Hin forna lögbók Islendínga sem nefnist Grágás. Codex juris Islandorum antiqvissimus, qvi nominatur Grágás.

Added t.-p., engraved.

Kvæði Eggerts Ólafssonar : útgefin eptir þeim beztu handritum er feingizt gátu."

Edited and published by E. Jónsson, Th. Sæmundsson, and S. Thorarensen.

Kloppstokks Messías, einn hetju-diktr um endrlausnina,

Called 1-20 bók.

Human geography /

Cover-title.

Platons ausgewählte schriften : für den schulgebrauch /

v.1 Apology, Crito ed Cron, 1888;--v.2 Gorgias, ed. Deuschle 1886;--v.3 Laches, Euthyphro, ed. Cron, 1882;--v.4 Protagoras ed. Deuschle, 1884;--v.5 Symposium ed. Arnold Hug, 1884;--v.6 Phaedo, ed. Martinus Wohlrab, 1884;--v.7 Republic bk. 1 ed. Wohlrab, 1893.

Geschiedenis der Middennederlandsche dichtkunst.

CONTENTS: 1. deel. Voorbericht. Naamlijst van inteekenaren. Inleiding. 1. bk. Oudste volkspoëzie. 2. bk. Aanvang der ridderpoëzie.--2. deel. 3. bk. Bloei der ridderpoëzie. 4. bk. Verval der ridderpoëzie.--3. deel. 5. bk. Burgerlijke poëzie. 6. bk. Poëtische terugwerking. 7. bk. Lyrische en dramatische poëzie. Bijlagen. Uittreksels uit de ms. rekeningen der graven van Holland en van Bloys, berustende op hets Rijks archief te's Hage.

The Elson readers / by William H. Elson.

Primer. Revised edition of Elson-Runkel primer.--Bks.1-4. Revision of Elson primary school reader, books one to four.--Bks.5-6. Revision of Elson grammar school reader, books one to two.--Bk.7. Revision of junior high school literature, book one.

Muriel Sterling : a tale of the African veldt /

Wright, L.H. Amer. fiction, 1876-1900,

The works of Francis Rabelais, M.D.

Classified for chess, bk. 5, ch. 25-26.

A text book of physiology /

Includes indexes.

Die syntaktischen verhältnisse des Suaheli ...

Inaug.-diss.--Leipzig.

Population trends in Wisconsin urbanized areas and other cities of over 10,000, 1970-1975 /

WI docs no.: Adm.3/2:P 6/4

Epstein-Barr virus-mediated protection against etoposide-induced apoptosis in BJA-B B cell lymphoma cells: role of Bcl-2 and caspase proteins

Epstein-Barr virus (EBV)-infected B cell lymphomas are resistant to apoptosis during cancer development and treatment with therapies. The molecular controls that determine why EBV infection causes apoptosis resistance need further definition. EBV-positive and EBV-negative BJA-B B cell lymphoma cell lines were used to compare the expression of selected apoptosis-regulating Bcl-2 and caspase proteins in EBV-related apoptosis resistance, after 8 hr or 18-24 hr etoposide treatment (80 muM). Apoptosis was quantified using morphology and verified with Hoechst 33258 nuclear stain and electron microscopy. Fluorescence activated cell sorting (FACS) was used to analyse effects on cell cycle of the EBV infection as well as etoposide treatment. Anti-apoptotic Bcl-2 and Bcl-XL, pro-apoptotic Bax, caspase-3 and caspase-9 expression and activation were analysed using Western immunoblots and densitometry. EBV-positive cultures had significantly lower levels of apoptosis in untreated and etoposide-treated cultures in comparison with EBV-negative cultures (p < 0.05). FACS analysis indicated a strong G2/M block in both cell sublines after etoposide treatment. Endogenous Bcl-2 was minimal in the EBV-negative cells in comparison with strong expression in EBV-positive cells. These levels did not alter with etoposide treatment. Bcl-XL was expressed endogenously in both cell lines and had reduced expression in EBV-negative cells after etoposide treatment. Bax showed no etoposide-induced alterations in expression. Pro-caspase-9 and -3 were seen in both EBV-positive and -negative cells. Etoposide induced cleavage of caspase-9 in both cell lines, with the EBV-positive cells having proportionally less cleavage product, in agreement with their lower levels of apoptosis. Caspase-3 cleavage occurred in the EBV-negative etoposide-treated cells but not in the EBV-positive cells. The results indicate that apoptosis resistance in EBV-infected B cell lymphomas is promoted by an inactive caspase-3 pathway and elevated expression of Bcl-2 that is not altered by etoposide drug treatment.

Transfer of resistance training to enhance rapid coordinated force production by older adults

The purpose of this study was to examine the capacity of resistance training to enhance the rapid and coordinated production of force by older people. Thirty adults (greater than or equal to 60 years) completed a visually guided aiming task that required the generation of isometric torque in 2 df about the elbow prior to and following a 4-week training period. Groups of six participants were allocated to two progressive ( 40 - 100% maximal voluntary contraction (MVC)) resistance-training (PRT) groups, to two constant low-load (10% MVC) training groups (CLO) and to one no-training control group. Training movements required the generation of either combined flexion and supination (FLESUP), or combined extension and supination (EXTSUP). In response to training, target acquisition times in the aiming task decreased for all groups; however, both the nature of the training load and the training movement influenced the pattern and magnitude of improvements (EXTSUP_ CLO: 36%, FLESUP_ PRT 26%, EXTSUP_ PRT 22%, FLESUP_ CLO 20%, CONTROL 15%). For one group that trained with progressively increasing loads, there arose a subsequent decrease in performance in one condition of the transfer task. For each group, these adaptations were accompanied by systematic changes in the coordination of muscles about the elbow joint, particularly the biceps brachii.

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70

The high-affinity ligand-binding form of unactivated steroid receptors exists as a multicomponent complex that includes heat shock protein (Hsp)90; one of the immunophilins cyclophilin 40 (CyP40), FKBP51, or FKBP52; and an additional p23 protein component. Assembly of this heterocomplex is mediated by Hsp70 in association with accessory chaperones Hsp40, Hip, and Hop. A conserved structural element incorporating a tetratricopeptide repeat (TPR) domain mediates the interaction of the immunophilins with Hsp90 by accommodating the C-terminal EEVD peptide of the chaperone through a network of electrostatic and hydrophobic interactions. TPR cochaperones recognize the EEVD structural motif common to both Hsp90 and Hsp70 through a highly conserved clamp domain. In the present study, we investigated in vitro the molecular interactions between CyP40 and FKBP52 and other stress-related components involved in steroid receptor assembly, namely Hsp70 and Hop. Using a binding protein-retention assay with CyP40 fused to glutathione S-transferase immobilized on glutathione-agarose, we have identified the constitutively expressed form of Hsp70, heat shock cognate (Hsc)70, as an additional target for CyP40. Deletion mapping studies showed the binding determinants to be similar to those for CyP40-Hsp90 interaction. Furthermore, a mutational analysis of CyP40 clamp domain residues confirmed the importance of this motif in CyP40-Hsc70 interaction. Additional residues thought to mediate binding specificity through hydrophobic interactions were also important for Hsc70 recognition. CyP40 was shown to have a preference for Hsp90 over Hsc70. Surprisingly, FKBP52 was unable to compete with CyP40 for Hsc70 binding, suggesting that FKBP52 discriminates between the TPR cochaperone-binding sites in Hsp90 and Hsp70. Hop, which contains multiple units of the TPR motif, was shown to be a direct competitor with CyP40 for Hsc70 binding. Similar to Hop, CyP40 was shown not to influence the adenosine triphosphatase activity of Hsc70. Our results suggest that CyP40 may have a modulating role in Hsc70 as well as Hsp90 cellular function.