literary work. The study shows that water has multiple functions in these texts: it is linked to major themes and creates an enigmatic atmosphere by its association with the unknown, the inexplicable and the unconscious. The strong presence of water in Duras’s texts is striking. References to the water element can be found in several titles throughout her career, from early works such as Un barrage contre le Pacifique (1950) to La mer écrite (1996), published just after her death. Almost all of her fiction take place near water – and the rain or the sound of waves serve as leitmotifs in specific novels. The water motif can play a metonymic as well as a metaphoric role in the texts and it sometimes takes on human or animalistic characteristics (Chapter 4). Several emblematic Durassian characters (e.g. the beggar-woman, Anne-Marie Stretter and Lol V. Stein) have a close relationship to water (Chapter 5). The water motif is linked to many major Durassian themes, and illustrates themes with positive connotations, for example, creation, fecundity, maternity, liberty and desire, as well as themes with negative connotations such as destruction and death (Chapter 6). A close reading of three novels, La vie tranquille (1944), L’après-midi de Monsieur Andesmas (1962) and La maladie de la mort (1982), shows that the realism of the first novel is replaced by intriguing evocations of the sea and the pond in the second text, motifs which resist straightforward interpretation. The enigmatic feeling persists in the last novel, in which the sea illustrates the overall sombre mood of the story (Chapter 7). Finally, the role of the water element in psychoanalytic theory is discussed (Chapter 8), and a parallel is drawn between the Jungian concept of the mother archetype and the water motif in Duras’s texts. The suggestion is made in this last chapter that water is used to illustrate an oriental influence (Taoist or Buddhist) of some of the female characters in Duras’s work.

Specialpedagogers och speciallärares olika roller och uppdrag : skilda föreställningar möts och möter en pedagogisk praktik

Syftet med artikeln är att belysa olika föreställningar kring specialpedagogers och speciallärares roller och uppdrag samt att förstå varför denna olikhet finns. Syftet är också att problematisera  dessa föreställningar  och synliggöra dilemman som kommer till uttryck i talet om de båda yrkesgruppernas roller och uppdrag.  Bakgrunden till studien är de skilda och ofta disparata uppfattningar som råder om vad yrkesgrupperna ska arbeta med, hur de ska genomföra sina uppdrag och varför. Konsekvenserna av detta kan leda till att uppdrag genomförs på ett sätt som inte står i överensstämmelse med styrdokumentens föreskrivna demokrati-, samhälls- och kunskapsuppdrag. Samtal har genomförts med specialpedagoger, speciallärare utbildade efter 2008 och rektorer. Den metodologiska ansatsen har varit kunskapande samtal. Kunskapande samtal utgår från ett kommunikationsteoretiskt perspektiv och bygger på Jürgen Habermas teori om det kommunikativa handlandet. Karen Barads teori om agentisk realism har använts för att förstå hur olika föreställningar kring roller och uppdrag uppstår, skapas och förändras i samspel med andras uppfattningar men även i samspel med exempelvis rum, texter och metoder. Olika föreställningar om roller och uppdrag belyses liksom dilemman som dessa föreställningar kan ge upphov till då yrkesrollerna möts i, och möter, en pedagogisk praktik. Resultatet visar att specialpedagoger och speciallärare behöver finnas med i det kontinuerliga arbetet ute på skolor och förskolor men att det kan betyda olika slags organisatoriska lösningar för yrkesgrupperna. En fråga som uppstår är om de specialpedagogiska yrkesgrupperna alltid och i alla sammanhang bör finns så nära barnen/eleverna som möjligt eller om det finns grund för ett mer distanserat sätt att arbeta? Författaren föreslår att svensk förskola och skola bör utnyttja det faktum att det finns två olika specialpedagogiska yrkesgrupper och särskilja deras roller och uppdrag på ett tydligt sätt. Om specialpedagogik dessutom tar avstamp i ett kommunikationsteoretiskt perspektiv skapas förutsättningar och möjligheter för barns/elevers lärande utifrån ett inkluderande synsätt.

Vernacular meaning making : Examples of narrative impact in fiction film questioning the 'banal' notion in mediatization of religion theory

The outcome of an audience study supports theories stating that stories are a primary means by which we make sense of our experiences over time. Empirical examples of narrative impact are presented in which specific fiction film scenes condense spectators' lives, identities and beliefs. One conclusion is that spectators test the emotional realism of the narative for greater significance, connecting diegetic fiction experiences with their extra-diegetic world in their quest for meaning, self and identity. The 'banal' notion of the mediatization of religion theory is questioned as unsatisfactory in the theoretical context of individualized meaning-making processes. As a semantically negatively charged concept, it is problematic when analyzing empirical examples of spectators' use of fictional narratives, especially when trying to characterize the idiosyncratic and complex interplay between spectators' fiction emotions and their testing of mediated narratives in an exercise to find moral significance in extra-filmic life. Instead vernacular meaning-making is proposed.

Can France really stop them? : A study grounded on the realist perspective about the French foreign policy towards Syria as the root cause of the Phenomenon of French Foreign Fighters

During the Syrian conflict the number of European Foreign Fighters has increased exponentially and has become an ever-growing concern for European policymakers. This phenomenon presents host of major security challenges for European policymakers and governments. Among European countries, France provides the highest number of citizens who have gone to Syria to fight against Assad´s regime. The French authorities have estimated that by mid-2014, over 700 French citizens have left France and travelled to Syria to fight. Historically France has had a relationship with Syria which started with its role as a border-drawing colonial power. Grounded in a framework of realism, that emphasizes nation-states as the primary actor within the international system, the analysis concentrates on the role of France´s foreign policy on the Syria as push factor for terrorism and radicalization. This paper attempts to determinate a specific correlation between the policy that France has been conducting towards Syria between 2000 and 2015, and the phenomenon of French Foreign Fighters. Findings suggest that France´s foreign policy towards Syria is the main root cause of the French Foreign Fighters phenomenon.

Socio-cultural Degeneration and State Patronage of the Arts: Mapplethorpe, Cultural Crisis, and the NEA

The goal of this paper is to investigate how the Untied States federal government, specifically through the National Endowment for the Arts, or NEA, has acted in the position of an arts patron in the past few decades. Specifically, this paper will focus on the past decade and a half since the 'arts crisis' of the late 1980s and the social and political backlash against the art community in the 1990s, which was only against ‘offensive’ art that was seen as morally and culturally corruptive. I explore the political, social, and economic forms the backlash took, particularly rooted in a perceived fear of degenerative arts as a corruption of and a catalyst for the eventual collapse of American culture and values. Additionally, I analyse the role the federal government played in ‘ameliorating’ the situation. I investigate how state arts patronage has affected and continues to affect both the concepts behind and the manifestations of art, as well as who is encouraged, sanctioned, or neglected in the production of art. To accomplish this, I explore how and why the federal government employs the arts to define and redefine morality and culture, and how does it express/allow the expressions of these through art.

Harold Pinter, cinema e literatura : os limites da realidade

Partindo de duas questões teóricas preliminares, uma, da representação (literária e cinematográfica)do real e do imaginário, tanto no ângulo da produção como no da sua recepção e, a outra, da articulação entre formas de expressão artísticas distintas, ou seja, da interdisciplinaridade, este trabalho examina a presença do tema relativo aos limites entre realidade e fantasia no teatro, no cinema e na literatura, centrando sua atenção na obra de Harold Pinter. Consta de duas partes, cada uma com três capítulos. Na primeira, "Os pressupostos," discute-se as questões que fornecem seu substrato teórico. A segunda é dedicada ao corpus, identificando em seu título o tema investigado: "Os limites da realidade." Quanto à questão da representação, procura-se refutar "a afirmação de que a arte seja uma imitação da realidade. Uma releitura da Poética, de Aristóteles, reforçada pela opinião de diversos estudiosos da mesma, permite afirmar que a mÍmese corresponde, isto sim, a uma representação que envolve uma construção em que elementos da realidade são organizados segundo uma verdade criada pela própria obra, de acordo com critérios inerentes a ela. Além disso, através de uma leitura de Kathryn Hume, procura-se afirmar a interação sinestésica quase que permanente dos impulsos realista e da fantasiana literatura, identificando os tipos com que a fantasia se manifesta e as técnicas usadas para sua criação. A primeira parte encerra-se com um exame do relacionamento da literatura com as artes visuais e dramáticas, relações inter-disciplinares que situam este trabalho na literatura comparada.Dentre vários autores cujas obras contribuem para tal fim, destaca-se Martin Esslin, que estabelece os limitesde cada uma das artes dramáticas, identifica contatos delas com a literatura e permite, através de uma leitura de seu estudo sobre o teatro do absurdo, seja estabelecida a evolução que liga Aristóteles a Pinter. O corpus centra-se na obra de Pinterpara o teatro e para o cinema, sem limitar-se a ela,pois são também analisadas obras de outros escritores e cineastas, estabelendo-se aproximações ou contrastes entre elas. No quarto capítulo estão agrupadas obras nas quais desponta a imposição de verdades pela força fisica ou verbal. A luta pelo poder, a expulsão de elementos estranhos, dúvidas sobre a identidade e a inter-penetrablidade arte-vida caracterizam o capítulo seguinte. A ênfase temática do sexto capítulo recai sobre as limitações impostas pela condição humana. Praticamente todas as obras expressam a impossibilidade da existência de certezas absolutas e de uma perfeita distinção dos limites da realidade. Com isso, é possível afirmar não ser o objetivo da arte reproduzir a realidade. Mesmo que o fosse, tal tentativa resultaria infrutífera devido às limitações humanas.

The Indetermination of Senior

The commitments and working requirements of abstract, applied, and art of, economics are assessed within an analogy with the fields of inert matter and life. Abstract economics is the pure logic of the phenomenon. Applied positive economics presupposes many distinct abstract sciences. Art presupposes applied economics and direct knowledge of the specificities which characterize the time-space individuality of the phenomenon. This is an indetermination clearly formulated by Senior and Mill; its connection with institutionalism is discussed. The Ricardian Vice is the habit of ignoring the indetermination; its prevalence in mainstream economics is exemplified, and its causes analyzed.

The Ricardian vice and the indetermination of senior

The general commitments and working requirements of abstract, applied, and art of science, including economics, are assessed. Pure economics deals with the logic of the phenomenon. Positive socio-economics presupposes pure economics and many distinct sciences. Art presupposes socio-economics and direct knowledge of the specificities which characterize the time-space individuality of the phenomenon. This indetermination was partially formulated by Senior and Mill; graduate education in economics is considered in its light. The habit of ignoring it is the Ricardian Vice, as named by Schumpeter; the prevalence of the vice is exemplified, and its causes analyzed.

Empirismo e sua relação com o direito: precedente e súmula vinculante

Esse trabalho de conclusão de curso se propõe a relacionar Empirismo e direito. Para isso se faz necessário considerar que a concepção empírica (conhecimento como fruto da experiência) é corrente no sistema jurídico da Common Law, sendo o Empirismo responsável também pela matriz epistemológica que originou o Realismo Jurídico. Considerando que o sistema jurídico pátrio é o da Civil Law, buscou-se realizar uma comparação - através de suas características principais - entre os dois institutos de efeito vinculante de nosso país. Em ambos os sistemas os aludidos institutos são oriundos de decisões dos Tribunais Superiores, por esta razão o trabalho tem como objetivo principal constatar se as Súmulas Vinculantes representam uma versão nacional dos Precedentes norte-americanos. A hipótese criada não foi ratificada dado que verificou-se a impossibilidade de comparação literal entre os institutos. Afinal as distinções superam as semelhanças.

O hate speech e suas limitações

O objetivo deste trabalho de conclusão de curso é externar a relevância do direito à liberdade de expressão, especialmente em casos de discursos ofensivos e de incitação ao ódio, além de investigar se em algumas situações ele pode ser limitado para ceder a outros valores e de que forma. Por exemplo, através da técnica da ponderação ou de outros parâmetros pré-estabelecidos, os quais têm a função facilitar a resolução de casos difíceis, isto é, situações em que há a colisão entre direitos e deve-se chegar à conclusão de qual deles deve preponderar.