STUDIES OF DISULFOTON TOLERANCE IN RATS

Disulfoton (O,O, diethyl S-2-(ethylthio)ethyl phosphorodithioate) and other organophosphorus ester compounds are insecticides which inhibit acetylcholinesterase. Chemicals of this class cause signs of toxicity in mammals which are referable to acculmulation of acetylcholine at neuroeffector sites. A tolerance to this toxic action can be induced in experimental animals by giving multiple, sublethal doses of the compounds. There is strong evidence that disulfoton tolerance occurs because of a reduction in the sensitivity of tissues in the affected animals to acetylcholine.^ Experiments were designed to test the possibility that a decrease in the number of muscarinic cholinergic receptors could be downmodulating the sensitivity of tissues to acetylcholine. It was found that, concomitant with the onset of disulfoton tolerance, there was a decrease relative to control values in the specific binding of {('3)H} quinuclidinyl benzilate ({('3)H}QNB, a compound which selectively labels muscarinic cholinergic receptors) to homogenates of rat brain and ileal muscle. The decrease in {('3)H}QNB binding was due to a reduction in the density of muscarinic receptors. There was, however, no alteration in the binding of {('3)H} QNB, or the muscarinic agonists {('3)H} oxotremorine-M and oxotremorine to atria from disulfoton-tolerant rats. The possibility that cardiac tissue was not subsensitive to cholinergic agonists was ruled out in experiments testing the effect of the muscarinic agonist carbachol on heart rate in vivo, and the negative chronotropic effect of oxotremorine on atria from disulfoton-tolerant rats: a clear reduction in the sensitivity to cholinergic agonists was seen in each case. It was, therefore concluded that the specificity and temporal correlation of {('3)H}QNB binding decreases suggested that the loss of muscarinic receptors might play a role in modulating the sensitivity of several tissues to acetylcholine, but that other mechanisms also contribute to the tolerance phenomenon.^ Other experiments revealed that disulfoton tolerance, as measured by resistance to the lethal effects of carbachol, could be induced by feeding rats low levels of the organophosphorus ester in the diet. The concentration of disulfoton used inhibited acetylcholinesterase, but not to the extent that overt signs of toxicity were observed. These results suggested that tolerance to organophosphorus ester insecticides could be induced in rodents with a dosing scheme which more closely modeled the sort of low level exposures which would be expected in humans environmentally or occupationally in contact with these compounds. ^

CHOLINERGIC MODULATION OF THALAMIC INPUT INTO THE CINGULATE CORTEX

This research demonstrates cholinergic modulation of thalamic input into the limbic cortex. A projection from the mediodorsal thalamus (MD) to the anterior cingulate cortex was defined anatomically and physiologically. Injections of horse-radish peroxidase into the anterior cingulate cortex labels neurons in the lateral, parvocellular, region of MD. Electrical Stimulation of this area produces a complex field potential in the anterior cingulate cortex which was further characterized by current density analysis and single cell recordings.^ The monsynaptic component of the response was identified as a large negative field which is maximal in layer IV of the anterior cingulate cortex. This response shows remarkable tetanic potentiation of frequencies near 7 Hz. During a train of 50 or more stimuli, the response would grow quickly and remain at a fairly stable potentiated level throughout the train.^ Cholinergic modulation of this thalamic response was demonstrated by iontophoretic application of the cholinergic agonist carbachol decreased the effectiveness of the thalamic imput by rapidly attenuation the response during a train of stimuli. The effect was apparently mediated by muscarinic receptors since the effect of carbachol was blocked by atropine but not by hexamethonium.^ To determine the source of the cingulate cortex cholinergic innervation, lesions were made in the anterior and medial thalamus and in the nucleus of the diagonal band of Broca. The effects of these lesions on choline acetyltranferase activity in the cingulate cortex were determined by a micro-radio-enzymatical assay. Only the lesions of the nucleus of the diagonal band significantly decreased the choline acetyltransferase activity in the cingulate cortex regions. Therefore, the diagonal band appears to be a major source of sensory cholinergic innervation and may be involved in gating of sensory information from the thalamus into the limbic cortex. Attempts to modulate the cingulate response to MD stimulation with electrical stimulation of the diagonal band, however were not successful.^

INFLUENCE OF A CLINIC BASED IMMUNIZATION INFORMATION SYSTEM ON INFANT IMMUNIZATIONS

This study focuses on the impact of a clinic-based intervention program on the immunization status of limited-income urban children. The intervention program consisted of an information session for clinic health care providers and the placement of individualized immunization information labels on clinic notes at the time of each visit. The degree of impact of the intervention on immunization administration was ascertained through a comparison of two similar groups of infants born in the same months of the year immediately before (N = 201) and after (N = 203) the information session and initiation of the labeling system. The timeliness of administration of each diphtheria, pertussis, tetanus and trivalent oral polio vaccine (DPT/TOPV) in the first year series of three was compared pre- to postintervention. Significantly more third immunizations were given the postintervention subjects within ten days of the recommended time of application ( p = .0361). Life table analysis indicated that the probability of an infant's passing one year of age without the administration of the third immunization decreased for postintervention infants (p = .0515). The intervention was most successful in assuring administration of the series of immunizations in those infants who were seen by the health care provider for at least 50% of their first year visits. Results indicate that minor changes in the format of information given a relatively continuous provider can increase completion of immunization series in infants. ^

Labeling in the Classroom: Teacher Expectations and their Effects on Students' Academic Potential

The transition to high school can be challenging for some adolescents, resulting in drops of academic functioning (Barber & Olsen, 2004; Smith, 2006). While changes in academic demands and the disparity between adolescent needs and the environmental characteristics of high school have both been cited as possible contributors to this decrease in academic and personal functioning (Barber & Olsen, 2004), it is possible that teachers may play an even larger role in undermining these students’ functioning, specifically through labeling. Although labeling, and how it can lead to self-fulfilling prophesies, is a concept that has been thoroughly researched and applied to the field of criminology and deviant behavior, it is the goal of this current study to investigate if labeling also occurs in the classroom setting and how such labels ultimately effect the academic potential of high school students.

Assessment of markers of medication literacy in a US-Mexico border community

Each year an estimated 180,000 people in the United States (U.S.) die as a result of medication errors, now considered a major public health problem. If a patient cannot correctly act on information related to medication use or "Medication Literacy" there is an increased potential for error. Medication use issues are unique on the US-Mexico border because they include high rates of herbal products and medication products from Mexico as well as issues related to the preferred language (English or Spanish) of the patient. To evaluate the medication literacy in a US-Mexico border community, this retrospective study evaluates 180 subjects representing four diverse economic segments of a metropolitan US-Mexico Border community who have taken a Medication Literacy Assessment. The assessment tool has been created to understand how patients interpret medication information for prescription, over-the-counter, herbal, and Mexican medication product use, and how they problem-solve medication questions. The Medication Literacy Assessment tool specifically assesses document literacy (e.g., prescription labels), prose literacy (e.g., patient leaflets), numeracy (e.g., calculations and measurements) as well as qualitative data related to medication use practices. The main hypothesis of this study is that the ability to interpret and use medications will vary based on education, language (Spanish or English), and recruitment sites (economically diverse communities). The results will provide information to better characterize medication use in a primarily Hispanic population on the US-Mexico border and may be used to influence policy decisions regarding prescription and over-the-counter product information.^

A promotora de salud CVD intervention: Participant responses after Su Corazon, Su Vida education

In this study we sought to identify and understand feelings, benefits and barriers to making heart healthy behavioral changes by reviewing and analyzing participant responses to a follow-up telephone survey conducted as part of the HEART project (Health Education Awareness Research Team). Individuals who participated in HEART attended classes and received “Su Corazon, Su Vida” education. The HEART follow-up telephone survey was conducted only on those participants who were part of the experimental group. A total of 93 individuals from this group were successfully contacted for participation in the telephone survey after the classes ended. Quantitative data regarding ‘feelings’ and ‘difficulty making heart healthy behavioral changes’ were analyzed by calculating frequencies of each category of response for post-intervention weeks 9, 13, and 15. In addition, Wilcoxon rank-sum tests were conducted for post-intervention at weeks 9, 13, and 15 to measure associations between feelings and difficulties making heart healthy behavioral changes. Changes in responses over time for feelings and difficulties making heart healthy behavioral changes were looked at by counting differences in responses between pairs of follow up weeks. Qualitative responses to the survey were analyzed by categorizing content of responses under themes in order to identify factors related to feelings and difficulties making heart healthy behavioral changes. Telephone survey participants showed positive attitudes towards making nutritional and physical activity changes. Out of the 93 telephone survey respondents, 53 (57%) reported some type of physical activity change during the follow-up period while 46 (49%) reported specific changes in nutrition. Data from the “difficulty to making changes” responses were categorized under constructs from the Health Belief Model, perceived benefits and barriers. Overall, the barriers for physical activity were health issues, individual habits and time. Barriers to eating healthy were family support, individual habits, and knowledge. This study suggests that with respect to nutritional knowledge barriers, educational programs should explore other ways of teaching and familiarizing individuals with information sources that may be more appropriate for those populations not accustomed to them. For example, nutrition labels, portions, recipes, and use of photonovelas. Our findings of the barriers to changes in food preparation due to lack of family support may also suggest the need for the development of programs where influential partners or relatives are involved in order to create a more supportive environment which may provide more opportunity for change toward healthier lifestyle behaviors. Finally, the physical activity barriers found suggest that it may be beneficial to recommend appropriate exercises for those with specific health problems or those with time restrictions due to work or travel so that physical activity is not completely avoided.^

Legal regulation of the food industry as a public health measure

Background. The Food and Drug Administration (FDA) is an agency of the federal government that is responsible for monitoring and maintaining public health through the regulation of many industries, including food safety. Through the Nutrition Labeling and Education Act of 1990, the FDA was granted authority over the implementation and regulation of nutrition labeling on packaged foods. Many nutrients are printed on nutrition labels as well as their percent Daily Values. Research has been undertaken to examine the evidentiary basis the FDA relied upon in making its determinations regarding which nutrients to include on nutrition labels as well as their Daily Values. ^ Methods. Relevant legal policies, scientific studies, and other published literature (either in print or electronic form) were used to collect data. ^ Results. Results demonstrated that the FDA did not employ one single method in its determination of which nutrients to select for inclusion on food labels. The agency relied upon current public heath studies of that time as well as recommendations from the U.S. Surgeon General.^

Commentary on "Alternative Strategies for Identifying High-Performing Charter Schools in Texas"

In the last few years policy makers and practitioners nationally have shown much interest in identifying, recognizing, and replicating successful charter schools, many of which are showing that they can educate low-income and otherwise at-risk students remarkably well. However past efforts to identify high performing schools have been problematic. Using these systematic, rigorous value-added methods, the authors identify 44 Open Enrollment charter schools that merit a “high-performer” rating. Nearly all of those campuses identified serve a disadvantaged student population. The article also finds that most of those high performers are highly cost-effective, earning high ratings on the cost-efficiency measures. The authors argue for more widespread use of value-added modeling in the state accountability system. The approach taken to identifying high-performers is sensible and fair, but any formulaic approach to school labels comes with some limitations.

Menu labeling and food choice: A systematic review of the literature concerning the effects of menu labeling on consumer food choices

Objective: To review published literature on the impact of restaurant menu labeling on consumer food choices.^ Method: To examine all relevant studies published on the topic from 2002 to 2012.^ Results: Sixteen studies were identified as relevant and suitable for review. These studies comprised of one systematic review, one health impact assessment, and fourteen research studies conducted at restaurants, cafeterias, and laboratories. Three of ten studies conducted at restaurants and cafeterias and two of four studies conducted at laboratories found positive effects of menu labeling on consumer food choices. Conversely, the systematic review identified for this review found that five out of six studies resulted in weakly positive effects. The health impact assessment estimated positive effects; however, the results of this assessment must be cautiously interpreted since the authors used simulated data.^ Conclusion: Overall, there is insufficient evidence to provide support for the majority of the types of menu labels identified in this review on consumer food choice.^

Los adolescentes y los estigmas

En este trabajo se desarrolla el tema de los diagnósticos tempranos en los que se rotula a un niño como deficitario y de las dificultades de los adolescentes que llegan a esa etapa crítica de la vida portando algún “cartel" que los señala como un “sindrome" o un “trastorno de...". Este estigma suele dificultarles el rearmado narcisista, la relación con el grupo de pares y la salida exogámica. Se habla de la crisis adolescente y de los avatares particulares de la sexualidad en estos casos.

Diseño gráfico de etiquetas para envases de vino : definición de descriptores para un análisis de componentes sintácticas

Las gráficas de etiquetas para envases de vino son diseñadas a partir de características sintácticas, semánticas y pragmáticas. Este trabajo tiene por objetivos realizar una recopilación, clasificación, análisis y jerarquización de los componentes de la configuración de etiquetas de vino, y además, proveer un instrumento que permita un análisis de estas piezas gráficas, de manera individual, con carácter de sistema o en comparación. Podrá ser aplicado por los profesionales que diseñan etiquetas y envases, por docentes en el campo del diseño y en guías para el público usuario. (…) “los diseñadores nos convertimos en el nexo simbólico entre la calidad de los productos elaborados por nuestros clientes y la calidad de vida de aquéllos que los disfrutan. Somos los que preparamos la logística simbólica que explicita estéticamente lo que un buen vino necesita para llamar la atención. Se trata de crear la imagen que represente fielmente al conjunto de atributos del vino, y de resaltar visualmente esta red de placeres que están presentes en él. Sólo así se logra una relación de confianza con la marca". (Santiago Zemma, 2005).

Plotino y Nicolás de Cusa : Semejanzas y diferencias

La tradición ha reunido a Plotino y a Nicolás de Cusa en una misma corriente de pensamiento, al primero en tanto punto de partida y al segundo, acaso, como culminación. Más allá de las etiquetas historiográficas, intentaré establecer cuáles son aquellos aspectos del pensamiento de Plotino que persisten en el de Nicolás de Cusa a punto tal que permiten legítimamente entender en qué sentido ambos filósofos pueden ser denominados ?neoplatónicos?. Ciertamente, Plotino y Nicolás de Cusa difieren en núcleos doctrinales que pueden considerarse lo suficientemente relevantes como para negar la posibilidad de pensarlos miembros de una misma corriente y, a las diferencias entre sistemas, se agrega el hecho de que nada indica que Nicolás haya tenido contacto con la obra plotiniana. Sin embargo, ambos han reflexionado acerca de problemas similares y han brindado, cada uno a su modo y en su propia porción de tiempo, propuestas, en algunos casos, paralelas

Ecología y praxis ambiental : Una revisión de presupuestos

Esta tesis problematiza los vínculos entre las sociedades y sus entornos. "Ecología" y "Praxis Ambiental" constituyen dos polos en tensión. Son palabras que remiten a sistemas de entidades Ecología y Praxis Ambiental, lejos de constituirse desde una red semántica y simbólica afín, aparecen en las prácticas como términos muchas veces antagónicos. Vivimos en un mundo afectado por una crisis ambiental sin parangones producto de las intervenciones humanas en el contexto de las prácticas productivas capitalistas globalizadas. Esta tesis busca contrastar ciertas conceptualizaciones abstractas con los fenómenos concretos cuya contundencia se nos impone. Sigo un camino que parte de la revisión de la ecología como disciplina científica, su articulación (o no) con los movimientos ambientalista para, desde estos sitios de acción, investigación y movilización, avanzar sobre los temas que permanecen como problemas. Tomé como guía la problemática dualidad sobre la que se edificó el pensamiento y la praxis moderna: la escisión antagónica y excluyente entre sociedad y naturaleza, asociada a la idea del hombre como ser de máximo desarrollo, cuya cercanía a la razón permitía justificar su dominio sobre todo lo no-humano, fundamento de la evaluación de lo diferente en términos peyorativos. Exploro el modo en que "lo natural" se consideró como menos desarrollado, con potencialidades que sólo lograría en caso de estar dominado por un ser efectivamente desarrollado y adopto las revisiones en torno a conceptos claves como género, etnia y clase para discutir la noción de naturaleza que subyace en esa presunción de dominio. La metodología de estudio siguió algunas premisas. La primera de ellas es que la edificación de las ideas es un proceso eminentemente histórico. La segunda es que los conceptos, lejos de edificarse desde ejercicios abstractos, se constituyen en permanente vínculo con el plano de las prácticas. La tercera es que en el fondo de la red simbólica antes mencionada se encuentra el paternalismo como diferenciación fundamental. A modo de esquema general, las herramientas adoptadas para analizar escenarios y elaborar reflexiones pueden resumirse en los siguientes puntos:La indagación en las formas hegemónicas de discurso-dominio en la ecología científica. La apropiación de la perspectiva feminista como discurso contrahegemónico.La revisión de las formas específicas de dominio como clave reconstructiva.El análisis de las prácticas instituidas, en las prácticas científicas y las esferas de gobierno, a la luz de modos alternativos que implican el reconocimiento de prácticas sociales y saberes edificados desde la experiencia.A partir de remover la idea de naturaleza que subyace en las reflexiones problematizadas, impugno que la única organización social posible sea jerárquica. Desde aquí argumento en contra de uno de los principales argumentos totalitarios, la visión de los intereses de la naturaleza como opuestos a los humanos, destacando la necesidad de abandonar la dualidad para no llegar al consecuente incremento de formas opresivas. En el cierre desmonto el carácter construido de lo normal, desnaturalizo lo natural para repensarnos como seres humanos capaces de cambiar aquello que consideramos injusto.

El MST en Brasil y las organizaciones sociales kirchneristas en Argentina : Roles, identificación y relaciones dentro del conglomerado oficialista

En el marco de una investigación más amplia que examina en forma comparada los oficialismos de Lula en Brasil y de Kirchner en Argentina durante 2005-2006, el presente trabajo se propone estudiar, la relación que algunos movimientos sociales mantuvieron con el gobierno, como parte integral o como aliados del mismo, en el período consignado. En ese sentido, el Movimento dos Trabalhadores Rurais Sem Terra (MST), en Brasil, y organizaciones como la Federación Tierra y Vivienda (FTV), el Frente Transversal Nacional y Popular, el Movimiento Evita, y Libres del Sur, en Argentina, constituyen uno de los distintos sujetos de dos conjuntos oficialistas que difícilmente puedan ser caracterizados, como se hacía en el pasado, como "partido oficial" o "coaliciones de partidos". Los oficialismos en cuestión no sólo aglutinan en su seno a un conglomerado muy heterogéneo de actores políticos individuales y de dirigentes de múltiples fuerzas y sellos partidarios -con sus respectivas redes de poder territorial-, sino que incluyen también a estas organizaciones populares, protagonistas de históricos procesos de amplia movilización y lucha social. ¿Qué identidad reivindican esas organizaciones en su apoyo al gobierno? ¿Cómo conciben su propio rol dentro del oficialismo? ¿Cómo definen a ese conjunto al que pertenecen o se asocian? ¿Cuál es su relación con el presidente?

Social relations and power

This paper presents an explanatory typology of social relations which moves forward from those habitual and known by social disciplines, and labels the three types: actions - strategies - institutions . We set out to research characteristics, specificities, relevance of and differences between each type, as well as their interactions and interweaving, which make up the complexity of social relations. Moreover, mutual interdependence between the said social categories is established, which corresponds to a new conceptualization of power . This avoids traditional reductionism and rescues rarely taken-into-account capacities and determinations. The pair "social relations and power" makes up a necessary and indispensable framework to tackle the various problems of the social world.