1000 resultados para Vacinas contra Papillomavirus


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The aim of this article is to analyze accurately the role played by two classical references, Venus and Oedipus, in Tennessee Williams¿s Suddenly Last Summer, in accordance with the usual nature of studies on Classical Tradition ¿Greek and Roman- and focusing in this case on the relationship between literature and mythology. It is thanks to Venus and Oedipus that the playwright succeeds in showing the magnitude of men¿s and women¿s tragedy, which from his point of view is simply that they have failed to see either kindness in the face of God or to feel his loving and fatherly providence.

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The aim of this article is to analyze accurately the role played by two classical references, Venus and Oedipus, in Tennessee Williams's Suddenly Last Summer, in accordance with the usual nature of studies on Classical Tradition -Greek and Roman- and focusing in this case on the relationship between literature and mythology. It is thanks to Venus and Oedipus that the playwright succeeds in showing the magnitude of men¿s and women¿s tragedy, which from his point of view is simply that they have failed to see either kindness in the face of God or to feel his loving and fatherly providence.

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There is growing interest in understanding the role of the non-injured contra-lateral hemisphere in stroke recovery. In the experimental field, histological evidence has been reported that structural changes occur in the contra-lateral connectivity and circuits during stroke recovery. In humans, some recent imaging studies indicated that contra-lateral sub-cortical pathways and functional and structural cortical networks are remodeling, after stroke. Structural changes in the contra-lateral networks, however, have never been correlated to clinical recovery in patients. To determine the importance of the contra-lateral structural changes in post-stroke recovery, we selected a population of patients with motor deficits after stroke affecting the motor cortex and/or sub-cortical motor white matter. We explored i) the presence of Generalized Fractional Anisotropy (GFA) changes indicating structural alterations in the motor network of patientsâeuro? contra-lateral hemisphere as well as their longitudinal evolution ii) the correlation of GFA changes with patientsâeuro? clinical scores, stroke size and demographics data iii) and a predictive model.

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Harassment is illegal in all areas protected by Iowa Code Chapter 216. This includes education, employment, public accommodations, credit and housing. Acts of harassment take place every day in schools across the country. Frequently these acts, even if reported to administration, are dismissed as harmless, as "kids will be kids," or as "no big deal." Many people do not realize that harassment that interferes with a person's educational progress is illegal, just as it is illegal in the workplace.

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Cervical cancer results from infection with high-risk type human papillomaviruses (HPV). Therapeutic vaccines aiming at controlling existing genital HPV infections and associated lesions are usually tested in mice with HPV-expressing tumor cells subcutaneously implanted into their flank. However, effective vaccine-induced regression of these ectopic tumors strongly contrasts with the poor clinical results of these vaccines produced in patients with HPV-associated genital neoplasia. To assess HPV therapeutic vaccines in a more relevant setting, we have, here, established an orthotopic mouse model where tumors in the genital mucosa (GM) develop after an intravaginal instillation of HPV16 E6/E7-expressing tumor cells transduced with a luciferase-encoding lentiviral vector for in vivo imaging of tumor growth. Tumor take was 80-90% after nonoxynol-9 induced damage of the epithelium. Tumors remained localized in the genital tract, and histological analysis showed that most tumors grew within the squamous epithelium of the vaginal wall. Those tumors induced (i) E7-specific CD8 T cells restricted to the GM and draining lymph nodes, in agreement with their mucosal location and (ii) high Foxp3+ CD4+ infiltrates, similarly to those found in natural non-regressing HPV lesions. This novel genital HPV-tumor model by requiring GM homing of vaccine-induced immune responses able to overcome local immuno-suppression may be more representative of the situation occurring in patients upon therapeutic vaccination.

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Este artigo baseia-se em uma série de idéias e conceitos desenvolvidos pelo sociólogo britânico Basil Bernstein para analisar os desafios e as mudanças enfrentados recentemente por indivíduos com ocupações profissionais, inclusive os das áreas de ensino e pesquisa na educação superior. O artigo discute e procura desenvolver a análise de Bernstein sobre como estruturas particulares do conhecimento podem estar relacionadas com a formação de identidades ocupacionais, centradas naquilo a que o autor se refere como "interioridade" e "dedicação interna". A seguir, examina a gama de desafios para essas identidades, em especial aqueles que surgem da "regionalização" do conhecimento e do "genericismo". Na conclusão, avalia as perspectivas de perpetuação dessas identidades em uma era de crescente mercantilização e gerencialismo.

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O artigo ambiciona colocar em causa a proliferação discursiva contemporânea em torno das condutas do alunado tidas como indisciplinadas, situando-a, em diálogo com a conceituação foucaultiana, no interior de um quadro socio-histórico e institucional atravessado por demandas multiformes de governamento dos sujeitos escolares. Para tanto, o texto oferece primeiramente uma configuração preliminar da produção acadêmica brasileira sobre a temática disciplinar nas últimas três décadas, bem como problematiza os nortes teórico-metodológicos da investigação voltada ao âmbito (contra)normativo do cotidiano escolar. Em seguida, apresenta os resultados de uma investigação baseada nos registros das ocorrências disciplinares que tomaram lugar no ensino médio de uma escola pública na cidade de São Paulo, num intervalo de cinco anos (2003-2007). Por fim, opera algumas aproximações analíticas do problema, apontando que se as queixas disciplinares parecem ser, num primeiro momento, solidárias a uma espécie de esgarçadura do modus operandi escolar clássico, num segundo momento, elas passam a apontar para a irrupção de modos sutis de controle das condutas não apenas discentes, mas também dos profissionais, de modo consoante aos processos de governamentalização em ação na contemporaneidade.

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The genotyping of human papillomaviruses (HPV) is essential for the surveillance of HPV vaccines. We describe and validate a low-cost PGMY-based PCR assay (PGMY-CHUV) for the genotyping of 31 HPV by reverse blotting hybridization (RBH). Genotype-specific detection limits were 50 to 500 genome equivalents per reaction. RBH was 100% specific and 98.61% sensitive using DNA sequencing as the gold standard (n = 1,024 samples). PGMY-CHUV was compared to the validated and commercially available linear array (Roche) on 200 samples. Both assays identified the same positive (n = 182) and negative samples (n = 18). Seventy-six percent of the positives were fully concordant after restricting the comparison to the 28 genotypes shared by both assays. At the genotypic level, agreement was 83% (285/344 genotype-sample combinations; κ of 0.987 for single infections and 0.853 for multiple infections). Fifty-seven of the 59 discordant cases were associated with multiple infections and with the weakest genotypes within each sample (P < 0.0001). PGMY-CHUV was significantly more sensitive for HPV56 (P = 0.0026) and could unambiguously identify HPV52 in mixed infections. PGMY-CHUV was reproducible on repeat testing (n = 275 samples; 392 genotype-sample combinations; κ of 0.933) involving different reagents lots and different technicians. Discordant results (n = 47) were significantly associated with the weakest genotypes in samples with multiple infections (P < 0.0001). Successful participation in proficiency testing also supported the robustness of this assay. The PGMY-CHUV reagent costs were estimated at $2.40 per sample using the least expensive yet proficient genotyping algorithm that also included quality control. This assay may be used in low-resource laboratories that have sufficient manpower and PCR expertise.

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Los malos estudiantes de historia se lamentan de tener que leer y digerir las opiniones de diversos autores. Estas opiniones son en muchos casos divergentes o contradictorias y una de las primeras funciones de los estudios históricos y de los manuales de historia debería ser hacerles comprender el porqué de esta situación. Diversas personas llegan a diversas conclusiones a partir de los mismos hechos históricos porque, sencillamente, cada uno de nosotros es único y ve el mundo que le rodea de manera diferente. ¿Es difícil, entonces, llegar a conclusiones de tipo histórico? ¿Es difícil escribir historia?

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We performed an international proficiency study of Human Papillomavirus (HPV) type 16 serology. A common methodology for serology based on virus-like particle (VLP) ELISA was used by 10 laboratories in 6 continents. The laboratories used the same VLP reference reagent, which was selected as the most stable, sensitive and specific VLP preparation out of VLPs donated from 5 different sources. A blinded proficiency panel consisting of 52 serum samples from women with PCR-verified HPV 16-infection, 11 control serum samples from virginal women and the WHO HPV 16 International Standard (IS) serum were distributed. The mean plus 3 standard deviations of the negative control serum samples was the most generally useful "cut-off" criterion for distinguishing positive and negative samples. Using sensitivity of at least 50% and a specificity of 100% as proficiency criteria, 6/10 laboratories were proficient. In conclusion, an international Standard Operating Procedure for HPV serology, an international reporting system in International Units (IU) and a common "cut-off" criterion have been evaluated in an international HPV serology proficiency study.

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[La cité de Dieu (latin). 1467]

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Les reflexions que volem fer aquí sobre les activitats d'animació de la lectura tenen el seu origen en l'experiència pròpia de la biblioteca pública de Can Sumarro, però també en les converses informals tingudes esporàdicament sobre aquest tema amb altres persones, professionals de la biblioteca pública igualment. Això no vol dir que les tesis exposades siguin compartides per aquestes persones, sinó simplement que es tracta d'un tema quotidià i d'un cert interès general. Com a mínim així ho esperem.