Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation

The South African Boer goat displays a characteristic white spotting phenotype, in which the pigment is limited to the head. Exploiting the existing phenotype variation within the breed, we mapped the locus causing this white spotting phenotype to chromosome 17 by genome wide association. Subsequent whole genome sequencing identified a 1 Mb copy number variant (CNV) harboring 5 genes including EDNRA. The analysis of 358 Boer goats revealed 3 alleles with one, two, and three copies of this CNV. The copy number is correlated with the degree of white spotting in goats. We propose a hypothesis that ectopic overexpression of a mutant EDNRA scavenges EDN3 required for EDNRB signaling and normal melanocyte development and thus likely lead to an absence of melanocytes in the non-pigmented body areas of Boer goats. Our findings demonstrate the value of domestic animals as reservoir of unique mutants and for identifying a precisely defined functional CNV.

Incubation experiments to examine the production and loss of CH3I in surface seawater

In order to investigate production pathways of methyl iodide and controls on emissions from the surface ocean, a set of repeated in-vitro incubation experiments were performed over an annual cycle in the context of a time-series of in-situ measurements in Kiel Fjord (54.3 N, 10.1E). The incubation experiments revealed a diurnal variation of methyl iodide in samples exposed to natural light, with maxima during day time and losses during night hours. The amplitude of the daily accumulation varied seasonally and was not affected by filtration (0.2µm), consistent with a photochemical pathway for CH3I production. The methyl iodide loss rate during night time correlated with the concentration accumulated during daytime. Daily (24 hour) net production (Pnet) was similar in magnitude between in vitro and in situ mass balances. However, the estimated gross production (Pgross) of methyl iodide ranged from -0.07 to 2.24 pmol/day and were 5 times higher in summer than Pnet calculated from the in-situ study [Shi et al., 2014]. The large excess of Pgross over Pnet revealed by the in-vitro (incubation) experiments in summer is a consequence of large losses of CH3I by as-yet uncharacterized processes (e.g. biological degradation or chemical pathways other than Cl- substitution).

Waterfowl decline in the Mississippi Flyway [microform] : hearing before the Subcommittee on Fisheries and Wildlife Conservation and the Environment of the Committee on Merchant Marine and Fisheries, House of Representatives, One Hundredth Congress, second session, on the decline of waterfowl in the Mississippi Flyway and the loss of wintering habitat in the Mississippi Flood Plain, September 22, 1988.

"Serial no. 100-91."

Statistical fluctuations in the energy loss of 5.8 MeV alpha particles passing through an absorber of variable thickness /

"Contract No. AT(30-1)-2740."

On the loss of the teeth and on the best means of restoring them /

Mode of access: Internet.

The narrative of the Honourable John Byron (Commodore in a late expedition round the world) : containing an account of the great distresses suffered by himself and his companions on the coasts of Patagonia from the year 1740, till their arrival in England, 1746. With a description of St. Jago de Chili, and the manners and customs of the inhabitants. Also a relation of the loss of the Wager man of war...

MTSD 38.

On aphasia, or loss of speech in cerebral disease.

Reprinted from the Journal of mental science.

Loss of the steamer Jeannette. : Letter from the secretary of the navy, relative to the loss of the steamer Jeannette.

March 2, 1883--referred to the Committee on naval affairs and ordered to be printed.

The south sea whaler : a story of the loss of the "Champion" and the adventures of her crew /

Some illustrations signed Riou, F. Pierdon, Hildibrand, Pannemaker, P. (Pierre?) Ferat.

The wreck of the "Grosvenor" : an account of the mutiny of the crew and the loss of the ship when trying to make the Bermudas /

Mode of access: Internet.

The causes for the loss of the battle of Waterloo

Mode of access: Internet.

An authentic narrative of the loss of the American brig Commerce, wrecked on the western coast of Africa, in the month of August, 1815, with an account of the sufferings of the surviving officers and crew, who were enslaved by the wandering Arabs, on the African desaert, or Zahahrah; and observations historical, geographical, &c. made during the travels of the author, while a slave to the Arabs, and in the empire of Morocco ...

Bound in brown leather; stamped in gold and blind.

Narrative of the loss of the steam-packet Pulaski, which burst her boiler and sank on the coast of North-Carolina, June 14, 1838.

"Fourth-page of cover printed". S.S.R.

The voice of God in calamity: or, Reflections on the loss of thesteam-boat Home, October 9, 1837.

Mode of access: Internet.

Shipwreck investigated for the cause of the great loss of lives with which it is frequently attended and a remedy provided in a portable and practicable life preserving apparatus ...

Mode of access: Internet.