Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.

The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits identification. Furthermore, the understanding of the pathophysiology of AGA is incomplete, and each newly associated locus may provide novel insights into contributing biological pathways. The aim of this study was to identify unknown AGA risk loci by replicating SNPs at the 12 genomic loci that showed suggestive association (5 × 10(-8)<P<10(-5)) with AGA in a recent meta-analysis. We analyzed a replication set comprising 2,759 cases and 2,661 controls of European descent to confirm the association with AGA at these loci. Combined analysis of the replication and the meta-analysis data identified four genome-wide significant risk loci for AGA on chromosomes 2q35, 3q25.1, 5q33.3, and 12p12.1. The strongest association signal was obtained for rs7349332 (P=3.55 × 10(-15)) on chr2q35, which is located intronically in WNT10A. Expression studies in human hair follicle tissue suggest that WNT10A has a functional role in AGA etiology. Thus, our study provides genetic evidence supporting an involvement of WNT signaling in AGA development.

A-1A Supplemental Security Income Program, April 2006

Supplemental Security Income Program, April 2006

A-1A Supplemental Security Income Program, March 2006

A-1A Supplemental Security Income Program, March 2006

A-1A Supplemental Security Income Program, July 2006

Supplemental Security Income Program, May 2006

A-1A Supplemental Security Income Program, May 2006

Supplemental Security Income Program, May 2006

A-1A Supplemental Security Income Program, June 2006

Supplemental Security Income Program, May 2006

A-1A Supplemental Security Income Program, August 2006

A-1A Supplemental Security Income Program, August 2006

A-1A Supplemental Security Income Program, September 2006

A-1A Supplemental Security Income Program produced by the Department of Human Services

A-1A Supplemental Security Income Program, June 2002

Monthly report from Iowa Department of Human Services on income.

A-1A Supplemental Security Income Program, January 2002

Monthly report from Iowa Department of Human Services on income.

A-1A Supplemental Security Income Program, February 2002

Monthly report from Iowa Department of Human Services on income.

A-1A Supplemental Security Income Program, March 2002

Monthly report from Iowa Department of Human Services on income.

Social spending and demographics: The role of public policies in the intergenerational redistribution of income. Empirical evidence from Spain and Catalonia

The demographic shift underway in Southern Europe requires a revision of some of the fundamental principles of the traditional welfare state. We analyze the evolution of several aspects of welfare and social expenditure over the last two decades. We find that in the context of the present demographic changes and real estate boom current social and pension policy leads to a new distribution of benefits and burdens which is highly intergenerationally unequal. We argue for a revised definition of public policy based on Musgrave's proposition as a possible rule for an intergenerationally fair distribution.