Asymptotic and computational analysis of mistuning effects on the dynamics of bladed disks

Es bien conocido que las pequeñas imperfecciones existentes en los álabes de un rótor de turbomaquinaria (conocidas como “mistuning”) pueden causar un aumento considerable de la amplitud de vibración de la respuesta forzada y, por el contrario, tienen típicamente un efecto beneficioso en el flameo del rótor. Para entender estos efectos se pueden llevar a cabo estudios numéricos del problema aeroelástico completo. Sin embargo, el cálculo de “mistuning” usando modelos de alta resolución es una tarea difícil de realizar, ya que los modelos necesarios para describir de manera precisa el componente de turbomáquina (por ejemplo rotor) tienen, necesariamente, un número muy elevado de grados de libertad, y, además, es necesario hacer un estudio estadístico para poder explorar apropiadamente las distribuciones posibles de “mistuning”, que tienen una naturaleza aleatoria. Diferentes modelos de orden reducido han sido desarrollados en los últimos años para superar este inconveniente. Uno de estos modelos, llamado “Asymptotic Mistuning Model (AMM)”, se deriva de la formulación completa usando técnicas de perturbaciones que se basan en que el “mistuning” es pequeño. El AMM retiene sólo los modos relevantes para describir el efecto del mistuning, y permite identificar los mecanismos clave involucrados en la amplificación de la respuesta forzada y en la estabilización del flameo. En este trabajo, el AMM se usa para estudiar el efecto del “mistuning” de la estructura y de la amortiguación sobre la amplitud de la respuesta forzada. Los resultados obtenidos son validados usando modelos simplificados del rotor y también otros de alta definición. Además, en el marco del proyecto europeo FP7 "Flutter-Free Turbomachinery Blades (FUTURE)", el AMM se aplica para diseñar distribuciones de “mistuning” intencional: (i) una que anula y (ii) otra que reduce a la mitad la amplitud del flameo de un rotor inestable; y las distribuciones obtenidas se validan experimentalmente. Por último, la capacidad de AMM para predecir el comportamiento de flameo de rotores con “mistuning” se comprueba usando resultados de CFD detallados. Abstract It is well known that the small imperfections of the individual blades in a turbomachinery rotor (known as “mistuning”) can cause a substantial increase of the forced response vibration amplitude, and it also typically results in an improvement of the flutter vibration characteristics of the rotor. The understanding of these phenomena can be attempted just by performing numerical simulations of the complete aeroelastic problem. However, the computation of mistuning cases using high fidelity models is a formidable task, because a detailed model of the whole rotor has to be considered, and a statistical study has to be carried out in order to properly explore the effect of the random mistuning distributions. Many reduced order models have been developed in recent years to overcome this barrier. One of these models, called the Asymptotic Mistuning Model (AMM), is systematically derived from the complete bladed disk formulation using a consistent perturbative procedure that exploits the smallness of mistuning to simplify the problem. The AMM retains only the essential system modes that are involved in the mistuning effect, and it allows to identify the key mechanisms of the amplification of the forced response amplitude and the flutter stabilization. In this work, AMM methodolgy is used to study the effect of structural and damping mistuning on the forced response vibration amplitude. The obtained results are verified using a one degree of freedom model of a rotor, and also high fidelity models of the complete rotor. The AMM is also applied, in the frame of the European FP7 project “Flutter-Free Turbomachinery Blades (FUTURE)”, to design two intentional mistuning patterns: (i) one to complete stabilize an unstable rotor, and (ii) other to approximately reduce by half its flutter amplitude. The designed patterns are validated experimentally. Finally, the ability of AMM to predict the flutter behavior of mistuned rotors is checked against numerical, high fidelity CFD results.

Movement analysis in infancy may be useful for early diagnosis of autism

All of the 17 autistic children studied in the present paper showed disturbances of movement that with our methods could be detected clearly at the age of 4–6 months, and sometimes even at birth. We used the Eshkol–Wachman Movement Analysis System in combination with still-frame videodisc analysis to study videos obtained from parents of children who had been diagnosed as autistic by conventional methods, usually around 3 years old. The videos showed their behaviors when they were infants, long before they had been diagnosed as autistic. The movement disorders varied from child to child. Disturbances were revealed in the shape of the mouth and in some or all of the milestones of development, including, lying, righting, sitting, crawling, and walking. Our findings support the view that movement disturbances play an intrinsic part in the phenomenon of autism, that they are present at birth, and that they can be used to diagnose the presence of autism in the first few months of life. They indicate the need for the development of methods of therapy to be applied from the first few months of life in autism.

Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae

In the nuclear genome of Saccharomyces cerevisiae, simple, repetitive DNA sequences (microsatellites) mutate at rates much higher than nonrepetitive sequences. Most of these mutations are deletions or additions of repeat units. The yeast mitochondrial genome also contains many microsatellites. To examine the stability of these sequences, we constructed a reporter gene (arg8m) containing out-of-frame insertions of either poly(AT) or poly(GT) tracts within the coding sequence. Yeast strains with this reporter gene inserted within the mitochondrial genome were constructed. Using these strains, we showed that poly(GT) tracts were considerably less stable than poly(AT) tracts and that alterations usually involved deletions rather than additions of repeat units. In contrast, in the nuclear genome, poly(GT) and poly(AT) tracts had similar stabilities, and alterations usually involved additions rather than deletions. Poly(GT) tracts were more stable in the mitochondria of diploid cells than in haploids. In addition, an msh1 mutation destabilized poly(GT) tracts in the mitochondrial genome.

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5

Chromosome 7q22 has been the focus of many cytogenetic and molecular studies aimed at delineating regions commonly deleted in myeloid leukemias and myelodysplastic syndromes. We have compared a gene-dense, GC-rich sub-region of 7q22 with the orthologous region on mouse chromosome 5. A physical map of 640 kb of genomic DNA from mouse chromosome 5 was derived from a series of overlapping bacterial artificial chromosomes. A 296 kb segment from the physical map, spanning Ache to Tfr2, was compared with 267 kb of human sequence. We identified a conserved linkage of 12 genes including an open reading frame flanked by Ache and Asr2, a novel cation-chloride cotransporter interacting protein Cip1, Ephb4, Zan and Perq1. While some of these genes have been previously described, in each case we present new data derived from our comparative sequence analysis. Adjacent unfinished sequence data from the mouse contains an orthologous block of 10 additional genes including three novel cDNA sequences that we subsequently mapped to human 7q22. Methods for displaying comparative genomic information, including unfinished sequence data, are becoming increasingly important. We supplement our printed comparative analysis with a new, Web-based program called Laj (local alignments with java). Laj provides interactive access to archived pairwise sequence alignments via the WWW. It displays synchronized views of a dot-plot, a percent identity plot, a nucleotide-level local alignment and a variety of relevant annotations. Our mouse–human comparison can be viewed at http://web.uvic.ca/~bioweb/laj.html. Laj is available at http://bio.cse.psu.edu/, along with online documentation and additional examples of annotated genomic regions.

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.

Five to ten percent of individuals with melanoma have another affected family member, suggesting familial predisposition. Germ-line mutations in the cyclin-dependent kinase (CDK) inhibitor p16 have been reported in a subset of melanoma pedigrees, but their prevalence is unknown in more common cases of familial melanoma that do not involve large families with multiple affected members. We screened for germ-line mutations in p16 and in two other candidate melanoma genes, p19ARF and CDK4, in 33 consecutive patients treated for melanoma; these patients had at least one affected first or second degree relative (28 independent families). Five independent, definitive p16 mutations were detected (18%, 95% confidence interval: 6%, 37%), including one nonsense, one disease-associated missense, and three small deletions. No mutations were detected in CDK4. Disease-associated mutations in p19ARF, whose transcript is derived in part from an alternative codon reading frame of p16, were only detected in patients who also had mutations inactivating p16. We conclude that germ-line p16 mutations are present in a significant fraction of individuals who have melanoma and a positive family history.

Developing Civil Society and a New Leadership Class in Iraq: A Comprehensive Analysis and Business Plan

Following De-Ba'athification, forming a new leadership class will be critical to the success of creating a strong civil society in modern-day Iraq. Implementation of youth educational exchange programs, specifically promoting leadership skills, is a significant part of the solution to stimulating a new generation of leaders. Using the reign of Saddam Hussein and his toppling as a frame of reference, a brief history of Iraq's civil society reveals a need for a new leadership class through the lens of democratic transition and consolidation. After exploring the leadership challenges of post-war nation building, the proposed business plan focuses on implementing a youth leadership program in Iraq, employing a wider participation model, and a lengthier, more involved learning model from existing programs.

The representation of the world in national Arab news agencies: an exploration of (trans)national networks in the official Arab media

The purpose of this paper is to draw a map of the representation of the world and of Arab states as reflected by the countries of the region. To do so, we have analysed the news (4,093 news randomly collected on February and August 2005) produced by the governments of the Arab states through their national news agencies. Several regional and world maps had been constructed to show the official Arab representation of the World, the Arab countries conflict agenda, the persistence of colonial ties (with the European metropolis) and the emergence of new relationships (Asian countries). The representation of the world that appeared in the analysis focuses its interest on the USA, the war in Iraq, the Israel-Palestine conflict, the United Kingdom, France, and Iran. The Arab regional powers organise the flow of information (Saudi Arabia and Egypt) and the colonial past determines the current structure of communication (French-speaking bloc and English-speaking bloc).