Audit report on Henry County, Iowa for the year ended June 30, 2014

Audit report on Henry County, Iowa for the year ended June 30, 2014

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.

Journal of the House of Representatives, 1842-1845

The published daily journals of the transactions of the House of Representatives for the current legislative session and the official bound journals printed after adjournment for previous legislative sessions. Four consecutive volumes bound as one.

Journal of the Council [Currently known as the Senate Journal], 1839-1842

The published daily journals of the transactions of the Senate for the current legislative session and the official bound journals printed after adjournment for previous legislative sessions.